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Article ; Online: Current recommendations for endovascular interventions in the treatment of ischemic stroke.

Appelboom, Geoffrey / Strozyk, Dorothea / Meyers, Philip M / Higashida, Randall T

2010 Volume 12, Issue 4, Page(s) 244–250

Abstract: Ischemic stroke remains one of the leading cause of adult death and disability in the United States. Reperfusion of the occluded vessel is the standard of care in the setting of acute ischemic stroke according to established guidelines. Since the ... ...

Abstract	Ischemic stroke remains one of the leading cause of adult death and disability in the United States. Reperfusion of the occluded vessel is the standard of care in the setting of acute ischemic stroke according to established guidelines. Since the introduction of intravenous (IV) recombinant tissue plasminogen activator (rt-PA) in the late 1990s, significant advances have been made in methods to deliver thrombolytic agents and in devices for mechanical recanalization of occluded vessels. Furthermore, improvements in patient selection contribute to achievement of good clinical outcomes after endovascular therapy. This article summarizes findings from recent clinical trials and presents evidence-based guidelines for endovascular interventions in the treatment of ischemic stroke.
MeSH term(s)	Adult ; Brain Ischemia/complications ; Brain Ischemia/therapy ; Clinical Trials as Topic ; Fibrinolytic Agents/administration & dosage ; Humans ; Patient Selection ; Reperfusion/methods ; Stroke/etiology ; Stroke/therapy ; Thrombectomy ; Tissue Plasminogen Activator/administration & dosage
Chemical Substances	Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2010-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2057369-8
ISSN	1534-6242 ; 1523-3804
ISSN (online)	1534-6242
ISSN	1523-3804
DOI	10.1007/s11883-010-0115-6
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Article ; Online: Yeast as a model system for identification of metabolic targets of a 'glucosamine complex' used as a therapeutic agent of osteoarthritis.

Dillemans, Monique / Appelboom, Thierry / Van Nedervelde, Laurence

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2008 Volume 62, Issue 9, Page(s) 645–650

Abstract: This manuscript describes the effect of a glucosamine complex and its different constituents on the metabolism of yeast cells. Indeed, the yeast model biosystem offers important advantages in the understanding of basic cellular and molecular processes. ... ...

Abstract	This manuscript describes the effect of a glucosamine complex and its different constituents on the metabolism of yeast cells. Indeed, the yeast model biosystem offers important advantages in the understanding of basic cellular and molecular processes. For example, the possibility to differentiate aerobic and anaerobic metabolism allows the measurement of glycolysis and mitochondria importance in the control of energetic metabolism and stress-responsive. Yeast growth and division can be controlled efficiently and effectively by adjusting environmental conditions that mimic some aspect of those experienced by chondrocytes in an osteoarthritic milieu, such as low oxygen and nutriment availabilities, high oxidative stress, etc. The glucosamine complex or some of its components (glucosamine sulphate, MSM, Ribes nigrum and silicon) enhanced cellular proliferation and CO(2) production of yeast cells cultured under severe conditions. In addition, it allows a larger output of protons from the cells into the medium. Glucosamine complex supplementation also boosted cellular resistance to stresses such as heat shock, H(2)O(2)-induced peroxidation and ethanol. The beneficial effects of the complex were primarily due to R. nigrum and to glucosamine sulphate components. The protective effect of the glucosamine complex can be explained by an increase of cellular energy level through intensification of mitochondrial functionality and intracellular machinery (anaerobic glycolysis). An additional effect on protein kinase activation is not unlikely.
MeSH term(s)	Carbon Dioxide/metabolism ; Cell Proliferation/drug effects ; Culture Media ; Dimethyl Sulfoxide/pharmacology ; Ethanol/pharmacology ; Glucosamine/pharmacology ; Glucosamine/therapeutic use ; Heat-Shock Response ; Hydrogen Peroxide/pharmacology ; Hydrogen-Ion Concentration ; Osteoarthritis/drug therapy ; Oxidative Stress ; Plant Extracts/pharmacology ; Ribes ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/metabolism ; Silicon/pharmacology ; Sulfones/pharmacology
Chemical Substances	Culture Media ; Plant Extracts ; Sulfones ; Carbon Dioxide (142M471B3J) ; Ethanol (3K9958V90M) ; dimethyl sulfone (9H4PO4Z4FT) ; Hydrogen Peroxide (BBX060AN9V) ; Glucosamine (N08U5BOQ1K) ; Dimethyl Sulfoxide (YOW8V9698H) ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2008-11
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2008.06.032
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Article: A history of vision screening.

Appelboom, T M

The Journal of school health

1985 Volume 55, Issue 4, Page(s) 138–141

Abstract: The vision screening program has a long and interesting history involving educators, pediatricians, optometrists, and ophthalmologists. Since, the earliest screening program initiated in 1899, many alterations in the original program have resulted from ... ...

Abstract	The vision screening program has a long and interesting history involving educators, pediatricians, optometrists, and ophthalmologists. Since, the earliest screening program initiated in 1899, many alterations in the original program have resulted from consideration of test reliability, testing conditions, and child maturity. Indeed, even the basic concept of vision screening had to be proven beneficial before it was widely accepted. The three basic areas of the exam - visual acuity, hyperopia, and heterophoria - developed independently into a concise, thorough screening system. Minor controversies continue, causing continuing modification and improvement.
MeSH term(s)	Amblyopia/diagnosis ; Child ; Child, Preschool ; History, 20th Century ; Humans ; Hyperopia/diagnosis ; Refractive Errors/diagnosis ; School Health Services/history ; United States ; Vision Tests/methods ; Visual Acuity
Language	English
Publishing date	1985-04
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	952835-0
ISSN	1746-1561 ; 0022-4391
ISSN (online)	1746-1561
ISSN	0022-4391
DOI	10.1111/j.1746-1561.1985.tb04102.x
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Article: Effects of Site Preparation for Pine Forest/Switchgrass Intercropping on Water Quality.

Muwamba, A / Amatya, D M / Ssegane, H / Chescheir, G M / Appelboom, T / Tollner, E W / Nettles, J E / Youssef, M A / Birgand, F / Skaggs, R W / Tian, S

Journal of environmental quality

2015 Volume 44, Issue 4, Page(s) 1263–1272

Abstract: A study was initiated to investigate the sustainability effects of intercropping switchgrass ( L.) in a loblolly pine ( L.) plantation. This forest-based biofuel system could possibly provide biomass from the perennial energy grass while maintaining the ... ...

Abstract	A study was initiated to investigate the sustainability effects of intercropping switchgrass ( L.) in a loblolly pine ( L.) plantation. This forest-based biofuel system could possibly provide biomass from the perennial energy grass while maintaining the economics and environmental benefits of a forest managed for sawtimber. Operations necessary for successful switchgrass establishment and growth, such as site preparation, planting, fertilizing, mowing and baling, may affect hydrology and nutrient runoff. The objectives of this study were (i) to characterize the temporal effects of management on nutrient concentrations and loadings and (ii) to use pretreatment data to predict those treatment effects. The study watersheds (∼25 ha each) in the North Carolina Atlantic Coastal Plain were a pine/switchgrass intercropped site (D1), a midrotation thinned pine site with natural understory (D2), and a switchgrass-only site (D3). Rainfall, drainage, water table elevation, nitrogen (total Kjedahl N, NH-N, and NO-N), and phosphate were monitored for the 2007-2008 pretreatment and the 2009-2012 treatment periods. From 2010 to 2011 in site D1, the average NO-N concentration effects decreased from 0.18 to -0.09 mg L, and loads effects decreased from 0.86 to 0.49 kg ha. During the same period in site D3, the average NO-N concentration effects increased from 0.03 to 0.09 mg L, and loads effects increased from -0.26 to 1.24 kg ha. This study shows the importance of considering water quality effects associated with intensive management operations required for switchgrass establishment or other novel forest-based biofuel systems.
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	120525-0
ISSN	1537-2537 ; 0047-2425
ISSN (online)	1537-2537
ISSN	0047-2425
DOI	10.2134/jeq2014.11.0505
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Article: Comparative efficacy and safety of two different molecular weight (MW) hyaluronans F60027 and Hylan G-F20 in symptomatic osteoarthritis of the knee (KOA). Results of a non inferiority, prospective, randomized, controlled trial.

Maheu, E / Zaim, M / Appelboom, T / Jeka, S / Trc, T / Berenbaum, F / Maasalu, K

Clinical and experimental rheumatology

2011 Volume 29, Issue 3, Page(s) 527–535

Abstract: Objectives: To compare the efficacy and safety of a 'medium' molecular weight (MW) hyaluronan product (F60027, Structovial) with a 'high' MW (Hylan G-F20, Synvisc).: Methods: Prospective, randomised, multicentre, double-blind, active controlled, ... ...

Abstract	Objectives: To compare the efficacy and safety of a 'medium' molecular weight (MW) hyaluronan product (F60027, Structovial) with a 'high' MW (Hylan G-F20, Synvisc). Methods: Prospective, randomised, multicentre, double-blind, active controlled, parallel-group study with a non-inferiority design. Patients with symptomatic KOA, global pain ≥ 40 mm (VAS, 0-100), Lequesne index (LFI, 0-24) score >7 and radiological Kellgren-Lawrence grade 2/3 were centrally randomised to receive F60027 or Hylan G-F20, administered via three weekly injections, with regular follow-up evaluations up to week 24 (W24). The primary outcome was LFI score change over 24 weeks. Secondary outcomes comprised pain VAS, quality of life, patient's and physician's global assessments, rescue medication consumption and OMERACT-OARSI responders rate. Results: 276 patients were analysed in the full analysis dataset (FAS), 236 in the Per Protocol dataset (PP). In the main efficacy analysis (PP), the difference of the LFI score change over 24 weeks between F60027 (-4.67 (0.27)) and Hylan G-F20 (-4.54 (0.28)) was 0.132 [95%CI: -0.598, 0.861] which met the predefined non-inferiority margin. Analyses of secondary efficacy criteria showed clinically relevant improvements of all outcomes at W24 for each treatment on both PP/FAS populations. Changes of LFI score between baseline and W24 were -5.73 in the F60027 and -5.57 in the Hylan G-F20 group (PP dataset). Few local reactions were reported: 3.6% of patients in each group. Conclusions: F60027 and Hylan G-F20 were equally effective in reducing functional impairment and relieving pain in KOA patients, and well-tolerated.
MeSH term(s)	Aged ; Double-Blind Method ; Female ; Humans ; Hyaluronic Acid/administration & dosage ; Hyaluronic Acid/adverse effects ; Hyaluronic Acid/analogs & derivatives ; Hyaluronic Acid/therapeutic use ; Injections, Intra-Articular ; Male ; Middle Aged ; Molecular Weight ; Osteoarthritis, Knee/drug therapy ; Outcome Assessment (Health Care) ; Patient Satisfaction ; Prospective Studies ; Quality of Life ; Treatment Outcome
Chemical Substances	hylan (125935-84-4) ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2011-05
Publishing country	Italy
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article: Temperature Coefficient for Modeling Denitrification in Surface Water Sediments Using the Mass Transfer Coefficient

Appelboom, T.W / Chescheir, G.M / Birgand, F / Skaggs, R.W / Gilliam, J.W / Amatya, D

Transactions of the ASABE. 2010 Mar-Apr, v. 53, no. 2

2010

Abstract: Watershed modeling has become an important tool for researchers. Modeling nitrate transport within drainage networks requires quantifying the denitrification within the sediments in canals and streams. In a previous study, several of the authors ... ...

Abstract	Watershed modeling has become an important tool for researchers. Modeling nitrate transport within drainage networks requires quantifying the denitrification within the sediments in canals and streams. In a previous study, several of the authors developed an equation using a term called a mass transfer coefficient to mathematically describe sediment denitrification. This equation takes into account the effect that water column nitrate concentration and flow depth have on denitrification in the sediments. Water column temperature also has a marked effect on the rate of denitrification in the sediments. In the present study, a relationship between denitrification rate and temperature was developed. This relationship was inserted into the original mathematical relationship to improve its ability to predict nitrate removal due to denitrification within drainage networks. The modified equation was tested by comparing predicted and measured nitrate concentrations over time in denitrification tanks at various temperatures. Results show that the modified equation increased the accuracy of predicting nitrate removal by denitrification in drainage canals. Overall Nash-Sutcliffe model efficiency values ranged from 0.72 to 0.76 for the original equation and from 0.90 to 0.97 for the equation developed in this study. The effective temperature range for the equation is 0°C to 4°C. The equation has also only been tested under stagnant/low-flow conditions.
Keywords	surface water ; sediments ; denitrification ; denitrifying microorganisms ; water temperature ; mathematical models ; simulation models ; mass transfer ; watersheds ; pollution load ; water pollution
Language	English
Dates of publication	2010-03
Size	p. 465-474.
Document type	Article
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Article: Sympathetic nerve blocks in refractory sympathetic dystrophy syndrome.

Hennart, D / Leon, M / Sylin, P / Appelboom, T

Acta orthopaedica Belgica

1999 Volume 65, Issue 1, Page(s) 83–85

Abstract: The authors tried to evaluate the benefit of sympathetic nerve blocks with guanethidine in 32 patients with a sympathetic dystrophy syndrome who failed to respond to conventional treatment. ...

Abstract	The authors tried to evaluate the benefit of sympathetic nerve blocks with guanethidine in 32 patients with a sympathetic dystrophy syndrome who failed to respond to conventional treatment.
MeSH term(s)	Autonomic Nerve Block ; Guanethidine/administration & dosage ; Guanethidine/therapeutic use ; Humans ; Pain Management ; Reflex Sympathetic Dystrophy/therapy ; Sympatholytics/administration & dosage ; Sympatholytics/therapeutic use ; Treatment Outcome
Chemical Substances	Sympatholytics ; Guanethidine (ZTI6C33Q2Q)
Language	English
Publishing date	1999-03
Publishing country	Belgium
Document type	Clinical Trial ; Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
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Article: Was the gastric ulcer due to cytomegalovirus?

Golstein, M / Appelboom, T / Gangji, V

Clinical rheumatology

1997 Volume 16, Issue 1, Page(s) 107–108

MeSH term(s)	Biopsy ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Female ; Gastroscopy ; Humans ; Middle Aged ; Stomach Ulcer/diagnosis ; Stomach Ulcer/etiology ; Stomach Ulcer/virology
Language	English
Publishing date	1997-01
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	604755-5
ISSN	0770-3198
ISSN	0770-3198
DOI	10.1007/bf02238775
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Article: Nitrogen Balance for a Plantation Forest Drainage Canal on the North Carolina Coastal Plain

Appelboom, T.W / Chescheir, G.M / Skaggs, R.W / Gilliam, J.W / Amatya, D.M

Transactions of the ASABE. 2008 July-Aug, v. 51, no. 4

2008

Abstract: ... outputs, and inferred in-stream processes responsible for nitrogen transformations and removal in a 1900 m ...

Abstract	Human alteration of the nitrogen cycle has led to increased riverine nitrogen loads, contributing to the eutrophication of lakes, streams, estuaries, and near-coastal oceans. These riverine nitrogen loads are usually less than the total nitrogen inputs to the system, indicating nitrogen removal during transport through the drainage network. A two-year monitoring study quantified the ammonium, nitrate, and organic-N inputs, outputs, and inferred in-stream processes responsible for nitrogen transformations and removal in a 1900 m reach of a drainage canal located in a managed pine plantation. Total nitrogen inputs to the canal section were 527.8 kg in 2001 and 1422.7 kg in 2002. Total nitrogen discharge at the outlet was 502 kg in 2001 and 1458 kg in 2002. The mass balance of nitrogen inputs and outputs indicated a loss of 25.8 kg (5.1%) of total nitrogen from the system in 2001, and a gain of 35.3 kg (2.4%) of total nitrogen to the system in 2002. Variability in the input and output estimates was high, especially for groundwater exchange. Different hydrologic and nitrogen inputs and outputs were identified and quantified, but measurement variability obscured any potential nitrogen removal from the system.
Keywords	forest plantations ; Pinus ; drainage channels ; losses from soil ; forest soils ; ammonium nitrogen ; nitrate nitrogen ; organic nitrogen compounds ; nitrogen ; drainage ; drainage water ; streams ; hydrochemistry ; water quality ; balance studies ; coastal plains ; groundwater ; base flow ; storms ; North Carolina
Language	English
Dates of publication	2008-07
Size	p. 1215-1233.
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Article: Estimating Nitrogen, Phosphorus, and Carbon Fluxes in Forested and Mixed-Use Watersheds of the Lower Coastal Plain of North Carolina: Uncertainties Associated with Infrequent Sampling

Birgand, F / Appelboom, T.W / Chescheir, G.M / Skaggs, R.W

Transactions of the ASABE. 2011 , v. 54, no. 6

2011

Abstract: Assessing the impact of a land use change or the water quality improvement provided by a treatment system almost always involves computation of the difference in nutrient loads before and after implementation, or upstream and downstream of the system ... ...

Abstract	Assessing the impact of a land use change or the water quality improvement provided by a treatment system almost always involves computation of the difference in nutrient loads before and after implementation, or upstream and downstream of the system studied. Reporting meaningful values on mass balance or differences in nutrient loads implies that the uncertainty in the computed loads is several times smaller than the difference itself. This may imply very small uncertainties for the nutrient load measurements. The level of uncertainty induced by infrequent sampling on annual loads was investigated for a suite of nutrients in runoff from a forested watershed and a mixed land use watershed in the lower coastal plain of North Carolina. Reference data were used to simulate discrete sampling and to calculate new annual load estimators, which were then compared to the reference loads to calculate the level of uncertainty. Uncertainties depended on the watershed and the nutrients and other constituents, but their level was generally found to be high, around +/-20% and +/-40% or more for weekly and monthly sampling for most nutrients. This was generally attributed to the short periods of active flow in these watersheds and the flashiness of flow associated with subsurface drainage. The results suggest that to obtain uncertainties of +/-2% or +/-5% for nitrogen forms, 100 or more than 200 samples over six months of the year might be necessary in the forested and mixed-use watersheds of the lower coastal plain.
Keywords	carbon ; coastal plains ; forested watersheds ; land use change ; nitrogen ; nutrients ; phosphorus ; pollution load ; runoff ; subsurface drainage ; uncertainty ; water quality ; North Carolina
Language	English
Dates of publication	2011-11
Size	p. 2099-2110.
Document type	Article
ISSN	2151-0032
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