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  1. Book: Sequential experimentation in clinical trials

    Bartroff, Jay / Lai, Tze Leung / Shih, Mei-Chiung

    design and analysis

    (Springer series in statistics)

    2013  

    Author's details Jay Bartroff ; Tze Leung Lai ; Mei-Chiung Shih
    Series title Springer series in statistics
    Language English
    Size XV, 237 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017512286
    ISBN 978-1-4614-6113-5 ; 9781461461142 ; 1-4614-6113-8 ; 1461461146
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 A 4799 order for loan Magazin

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  2. Book: Active risk management

    Lai, Tze Leung / Xing, Haipeng

    financial models and statistical methods

    (Chapman & Hall)

    2015  

    Author's details Tze Leung Lai, Haipeng Xing
    Series title Chapman & Hall
    Language English
    Size 1 volume, illustrations (black and white), 24 cm
    Publisher CRC Press Taylor & Francis Group
    Publishing place Boca Raton ; London ; New York
    Document type Book
    ISBN 9781439839485 ; 1439839484
    Database ECONomics Information System

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  3. Article ; Online: A new approach to regression analysis of censored competing-risks data.

    Jin, Yuxue / Lai, Tze Leung

    Lifetime data analysis

    2016  Volume 23, Issue 4, Page(s) 605–625

    Abstract: An approximate likelihood approach is developed for regression analysis of censored competing-risks data. This approach models directly the cumulative incidence function, instead of the cause-specific hazard function, in terms of explanatory covariates ... ...

    Abstract An approximate likelihood approach is developed for regression analysis of censored competing-risks data. This approach models directly the cumulative incidence function, instead of the cause-specific hazard function, in terms of explanatory covariates under a proportional subdistribution hazards assumption. It uses a self-consistent iterative procedure to maximize an approximate semiparametric likelihood function, leading to an asymptotically normal and efficient estimator of the vector of regression parameters. Simulation studies demonstrate its advantages over previous methods.
    MeSH term(s) Bone Marrow Transplantation ; Computer Simulation ; Data Interpretation, Statistical ; Humans ; Leukemia/mortality ; Leukemia/therapy ; Life Tables ; Likelihood Functions ; Models, Statistical ; Normal Distribution ; Proportional Hazards Models ; Regression Analysis ; Risk
    Language English
    Publishing date 2016-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1479719-7
    ISSN 1572-9249 ; 1380-7870
    ISSN (online) 1572-9249
    ISSN 1380-7870
    DOI 10.1007/s10985-016-9378-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Adaptive enrichment designs for confirmatory trials.

    Lai, Tze Leung / Lavori, Philip W / Tsang, Ka Wai

    Statistics in medicine

    2018  Volume 38, Issue 4, Page(s) 613–624

    Abstract: After an overview of the Food and Drugs Administration's 2012 draft guidance on enrichment strategies for clinical trials to support drug/biologic approval, we describe subsequent advances in adaptive enrichment designs in this direction. We also provide ...

    Abstract After an overview of the Food and Drugs Administration's 2012 draft guidance on enrichment strategies for clinical trials to support drug/biologic approval, we describe subsequent advances in adaptive enrichment designs in this direction. We also provide a concrete application in the enrichment design of the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 3 trial comparing a new endovascular treatment with standard of care for ischemic stroke patients.
    MeSH term(s) Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Drug Approval/methods ; Humans ; Models, Statistical ; Sample Size ; United States ; United States Food and Drug Administration/standards
    Language English
    Publishing date 2018-09-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.7946
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Credit Portfolios, Credibility Theory, and Dynamic Empirical Bayes

    Tze Leung Lai

    ISRN Probability and Statistics, Vol

    2012  Volume 2012

    Keywords Probabilities. Mathematical statistics ; QA273-280 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Statistics ; DOAJ:Mathematics and Statistics
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: State price density estimation and nonparametric pricing of basket options

    Kuang, Yuming / Lai, Tze Leung

    Journal of mathematical finance Vol. 5, No. 5 , p. 448-456

    2015  Volume 5, Issue 5, Page(s) 448–456

    Author's details Yuming Kuang, Tze Leung Lai (Department of Statistics, Stanford University, Stanford, CA, USA)
    Keywords Basket Options ; Portfolio Weights ; Joint State Price Density
    Language English
    Publisher Scientific Research
    Publishing place [S.l.]
    Document type Article
    ZDB-ID 2657377-5 ; 2657378-7
    ISSN 2162-2442 ; 2162-2434
    ISSN (online) 2162-2442
    ISSN 2162-2434
    Database ECONomics Information System

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  7. Article: Efficient Adaptive Randomization and Stopping Rules in Multi-arm Clinical Trials for Testing a New Treatment.

    Lai, Tze Leung / Liao, Olivia Yueh-Wen

    Sequential analysis

    2015  Volume 31, Issue 4, Page(s) 441–457

    Abstract: Motivated by applications to confirmatory clinical trials for testing a new treatment against a placebo or active control when the new treatment ... ...

    Abstract Motivated by applications to confirmatory clinical trials for testing a new treatment against a placebo or active control when the new treatment has
    Language English
    Publishing date 2015-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1476945-1
    ISSN 1532-4176 ; 0747-4946 ; 0731-177X
    ISSN (online) 1532-4176
    ISSN 0747-4946 ; 0731-177X
    DOI 10.1080/07474946.2012.719433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 vaccines and risks of hematological abnormalities: Nested case-control and self-controlled case series study.

    Sing, Chor-Wing / Tang, Casey Tze Lam / Chui, Celine Sze Ling / Fan, Min / Lai, Francisco Tsz Tsun / Li, Xue / Wan, Eric Yuk Fai / Wong, Carlos King Ho / Chan, Esther Wai Yin / Hung, Ivan Fan Ngai / Leung, Anskar Yu-Hung / Cheung, Ching-Lung / Wong, Ian Chi Kei

    American journal of hematology

    2022  Volume 97, Issue 4, Page(s) 470–480

    Abstract: Several studies reported hematological abnormalities after vaccination against the coronavirus disease 2019 (COVID-19). We evaluated the association between COVID-19 vaccines (CoronaVac and BNT162b2) and hematological abnormalities. We conducted nested ... ...

    Abstract Several studies reported hematological abnormalities after vaccination against the coronavirus disease 2019 (COVID-19). We evaluated the association between COVID-19 vaccines (CoronaVac and BNT162b2) and hematological abnormalities. We conducted nested case-control and self-controlled case series analyses using the data from the Hong Kong Hospital Authority and the Department of Health, HKSAR. Outcomes of interest were thrombocytopenia, leukopenia, and neutropenia. Adjusted odds ratios (aORs), incidence rate ratios (IRRs), and 95% confidence intervals (CIs) were estimated using conditional logistic regression. In total, 1 643 419 people received COVID-19 vaccination (738 609 CoronaVac; 904 810 BNT162b2). We identified 457 and 422 cases after CoronaVac and BNT162b2 vaccination, respectively. For CoronaVac, the incidence of thrombocytopenia, leukopenia, and neutropenia was 2.51, 1.08, and 0.15 per 10 000 doses. For BNT162b2, the corresponding incidence was 1.39, 1.17, and 0.26 per 10 000 doses. The incidence per 10 000 COVID-19 cases were 1254, 2341, and 884, respectively. We only observed an increased risk of leukopenia following the second dose of BNT162b2 (aOR 1.58, 95% CI 1.24-2.02; day 0-14, IRR 2.21; 95% CI 1.59-3.08). There was no increased risk of any hematological abnormalities after CoronaVac vaccination. We observed an increased risk of leukopenia shortly after the second dose of BNT162b2. However, the incidence was much lower than the incidence following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. There was no association between CoronaVac and hematological abnormalities. The benefits of vaccination against COVID-19 still outweigh the risk of hematological abnormalities.
    MeSH term(s) BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Case-Control Studies ; Humans ; Research Design ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
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  9. Article ; Online: Cognitive Stimulating Play Intervention for Dementia: A Feasibility Randomized Controlled Trial.

    Cheung, Daphne Sze Ki / Li, Bingyu / Lai, Daniel Wing Leung / Leung, Angela Yee Man / Yu, Clare Tze Kiu / Tsang, Ka Tat

    American journal of Alzheimer's disease and other dementias

    2018  Volume 34, Issue 1, Page(s) 63–71

    Abstract: This study investigates the feasibility and the preliminary efficacy of a Cognitive Stimulating Play Intervention on cognitive functions. Thirty older people with early to moderate dementia were recruited from 2 day-care centers, which were randomized ... ...

    Abstract This study investigates the feasibility and the preliminary efficacy of a Cognitive Stimulating Play Intervention on cognitive functions. Thirty older people with early to moderate dementia were recruited from 2 day-care centers, which were randomized into intervention and control groups. The recruitment, attendance, completion rates, and the interview with staff showed that the intervention was feasible. Analysis of covariance results showed that there was a significant difference between groups on memory storage and retrieval functions. The mean memory storage and retrieval functions were 5.92 (95% confidence interval [CI]: 1.83-9.91; P = .006) and 4.12 (95% CI: 0.75-7.50; P = .018) points higher than that for the control group, respectively, which contributed moderate to large effects (partial η
    MeSH term(s) Adult Day Care Centers ; Aged ; Aged, 80 and over ; Cognitive Remediation/methods ; Dementia/physiopathology ; Dementia/rehabilitation ; Feasibility Studies ; Female ; Humans ; Male ; Mental Recall/physiology ; Play and Playthings ; Psychotherapy, Group ; Treatment Outcome
    Language English
    Publishing date 2018-10-28
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1283069-0
    ISSN 1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
    ISSN (online) 1938-2731
    ISSN 0895-5336 ; 1082-5207 ; 1533-3175
    DOI 10.1177/1533317518808036
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    Zs.A 3299: Show issues Location:
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  10. Article ; Online: Innovative designs of point-of-care comparative effectiveness trials.

    Shih, Mei-Chiung / Turakhia, Mintu / Lai, Tze Leung

    Contemporary clinical trials

    2015  Volume 45, Issue Pt A, Page(s) 61–68

    Abstract: One of the provisions of the health care reform legislation in 2010 was for funding pragmatic clinical trials or large observational studies for comparing the effectiveness of different approved medical treatments, involving broadly representative ... ...

    Abstract One of the provisions of the health care reform legislation in 2010 was for funding pragmatic clinical trials or large observational studies for comparing the effectiveness of different approved medical treatments, involving broadly representative patient populations. After reviewing pragmatic clinical trials and the issues and challenges that have made them just a small fraction of comparative effectiveness research (CER), we focus on a recent development that uses point-of-care (POC) clinical trials to address the issue of "knowledge-action gap" in pragmatic CER trials. We give illustrative examples of POC-CER trials and describe a trial that we are currently planning to compare the effectiveness of newly approved oral anticoagulants. We also develop novel stage-wise designs of information-rich POC-CER trials under competitive budget constraints, by using recent advances in adaptive designs and other statistical methodologies.
    MeSH term(s) Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Comparative Effectiveness Research/economics ; Comparative Effectiveness Research/methods ; Humans ; Random Allocation ; Randomized Controlled Trials as Topic/economics ; Randomized Controlled Trials as Topic/methods ; Research Design
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2015.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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