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Article ; Online: Evaluating the Effects of Kidney Preservation at 10 °C with Hemopure and Sodium Thiosulfate in a Rat Model of Syngeneic Orthotopic Kidney Transplantation.

Abou Taka, Maria / Dugbartey, George J / Richard-Mohamed, Mahms / McLeod, Patrick / Jiang, Jifu / Major, Sally / Arp, Jacqueline / O'Neil, Caroline / Liu, Winnie / Gabril, Manal / Moussa, Madeleine / Luke, Patrick / Sener, Alp

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: ... for kidney preservation is static cold storage (SCS) at 4 °C. However, SCS contributes to renal graft damage ... sodium thiosulfate (STS), at 4 °C. Therefore, this study aims to investigate whether SCS at 10 °C ... we subjected rat renal proximal tubular epithelial cells to hypoxia-reoxygenation for 24 h at 10 °C with or ...

Abstract	Kidney transplantation is preferred for end-stage renal disease. The current gold standard for kidney preservation is static cold storage (SCS) at 4 °C. However, SCS contributes to renal graft damage through ischemia-reperfusion injury (IRI). We previously reported renal graft protection after SCS with a hydrogen sulfide donor, sodium thiosulfate (STS), at 4 °C. Therefore, this study aims to investigate whether SCS at 10 °C with STS and Hemopure (blood substitute), will provide similar protection. Using in vitro model of IRI, we subjected rat renal proximal tubular epithelial cells to hypoxia-reoxygenation for 24 h at 10 °C with or without STS and measured cell viability. In vivo, we preserved 36 donor kidneys of Lewis rats for 24 h in a preservation solution at 10 °C supplemented with STS, Hemopure, or both followed by transplantation. Tissue damage and recipient graft function parameters, including serum creatinine, blood urea nitrogen, urine osmolality, and glomerular filtration rate (GFR), were evaluated. STS-treated proximal tubular epithelial cells exhibited enhanced viability at 10 °C compared with untreated control cells (
MeSH term(s)	Rats ; Animals ; Kidney Transplantation ; Organ Preservation ; Graft Survival ; Rats, Inbred Lew ; Kidney ; Reperfusion Injury/drug therapy ; Reperfusion Injury/prevention & control ; Hemoglobins ; Thiosulfates
Chemical Substances	HBOC 201 (1XQE66T19H) ; sodium thiosulfate (HX1032V43M) ; Hemoglobins ; Thiosulfates
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042210
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Article ; Online: Liver function tests in primary care provide a key opportunity to diagnose and engage patients with hepatitis C.

McLeod, A / Hutchinson, S J / Weir, A / Barclay, S / Schofield, J / Frew, C Gillespie / Goldberg, D J / Heydtmann, M / Wilson-Davies, E

Epidemiology and infection

2022 Volume 150, Page(s) e133

Abstract: Since the advent of direct-acting antiviral therapy, the elimination of hepatitis c virus (HCV ...

Abstract	Since the advent of direct-acting antiviral therapy, the elimination of hepatitis c virus (HCV) as a public health concern is now possible. However, identification of those who remain undiagnosed, and re-engagement of those who are diagnosed but remain untreated, will be essential to achieve this. We examined the extent of HCV infection among individuals undergoing liver function tests (LFT) in primary care. Residual biochemistry samples for 6007 patients, who had venous blood collected in primary care for LFT between July 2016 and January 2017, were tested for HCV antibody. Through data linkage to national and sentinel HCV surveillance databases, we also examined the extent of diagnosed infection, attendance at specialist service and HCV treatment for those found to be HCV positive. Overall HCV antibody prevalence was 4.0% and highest for males (5.0%), those aged 37-50 years (6.2%), and with an ALT result of 70 or greater (7.1%). Of those testing positive, 68.9% had been diagnosed with HCV in the past, 84.9% before the study period. Most (92.5%) of those diagnosed with chronic infection had attended specialist liver services and while 67.7% had ever been treated only 38% had successfully cleared infection. More than half of HCV-positive people required assessment, and potentially treatment, for their HCV infection but were not engaged with services during the study period. LFT in primary care are a key opportunity to diagnose, re-diagnose and re-engage patients with HCV infection and highlight the importance of GPs in efforts to eliminate HCV as a public health concern.
MeSH term(s)	Antiviral Agents/therapeutic use ; Hepacivirus ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C Antibodies ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Liver Function Tests ; Male ; Primary Health Care
Chemical Substances	Antiviral Agents ; Hepatitis C Antibodies
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268822000978
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Article ; Online: Facilitating engagement of persons with opioid use disorder in treatment for hepatitis C virus infection via telemedicine: Stories of onsite case managers.

Talal, Andrew H / Jaanimägi, Urmo / Davis, Kathleen / Bailey, Jordan / Bauer, Barbara M / Dharia, Arpan / George, Saliyah / McLeod, Anthony / Morton, Karen / Nugent, Ann / Zeremski, Marija / Dinani, Amreen / Des Jarlais, Don C / Perumalswami, Ponni V / Tobin, Jonathan N / Dickerson, Suzanne S

Journal of substance abuse treatment

2021 Volume 127, Page(s) 108421

Abstract: Although hepatitis C virus (HCV) infection has high prevalence and incidence in persons with opioid ...

Abstract	Although hepatitis C virus (HCV) infection has high prevalence and incidence in persons with opioid use disorder (PWOUD), their engagement in HCV care has been limited due to a variety of factors. In an ongoing multisite study at 12 opioid treatment programs (OTPs) throughout New York State (NYS), we have been evaluating telemedicine accompanied by onsite administration of direct acting antiviral (DAA) medications compared with usual care including offsite referral to a liver specialist for HCV management. Each site has a case manager (CM) who is responsible for all study-related activities including participant recruitment, facilitating telemedicine interactions, retention in care, and data collection. Our overall objective is to analyze CM experiences of clients' stories and events to understand how the telemedicine model facilitates HCV treatment. Hermeneutic phenomenology was used to interpret and to explicate common meanings and shared practices of the phenomena of case management, and a focus group with CMs was conducted to reinforce and expand on key themes identified from the CMs' stories. We identified three themes: (1) building trust, (2) identification of multiple competing priorities, and (3) development of personalized care approaches. Our results illustrate that trust is a fundamental pillar on which the telemedicine system can be based. Participants' experiences at the OTP can reinforce trust. Understanding the specific competing priorities and routinizing dedicated personalized approaches to overcome them are key to increasing participation in HCV care among PWOUD.
MeSH term(s)	Antiviral Agents/therapeutic use ; Case Managers ; Hepacivirus ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; New York ; Opiate Substitution Treatment ; Opioid-Related Disorders/drug therapy ; Telemedicine
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605923-5
ISSN	1873-6483 ; 0740-5472
ISSN (online)	1873-6483
ISSN	0740-5472
DOI	10.1016/j.jsat.2021.108421
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Article ; Online: Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases.

Journal of medicinal chemistry

2020 Volume 63, Issue 21, Page(s) 12511–12525

Abstract: ... against class A, C, and D serine β-lactamases. The ester prodrug of ETX1317, ETX0282, is orally ...

Abstract	Multidrug resistant Gram-negative bacterial infections are an increasing public health threat due to rapidly rising resistance toward β-lactam antibiotics. The hydrolytic enzymes called β-lactamases are responsible for a large proportion of the resistance phenotype. β-Lactamase inhibitors (BLIs) can be administered in combination with β-lactam antibiotics to negate the action of the β-lactamases, thereby restoring activity of the β-lactam. Newly developed BLIs offer some advantage over older BLIs in terms of enzymatic spectrum but are limited to the intravenous route of administration. Reported here is a novel, orally bioavailable diazabicyclooctane (DBO) β-lactamase inhibitor. This new DBO, ETX1317, contains an endocyclic carbon-carbon double bond and a fluoroacetate activating group and exhibits broad spectrum activity against class A, C, and D serine β-lactamases. The ester prodrug of ETX1317, ETX0282, is orally bioavailable and, in combination with cefpodoxime proxetil, is currently in development as an oral therapy for multidrug resistant and carbapenem-resistant
MeSH term(s)	Administration, Oral ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds/chemistry ; Azabicyclo Compounds/metabolism ; Azabicyclo Compounds/pharmacology ; Azabicyclo Compounds/therapeutic use ; Drug Design ; Drug Evaluation, Preclinical ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Half-Life ; Humans ; Mice ; Microbial Sensitivity Tests ; Penicillin-Binding Proteins/chemistry ; Penicillin-Binding Proteins/metabolism ; Prodrugs/chemistry ; Prodrugs/metabolism ; Protein Binding ; Rats ; Skin Diseases/drug therapy ; Skin Diseases/pathology ; Skin Diseases/veterinary ; Structure-Activity Relationship ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamase Inhibitors/metabolism ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamase Inhibitors/therapeutic use ; beta-Lactamases/chemistry ; beta-Lactamases/metabolism
Chemical Substances	Anti-Bacterial Agents ; Azabicyclo Compounds ; Penicillin-Binding Proteins ; Prodrugs ; beta-Lactamase Inhibitors ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2020-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.0c00579
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Article ; Online: Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease.

Norrish, Gabrielle / Kadirrajah, Vidthya / Field, Ella / Dady, Kathleen / Tollit, Jennifer / McLeod, Karen / McGowan, Ruth / Cervi, Elena / Kaski, Juan Pablo

Circulation. Genomic and precision medicine

2023 Volume 16, Issue 5, Page(s) 483–485

MeSH term(s)	Humans ; Child ; Myosin Heavy Chains/genetics ; Cardiomyopathy, Hypertrophic/genetics ; Phenotype ; Carrier Proteins/genetics
Chemical Substances	Myosin Heavy Chains (EC 3.6.4.1) ; myosin-binding protein C ; Carrier Proteins
Language	English
Publishing date	2023-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-8300
ISSN (online)	2574-8300
DOI	10.1161/CIRCGEN.123.004118
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Article ; Online: Postoperative C-reactive protein concentrations to predict infective complications following gastrectomy for cancer.

van Winsen, Marjolein / McSorley, Stephen T / McLeod, Ross / MacDonald, Andrew / Forshaw, Matthew J / Shaw, Martin / Puxty, Kathryn

Journal of surgical oncology

2021 Volume 124, Issue 7, Page(s) 1060–1069

Abstract: ... postoperative complications. C-reactive protein (CRP) is a useful biomarker in the early detection of infective complications ...

Abstract	Background and objectives: Gastrectomy for gastric cancer is associated with significant infective postoperative complications. C-reactive protein (CRP) is a useful biomarker in the early detection of infective complications following major abdominal surgery. This single-centre retrospective study aimed to determine the relationship between postoperative CRP levels and development of postoperative infective complications after gastrectomy. Methods: Daily postoperative CRP levels were analyzed to determine a CRP threshold associated with infective complications. ROC curve analysis was used to determine which postoperative day (POD) gave the optimal cutoff. Multivariate analysis was performed to determine significant factors associated with complications. Results: One hundred and forty-four patients were included. A total of 61 patients (42%) had at least one infective complication. A CRP level of 220 mg/L was associated with the highest AUC (0.765) with a sensitivity of 70% and specificity of 76% (positive predictive value, 67%; negative predictive value, 78%). More patients with a CRP > 220 mg/L on POD 3 developed infective complications (67% vs. 21%, p < 0.001). Conclusions: A CRP of more than 220 mg/L on POD 3 may be useful to alert clinicians to the increased risk of a postoperative infective complication or enable earlier safe discharge from critical care for those with a lower value.
MeSH term(s)	Aged ; Biomarkers/analysis ; C-Reactive Protein/analysis ; Female ; Gastrectomy/adverse effects ; Humans ; Male ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity ; Stomach Neoplasms/surgery ; Surgical Wound Infection/diagnosis
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.26613
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Article ; Online: A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms.

Sharkawy, Rasha El / Bayoumi, Ali / Metwally, Mayada / Mangia, Alessandra / Berg, Thomas / Romero-Gomez, Manuel / Abate, Maria Lorena / Irving, William L / Sheridan, David / Dore, Gregory J / Spengler, Ulrich / Lampertico, Pietro / Bugianesi, Elisabetta / Weltman, Martin / Mollison, Lindsay / Cheng, Wendy / Riordan, Stephen / Santoro, Rosanna / Gallego-Durán, Rocío /

Fischer, Janett / Nattermann, Jacob / D'Ambrosio, Roberta / McLeod, Duncan / Powell, Elizabeth / Latchoumanin, Olivier / Thabet, Khaled / Najim, Mustafa A M / Douglas, Mark W / Liddle, Christopher / Qiao, Liang / George, Jacob / Eslam, Mohammed

Scientific reports

2019 Volume 9, Issue 1, Page(s) 1439

Abstract: ... their impact on the liver. Here, we demonstrate in 1689 patients with chronic hepatitis C (CHC) (1,501 with CHC ...

Abstract	Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. The role of these variants on hepatic inflammation and fibrosis that are closely associated with HCC development is not known, nor are the biological mechanisms underlying their impact on the liver. Here, we demonstrate in 1689 patients with chronic hepatitis C (CHC) (1,501 with CHC and 188 with HCV-related HCC), that the MICA (T) allele, despite not being associated with HCC susceptibility, is associated with increased fibrosis stage (OR: 1.47, 95% CI: 1.05-2.06, p = 0.02) and fibrosis progression rate (hazards ratio: 1.41, 95% CI: 1.04-1.90, p = 0.02). The DEPDC5 variant was not associated with any of these phenotypes. MICA expression was down-regulated in advanced fibrosis stages. Further, (T) allele carriage was associated with lower MICA expression in liver and serum. Transforming growth factor-β1 (TGF-β1) expression suppresses MICA expression in hepatic stellate cells. Our findings suggest a novel mechanism linking susceptibility to advanced fibrosis and subsequently indirectly to HCC, to the level of MICA expression through TGF-β1-dependent mechanisms.
MeSH term(s)	Female ; GTPase-Activating Proteins/genetics ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/pathology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Liver/metabolism ; Liver Cirrhosis/etiology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Male ; Polymorphism, Single Nucleotide ; Signal Transduction ; Transforming Growth Factor beta1/metabolism
Chemical Substances	DEPDC5 protein, human ; GTPase-Activating Proteins ; Histocompatibility Antigens Class I ; MHC class I-related chain A ; Transforming Growth Factor beta1
Language	English
Publishing date	2019-02-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-35736-2
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Article ; Online: Population impact of direct-acting antiviral treatment on new presentations of hepatitis C-related decompensated cirrhosis: a national record-linkage study.

Hutchinson, Sharon J / Valerio, Heather / McDonald, Scott A / Yeung, Alan / Pollock, Kevin / Smith, Shanley / Barclay, Stephen / Dillon, John F / Fox, Raymond / Bramley, Peter / Fraser, Andrew / Kennedy, Nicholas / Gunson, Rory N / Templeton, Kate / Innes, Hamish / McLeod, Allan / Weir, Amanda / Hayes, Peter C / Goldberg, David

Gut

2020 Volume 69, Issue 12, Page(s) 2223–2231

Abstract: Objective: Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis ...

Abstract	Objective: Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. Design: Through analysis of national surveillance data (involving linkage of HCV diagnosis and clinical databases to hospital and deaths registers), we determined i) the scale-up in the number of patients treated and achieving a sustained viral response (SVR), and ii) the change in the trend of new presentations with HCV-related DC, with the introduction of DAAs. Results: Approximately 11 000 patients had been treated in Scotland over the 8-year period 2010/11 to 2017/18. The scale-up in the number of patients achieving SVR between the pre-DAA and DAA eras was 2.3-fold overall and 5.9-fold among those with compensated cirrhosis (the group at immediate risk of developing DC). In the pre-DAA era, the annual number of HCV-related DC presentations increased 4.6-fold between 2000 (30) and 2014 (142). In the DAA era, presentations decreased by 51% to 69 in 2018 (and by 67% among those with chronic infection at presentation), representing a significant change in trend (rate ratio 0.88, 95% CI 0.85 to 0.90). With the introduction of DAAs, an estimated 330 DC cases had been averted during 2015-18. Conclusions: National scale-up in interferon-free DAA treatment is associated with the rapid downturn in presentations of HCV-related DC at the population-level. Major progress in averting HCV-related DC in the short-term is feasible, and thus other countries should strive to achieve the same.
MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Databases, Factual ; Female ; Hepacivirus/genetics ; Hepacivirus/immunology ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Liver Cirrhosis/epidemiology ; Male ; Medical Record Linkage ; Middle Aged ; Registries ; Scotland/epidemiology ; Sustained Virologic Response
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2020-03-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2019-320007
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Article ; Online: Cardiac myosin binding protein-C variants in paediatric-onset hypertrophic cardiomyopathy: natural history and clinical outcomes.

Field, Ella / Norrish, Gabrielle / Acquaah, Vanessa / Dady, Kathleen / Cicerchia, Marcos Nicolas / Ochoa, Juan Pablo / Syrris, Petros / McLeod, Karen / McGowan, Ruth / Fell, Hannah / Lopes, Luis R / Cervi, Elena / Kaski, Juan Pablo Pablo

Journal of medical genetics

2021 Volume 59, Issue 8, Page(s) 768–775

Abstract: Background: Variants in the cardiac myosin-binding protein C gene (: Methods and results ...

Abstract	Background: Variants in the cardiac myosin-binding protein C gene ( Methods and results: Longitudinal data from 62 consecutive patients diagnosed with HCM under 18 years of age and carrying at least one P/LP Conclusions: MYBPC3
MeSH term(s)	Adolescent ; Cardiac Myosins/genetics ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/genetics ; Carrier Proteins/genetics ; Child ; Child, Preschool ; Cytoskeletal Proteins/genetics ; Female ; Heart ; Humans ; Infant ; Male ; Mutation
Chemical Substances	Carrier Proteins ; Cytoskeletal Proteins ; myosin-binding protein C ; Cardiac Myosins (EC 3.6.1.-)
Language	English
Publishing date	2021-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	220881-7
ISSN	1468-6244 ; 0022-2593
ISSN (online)	1468-6244
ISSN	0022-2593
DOI	10.1136/jmedgenet-2021-107774
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Article ; Online: Integrated, Co-located, Telemedicine-based Treatment Approaches for Hepatitis C Virus Management in Opioid Use Disorder Patients on Methadone.

Talal, Andrew H / Andrews, Phyllis / Mcleod, Anthony / Chen, Yang / Sylvester, Clewert / Markatou, Marianthi / Brown, Lawrence S

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2018 Volume 69, Issue 2, Page(s) 323–331

Abstract: Background: Despite high hepatitis C virus (HCV) prevalence, opioid use disorder (OUD) patients ...

Abstract	Background: Despite high hepatitis C virus (HCV) prevalence, opioid use disorder (OUD) patients on methadone rarely engage in HCV treatment. We investigated the effectiveness of HCV management via telemedicine in an opioid substitution therapy (OST) program. Methods: OUD patients on methadone underwent biweekly telemedicine sessions between a hepatologist and physician assistant during the entire HCV treatment course. All pretreatment labs (HCV RNA, genotype, and noninvasive fibrosis assessments) were obtained onsite and direct-acting antivirals were coadministered with methadone using modified directly observed therapy. We used multiple correspondence analysis, least absolute shrinkage and selection operator, and logistic regression to identify variables associated with pursuit of HCV care. Results: Sixty-two HCV RNA-positive patients (24% human immunodeficiency virus [HIV] infected, 61% male, 61% African American, 25.8% Hispanic) were evaluated. All patients were stabilized on methadone and all except 4 were HCV genotype 1 infected. Advanced fibrosis/cirrhosis was present in 34.5% of patients. Of the 45 treated patients, 42 (93.3%) achieved viral eradication. Of 17 evaluated patients who were not treated, 5 were discontinued from the drug treatment program or did not follow up after the evaluation, 2 had HIV adherence issues, and 10 had insurance authorization issues. Marriage and a mental health diagnosis other than depression were the strongest positive predictors of treatment pursuit, whereas being divorced, separated, or widowed was the strongest negative predictor. Conclusions: HCV management via telemedicine integrated into an OST program is a feasible model with excellent virologic effectiveness. Psychosocial and demographic variables can assist in identification of subgroups with a propensity or aversion to pursue HCV treatment.
MeSH term(s)	Adult ; Aged ; Analgesics, Opioid/administration & dosage ; Antiviral Agents/therapeutic use ; Disease Management ; Female ; Hepatitis C/drug therapy ; Humans ; Male ; Methadone/administration & dosage ; Middle Aged ; Opiate Substitution Treatment/methods ; Substance-Related Disorders/therapy ; Sustained Virologic Response ; Systems Integration ; Telemedicine/methods ; Treatment Outcome
Chemical Substances	Analgesics, Opioid ; Antiviral Agents ; Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2018-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciy899
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