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  1. Article: Addiction in the times of pandemic.

    Cherkasova, Mariya

    The Canadian journal of addiction

    2020  Volume 11, Issue 2, Page(s) 9–12

    Language English
    Publishing date 2020-06-03
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2780140-8
    ISSN 2368-4720
    ISSN 2368-4720
    DOI 10.1097/CXA.0000000000000082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7044: Show issues Location:
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  3. Article: Noninvasive Neuromodulation in Parkinson's Disease: Insights from Animal Models.

    Muksuris, Katherine / Scarisbrick, David M / Mahoney, James J / Cherkasova, Mariya V

    Journal of clinical medicine

    2023  Volume 12, Issue 17

    Abstract: The mainstay treatments for Parkinson's Disease (PD) have been limited to pharmacotherapy and deep brain stimulation. While these interventions are helpful, a new wave of research is investigating noninvasive neuromodulation methods as potential ... ...

    Abstract The mainstay treatments for Parkinson's Disease (PD) have been limited to pharmacotherapy and deep brain stimulation. While these interventions are helpful, a new wave of research is investigating noninvasive neuromodulation methods as potential treatments. Some promising avenues have included transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), and focused ultrasound (FUS). While these methods are being tested in PD patients, investigations in animal models of PD have sought to elucidate their therapeutic mechanisms. In this rapid review, we assess the available animal literature on these noninvasive techniques and discuss the possible mechanisms mediating their therapeutic effects based on these findings.
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12175448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Risk-promoting effects of reward-paired cues in human sign- and goal-trackers.

    Cherkasova, Mariya V / Clark, Luke / Barton, Jason J S / Stoessl, A Jon / Winstanley, Catharine A

    Behavioural brain research

    2024  Volume 461, Page(s) 114865

    Abstract: ... the location of impending reward delivery. In Study 1 (Cherkasova et al., 2018), participants were randomly ...

    Abstract Animal research suggests trait-like individual variation in the degree of incentive salience attribution to reward-predictive cues, defined phenotypically as sign-tracking (high) and goal-tracking (low incentive salience attribution). While these phenotypes have been linked to addiction features in rodents, their translational validity is less clear. Here, we examined whether sign- and goal-tracking in healthy human volunteers modulates the effects of reward-paired cues on decision making. Sign-tracking was measured in a Pavlovian conditioning paradigm as the amount of eye gaze fixation on the reward-predictive cue versus the location of impending reward delivery. In Study 1 (Cherkasova et al., 2018), participants were randomly assigned to perform a binary choice task in which rewards were either accompanied (cued, n = 63) or unaccompanied (uncued, n = 68) by money images and casino jingles. In Study 2, participants (n = 58) performed cued and uncued versions of the task in a within-subjects design. Across both studies, cues promoted riskier choice. Sign-tracking was not associated with risky choice in either study. Goal-tracking rather than sign-tracking was significantly associated with greater risk-promoting effects of cues in Study 1 but not in Study 2, although the direction of findings was consistent across both studies. These findings are at odds with the notion of sign-trackers being preferentially susceptible to the influence of reward cues on behavior and point to the role of mechanisms besides incentive salience in mediating such influences.
    MeSH term(s) Humans ; Cues ; Goals ; Motivation ; Reward
    Language English
    Publishing date 2024-01-14
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2024.114865
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1599: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Antibodies to the phosphatidylserine/prothrombin complex in the diagnosis of antiphospholipid syndrome

    Tatiana M. Reshetnyak / Fariza A. Cheldieva / Mariya V. Cherkasova / Aleksander M. Lila / Evgeny L. Nasonov

    Терапевтический архив, Vol 94, Iss 5, Pp 628-

    2022  Volume 634

    Abstract: Aim. To determine the significance of antibodies to the phosphatidylserine/prothrombin complex (aPS/PT) in patients with systemic lupus erythematosus (SLE) antiphospholipid syndrome (APS). Materials and methods. A total of 190 patients were included in ... ...

    Abstract Aim. To determine the significance of antibodies to the phosphatidylserine/prothrombin complex (aPS/PT) in patients with systemic lupus erythematosus (SLE) antiphospholipid syndrome (APS). Materials and methods. A total of 190 patients were included in the study: 123 (64.7%) with reliable SLE and 55 (29%) with PAPS. The control group included 100 relatively healthy subjects of comparable age. All patients were tested for classical aPL as well as IgG/IgM-anti-PS/PT by enzyme immunoassay. Results. Based on the average values of IgG/IgM aPS/PT of the control group, the levels of positivity were allocated mean (M) + 3 or 5 standard deviations (SD): M+3SD and M+5SD. IgG aPS/PT levels above 73.6 U/ml (M+5SD) were more accurate diagnostic, for IgM aPS/PT above 18.0 U/ml. IgG-aPS/PT were detected in 84 (44%) of 190 patients. Levels above diagnostic levels were detected in 68 (65%) of 104 patients with APS (55 with PAPS and 59 with SLE+APS). Thrombosis was significantly more common in patients with IgG aPS/PT compared with patients negative for IgG aPS/PT. Arterial but not venous thrombosis was associated with IgG aPS/PT positivity. Conclusion. The frequency of detection of IgG aPS/PT in the examined patients was 44%, IgM aPS/PT 29% and their combination 19% of 190 patients. Half of the patients with probable APS had positive IgG aPS/PT and third IgM aPS/PT. Median IgG aPS/PT were significantly higher in patients with APS compared to patients without APS and the control group. Thrombosis was associated with IgG aPS/PT. Arterial thrombosis was significantly more frequently reported in patients with IgG aPS/PT. The sensitivity of IgG aPS/PT for reliable APS at levels greater than 73.6 units/ml was 59%, specificity 92%, for IgM aPS/PT 35% and 91%, respectively.
    Keywords antiphospholipid syndrome ; systemic lupus erythematosus ; antibodies to phosphatidylserine/prothrombin complex ; antiphospholipid antibodies ; Medicine ; R
    Subject code 610 ; 616
    Language Russian
    Publishing date 2022-06-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A brain network response to sham surgery.

    Cherkasova, Mariya V / Stoessl, A Jon

    The Journal of clinical investigation

    2014  Volume 124, Issue 8, Page(s) 3285–3288

    Abstract: Evaluation of potential therapies for neurological disease has been challenging due to beneficial responses in patients receiving the sham/placebo treatment. Placebo effects are especially prominent in Parkinson's disease (PD), which has become a useful ... ...

    Abstract Evaluation of potential therapies for neurological disease has been challenging due to beneficial responses in patients receiving the sham/placebo treatment. Placebo effects are especially prominent in Parkinson's disease (PD), which has become a useful model for studying the neurobiology of placebo responses. In this issue of the JCI, Ko and colleagues identify a neural circuit associated with the placebo response in a PD patient cohort. The observed placebo effect-associated pattern involved metabolic activity increases that corresponded with long-term motor improvements after sham surgery. Presurgery activity in this network was inversely related to sham response, suggesting that this network has potential for identifying sham responders and thus reducing placebo-related variance in surgical trials.
    MeSH term(s) Brain/metabolism ; Brain/surgery ; Female ; Humans ; Male ; Parkinson Disease/metabolism ; Parkinson Disease/surgery ; Placebo Effect
    Language English
    Publishing date 2014-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI77193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.184: Show issues Location:
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  7. Article ; Online: Size Matters Stature Is Related to Diagnoses of Depression in Young Military Men

    Valery Krupnik / Mariya V. Cherkasova

    SAGE Open, Vol

    2014  Volume 4

    Abstract: Evolutionary theories suggest that depression has evolved as an adaptation to insurmountable adversity or defeat. One prediction stemming from these models is that individual attributes associated with defeat in a given social environment could be risk ... ...

    Abstract Evolutionary theories suggest that depression has evolved as an adaptation to insurmountable adversity or defeat. One prediction stemming from these models is that individual attributes associated with defeat in a given social environment could be risk factors for depression. We hypothesized that in young military men, where physical prowess was important, short stature might constitute a risk of depression and that this risk would be specific to depression and not to other prevalent mental disorders such as anxiety. A preliminary analysis of the diagnostic profile of a sample of male military personnel treated for mental health indicates that men both shorter and taller than average by 1 standard deviation may be predisposed to higher rates of depressive but not anxiety disorders. Practical and theoretical implications of our findings are discussed.
    Keywords History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
    Subject code 150
    Language English
    Publishing date 2014-07-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Skewed by Cues? The Motivational Role of Audiovisual Stimuli in Modelling Substance Use and Gambling Disorders.

    Barrus, Michael M / Cherkasova, Mariya / Winstanley, Catharine A

    Current topics in behavioral neurosciences

    2016  Volume 27, Page(s) 507–529

    Abstract: The similarity between gambling disorder (GD) and drug addiction has recently been recognized at the diagnostic level. Understanding the core cognitive processes involved in these addiction disorders, and in turn their neurobiological mechanisms, remains ...

    Abstract The similarity between gambling disorder (GD) and drug addiction has recently been recognized at the diagnostic level. Understanding the core cognitive processes involved in these addiction disorders, and in turn their neurobiological mechanisms, remains a research priority due to the enormous benefits such knowledge would have in enabling effective treatment design. Animal models can be highly informative in this regard. Although numerous rodent behavioural paradigms that capture different facets of gambling-like behaviour have recently been developed, the motivational power of cues in biasing individuals towards risky choice has so far received little attention despite the central role played by drug-paired cues in successful laboratory models of chemical dependency. Here, we review some of the comparatively simple paradigms in which reward-paired cues are known to modulate behaviour in rodents, such as sign-tracking, Pavlovian-to-instrumental transfer and conditioned reinforcement. Such processes are thought to play an important role in mediating responding for drug reward, and the need for future studies to address whether similar processes contribute to cue-driven risky choice is highlighted.
    MeSH term(s) Acoustic Stimulation ; Animals ; Attention ; Choice Behavior ; Conditioning, Classical ; Cues ; Disease Models, Animal ; Gambling/psychology ; Humans ; Motivation ; Photic Stimulation ; Reward ; Rodentia ; Substance-Related Disorders/psychology
    Language English
    Publishing date 2016
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2015_393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Do pupillary responses during authentic slot machine use reflect arousal or screen luminance fluctuations? A proof-of-concept study.

    Kim, Andy J / Murch, W Spencer / Limbrick-Oldfield, Eve H / Ferrari, Mario A / MacDonald, Kent I / Fooken, Jolande / Cherkasova, Mariya V / Spering, Miriam / Clark, Luke

    PloS one

    2022  Volume 17, Issue 7, Page(s) e0272070

    Abstract: Modern slot machines are among the more harmful forms of gambling. Psychophysiological measures may provide a window into mental processes that underpin these harms. Here we investigated pupil dilation derived from eye tracking as a means of capturing ... ...

    Abstract Modern slot machines are among the more harmful forms of gambling. Psychophysiological measures may provide a window into mental processes that underpin these harms. Here we investigated pupil dilation derived from eye tracking as a means of capturing changes in sympathetic nervous system arousal following outcomes on a real slot machine. We hypothesized that positively reinforcing slot machine outcomes would be associated with increases in arousal, reflected in larger pupil diameter. We further examined the contribution of game luminance fluctuations on pupil diameter. In Experiment 1A, experienced slot machine gamblers (N = 53) played a commercially-available slot machine in a laboratory for 20 minutes while wearing mobile eye tracking glasses. Analyses differentiated loss outcomes, wins, losses-disguised-as-wins, and (free-spin) bonus features. Bonus features were associated with rapid increases in pupil diameter following the onset of outcome-related audiovisual feedback, relative to losses. In Experiment 1B, luminance data were extracted from captured screen videos (derived from Experiment 1A) to characterize on-screen luminance changes that could modulate pupil diameter. Bonus features and wins were associated with pronounced and complex fluctuations in screen luminance (≈50 L and ≈25L, respectively). However, the pupil dilation that was observed to bonus features in Experiment 1A coincided temporally with only negligible changes in screen luminance, providing partial evidence that the pupil dilation to bonus features may be due to arousal. In Experiment 2, 12 participants viewed pairs of stimuli (scrambled slot machine images) at luminance difference thresholds of ≈25L, ≈50L, and ≈100L. Scrambled images presented at luminance differences of ≈25L and greater were sufficient to cause pupillary responses. Overall, pupillometry may detect event-related changes in sympathetic nervous system arousal following gambling outcomes, but researchers must pay careful attention to substantial in-game luminance changes that may confound arousal-based interpretations.
    MeSH term(s) Arousal/physiology ; Gambling ; Humans ; Pupil
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0272070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Gambling disorder is associated with reduced sensitivity to expected value during risky choice.

    Limbrick-Oldfield, Eve H / Cherkasova, Mariya V / Kennedy, Dawn / Goshko, Caylee-Britt / Griffin, Dale / Barton, Jason J S / Clark, Luke

    Journal of behavioral addictions

    2020  Volume 9, Issue 4, Page(s) 1044–1055

    Abstract: Background and aims: Individuals with gambling disorder display increased levels of risk-taking, but it is not known if it is associated with an altered subjective valuation of gains and/or losses, perception of their probabilities, or integration of ... ...

    Abstract Background and aims: Individuals with gambling disorder display increased levels of risk-taking, but it is not known if it is associated with an altered subjective valuation of gains and/or losses, perception of their probabilities, or integration of these sources of information into expected value.
    Methods: Participants with gambling disorder (n = 48) were compared with a healthy comparison group (n = 35) on a two-choice lottery task that involved either gains-only or losses-only gambles. On each trial, two lotteries were displayed, showing the associated probability and magnitude of the possible outcome for each. On each trial, participants chose one of the two lotteries, and the outcome was revealed.
    Results: Choice behaviour was highly sensitive to the expected value of the two gambles in both the gain and loss domains. This sensitivity to expected value was attenuated in the group with gambling disorder. The group with gambling disorder used both probability and magnitude information less, and this impairment was greater for probability information. By contrast, they used prior feedback (win vs loss) to inform their next choice, despite the independence of each trial. Within the gambling disorder group, problem gambling severity and trait gambling-related cognitions independently predicted reduced sensitivity to expected value. The majority of observed effects were consistent across both gain and loss domains.
    Discussion and conclusions: Our results provide a thorough characterization of decision processes in gain and loss domains in gambling disorder, and place these problems in the context of theoretical constructs from behavioural economics.
    MeSH term(s) Choice Behavior ; Cognition ; Decision Making ; Gambling ; Humans ; Probability ; Risk-Taking
    Language English
    Publishing date 2020-11-26
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 2817933-X
    ISSN 2063-5303 ; 2063-5303
    ISSN (online) 2063-5303
    ISSN 2063-5303
    DOI 10.1556/2006.2020.00088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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