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  1. Article ; Online: Second M

    Kistemaker, Loes E M / Elzinga, Carolina R S / Tautermann, Christofer S / Pieper, Michael P / Seeliger, Daniel / Alikhil, Suraya / Schmidt, Martina / Meurs, Herman / Gosens, Reinoud

    British journal of pharmacology

    2019  Volume 176, Issue 16, Page(s) 2864–2876

    Abstract: ... on the M: Experimental approach: ACh, tiotropium, and atropine binding to M: Key results ... Molecular dynamics simulation revealed extracellular vestibule binding of tiotropium, and not atropine, to M: Conclusions and ... implications: We propose that tiotropium has two binding sites at the M ...

    Abstract Background and purpose: The bronchodilator tiotropium binds not only to its main binding site on the M
    Experimental approach: ACh, tiotropium, and atropine binding to M
    Key results: Molecular dynamics simulation revealed extracellular vestibule binding of tiotropium, and not atropine, to M
    Conclusions and implications: We propose that tiotropium has two binding sites at the M
    MeSH term(s) Acetylcholine/metabolism ; Adrenergic beta-2 Receptor Agonists/pharmacology ; Animals ; Binding Sites ; Bronchodilator Agents/pharmacology ; Cattle ; Cholinergic Antagonists/pharmacology ; Humans ; In Vitro Techniques ; Molecular Dynamics Simulation ; Receptor, Muscarinic M3/metabolism ; Tiotropium Bromide/pharmacology ; Trachea/drug effects ; Trachea/physiology
    Chemical Substances Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents ; Cholinergic Antagonists ; Receptor, Muscarinic M3 ; Acetylcholine (N9YNS0M02X) ; Tiotropium Bromide (XX112XZP0J)
    Language English
    Publishing date 2019-07-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14707
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  2. Article ; Online: Safety evaluation of the food additive steviol glycosides, predominantly Rebaudioside M, produced by fermentation using

    Younes, Maged / Aquilina, Gabriele / Degen, Gisela / Engel, Karl-Heinz / Fowler, Paul / Frutos Fernandez, Maria Jose / Fürst, Peter / Gundert-Remy, Ursula / Gürtler, Rainer / Husøy, Trine / Manco, Melania / Mennes, Wim / Passamonti, Sabina / Moldeus, Peter / Shah, Romina / Waalkens-Berendsen, Ine / Wright, Matthew / Barat Baviera, José Manuel / Gott, David /
    Herman, Lieve / Leblanc, Jean-Charles / Wölfle, Detlef / Entrena, Jaime Aguilera / Consuelo, Civitella / Mech, Agnieszka / Multari, Salvatore / Palaniappan, Vasantha / Ruggeri, Laura / Smeraldi, Camilla / Tard, Alexandra / Castle, Laurence

    EFSA journal. European Food Safety Authority

    2023  Volume 21, Issue 12, Page(s) e8387

    Abstract: The EFSA Panel on Food Additive and Flavourings (FAF Panel) provides a scientific opinion on the safety of a new process to produce steviol glycosides by fermentation of simple sugars using a genetically modified strain ... ...

    Abstract The EFSA Panel on Food Additive and Flavourings (FAF Panel) provides a scientific opinion on the safety of a new process to produce steviol glycosides by fermentation of simple sugars using a genetically modified strain of
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2540248-1
    ISSN 1831-4732 ; 1831-4732
    ISSN (online) 1831-4732
    ISSN 1831-4732
    DOI 10.2903/j.efsa.2023.8387
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  3. Book ; Online: “I’m not Working from Home, I’m Living at Work”

    Hayes, Sherrill / Priestley, Jennifer L. / Ishmakhametov, Namazbia / Ray, Herman E.

    Perceived Stress and Work-Related Burnout before and during COVID-19

    2020  

    Abstract: The purpose of the study was to better understand the relationships among stress, work-related burnout, and remote working brought on by social distancing efforts and stay at home orders put in place during the COVID-19 pandemic. The authors developed a ... ...

    Abstract The purpose of the study was to better understand the relationships among stress, work-related burnout, and remote working brought on by social distancing efforts and stay at home orders put in place during the COVID-19 pandemic. The authors developed a questionnaire incorporating valid and reliable self-report stress and burnout measures (Perceived Stress Scale & Copenhagen Burnout Inventory), demographic, and work-related questions. The questions were used primarily to determine workers’ levels of stress before and during the pandemic, to assess potential burnout, and to establish the extent of their previous experience with remote work/telecommuting. The questionnaire was open from March 23rd to May 19th 2020 and distributed through a survey link on social media and by Qualtrics research services. Results from the analyses suggest that perceived stress did increase during the COVID-19 restrictions, especially for people that had limited experience working from home and were female. Individuals who worked from home before COVID-19 had higher levels of work-related burnout but did not differ based on gender or part-time work status. The results suggest that working from home may create more stress and result in more burnout, which challenges the current moves by some employers to make working from home a permanent arrangement. The authors believe that having research based on valid and reliable instruments will help employers and schools make better decisions about how to support those who can remain at home to avoid the potential for secondary outbreaks.
    Keywords covid19
    Publisher Center for Open Science
    Publishing country us
    Document type Book ; Online
    DOI 10.31234/osf.io/vnkwa
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Correction: Holland, J.M., et al. Approaches to Identify the Value of Seminatural Habitats for Conservation Biological Control.

    Holland, John M / Jeanneret, Philippe / Moonen, Anna-Camilla / van der Werf, Wopke / Rossing, Walter A H / Antichi, Daniele / Entling, Martin H / Giffard, Brice / Helsen, Herman / Szalai, Mark / Rega, Carlo / Gibert, Caroline / Veromann, Eve

    Insects

    2020  Volume 11, Issue 5

    Abstract: We would like to change the authors' names and email addresses on page 195 of paper [ ... ]. ...

    Abstract We would like to change the authors' names and email addresses on page 195 of paper [...].
    Language English
    Publishing date 2020-04-29
    Publishing country Switzerland
    Document type Published Erratum
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects11050272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit.

    Hagen, Bas / van Dijk, J Hessel M / Zhang, Qingju / Overkleeft, Herman S / van der Marel, Gijsbert A / Codée, Jeroen D C

    Organic letters

    2017  Volume 19, Issue 10, Page(s) 2514–2517

    Abstract: The synthesis of the Staphylococcus aureus strain M capsular polysaccharide repeating unit is ...

    Abstract The synthesis of the Staphylococcus aureus strain M capsular polysaccharide repeating unit is reported. A postglycosylation oxidation strategy was utilized for the construction of the α-galactosaminuronic acid linkages, relying on a stereoselective 2-azido-4,6-O-di-tert-butylsilylidene galactopyranoside donor, for which the selectivity was assessed by model glycosylations. The α-fucosamine linkage was installed stereoselectively, using a reactive 2-azidofucosyl donor. An unexpected glycosidic bond cleavage during the TEMPO/PhI(OAc)
    MeSH term(s) Glycosylation ; Molecular Structure ; Oxidation-Reduction ; Polysaccharides, Bacterial ; Staphylococcus aureus
    Chemical Substances Polysaccharides, Bacterial
    Language English
    Publishing date 2017-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.7b00747
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  6. Article ; Online: Avery D. Weisman, M.D.

    Cromwell, Julia C / Herman, John B / Stern, Theodore A

    Psychosomatics

    2017  Volume 58, Issue 6, Page(s) 592–593

    Language English
    Publishing date 2017-08-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 209487-3
    ISSN 1545-7206 ; 0033-3182
    ISSN (online) 1545-7206
    ISSN 0033-3182
    DOI 10.1016/j.psym.2017.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 440: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Profil Pasien COVID-19 dengan Komorbid yang Dirawat di RSUP Dr. M. Djamil Padang

    Hamni Tanjung / Julizar Julizar / Sabrina Ermayanti / Deddy Herman / Liganda Endo Mahata / Syandrez Prima Putra

    Jurnal Ilmu Kesehatan Indonesia, Vol 4, Iss 1, Pp 41-

    2023  Volume 50

    Abstract: ... COVID-19 dengan komorbid yang dirawat di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini ...

    Abstract Latar Belakang: Coronavirus Disease 2019 (COVID-19) yang disebabkan Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2) telah menjadi perhatian dunia sejak awal ditemukan hingga saat ini. Keparahan kondisi pasien COVID-19 dengan komorbid dipengaruhi dengan berbagai faktor yang dapat meningkatkan morbiditas dan mortalitas pasien COVID-19. Objektif: Penelitian ini bertujuan untuk mengetahui profil pasien COVID-19 dengan komorbid yang dirawat di RSUP Dr. M. Djamil Padang. Metode: Jenis penelitian ini merupakan observasional deskriptif dengan pendekatan cross-sectional. Data penelitian diambil dari data rekam medis dengan teknik pengambilan total sampling pada pasien yang dirawat pada 1 Oktober sampai 31 Desember 2020. Hasil: Penelitian ini mendapatkan dari total 144 pasien, 34% pasien COVID-19 dengan komorbid merupakan kelompok usia 50-59 tahun, 50,7% berjenis kelamin laki-laki, 59,7% memiliki riwayat pendidikan tingkat menengah dan 53,5% berstatus IMT obesitas. Komorbid terbanyak yang ditemukan adalah 29,2% hipertensi dengan 73,6% pasien memiliki lebih dari satu komorbid, sebanyak 77,1% merupakan COVID-19 derajat sedang dengan 71,5% memiliki lama rawatan 14 hari atau kurang, serta 62,5% memiliki luaran COVID-19 sembuh. Kesimpulan: Penelitian ini menemukan sebagian besar pasien COVID-19 dengan komorbid yang dirawat merupakan kelompok usia tua, dengan komorbid terbanyak hipertensi, sebagian besar memiliki lebih dari satu komorbid, mengalami derajat sakit sedang dengan lama rawatan 14 hari atau kurang, dan luaran sembuh.
    Keywords profil ; covid-19 ; komorbid ; sars-cov-2 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Fakultas Kedokteran Universitas Andalas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: β-Lactamase Producing Escherichia coli Encoding blaCTX-M and blaCMY Genes in Chicken Carcasses from Egypt

    Abo-Almagd, Elham Elsayed / Sabala, Rana Fahmi / Abd-Elghany, Samir Mohammed / Jackson, Charlene R. / Ramadan, Hazem / Imre, Kálmán / Morar, Adriana / Herman, Viorel / Sallam, Khalid Ibrahim

    Foods. 2023 Feb. 01, v. 12, no. 3

    2023  

    Abstract: Escherichia coli with multidrug resistance and β-lactamase genes may constitute a great public health hazard due to the potential for their transmission to humans through the food chain. This study determined the prevalence, antibiotic resistance ... ...

    Abstract Escherichia coli with multidrug resistance and β-lactamase genes may constitute a great public health hazard due to the potential for their transmission to humans through the food chain. This study determined the prevalence, antibiotic resistance profiles, phylogroups, and β-lactamase genes of E. coli isolates from chicken carcasses marketed in Mansoura, Egypt. Interestingly, E. coli was detected in 98% (98/100) of the chicken carcasses examined, which seemed among the highest contamination rates by E. coli worldwide. From the 425 genetically verified uidA gene-positive E. coli, 85 isolates were further studied for antimicrobial resistance profiles, phylogroups, and β-lactamase genes. Interestingly, 89.41% of E. coli (76/85) strains tested against 24 different antibiotics were multidrug-resistant. Of the examined 85 E. coli isolates, 22 (25.88%) isolates harbored blaCTX₋M and were resistant to ampicillin, cefazoline, and ceftriaxone, while three of them were resistant to ceftazidime besides. Nine (10.59%) E. coli strains harbored AmpC- β-lactamase blaCMY and were resistant to ampicillin. One isolate co-carried blaCMY and blaCTX₋M genes, though it was negative for the blaTEM gene. Of the 35 isolates that harbored either extended-spectrum β-lactamase (ESBL) and/or AmpC β-lactamase genes, six strains (17.14%) were assigned to pathogenic phylogroup F and one to phylogroup E, whereas 28 (80%) isolates belonged to commensal phylogenetic groups.
    Keywords Escherichia coli ; ampicillin ; antibiotic resistance ; ceftazidime ; ceftriaxone ; chickens ; food chain ; genes ; health hazards ; multiple drug resistance ; phylogeny ; public health ; Egypt
    Language English
    Dates of publication 2023-0201
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12030598
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Character Education in Novel Mendayung Impian and Chiangmai by Reyhan M Abdurrohman

    Tahrirul Mar'ah / Herman J Waluyo / Raheni Suhita

    International Journal of Multicultural and Multireligious Understanding, Vol 8, Iss 2, Pp 175-

    2021  Volume 181

    Abstract: This study aims to describe the character education in the novel Mendayung Impian and Chiang Mai. The novel Mendayung Impian contains the persistence of a character to achieve goals, while the Chiang Mai novel contains the search for the identity of a ... ...

    Abstract This study aims to describe the character education in the novel Mendayung Impian and Chiang Mai. The novel Mendayung Impian contains the persistence of a character to achieve goals, while the Chiang Mai novel contains the search for the identity of a young man in facing life. The method used in this research is qualitative research. The validity of the data is in the form of theoretical triangulation. The results of this study are that there are three values of character education that stand out, namely hard work, social care, and being friendly.
    Keywords character education ; literature ; novel ; Social Sciences ; H ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher International journal of multicultural and multireligious understanding
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit

    Hagen, Bas / van Dijk J. Hessel M / Zhang Qingju / Overkleeft Herman S / van der Marel Gijsbert A / Codée Jeroen D. C

    Organic letters. 2017 May 19, v. 19, no. 10

    2017  

    Abstract: The synthesis of the Staphylococcus aureus strain M capsular polysaccharide repeating unit is ...

    Abstract The synthesis of the Staphylococcus aureus strain M capsular polysaccharide repeating unit is reported. A postglycosylation oxidation strategy was utilized for the construction of the α-galactosaminuronic acid linkages, relying on a stereoselective 2-azido-4,6-O-di-tert-butylsilylidene galactopyranoside donor, for which the selectivity was assessed by model glycosylations. The α-fucosamine linkage was installed stereoselectively, using a reactive 2-azidofucosyl donor. An unexpected glycosidic bond cleavage during the TEMPO/PhI(OAc)₂-mediated oxidation of a disaccharide intermediate was circumvented by a TEMPO/PhI(OAc)₂–Pinnick oxidation protocol.
    Keywords Staphylococcus aureus ; cleavage (chemistry) ; glycosidic linkages ; glycosylation ; models ; organic compounds ; oxidation ; polysaccharides ; stereoselectivity
    Language English
    Dates of publication 2017-0519
    Size p. 2514-2517.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021%2Facs.orglett.7b00747
    Database NAL-Catalogue (AGRICOLA)

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