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Article ; Online: Platelet-activating factor (PAF) enhances guinea pig detrusor smooth muscle contractile activities by stimulating voltage-dependent Ca

Obara, Keisuke / Kaneko, Mizuki / Yamashita, Mio / Liu, Ge / Yoshioka, Kento / Tanaka, Yoshio

2023 Volume 152, Issue 2, Page(s) 123–127

Abstract: We investigated the extracellular ... ...

Abstract	We investigated the extracellular Ca
MeSH term(s)	Guinea Pigs ; Animals ; Platelet Activating Factor/pharmacology ; Platelet Activating Factor/metabolism ; Muscle, Smooth/metabolism ; Muscle Contraction ; Calcium Channels/metabolism ; Verapamil ; Calcium/metabolism
Chemical Substances	Platelet Activating Factor ; Calcium Channels ; Verapamil (CJ0O37KU29) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-04-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2023.04.004
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Article ; Online: Platelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder.

Liu, Ge / Kaneko, Mizuki / Yoshioka, Kento / Obara, Keisuke / Tanaka, Yoshio

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2783

Abstract: In this study, we investigated the effects of platelet-activating factor (PAF) on the basal tone and spontaneous contractile activities of guinea pig (GP) and mouse urinary bladder (UB) smooth muscle (UBSM) tissues to determine whether PAF could induce ... ...

Abstract	In this study, we investigated the effects of platelet-activating factor (PAF) on the basal tone and spontaneous contractile activities of guinea pig (GP) and mouse urinary bladder (UB) smooth muscle (UBSM) tissues to determine whether PAF could induce UBSM tissue contraction. In addition, we examined the mRNA expression of the PAF receptor, PAF-synthesizing enzyme (lysophosphatidylcholine acyltransferase, LPCAT), and PAF-degrading enzyme (PAF acetylhydrolase, PAF-AH) in GP and mouse UB tissues using RT-qPCR. PAF (10
MeSH term(s)	Animals ; Guinea Pigs ; Male ; Mice ; Muscle Contraction/drug effects ; Muscle, Smooth/metabolism ; Platelet Activating Factor/pharmacology ; Urinary Bladder/metabolism
Chemical Substances	Platelet Activating Factor
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06535-7
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Article ; Online: Electric field control of natural optical activity in a multiferroic helimagnet.

Masuda, Ryoji / Kaneko, Yoshio / Tokura, Yoshinori / Takahashi, Youtarou

Science (New York, N.Y.)

2021 Volume 372, Issue 6541, Page(s) 496–500

Abstract: Controlling the chiral degree of freedom in matter has long been an important issue for many fields of science. The spin-spiral order, which exhibits a strong magnetoelectric coupling, gives rise to chirality irrespective of the atomic arrangement of ... ...

Abstract	Controlling the chiral degree of freedom in matter has long been an important issue for many fields of science. The spin-spiral order, which exhibits a strong magnetoelectric coupling, gives rise to chirality irrespective of the atomic arrangement of matter. Here, we report the resonantly enhanced natural optical activity on the electrically active magnetic excitation, that is, electromagnon, in multiferroic cupric oxide. The electric field control of the natural optical activity is demonstrated through magnetically induced chirality endowed with magnetoelectric coupling. These optical properties inherent to multiferroics may lead to optical devices based on the control of chirality.
Language	English
Publishing date	2021-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aaz4312
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Zs.MG 77: Show issues

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Article ; Online: Comparison of metronidazole

Sue, Soichiro / Oka, Hiroyuki / Kunishi, Yosuke / Suzuki, Yuichi / Suzuki, Shingo / Kaneko, Takashi / Komatsu, Kazuo / Naito, Makoto / Kato, Yoshio / Sasaki, Tomohiko / Kaneko, Hiroaki / Irie, Kuniyasu / Kondo, Masaaki / Maeda, Shin

JGH open : an open access journal of gastroenterology and hepatology

2024 Volume 8, Issue 4, Page(s) e13069

Abstract: Background and aim: To date, no randomized trials have compared the efficacy of 7-day vonoprazan, amoxicillin, and metronidazole triple therapy (VAM) : Methods: This prospective multicenter randomized trial was performed in Japan and involved 124 : ...

Abstract	Background and aim: To date, no randomized trials have compared the efficacy of 7-day vonoprazan, amoxicillin, and metronidazole triple therapy (VAM) Methods: This prospective multicenter randomized trial was performed in Japan and involved 124 Results: The intention-to-treat and per-protocol eradication rates of VAM were 91.3% (95% confidence interval [CI], 82.0-96.7%) and 92.6% (95% CI, 83.7-97.6%), respectively, and those of VAC were 89.1% (95% CI, 77.8-95.9%) and 96.1% (95% CI, 86.5-99.5%), respectively. No significant difference was observed between VAM and VAC in either analysis ( Conclusions: These findings suggest that VAM as a first-line treatment in Japan can be categorized as grade B (intention-to-treat cure rate of 90-95%) and have potential as a first-line national insurance -approved regimen.
Language	English
Publishing date	2024-04-22
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.13069
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Article: Effectiveness of treating menorrhagia using microwave endometrial ablation at a frequency of 2.45 GHz.

Kakinuma, Toshiyuki / Kaneko, Ayaka / Kakinuma, Kaoru / Matsuda, Yoshio / Yanagida, Kaoru / Takeshima, Nobuhiro / Ohwada, Michitaka

World journal of clinical cases

2023 Volume 11, Issue 24, Page(s) 5653–5659

Abstract: Background: Microwave endometrial ablation (MEA) is a minimally invasive treatment for menorrhagia. It has been covered by the national insurance in Japan since April 2012, and its demand has been increasing as the importance of women's health has ... ...

Abstract	Background: Microwave endometrial ablation (MEA) is a minimally invasive treatment for menorrhagia. It has been covered by the national insurance in Japan since April 2012, and its demand has been increasing as the importance of women's health has advanced in society. Aim: To examine the efficacy of MEA as a treatment option for menorrhagia. Methods: In this study, we retrospectively analyzed 76 patients who underwent MEA between January 2016 and March 2020 in our department. MEA was performed in the lithotomy position, under general anesthesia, and with transabdominal ultrasound guidance, including the entire endometrial circumference while confirming endometrial coagulation. The Microtaze AFM-712 and the Sounding Applicator CSA-40CBL-1006200C were used for MEA, and the endometrium was ablated using a Microtaze output of 70 W and coagulation energization time of 50 s per cycle. The visual analog scale (VAS) was used to evaluate menorrhagia, menstrual pain, and treatment satisfaction. Additionally, the hemoglobin (Hb) levels before and after MEA and associated complications were investigated. Results: The average age of the patients was 44.8 ± 4.0 years. While 14 patients had functional menorrhagia, 62 had organic menorrhagia, of whom 14 had endometrial polyps, 40 had uterine fibroids, and 8 had adenomyosis. The VAS score before MEA and 3 and 6 mo after the procedure were 10, 1.3 ± 1.3, and 1.3 ± 1.3, respectively, for menorrhagia and 10, 1.3 ± 1.8, and 1.3 ± 1.8, respectively, for menstrual pain, both showing improvements ( Conclusion: MEA is a safe and effective treatment for menorrhagia.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i24.5653
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Article ; Online: Dermatomyositis-like rash and inflammatory myopathy after mRNA-1273 vaccination.

Kondo, Yasushi / Oyama, Munenori / Nakamura, Yoshio / Matsubara, Shiro / Tanikawa, Akiko / Kaneko, Yuko

Rheumatology (Oxford, England)

2022 Volume 61, Issue 7, Page(s) e171–e173

MeSH term(s)	2019-nCoV Vaccine mRNA-1273/adverse effects ; Dermatomyositis/etiology ; Exanthema/chemically induced ; Humans ; Myositis/chemically induced ; Vaccination/adverse effects
Chemical Substances	2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keac038
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Article ; Online: Platelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder

Ge Liu / Mizuki Kaneko / Kento Yoshioka / Keisuke Obara / Yoshio Tanaka

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract In this study, we investigated the effects of platelet-activating factor (PAF) on the basal tone and spontaneous contractile activities of guinea pig (GP) and mouse urinary bladder (UB) smooth muscle (UBSM) tissues to determine whether PAF could ...

Abstract	Abstract In this study, we investigated the effects of platelet-activating factor (PAF) on the basal tone and spontaneous contractile activities of guinea pig (GP) and mouse urinary bladder (UB) smooth muscle (UBSM) tissues to determine whether PAF could induce UBSM tissue contraction. In addition, we examined the mRNA expression of the PAF receptor, PAF-synthesizing enzyme (lysophosphatidylcholine acyltransferase, LPCAT), and PAF-degrading enzyme (PAF acetylhydrolase, PAF-AH) in GP and mouse UB tissues using RT-qPCR. PAF (10−9–10−6 M) strongly enhanced the basal tone and spontaneous contractile activities (amplitude and frequency) of GP and mouse UBSM tissues in a concentration-dependent manner. The enhancing effects of PAF (10−6 M) on both GP and mouse UBSM contractile activities were strongly suppressed by pretreatment with apafant (a PAF receptor antagonist, GP: 10−5 M; mouse: 3 × 10−5 M). The PAF receptor (Ptafr), LPCAT (Lpcat1, Lpcat2), and PAF-AH (Pafah1b3, Pafah2) mRNAs were detected in GP and mouse UB tissues. These findings reveal that PAF strongly enhances the contractile mechanical activities of UBSM tissues through its receptor and suggest that the PAF-synthesizing and -degrading system exists in UBSM tissues. PAF may serve as both an endogenous UBSM constrictor and an endogenous mediator leading to detrusor overactivity.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatitis B surface antigen reduction is associated with hepatitis B core-specific CD8

Takahama, Shokichi / Yoshio, Sachiyo / Masuta, Yuji / Murakami, Hirotomo / Sakamori, Ryotaro / Kaneko, Shun / Honda, Takashi / Murakawa, Miyako / Sugiyama, Masaya / Kurosaki, Masayuki / Asahina, Yasuhiro / Takehara, Tetsuo / Appay, Victor / Kanto, Tatsuya / Yamamoto, Takuya

Frontiers in immunology

2023 Volume 14, Page(s) 1257113

Abstract: Despite treatment, hepatitis B surface antigen (HBsAg) persists in patients with chronic hepatitis B (CHB), suggesting the likely presence of the virus in the body. ... ...

Abstract	Despite treatment, hepatitis B surface antigen (HBsAg) persists in patients with chronic hepatitis B (CHB), suggesting the likely presence of the virus in the body. CD8
MeSH term(s)	Humans ; Hepatitis B Surface Antigens ; CD8-Positive T-Lymphocytes ; Hepatitis B virus ; Leukocytes, Mononuclear ; Hepatitis B, Chronic/drug therapy
Chemical Substances	Hepatitis B Surface Antigens
Language	English
Publishing date	2023-10-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1257113
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Article ; Online: Oral Corticosteroids Impair Mucin Production and Alter the Posttransplantation Microbiota in the Gut.

Okafuji, Hirofumi / Iida, Noriho / Kitamura, Kazuya / Seishima, Jun / Wang, Ziyu / Yutani, Masahiro / Yoshio, Takatoshi / Yamashita, Taro / Sakai, Yoshio / Honda, Masao / Yamashita, Tatsuya / Fujinaga, Yukako / Shinkura, Reiko / Hamaguchi, Yasuhito / Mizukoshi, Eishiro / Kaneko, Shuichi

Digestion

2022 Volume 103, Issue 4, Page(s) 269–286

Abstract: Introduction: Gut microbiota alterations cause inflammation in patients with ulcerative colitis (UC). Fecal microbiota transplantation (FMT) enables manipulating the microbiota's composition, but the mechanisms underlying colonization of the ... ...

Abstract	Introduction: Gut microbiota alterations cause inflammation in patients with ulcerative colitis (UC). Fecal microbiota transplantation (FMT) enables manipulating the microbiota's composition, but the mechanisms underlying colonization of the posttransplantation microbiota are poorly understood. Methods: In this open-label, nonrandomized study, the FMT efficacy and changes in the gut microbiota were evaluated in 8 UC patients with mild-to-moderately active endoscopic colonic lesions. Compositional changes in the fecal and mucosal microbiotas between donors and recipients were examined via 16S rRNA-based sequencing. To investigate the effects of oral corticosteroids on microbiota colonization, FMT was performed in germ-free prednisolone (PSL)-administered mice to examine the factors determining colonization. Results: Four UC patients achieved clinical remission (CR) after FMT, and 3 also achieved endoscopic remission. The fecal microbiotas of the CR patients changed similar to those of the donors after FMT. The mucin-coding gene, MUC2, was less expressed in the colons of the PSL-dependent patients than in the PSL-free patients. In the mice, PSL treatment decreased the fecal mucin production and altered the posttransplantation fecal microbiota composition. Adding either exogenous mucin or the mucin secretagogue, rebamipide, partially alleviated the PSL-induced dysbiosis of the gut microbiota. Administering rebamipide with FMT from healthy donors relieved inflammation in mice with Enterococcus faecium-induced colitis. Conclusion: Colonic mucin controlled the gut microbiota composition, and oral corticosteroid treatment modified the gut microbiota partly by reducing the colonic mucin.
MeSH term(s)	Adrenal Cortex Hormones ; Animals ; Colitis, Ulcerative/therapy ; Feces ; Inflammation ; Mice ; Microbiota ; Mucins ; RNA, Ribosomal, 16S/genetics ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones ; Mucins ; RNA, Ribosomal, 16S
Language	English
Publishing date	2022-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1712-7
ISSN	1421-9867 ; 0012-2823
ISSN (online)	1421-9867
ISSN	0012-2823
DOI	10.1159/000522039
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Article ; Online: Loss of CRMP1 and CRMP2 results in migration defects of Purkinje cells in the X lobule of the mouse cerebellum.

Akinaga, Satoshi / Harada, Sayaka / Takahashi, Miyuki / Kaneko, Aosa / Kolattukudy, Papachan / Goshima, Yoshio / Ohshima, Toshio

Brain research

2022 Volume 1783, Page(s) 147846

Abstract: The three-layered structure of the mammalian cerebellar cortex is generated through the coordinated migration of cerebellar neurons. Purkinje cells migrate and form a three- to four-cell-thick aggregate below the external granule cell layer during the ... ...

Abstract	The three-layered structure of the mammalian cerebellar cortex is generated through the coordinated migration of cerebellar neurons. Purkinje cells migrate and form a three- to four-cell-thick aggregate below the external granule cell layer during the embryonic stage, and align to form a monocellular arrangement in the Purkinje cell layer during the postnatal period. We previously reported the involvement of Cdk5-mediated CRMP2 phosphorylation in Purkinje cell migration and the synergistic roles of two other CRMPs, CRMP1 and CRMP4. In the present study, we investigated the loss of function of CRMP2 along with the synergistic function of CRMP1 in the migration and alignment of Purkinje cells. We found deficits in the migration and alignment of Purkinje cells in lobule X of the cerebella of CRMP1 and CRMP2 double knockout mice. Because lobule X, also called the flocculonodular lobe, is involved in the maintenance of balance equilibrium and muscle tone, we conducted balance beam and grip power tests in these mice and found impaired performance on the balance beam test and lower grip power in CRMP1 and CRMP2 double knockout mice, indicating the importance of these genes in proper cerebellar development.
MeSH term(s)	Animals ; Cell Movement ; Cerebellum ; Mammals ; Mice ; Mice, Knockout ; Neurogenesis ; Phosphorylation ; Purkinje Cells/physiology
Language	English
Publishing date	2022-02-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2022.147846
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