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  1. Article ; Online: Unilateral abducens nerve avulsion injury following trauma.

    Alkhatib, Rugaiyah Fuad / Chen, Robert Chun / Sing, Benjamin Wei Heng / Sanamandra, Sarat Kumar

    Singapore medical journal

    2023  

    Language English
    Publishing date 2023-11-09
    Publishing country India
    Document type Letter
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2022-222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Styrylpyrones from

    Chiu, Chun-Hung / Chang, Chun-Chao / Lin, Jia-Jing / Chen, Chin-Chu / Chyau, Charng-Cherng / Peng, Robert Y

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: Phellinus ... ...

    Abstract Phellinus linteus
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11050898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Letter to the Editor: Halting antiviral therapy in patients with cirrhosis and chronic hepatitis B: A dangerous game?

    Chen, Jacki / Tu, Thomas / Cohen, Chari / Wang, Su / Hsu, Yao-Chun / Gish, Robert G

    Hepatology (Baltimore, Md.)

    2023  Volume 79, Issue 5, Page(s) E132–E133

    MeSH term(s) Humans ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Liver Cirrhosis/drug therapy ; Antiviral Agents/therapeutic use ; Hepatitis B virus
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Inhibitory Effect of Styrylpyrone Extract of

    Chiu, Chun-Hung / Chen, Ming-Yao / Lieu, Jun-Jie / Chen, Chin-Chu / Chang, Chun-Chao / Chyau, Charng-Cherng / Peng, Robert Y

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: The prevalence of nonalcoholic fatty liver disease (NAFLD) is estimated to be approximately about 25.24% of the population worldwide. NAFLD is a complex syndrome and is characterized by a simple benign hepatocyte steatosis to more severe steatohepatitis ... ...

    Abstract The prevalence of nonalcoholic fatty liver disease (NAFLD) is estimated to be approximately about 25.24% of the population worldwide. NAFLD is a complex syndrome and is characterized by a simple benign hepatocyte steatosis to more severe steatohepatitis in the liver pathology.
    MeSH term(s) Humans ; AMP-Activated Protein Kinases/metabolism ; Fatty Acids, Nonesterified/metabolism ; Hep G2 Cells/drug effects ; Hep G2 Cells/metabolism ; Lipid Metabolism/drug effects ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Sirtuin 1/metabolism ; Biological Products/chemistry ; Biological Products/pharmacology ; Pyrones/chemistry ; Pyrones/pharmacology ; Phellinus/chemistry
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Fatty Acids, Nonesterified ; Sirtuin 1 (EC 3.5.1.-) ; Biological Products ; Pyrones
    Language English
    Publishing date 2023-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Lymphomatosis Cerebri: A diagnostic dilemma.

    Khan, Sibgha / Mubarak, Fatima / Minhas, Khurram / Kanwar, Dureshahwar / Chen, Robert Chun

    Annals of neurosciences

    2023  Volume 31, Issue 1, Page(s) 44–52

    Abstract: Background: Lymphomatosis cerebri (LC) is a rare manifestation of primary central nervous system lymphoma (PCNSL) with only a few cases reported in the literature, appearing as diffuse infiltrating process rather than a solitary mass. It is a non- ... ...

    Abstract Background: Lymphomatosis cerebri (LC) is a rare manifestation of primary central nervous system lymphoma (PCNSL) with only a few cases reported in the literature, appearing as diffuse infiltrating process rather than a solitary mass. It is a non-Hodgkin's type of lymphoma and is usually of the B-cell type origin.
    Purpose: We intend to report this unique case of LC which came across as a diagnostic challenge.
    Methods: A 53-year-old gentleman presented with complaints of two episodes of seizures 24 h apart followed by postictal confusion for 10-15 min. He underwent multiple MRI scans and underwent a biopsy of the lesion which reported infection, but he did not benefit from the treatment.
    Result: The imaging was reviewed, suspicion of LC was raised and a review of histopathology was requested which later confirmed primary CNS lymphoma.
    Conclusion: LC is a rare but established manifestation of PCNSL which mimics multiple other conditions. Understanding of the imaging pattern is important in making the diagnosis and differentiating it from other mimic conditions.
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2576191-2
    ISSN 0976-3260 ; 0972-7531
    ISSN (online) 0976-3260
    ISSN 0972-7531
    DOI 10.1177/09727531231203461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Author Correction: Engineering circular RNA for enhanced protein production.

    Chen, Robert / Wang, Sean K / Belk, Julia A / Amaya, Laura / Li, Zhijian / Cardenas, Angel / Abe, Brian T / Chen, Chun-Kan / Wender, Paul A / Chang, Howard Y

    Nature biotechnology

    2023  Volume 41, Issue 2, Page(s) 293

    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-022-01472-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  7. Article ; Online: Astrocytic pathology in Alpers' syndrome.

    Smith, Laura A / Chen, Chun / Lax, Nichola Z / Taylor, Robert W / Erskine, Daniel / McFarland, Robert

    Acta neuropathologica communications

    2023  Volume 11, Issue 1, Page(s) 86

    Abstract: Refractory epilepsy is the main neurological manifestation of Alpers' syndrome, a severe childhood-onset mitochondrial disease caused by bi-allelic pathogenic variants in the mitochondrial DNA (mtDNA) polymerase gamma gene (POLG). The pathophysiological ... ...

    Abstract Refractory epilepsy is the main neurological manifestation of Alpers' syndrome, a severe childhood-onset mitochondrial disease caused by bi-allelic pathogenic variants in the mitochondrial DNA (mtDNA) polymerase gamma gene (POLG). The pathophysiological mechanisms underpinning neuronal hyperexcitabilty leading to seizures in Alpers' syndrome remain unknown. However, pathological changes to reactive astrocytes are hypothesised to exacerbate neural dysfunction and seizure-associated cortical activity in POLG-related disease. Therefore, we sought to phenotypically characterise astrocytic pathology in Alpers' syndrome. We performed a detailed quantitative investigation of reactive astrocytes in post-mortem neocortical tissues from thirteen patients with Alpers' syndrome, eight neurologically normal controls and five sudden unexpected death in epilepsy (SUDEP) patients, to control for generalised epilepsy-associated astrocytic pathology. Immunohistochemistry to identify glial fibrillary acidic protein (GFAP)-reactive astrocytes revealed striking reactive astrogliosis localised to the primary visual cortex of Alpers' syndrome tissues, characterised by abnormal-appearing hypertrophic astrocytes. Phenotypic characterisation of individual GFAP-reactive astrocytes demonstrated decreased abundance of mitochondrial oxidative phosphorylation (OXPHOS) proteins and altered expression of key astrocytic proteins including Kir4.1 (subunit of the inwardly rectifying K
    MeSH term(s) Humans ; Child ; Astrocytes/metabolism ; Diffuse Cerebral Sclerosis of Schilder/genetics ; Diffuse Cerebral Sclerosis of Schilder/metabolism ; Sudden Unexpected Death in Epilepsy ; Seizures/genetics ; DNA, Mitochondrial/genetics ; Epilepsy/metabolism ; Glial Fibrillary Acidic Protein/metabolism
    Chemical Substances DNA, Mitochondrial ; Glial Fibrillary Acidic Protein
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-023-01579-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Conservative Management of Low Back Pain Related to an Unresectable Aggressive Sacral Hemangioma: A Case Report.

    Chu, Eric Chun-Pu / Trager, Robert J / Chen, Alan Te Chang

    The American journal of case reports

    2022  Volume 23, Page(s) e936984

    Abstract: BACKGROUND Aggressive sacral hemangiomas are extremely rare benign tumors that can extend into the spinal canal, causing neurologic symptoms. Research on these tumors is limited given their rarity, and they have no agreed-upon treatment strategy. We ... ...

    Abstract BACKGROUND Aggressive sacral hemangiomas are extremely rare benign tumors that can extend into the spinal canal, causing neurologic symptoms. Research on these tumors is limited given their rarity, and they have no agreed-upon treatment strategy. We report the first case of an aggressive sacral hemangioma responding well to conservative care, including manual therapies. CASE REPORT A 56-year-old Asian woman presented upon referral to a chiropractic office in Hong Kong with a 6-month exacerbation of chronic low back and lower extremity pain and weakness, requiring the use of a cane to walk. She had a known history of an aggressive sacral hemangioma with neural compromise and had been deemed ineligible for surgery and tumor ablation due to the large hemangioma size and risk of complications. Examination and imaging findings were consistent with compensatory myofascial pain, postural changes, sacral plexopathy, and lower cauda equina involvement. After coordinating with the neurosurgical team, the chiropractor carefully treated the patient with manual therapies, including thoracic spinal manipulation and instrument-assisted soft tissue manipulation, and mobility and strengthening exercises. She responded well, with symptom reduction lasting through 1-year follow-up, and no longer required the use of a cane. CONCLUSIONS This case illustrates the success of conservative chiropractic care for a patient with an aggressive sacral hemangioma not amenable to other treatments. As further research is needed on this topic, providers considering using manual therapies on patients with an aggressive sacral hemangioma should do so with caution and in collaboration with the patient's medical or surgical team.
    MeSH term(s) Conservative Treatment ; Female ; Hemangioma/complications ; Hemangioma/diagnosis ; Hemangioma/therapy ; Humans ; Low Back Pain/etiology ; Low Back Pain/therapy ; Middle Aged ; Sacrum/pathology ; Spinal Neoplasms/complications ; Spinal Neoplasms/diagnosis ; Spinal Neoplasms/therapy
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.936984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Concurrent Bell's Palsy and Facial Pain Improving with Multimodal Chiropractic Therapy: A Case Report and Literature Review.

    Chu, Eric Chun-Pu / Trager, Robert J / Chen, Alan Te-Chang

    The American journal of case reports

    2022  Volume 23, Page(s) e937511

    Abstract: BACKGROUND Bell's palsy, also called facial nerve palsy, occasionally co-occurs with trigeminal neuropathy, which presents as additional facial sensory symptoms and/or neck pain. Bell's palsy has a proposed viral etiology, in particular when occurring ... ...

    Abstract BACKGROUND Bell's palsy, also called facial nerve palsy, occasionally co-occurs with trigeminal neuropathy, which presents as additional facial sensory symptoms and/or neck pain. Bell's palsy has a proposed viral etiology, in particular when occurring after dental manipulation. CASE REPORT A 52-year-old Asian woman presented to a chiropractor with a 3-year history of constant neck pain and left-sided maxillary, eyebrow, and temporomandibular facial pain, paresis, and paresthesia, which began after using a toothpick, causing possible gum trauma. She had previously been treated with antiviral medication and prednisone, Chinese herbal medicine, and acupuncture, but her recovery plateaued at 60% after 1 year. The chiropractor ordered cervical spine magnetic resonance imaging, which demonstrated cervical spondylosis, with no evidence of myelopathy or major pathology. Treatment involved cervical and thoracic spinal manipulation, cervical traction, soft-tissue therapy, and neck exercises. The patient responded positively. At 1-month follow-up, face and neck pain and facial paresis were resolved aside from residual eyelid synkinesis. A literature review identified 12 additional cases in which chiropractic spinal manipulation with multimodal therapies was reported to improve Bell's palsy. Including the current case, 85% of these patients also had pain in the face or neck. CONCLUSIONS This case illustrates improvement of Bell's palsy and concurrent trigeminal neuropathy with multimodal chiropractic care including spinal manipulation. Limited evidence from other similar cases suggests a role of the trigeminal pathway in these positive treatment responses of Bell's palsy with concurrent face/neck pain. These findings should be explored with research designs accounting for the natural history of Bell's palsy.
    MeSH term(s) Antiviral Agents/therapeutic use ; Bell Palsy/complications ; Bell Palsy/diagnosis ; Bell Palsy/therapy ; Chiropractic ; Drugs, Chinese Herbal ; Facial Pain ; Facial Paralysis ; Female ; Humans ; Middle Aged ; Neck Pain/etiology ; Neck Pain/therapy ; Prednisone/therapeutic use ; Trigeminal Nerve Diseases/complications ; Trigeminal Nerve Diseases/drug therapy
    Chemical Substances Antiviral Agents ; Drugs, Chinese Herbal ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.937511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Trade-offs between the accumulation of cuticular wax and jasmonic acid-mediated herbivory resistance in maize.

    Liu, Jiong / Li, Lu / Xiong, Zhilong / Robert, Christelle A M / Li, Baozhu / He, Shan / Chen, Wenjie / Bi, Jiasheng / Zhai, Guanqing / Guo, Siyi / Zhang, Hui / Li, Jieping / Zhou, Shutang / Zhang, Xi / Song, Chun-Peng

    Journal of integrative plant biology

    2024  Volume 66, Issue 1, Page(s) 143–159

    Abstract: Plants have evolved complex physical and chemical defense systems that allow them to withstand herbivory infestation. Composed of a complex mixture of very-long-chain fatty acids (VLCFAs) and their derivatives, cuticular wax constitutes the first ... ...

    Abstract Plants have evolved complex physical and chemical defense systems that allow them to withstand herbivory infestation. Composed of a complex mixture of very-long-chain fatty acids (VLCFAs) and their derivatives, cuticular wax constitutes the first physical line of defense against herbivores. Here, we report the function of Glossy 8 (ZmGL8), which encodes a 3-ketoacyl reductase belonging to the fatty acid elongase complex, in orchestrating wax production and jasmonic acid (JA)-mediated defenses against herbivores in maize (Zea mays). The mutation of GL8 enhanced chemical defenses by activating the JA-dependent pathway. We observed a trade-off between wax accumulation and JA levels across maize glossy mutants and 24 globally collected maize inbred lines. In addition, we demonstrated that mutants defective in cuticular wax biosynthesis in Arabidopsis thaliana and maize exhibit enhanced chemical defenses. Comprehensive transcriptomic and lipidomic analyses indicated that the gl8 mutant confers chemical resistance to herbivores by remodeling VLCFA-related lipid metabolism and subsequent JA biosynthesis and signaling. These results suggest that VLCFA-related lipid metabolism has a critical role in regulating the trade-offs between cuticular wax and JA-mediated chemical defenses.
    MeSH term(s) Herbivory ; Zea mays/metabolism ; Plant Proteins/metabolism ; Oxylipins/metabolism ; Cyclopentanes/metabolism ; Arabidopsis/genetics ; Arabidopsis/metabolism
    Chemical Substances jasmonic acid (6RI5N05OWW) ; Plant Proteins ; Oxylipins ; Cyclopentanes
    Language English
    Publishing date 2024-01-03
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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