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Book ; Conference proceedings: Statements by the honorable Willis M. Hawkins and Dr. Edward S. Josephson on the Army food irradiation program before the Sub-Committee on Research Development and Radiation of the Joint Committee on Atomic Energy, Congress of the United States

Hawkins, Willis M / Josephson, Edward S

1965

Institution	United States. / Congress
Keywords	Radiation preservation of food/Review.
Language	English
Size	1 v. (various foliations) ;, 27 cm.
Publisher	Natick Laboratories
Publishing place	Natick, Mass
Document type	Book ; Conference proceedings
Note	Cover title. ; Caption title: Review of the Army Food Irradiation Program. ; "6 June 1965."
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Adding eye protection to universal masking reduces COVID-19 among frontline emergency clinicians to the level of community spread.

Hawkins, Edward S / Fertel, Baruch S / Muir, McKinsey R / Meldon, Stephen W / Delgado, Fernando J / Smalley, Courtney M

The American journal of emergency medicine

2020 Volume 46, Page(s) 792–793

MeSH term(s)	COVID-19/epidemiology ; COVID-19/transmission ; Disease Transmission, Infectious/prevention & control ; Emergency Service, Hospital/organization & administration ; Humans ; Masks ; Pandemics ; Physicians ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Letter
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2020.08.064
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Article ; Online: Impact of SARS-CoV-2 Infection on Long-Term Depression Symptoms among Veterans.

Chen, Jason I / Bui, David / Iwashyna, Theodore J / Shahoumian, Troy A / Hickok, Alex / Shepherd-Banigan, Megan / Hawkins, Eric J / Naylor, Jennifer / Govier, Diana J / Osborne, Thomas F / Smith, Valerie A / Bowling, C Barrett / Boyko, Edward J / Ioannou, George N / Maciejewski, Matthew L / O'Hare, Ann M / Viglianti, Elizabeth M / Bohnert, Amy S-B / Hynes, Denise M

Journal of general internal medicine

2024

Abstract: Background: Prior research demonstrates that SARS-COV-2 infection can be associated with a broad range of mental health outcomes including depression symptoms. Veterans, in particular, may be at elevated risk of increased depression following SARS-COV-2 ...

Abstract	Background: Prior research demonstrates that SARS-COV-2 infection can be associated with a broad range of mental health outcomes including depression symptoms. Veterans, in particular, may be at elevated risk of increased depression following SARS-COV-2 infection given their high rates of pre-existing mental and physical health comorbidities. However, few studies have tried to isolate SARS-COV-2 infection associations with long term, patient-reported depression symptoms from other factors (e.g., physical health comorbidities, pandemic-related stress). Objective: To evaluate the association between SARS-COV-2 infection and subsequent depression symptoms among United States Military Veterans. Design: Survey-based non-randomized cohort study with matched comparators. Participants: A matched-dyadic sample from a larger, stratified random sample of participants with and without known to SARS-COV-2 infection were invited to participate in a survey evaluating mental health and wellness 18-months after their index infection date. Sampled participants were stratified by infection severity of the participant infected with SARS-COV-2 (hospitalized or not) and by month of index date. A total of 186 participants in each group agreed to participate in the survey and had sufficient data for inclusion in analyses. Those in the uninfected group who were later infected were excluded from analyses. Main measures: Participants were administered the Patient Health Questionnaire-9 as part of a phone interview survey. Demographics, physical and mental health comorbidities were extracted from VHA administrative data. Key results: Veterans infected with SARS-COV-2 had significantly higher depression symptoms scores compared with those uninfected. In particular, psychological symptoms (e.g., low mood, suicidal ideation) scores were elevated relative to the comparator group (M Conclusion: SARS-COV-2 infection was associated with more depression symptoms among Veterans at 18-months post-infection. Routine evaluation of depression symptoms over time following SARS-COV-2 infection is important to facilitate adequate assessment and treatment.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-024-08630-z
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Article ; Online: Differences in microbial community response to nitrogen fertilization result in unique enzyme shifts between arbuscular and ectomycorrhizal-dominated soils.

Carrara, Joseph E / Walter, Christopher A / Freedman, Zachary B / Hostetler, Ashley N / Hawkins, Jennifer S / Fernandez, Ivan J / Brzostek, Edward R

Global change biology

2021 Volume 27, Issue 10, Page(s) 2049–2060

Abstract: While the effect of nitrogen (N) deposition on belowground carbon (C) cycling varies, emerging evidence shows that forest soils dominated by trees that associate with ectomycorrhizal fungi (ECM) store more C than soils dominated by trees that associate ... ...

Abstract	While the effect of nitrogen (N) deposition on belowground carbon (C) cycling varies, emerging evidence shows that forest soils dominated by trees that associate with ectomycorrhizal fungi (ECM) store more C than soils dominated by trees that associate with arbuscular mycorrhizae (AM) with increasing N deposition. We hypothesized that this is due to unique nutrient cycling responses to N between AM and ECM-dominated soils. ECM trees primarily obtain N through fungal mining of soil organic matter subsidized by root-C. As such, we expected the largest N-induced responses of C and N cycling to occur in ECM rhizospheres and be driven by fungi. Conversely, as AM trees rely on bacterial scavengers in bulk soils to cycle N, we predicted the largest AM responses to be driven by shifts in bacteria and occur in bulk soils. To test this hypothesis, we measured microbial community composition, metatranscriptome profiles, and extracellular enzyme activity in bulk, rhizosphere, and organic horizon (OH) soils in AM and ECM-dominated soils at Bear Brook Watershed in Maine, USA. After 27 years of N fertilization, fungal community composition shifted across ECM soils, but bacterial communities shifted across AM soils. These shifts were mirrored by enhanced C relative to N mining enzyme activities in both mycorrhizal types, but this occurred in different soil fractions. In ECM stands these shifts occurred in rhizosphere soils, but in AM stands they occurred in bulk soils. Additionally, ECM OH soils exhibited the opposite response with declines in C relative to N mining. As rhizosphere soils account for only a small portion of total soil volume relative to bulk soils, coupled with declines in C to N enzyme activity in ECM OH soils, we posit that this may partly explain why ECM soils store more C than AM soils as N inputs increase.
MeSH term(s)	Fertilization ; Maine ; Microbiota ; Mycorrhizae ; Nitrogen ; Soil ; Soil Microbiology ; Trees
Chemical Substances	Soil ; Nitrogen (N762921K75)
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.15523
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Article: Adding eye protection to universal masking reduces COVID-19 among frontline emergency clinicians to the level of community spread

Hawkins, Edward S / Fertel, Baruch S / Muir, McKinsey R / Meldon, Stephen W / Delgado, Fernando J / Smalley, Courtney M

Am. j. emerg. med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #731687
Database	COVID19

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Article ; Online: Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness.

Pirillo, Chiara / Birch, Flora / Tissot, Floriane S / Anton, Sara Gonzalez / Haltalli, Myriam / Tini, Valentina / Kong, Isabella / Piot, Cécile / Partridge, Ben / Pospori, Constandina / Keeshan, Karen / Santamaria, Salvatore / Hawkins, Edwin / Falini, Brunangelo / Marra, Andrea / Duarte, Delfim / Lee, Chiu Fan / Roberts, Edward / Lo Celso, Cristina

Blood advances

2022 Volume 6, Issue 10, Page(s) 3126–3141

Abstract: Acute myeloid leukemia (AML) is a blood cancer of the myeloid lineage. Its prognosis remains poor, highlighting the need for new therapeutic and precision medicine approaches. AML symptoms often include cytopenias linked to loss of healthy hematopoietic ... ...

Abstract	Acute myeloid leukemia (AML) is a blood cancer of the myeloid lineage. Its prognosis remains poor, highlighting the need for new therapeutic and precision medicine approaches. AML symptoms often include cytopenias linked to loss of healthy hematopoietic stem and progenitor cells (HSPCs). The mechanisms behind HSPC decline are complex and still poorly understood. Here, intravital microscopy (IVM) of a well-established experimental model of AML allows direct observation of the interactions between healthy and malignant cells in the bone marrow (BM), suggesting that physical dislodgment of healthy cells by AML through damaged vasculature may play an important role. Multiple matrix metalloproteinases (MMPs), known to remodel extracellular matrix, are expressed by AML cells and the BM microenvironment. We reason MMPs could be involved in cell displacement and vascular leakiness; therefore, we evaluate the therapeutic potential of MMP pharmacological inhibition using the broad-spectrum inhibitor prinomastat. IVM analyses of prinomastat-treated mice reveal reduced vascular permeability and healthy cell clusters in circulation and lower AML infiltration, proliferation, and cell migration. Furthermore, treated mice have increased retention of healthy HSPCs in the BM and increased survival following chemotherapy. Analysis of a human AML transcriptomic database reveals widespread MMP deregulation, and human AML cells show susceptibility to MMP inhibition. Overall, our results suggest that MMP inhibition could be a promising complementary therapy to reduce AML growth and limit HSPC loss and BM vascular damage caused by MLL-AF9 and possibly other AML subtypes.
MeSH term(s)	Animals ; Bone Marrow/pathology ; Hematopoietic Stem Cells/pathology ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Metalloproteases ; Mice ; Prognosis ; Tumor Microenvironment
Chemical Substances	Metalloproteases (EC 3.4.-)
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021004321
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Zs.A 7153: Show issues

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Article ; Online: Adding eye protection to universal masking reduces COVID-19 among frontline emergency clinicians to the level of community spread

Hawkins, Edward S. / Fertel, Baruch S. / Muir, McKinsey R. / Meldon, Stephen W. / Delgado, Fernando J. / Smalley, Courtney M.

The American Journal of Emergency Medicine ; ISSN 0735-6757

2020

Keywords	Emergency Medicine ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.ajem.2020.08.064
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin II Receptor Blockers: A Comparison of Outcomes in Patients With COVID-19.

Kalra, Ankur / Hawkins, Edward S / Nowacki, Amy S / Jain, Vardhmaan / Milinovich, Alex / Saef, Joshua / Thomas, George / Gebreselassie, Surafel K / Karnik, Sadashiva S / Jehi, Lara / Young, James B / Svensson, Lars G / Chung, Mina K / Mehta, Neil

Circulation. Cardiovascular quality and outcomes

2020 Volume 13, Issue 10, Page(s) e007115

MeSH term(s)	Aged ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
Keywords	covid19
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Comparative Study ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.120.007115
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Article: Differences in microbial community response to nitrogen fertilization result in unique enzyme shifts between arbuscular and ectomycorrhizal‐dominated soils

Carrara, Joseph E / Walter, Christopher A / Freedman, Zachary B / Hostetler, Ashley N / Hawkins, Jennifer S / Fernandez, Ivan J / Brzostek, Edward R

Global change biology. 2021 May, v. 27, no. 10

2021

Abstract	While the effect of nitrogen (N) deposition on belowground carbon (C) cycling varies, emerging evidence shows that forest soils dominated by trees that associate with ectomycorrhizal fungi (ECM) store more C than soils dominated by trees that associate with arbuscular mycorrhizae (AM) with increasing N deposition. We hypothesized that this is due to unique nutrient cycling responses to N between AM and ECM‐dominated soils. ECM trees primarily obtain N through fungal mining of soil organic matter subsidized by root‐C. As such, we expected the largest N‐induced responses of C and N cycling to occur in ECM rhizospheres and be driven by fungi. Conversely, as AM trees rely on bacterial scavengers in bulk soils to cycle N, we predicted the largest AM responses to be driven by shifts in bacteria and occur in bulk soils. To test this hypothesis, we measured microbial community composition, metatranscriptome profiles, and extracellular enzyme activity in bulk, rhizosphere, and organic horizon (OH) soils in AM and ECM‐dominated soils at Bear Brook Watershed in Maine, USA. After 27 years of N fertilization, fungal community composition shifted across ECM soils, but bacterial communities shifted across AM soils. These shifts were mirrored by enhanced C relative to N mining enzyme activities in both mycorrhizal types, but this occurred in different soil fractions. In ECM stands these shifts occurred in rhizosphere soils, but in AM stands they occurred in bulk soils. Additionally, ECM OH soils exhibited the opposite response with declines in C relative to N mining. As rhizosphere soils account for only a small portion of total soil volume relative to bulk soils, coupled with declines in C to N enzyme activity in ECM OH soils, we posit that this may partly explain why ECM soils store more C than AM soils as N inputs increase.
Keywords	carbon ; community structure ; ectomycorrhizae ; enzyme activity ; extracellular enzymes ; forests ; fungal communities ; global change ; nitrogen ; organic horizons ; rhizosphere ; soil organic matter ; streams ; vesicular arbuscular mycorrhizae ; watersheds ; Maine
Language	English
Dates of publication	2021-05
Size	p. 2049-2060.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.15523
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Lessons From the First Decade of the Native American Summer Research Internship at the University of Utah.

Holsti, Maija / Clark, Edward B / Fisher, Simon / Hawkins, Sam / Keenan, Heather / Just, Steven / Lee, Jaymus / Napia, Ed / Rodriguez, Jose E / Taylor, Franci / White, Richard / Willie, Scott / Byington, Carrie L

Academic medicine : journal of the Association of American Medical Colleges

2020 Volume 96, Issue 4, Page(s) 522–528

Abstract: ... AN people represent 2.0% of the U.S. population but only 0.2% of medical students and 0.1% of full-time ... During the first decade of the NARI program, 128 students from 22 U.S. states, representing 46 tribal ...

Abstract	Problem: American Indian/Alaska Native (AI/AN) populations are facing multiple health crises, including limited access to care, high rates of chronic disease, and early mortality that is far worse than other underrepresented minorities in the United States. According to the Association of American Indian Physicians, AI/AN people represent 2.0% of the U.S. population but only 0.2% of medical students and 0.1% of full-time faculty at MD-granting institutions. Increasing the number of AI/AN clinicians and scientists is one strategy to improve health outcomes in the AI/AN population and address these crises. Approach: In 2010, the University of Utah partnered with research, cultural, and professional mentors to create a 10-week summer Native American Research Internship (NARI) program for AI/AN college students across the United States who are interested in pursuing biomedical careers. NARI attracts and supports AI/AN students by offering mentored summer research internships in an innovative, culturally aware framework that adapts to observed challenges to optimize educational experiences and support biomedical career aspirations. Outcomes: During the first decade of the NARI program, 128 students from 22 U.S. states, representing 46 tribal nations and 57 colleges and universities, participated. Of those 128 students, 113 (88%) have completed a bachelor's degree and the remaining 15 (12%) are currently working toward a bachelor's degree. No NARI student has dropped out of college. Twenty-six (20%) NARI alumni have matriculated to medical school and 30 (23%) to graduate school. Eight (6%) participants have completed medical school, and 3 (2%) are pursuing a PhD in science. An additional 36 (28%) have gained employment in biomedical research fields. Next steps: The NARI program has increased the participation of AI/AN students in medicine and the biomedical sciences. The innovative, culturally aware, and adaptive framework is a model for other programs for AI/AN students and students in other underrepresented communities.
MeSH term(s)	Adult ; Alaska Natives/education ; Alaska Natives/statistics & numerical data ; Biomedical Research/education ; Biomedical Research/organization & administration ; Biomedical Research/statistics & numerical data ; Female ; Humans ; Internship and Residency/organization & administration ; Internship and Residency/statistics & numerical data ; Male ; Minority Groups/education ; Minority Groups/statistics & numerical data ; Universities/statistics & numerical data ; Utah ; Young Adult ; American Indian or Alaska Native/education ; American Indian or Alaska Native/statistics & numerical data
Language	English
Publishing date	2020-09-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000003759
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