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  1. Article ; Online: Treating electroconvulsive therapy–induced mania with more electroconvulsive therapy

    Rejish K Thomas / Patrick J White / Serdar Dursun

    SAGE Open Medical Case Reports, Vol

    Evidence for electroconvulsive therapy as the ultra-mood stabilizer

    2018  Volume 6

    Abstract: Electroconvulsive therapy has been described as a mood stabilizer, as it is effective in all stages of bipolar disorder. Electroconvulsive therapy–induced mania is a known and potentially dangerous risk of treating bipolar depression with ... ...

    Abstract Electroconvulsive therapy has been described as a mood stabilizer, as it is effective in all stages of bipolar disorder. Electroconvulsive therapy–induced mania is a known and potentially dangerous risk of treating bipolar depression with electroconvulsive therapy and there are no established guidelines for the management of electroconvulsive therapy–induced mania. We report a case of electroconvulsive therapy–induced mania where electroconvulsive therapy was continued as the sole, effective antimanic agent, which is the first described case in literature.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Treating electroconvulsive therapy-induced mania with more electroconvulsive therapy: Evidence for electroconvulsive therapy as the ultra-mood stabilizer.

    Thomas, Rejish K / White, Patrick J / Dursun, Serdar

    SAGE open medical case reports

    2018  Volume 6, Page(s) 2050313X18799236

    Abstract: Electroconvulsive therapy has been described as a mood stabilizer, as it is effective in all stages of bipolar disorder. Electroconvulsive therapy-induced mania is a known and potentially dangerous risk of treating bipolar depression with ... ...

    Abstract Electroconvulsive therapy has been described as a mood stabilizer, as it is effective in all stages of bipolar disorder. Electroconvulsive therapy-induced mania is a known and potentially dangerous risk of treating bipolar depression with electroconvulsive therapy and there are no established guidelines for the management of electroconvulsive therapy-induced mania. We report a case of electroconvulsive therapy-induced mania where electroconvulsive therapy was continued as the sole, effective antimanic agent, which is the first described case in literature.
    Language English
    Publishing date 2018-09-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X18799236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adapting to the impact of COVID-19 on mental health: an international perspective.

    Thomas, Rejish K / Suleman, Raheem / Mackay, Marnie / Hayer, Lovneet / Singh, Mohit / Correll, Christoph U / Dursun, Serdar

    Journal of psychiatry & neuroscience : JPN

    2020  Volume 45, Issue 4, Page(s) 229–233

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Disease Management ; Humans ; Internationality ; Mental Disorders/drug therapy ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Mental Health/statistics & numerical data ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country Canada
    Document type Editorial
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.200076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2105: Show issues Location:
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  4. Article: Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers.

    Matveychuk, Dmitriy / Thomas, Rejish K / Swainson, Jennifer / Khullar, Atul / MacKay, Mary-Anne / Baker, Glen B / Dursun, Serdar M

    Therapeutic advances in psychopharmacology

    2020  Volume 10, Page(s) 2045125320916657

    Abstract: Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that purpose, has garnered marked interest over the past two decades as an emerging treatment for major depressive disorder. With increasing evidence of its efficacy in ... ...

    Abstract Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that purpose, has garnered marked interest over the past two decades as an emerging treatment for major depressive disorder. With increasing evidence of its efficacy in treatment-resistant depression and its potential anti-suicidal action, a great deal of investigation has been conducted on elucidating ketamine's effects on the brain. Of particular interest and therapeutic potential is the ability of ketamine to exert rapid antidepressant properties as early as several hours after administration. This is in stark contrast to the delayed effects observed with traditional antidepressants, often requiring several weeks of therapy for a clinical response. Furthermore, ketamine appears to have a unique mechanism of action involving glutamate modulation
    Language English
    Publishing date 2020-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2646542-5
    ISSN 2045-1261 ; 2045-1253
    ISSN (online) 2045-1261
    ISSN 2045-1253
    DOI 10.1177/2045125320916657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid effectiveness of intravenous ketamine for ultraresistant depression in a clinical setting and evidence for baseline anhedonia and bipolarity as clinical predictors of effectiveness.

    Thomas, Rejish K / Baker, Glen / Lind, John / Dursun, Serdar

    Journal of psychopharmacology (Oxford, England)

    2018  Volume 32, Issue 10, Page(s) 1110–1117

    Abstract: Background: Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant ... ...

    Abstract Background: Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant depression patients remains understudied.
    Aims: This study aims to measure the response and remission rates in ultraresistant depression patients in a clinical setting by means of a retrospective, open label, database study. Secondarily, the study will attempt to support previous findings of clinical predictors of effectiveness with intravenous ketamine treatment.
    Methods: Fifty patients with ultraresistant depression were treated between May 2015-December 2016, inclusive, in two community hospitals in Edmonton using six ketamine infusions of 0.5 mg/kg over 40 min over 2-3 weeks. Data were collected retrospectively from inpatient and outpatient charts. Statistical analysis to investigate clinical predictors of effectiveness included logistic regression analysis using a dependent variable of a 50% reduction in rating scale score at any point during treatment.
    Results: At baseline, the average treatment resistance was severe, with a Maudsley Staging Method score of 12.1 out of 15, 90.0% were resistant to electroconvulsive therapy, and the average Beck Depression Inventory score was 34.2. The response rate was 44% and remission rate was 16%. As a single predictor, moderate or severe anhedonia at baseline predicted a 55% increased likelihood of response. As a combined predictor, this level of anhedonia at baseline with a diagnosis of bipolar depression predicted a 73% increase in likelihood of response.
    Conclusion: In a clinical setting, intravenous ketamine showed effectiveness in a complex, severely treatment-resistant, depressed population on multiple medication profiles concurrently. This study gave support to anhedonia and bipolar depression as clinical predictors of effectiveness.
    MeSH term(s) Adult ; Aged ; Anhedonia/drug effects ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/pharmacology ; Databases, Factual ; Depressive Disorder, Treatment-Resistant/drug therapy ; Depressive Disorder, Treatment-Resistant/physiopathology ; Excitatory Amino Acid Antagonists/administration & dosage ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Hospitals, Community ; Humans ; Infusions, Intravenous ; Ketamine/administration & dosage ; Male ; Middle Aged ; Remission Induction/methods ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Antidepressive Agents ; Excitatory Amino Acid Antagonists ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639313-5
    ISSN 1461-7285 ; 0269-8811
    ISSN (online) 1461-7285
    ISSN 0269-8811
    DOI 10.1177/0269881118793104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2311: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Adapting to the impact of COVID-19 on mental health: an international perspective

    Thomas, Rejish K / Suleman, Raheem / Mackay, Marnie / Hayer, Lovneet / Singh, Mohit / Correll, Christoph U / Dursun, Serdar

    J Psychiatry Neurosci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #616191
    Database COVID19

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  7. Article ; Online: Esketamine for treatment resistant depression.

    Swainson, Jennifer / Thomas, Rejish K / Archer, Shaina / Chrenek, Carson / MacKay, Mary-Anne / Baker, Glen / Dursun, Serdar / Klassen, Larry J / Chokka, Pratap / Demas, Michael L

    Expert review of neurotherapeutics

    2019  Volume 19, Issue 10, Page(s) 899–911

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Antidepressive Agents/therapeutic use ; Depressive Disorder, Treatment-Resistant/drug therapy ; Humans ; Ketamine/therapeutic use
    Chemical Substances Antidepressive Agents ; Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2019-07-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2019.1640604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6155: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article: Lactate in the brain: an update on its relevance to brain energy, neurons, glia and panic disorder.

    Riske, Laurel / Thomas, Rejish K / Baker, Glen B / Dursun, Serdar M

    Therapeutic advances in psychopharmacology

    2016  Volume 7, Issue 2, Page(s) 85–89

    Abstract: Lactate is considered an important metabolite in the human body, but there has been considerable debate about its roles in brain function. Research in recent years has suggested that lactate from astrocytes may be crucial for supporting axonal function, ... ...

    Abstract Lactate is considered an important metabolite in the human body, but there has been considerable debate about its roles in brain function. Research in recent years has suggested that lactate from astrocytes may be crucial for supporting axonal function, especially during times of high metabolic demands or hypoglycemia. The astrocyte-neuron lactate transfer shuttle system serves a protective function to ensure a supply of substrates for brain metabolism, and oligodendrocytes appear to also influence availability of lactate. There is increasing evidence for lactate acting as a signaling molecule in the brain to link metabolism, substrate availability, blood flow and neuronal activity. This review will attempt to connect evidence to the relationship lactate has to panic disorder (PD), which suggests that its transporters, receptors or metabolism warrant investigation as potential therapeutic targets in PD.
    Language English
    Publishing date 2016-10-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2646542-5
    ISSN 2045-1261 ; 2045-1253
    ISSN (online) 2045-1261
    ISSN 2045-1253
    DOI 10.1177/2045125316675579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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