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Article ; Online: Comparison of chemotherapy outcomes between normal and high serum cortisol concentration in dogs with lymphoma.

Yamazaki, Hiroki / Bunbai, Kaito / Deguchi, Tatsuya / Tamura, Masahiro / Ohota, Hiroshi

2024

Abstract: Background: Increased serum cortisol (COR) concentrations may induce glucocorticoid resistance by down-regulation of glucocorticoid receptor (GCR), resulting in decreased chemotherapy efficacy in dogs with lymphoma.: Hypothesis: Investigate the ... ...

Abstract	Background: Increased serum cortisol (COR) concentrations may induce glucocorticoid resistance by down-regulation of glucocorticoid receptor (GCR), resulting in decreased chemotherapy efficacy in dogs with lymphoma. Hypothesis: Investigate the relationship between serum COR concentrations and chemotherapy outcomes in dogs with lymphoma. Animals: Thirty client-owned dogs with lymphoma, with serum COR concentration measured using serum samples collected at diagnosis. Methods: Retrospective study. Dogs were divided into 2 groups based on serum COR concentrations: a normal group (n = 16) with COR concentrations <6 μg/dL and a high group (14) with COR concentrations ≥6 μg/dL. We compared signalment, clinical signs, stage, type of lymphoma, adrenal gland size, alkaline phosphatase (ALP) activity, response to chemotherapy, progression-free survival (PFS), overall survival (OS), and rate of P-glycoprotein (P-gp)- and GCR-positive cells between the 2 groups. Results: No significant differences were found in the demographic characteristics between the 2 groups. However, the high COR group exhibited a significantly lower response to chemotherapy, PFS, and OS compared with the normal COR group. Serum ALP activity was significantly higher in the high COR group than in the normal COR group. Adrenal gland size was also significantly larger in the high COR group. Although no significant differences were found in the rate of P-gp-positive cells between the 2 groups, the rate of GCR-positive cells was significantly lower in the high COR group. Conclusions and clinical importance: Our data suggests that measurement of serum COR concentrations may serve as a potential prognostic factor and evaluation index.
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.17044
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Article ; Online: Texture-Guided Transfer Learning for Low-Quality Face Recognition.

Zhang, Meng / Liu, Rujie / Deguchi, Daisuke / Murase, Hiroshi

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2023 Volume 33, Page(s) 95–107

Abstract: Although many advanced works have achieved significant progress for face recognition with deep learning and large-scale face datasets, low-quality face recognition remains a challenging problem in real-word applications, especially for unconstrained ... ...

Abstract	Although many advanced works have achieved significant progress for face recognition with deep learning and large-scale face datasets, low-quality face recognition remains a challenging problem in real-word applications, especially for unconstrained surveillance scenes. We propose a texture-guided (TG) transfer learning approach under the knowledge distillation scheme to improve low-quality face recognition performance. Unlike existing methods in which distillation loss is built on forward propagation; e.g., the output logits and intermediate features, in this study, the backward propagation gradient texture is used. More specifically, the gradient texture of low-quality images is forced to be aligned to that of its high-quality counterpart to reduce the feature discrepancy between the high- and low-quality images. Moreover, attention is introduced to derive a soft-attention (SA) version of transfer learning, termed as SA-TG, to focus on informative regions. Experiments on the benchmark low-quality face DB's TinyFace and QMUL-SurFace confirmed the superiority of the proposed method, especially more than 6.6% Rank1 accuracy improvement is achieved on TinyFace.
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2023.3335830
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Article ; Online: Giant cell arteritis of the middle cerebral artery.

Kinoshita, Akinori / Otsuka, Yuki / Deguchi, Kentaro / Wakabayashi, Hiroshi

BMJ case reports

2022 Volume 15, Issue 6

MeSH term(s)	Giant Cell Arteritis/diagnosis ; Giant Cell Arteritis/diagnostic imaging ; Humans ; Middle Cerebral Artery/diagnostic imaging
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-250318
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Article ; Online: Actions of remimazolam on inhibitory transmission of rat spinal dorsal horn neurons.

Hoshino, Rintaro / Ohashi, Nobuko / Uta, Daisuke / Ohashi, Masayuki / Deguchi, Hiroyuki / Baba, Hiroshi

Journal of pharmacological sciences

2024 Volume 155, Issue 2, Page(s) 63–73

Abstract: Remimazolam is an ultra-short benzodiazepine that acts on the benzodiazepine site of γ-aminobutyric acid (GABA) receptors in the brain and induces sedation. Although GABA receptors are found localized in the spinal dorsal horn, no previous studies have ... ...

Abstract	Remimazolam is an ultra-short benzodiazepine that acts on the benzodiazepine site of γ-aminobutyric acid (GABA) receptors in the brain and induces sedation. Although GABA receptors are found localized in the spinal dorsal horn, no previous studies have reported the analgesic effects or investigated the cellular mechanisms of remimazolam on the spinal dorsal horn. Behavioral measures, immunohistochemistry, and in vitro whole-cell patch-clamp recordings of dorsal horn neurons were used to assess synaptic transmission. Intrathecal injection of remimazolam induced behavioral analgesia in inflammatory pain-induced mechanical allodynia (six rats/dose; p < 0.05). Immunohistochemical staining revealed that remimazolam suppressed spinal phosphorylated extracellular signal-regulated kinase activation (five rats/group, p < 0.05). In vitro whole-cell patch-clamp analysis demonstrated that remimazolam increased the frequency of GABAergic miniature inhibitory post-synaptic currents, prolonged the decay time (six rats; p < 0.05), and enhanced GABA currents induced by exogenous GABA (seven rats; p < 0.01). However, remimazolam did not affect miniature excitatory post-synaptic currents or amplitude of monosynaptic excitatory post-synaptic currents evoked by Aδ- and C-fiber stimulation (seven rats; p > 0.05). This study suggests that remimazolam induces analgesia by enhancing GABAergic inhibitory transmission in the spinal dorsal horn, suggesting its potential utility as a spinal analgesic for inflammatory pain.
MeSH term(s)	Animals ; Posterior Horn Cells/drug effects ; Posterior Horn Cells/metabolism ; Male ; Synaptic Transmission/drug effects ; Rats, Sprague-Dawley ; Benzodiazepines/pharmacology ; Patch-Clamp Techniques ; Analgesics/pharmacology ; gamma-Aminobutyric Acid/metabolism ; Rats ; Injections, Spinal ; Hyperalgesia/drug therapy ; Receptors, GABA/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism
Chemical Substances	remimazolam (7V4A8U16MB) ; Benzodiazepines (12794-10-4) ; Analgesics ; gamma-Aminobutyric Acid (56-12-2) ; Receptors, GABA ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2024-04-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2024.04.002
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Article ; Online: Agent-based model using GPS analysis for infection spread and inhibition mechanism of SARS-CoV-2 in Tokyo.

Murakami, Taishu / Sakuragi, Shunsuke / Deguchi, Hiroshi / Nakata, Masaru

Scientific reports

2022 Volume 12, Issue 1, Page(s) 20896

Abstract: Analyzing the SARS-CoV-2 pandemic outbreak based on actual data while reflecting the characteristics of the real city provides beneficial information for taking reasonable infection control measures in the future. We demonstrate agent-based modeling for ... ...

Abstract	Analyzing the SARS-CoV-2 pandemic outbreak based on actual data while reflecting the characteristics of the real city provides beneficial information for taking reasonable infection control measures in the future. We demonstrate agent-based modeling for Tokyo based on GPS information and official national statistics and perform a spatiotemporal analysis of the infection situation in Tokyo. As a result of the simulation during the first wave of SARS-CoV-2 in Tokyo using real GPS data, the infection occurred in the service industry, such as restaurants, in the city center, and then the infected people brought back the virus to the residential area; the infection spread in each area in Tokyo. This phenomenon clarifies that the spread of infection can be curbed by suppressing going out or strengthening infection prevention measures in service facilities. It was shown that pandemic measures in Tokyo could be achieved not only by strong control, such as the lockdown of cities, but also by thorough infection prevention measures in service facilities, which explains the curb phenomena in real Tokyo.
MeSH term(s)	Humans ; SARS-CoV-2 ; Tokyo/epidemiology ; COVID-19/epidemiology ; Cities ; Infection Control
Language	English
Publishing date	2022-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25480-z
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Article ; Online: Agent-based model using GPS analysis for infection spread and inhibition mechanism of SARS-CoV-2 in Tokyo

Taishu Murakami / Shunsuke Sakuragi / Hiroshi Deguchi / Masaru Nakata

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 7

Abstract: Abstract Analyzing the SARS-CoV-2 pandemic outbreak based on actual data while reflecting the characteristics of the real city provides beneficial information for taking reasonable infection control measures in the future. We demonstrate agent-based ... ...

Abstract	Abstract Analyzing the SARS-CoV-2 pandemic outbreak based on actual data while reflecting the characteristics of the real city provides beneficial information for taking reasonable infection control measures in the future. We demonstrate agent-based modeling for Tokyo based on GPS information and official national statistics and perform a spatiotemporal analysis of the infection situation in Tokyo. As a result of the simulation during the first wave of SARS-CoV-2 in Tokyo using real GPS data, the infection occurred in the service industry, such as restaurants, in the city center, and then the infected people brought back the virus to the residential area; the infection spread in each area in Tokyo. This phenomenon clarifies that the spread of infection can be curbed by suppressing going out or strengthening infection prevention measures in service facilities. It was shown that pandemic measures in Tokyo could be achieved not only by strong control, such as the lockdown of cities, but also by thorough infection prevention measures in service facilities, which explains the curb phenomena in real Tokyo.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Bleeding risk factors and real-world antithrombotic therapies in elderly patients with atrial fibrillation undergoing percutaneous coronary intervention: a retrospective study.

Fujita, Kanako / Kohyama, Noriko / Sato, Miki / Deguchi, Tomokazu / Suzuki, Hiroshi / Ebato, Mio / Kogo, Mari

Journal of pharmaceutical health care and sciences

2023 Volume 9, Issue 1, Page(s) 41

Abstract: Background: Bleeding risk factors in elderly patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) are unclear and data on the use of antithrombotic drugs are lacking. We investigated the bleeding risk factors in elderly ... ...

Abstract	Background: Bleeding risk factors in elderly patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) are unclear and data on the use of antithrombotic drugs are lacking. We investigated the bleeding risk factors in elderly patients with atrial fibrillation undergoing PCI to help optimize antithrombotic therapy according to bleeding risk. We also investigated the association between the actual use of antithrombotic therapy and bleeding events. Methods: A retrospective cohort study was conducted on 134 elderly patients with atrial fibrillation who underwent primary PCI at the Department of Cardiology, Showa University Fujigaoka Hospital. The endpoint was a bleeding event within 1-year. Bleeding risk factors were identified using multivariate analysis. The association between the number of antithrombotics and bleeding events was evaluated using the chi-squared test. Results: The mean age of the patients was 76.0 ± 6.2 years. Bleeding events occurred in 41 (30.6%) patients. Age > 80 years (odds ratio [OR]: 2.54, 95% confidence interval [CI]: 1.10-5.85), multivessel disease (OR: 2.76, 95% CI: 1.22-6.23), and history of surgery (OR: 3.03, 95% CI: 1.14-8.06) were identified as bleeding risk factors. The proportion of patients receiving triple therapy was significantly higher in the bleeding group compared to the non-bleeding group (70.7% vs. 27.5%, p < 0.001). Conclusions: Age > 80, multivessel disease, and history of surgery were found to be risk factors for bleeding in elderly patients with atrial fibrillation undergoing PCI. In addition, dual therapy after PCI in elderly patients at high risk of bleeding should be considered to avoid bleeding events.
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2809913-8
ISSN	2055-0294
ISSN	2055-0294
DOI	10.1186/s40780-023-00308-8
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Book: The Rise of Japanese Visual Narratives

Deguchi, Hiroshi

(Translational systems science ; 5)

2015

Author's details	Deguchi, Hiroshi (Hrsg.); Tanaka, Hideyuki (Hrsg.); Koyama, Yusuke (Hrsg.)
Series title	Translational systems science ; 5
Language	English
Size	VIII, 60 S.
Publisher	Springer Verlag, Japan
Publishing place	Tokyo
Document type	Book
ISBN	9784431549123 ; 9784431549123 ; 4431549129 ; 4431549129
Database	ECONomics Information System

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Book ; Online: Agent-based model using GPS analysis for infection spread and inhibition mechanism of SARS-CoV-2 in Tokyo

Murakami, Taishu / Sakuragi, Shunsuke / Deguchi, Hiroshi / Nakata, Masaru

2022

Abstract	Analyzing the SARS-CoV-2 pandemic outbreak based on actual data while reflecting the characteristics of the real city provides beneficial information for taking reasonable infection control measures in the future. We demonstrate agent-based modeling for Tokyo based on GPS information and official national statistics and perform a spatiotemporal analysis of the infection situation in Tokyo. As a result of the simulation during the first wave of SARS-CoV-2 in Tokyo using real GPS data, the infection occurred in the service industry, such as restaurants, in the city center, and then the infected people brought back the virus to the residential area; the infection spread in each area in Tokyo. This phenomenon clarifies that the spread of infection can be curbed by suppressing going out or strengthening infection prevention measures in service facilities. It was shown that pandemic measures in Tokyo could be achieved not only by strong control, such as the lockdown of cities, but also by thorough infection prevention measures in service facilities, which explains the curb phenomena in real Tokyo. Comment: 9 pages, 6 figures
Keywords	Physics - Physics and Society ; Computer Science - Multiagent Systems ; Quantitative Biology - Populations and Evolution
Subject code	360
Publishing date	2022-05-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Full-length plasma skeletal muscle myosin isoform deficiency is associated with coagulopathy in acutely injured patients.

Coleman, Julia R / Deguchi, Hiroshi / Deguchi, Taichi K / Cohen, Mitchel J / Moore, Ernest E / Griffin, John H

Journal of thrombosis and haemostasis : JTH

2022 Volume 20, Issue 6, Page(s) 1385–1389

Abstract: Background: Skeletal muscle myosin (SkM) molecules are procoagulant both in vitro and in vivo. The association of plasma SkM isoforms with blood coagulability and hemostatic capacity has not been defined.: Objectives: We hypothesized that ... ...

Abstract	Background: Skeletal muscle myosin (SkM) molecules are procoagulant both in vitro and in vivo. The association of plasma SkM isoforms with blood coagulability and hemostatic capacity has not been defined. Objectives: We hypothesized that coagulopathy in acutely injured patients is associated with procoagulant plasma SkM heavy chain levels. Methods: To test this hypothesis, citrated whole blood and plasma from 104 trauma patients were collected and studied to obtain data for rapid thrombelastography, international normalized ratios, and plasma SkM levels. Coagulability parameters were dichotomized by the threshold for the hypercoagulable trauma-induced coagulopathy. Results: Lower plasma full-length SkM heavy chain (full-SkM) levels were associated with higher international normalized ratio values (>1.3) (p = .03). The full-SkM levels were also associated with a lower rate of clot propagation (thrombelastography angle <65°) (p = .004), and plasma full-SkM levels were positively correlated with the thrombelastography angle (r Conclusions: In acutely injured trauma patients, lower levels of plasma full-SkM levels are linked to hypocoagulability in trauma-induced coagulopathy, implying that SkM plays a role in the hemostatic capacity in trauma patients and may contribute to trauma-induced coagulopathy.
MeSH term(s)	Blood Coagulation Disorders/etiology ; Hemostatics ; Humans ; Plasma ; Protein Isoforms ; Skeletal Muscle Myosins ; Thrombelastography ; Wounds and Injuries/complications
Chemical Substances	Hemostatics ; Protein Isoforms ; Skeletal Muscle Myosins (EC 3.6.1.-)
Language	English
Publishing date	2022-03-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.15695
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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