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Article ; Online: rol-6

Sparling, A Clare / King, Dillon E / Meyer, Joel N

microPublication biology

2023 Volume 2023

Abstract: Collagen mutations are commonly used in the creation ... ...

Abstract	Collagen mutations are commonly used in the creation of
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.000798
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Article: Iris Chafing Syndrome Secondary to Iridociliary Adhesions in a Patient with a Single-Piece Acrylic Intraocular Lens: Case Report.

King, Jacob / Chen, Stephen / Goncz, Austin / Palko, Joel

Case reports in ophthalmology

2023 Volume 14, Issue 1, Page(s) 692–697

Abstract: Introduction: We present a unique case of iris chafing syndrome in a patient with a complex ophthalmologic history after successful placement of a single-piece in-the-bag intraocular lens (IOL) in an eye with healthy zonular support.: Case ... ...

Abstract	Introduction: We present a unique case of iris chafing syndrome in a patient with a complex ophthalmologic history after successful placement of a single-piece in-the-bag intraocular lens (IOL) in an eye with healthy zonular support. Case presentation: A patient with a previous history of multiple retinal surgeries presented with pain and elevated intraocular pressure (IOP) secondary to retained viscoelastic material in the anterior chamber. Following removal of the viscoelastic material in clinic, the patient underwent a combined cataract and glaucoma surgery. Subsequently, the patient developed signs and symptoms of iris chafing syndrome. Anterior segment imaging revealed the cause to be iridociliary adhesion causing an elimination of the sulcus space. Iris chafing syndrome was suspected when the patient presented post-operatively with changes in vision and anterior chamber inflammation. New iris transillumination defects present at the edge of the optic and haptic of the 1-piece lens helped confirm the diagnosis of UGH. Upon further investigation with gonioscopy, ultrasound biomicroscopy and anterior segment optical coherence tomography, it was determined that the patient had iridociliary adhesions. These adhesions eliminated the sulcus space, which resulted in iris chafing. The patient opted for conservative medical management. Best-corrected distance visual acuity remained stable at 20/100 and IOP remained well controlled. Conclusion: A complex ocular history of multiple retinal surgeries and retained viscoelastic material in the anterior chamber resulted in adhesions of the ciliary processes to the iris, leading to UGH syndrome in a patient with an otherwise unremarkable placement of a single-piece in-the-bag IOL.
Language	English
Publishing date	2023-12-12
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000535167
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Article ; Online: Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation.

Cron, David C / Husain, Syed A / King, Kristen L / Mohan, Sumit / Adler, Joel T

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2023 Volume 23, Issue 8, Page(s) 1209–1220

Abstract: The newest kidney allocation policy kidney allocation system 250 (KAS250) broadened geographic distribution while increasing allocation system complexity. We studied the volume of kidney offers received by transplant centers and the efficiency of kidney ... ...

Abstract	The newest kidney allocation policy kidney allocation system 250 (KAS250) broadened geographic distribution while increasing allocation system complexity. We studied the volume of kidney offers received by transplant centers and the efficiency of kidney placement since KAS250. We identified deceased-donor kidney offers (N = 907,848; N = 36,226 donors) to 185 US transplant centers from January 1, 2019, to December 31, 2021 (policy implemented March 15, 2021). Each unique donor offered to a center was considered a single offer. We compared the monthly volume of offers received by centers and the number of centers offered before the first acceptance using an interrupted time series approach (pre-/post-KAS250). Post-KAS250, transplant centers received more kidney offers (level change: 32.5 offers/center/mo, P < .001; slope change: 3.9 offers/center/mo, P = .003). The median monthly offer volume post-/pre-KAS250 was 195 (interquartile range 137-253) vs. 115 (76-151). There was no significant increase in deceased-donor transplant volume at the center level after KAS250, and center-specific changes in offer volume did not correlate with changes in transplant volume (r = -0.001). Post-KAS250, the number of centers to whom a kidney was offered before acceptance increased significantly (level change: 1.7 centers/donor, P < .001; slope change: 0.1 centers/donor/mo, P = .014). These findings demonstrate the logistical burden of broader organ sharing, and future allocation policy changes will need to balance equity in transplant access with the operational efficiency of the allocation system.
MeSH term(s)	Humans ; Tissue and Organ Procurement ; Tissue Donors ; Kidney ; Kidney Transplantation ; Transplants ; Waiting Lists
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1016/j.ajt.2023.05.005
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Article ; Online: Increased cytotoxicity of Pb

Lalwani, Pooja / King, Dillon E / Morton, Katherine S / Rivera, Nelson A / Huayta, Javier / Hsu-Kim, Heileen / Meyer, Joel N

Environmental science. Processes & impacts

2023 Volume 25, Issue 11, Page(s) 1743–1751

Abstract: ... Lead ( ... ...

Abstract	Lead (Pb
MeSH term(s)	Humans ; Lead/toxicity ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/metabolism ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology ; Mitochondria/metabolism ; Calcium Channels/metabolism ; Calcium Channels/pharmacology ; Calcium
Chemical Substances	mitochondrial calcium uniporter ; Lead (2P299V784P) ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (370-86-5) ; Calcium Channels ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2703814-2
ISSN	2050-7895 ; 2050-7887
ISSN (online)	2050-7895
ISSN	2050-7887
DOI	10.1039/d3em00188a
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Article ; Online: Reconsidering item response categories in gaming disorder symptoms measurement.

King, Daniel L / Nogueira-López, Abel / Galanis, Christina R / Hamamura, Toshitaka / Bäcklund, Christian / Giardina, Alessandro / Billieux, Joël / Delfabbro, Paul H

Journal of behavioral addictions

2023 Volume 12, Issue 4, Page(s) 873–877

Abstract: Gaming disorder (GD) screening often involves self-report survey measures to detect the presence of symptoms. Studies have shown that gamers' responses vary greatly across survey items. Some symptoms, such as preoccupation and tolerance, are frequently ... ...

Abstract	Gaming disorder (GD) screening often involves self-report survey measures to detect the presence of symptoms. Studies have shown that gamers' responses vary greatly across survey items. Some symptoms, such as preoccupation and tolerance, are frequently reported by highly engaged but non-problematic gamers, and therefore these symptoms are thought to lack specificity and are suggested to be less important in classification decisions. We argue that the influence of response categories (e.g., dichotomous responses, such as 'yes' or 'no'; or frequency categories, such as 'rarely' and 'often') on item responses has been relatively underexplored despite potentially contributing significantly to the psychometric performance of items and scales. In short, the type of item response may be just as important to symptom reporting as the content of survey questions. We propose some practical alternatives to currently used item categories across GD tools. Research should examine the performance of different response categories, including whether certain response categories aid respondents' comprehension and insight, and better capture pathological behaviours and harms.
MeSH term(s)	Humans ; Behavior, Addictive/diagnosis ; Video Games ; Disruptive, Impulse Control, and Conduct Disorders ; Surveys and Questionnaires ; Self Report
Language	English
Publishing date	2023-12-04
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2817933-X
ISSN	2063-5303 ; 2063-5303
ISSN (online)	2063-5303
ISSN	2063-5303
DOI	10.1556/2006.2023.00070
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Article ; Online: The breadth of macropinocytosis research.

Swanson, Joel A / King, Jason S

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2017 Volume 374, Issue 1765, Page(s) 20180146

MeSH term(s)	Animals ; Humans ; Macrophages/physiology ; Pinocytosis/physiology
Language	English
Publishing date	2017-05-08
Publishing country	England
Document type	Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2018.0146
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Article ; Online: An Introduction to Generative Artificial Intelligence in Mental Health Care: Considerations and Guidance.

King, Darlene R / Nanda, Guransh / Stoddard, Joel / Dempsey, Allison / Hergert, Sarah / Shore, Jay H / Torous, John

Current psychiatry reports

2023 Volume 25, Issue 12, Page(s) 839–846

Abstract: Purpose of review: This paper provides an overview of generative artificial intelligence (AI) and the possible implications in the delivery of mental health care.: Recent findings: Generative AI is a powerful technology that is changing rapidly. As ... ...

Abstract	Purpose of review: This paper provides an overview of generative artificial intelligence (AI) and the possible implications in the delivery of mental health care. Recent findings: Generative AI is a powerful technology that is changing rapidly. As psychiatrists, it is important for us to understand generative AI technology and how it may impact our patients and our practice of medicine. This paper aims to build this understanding by focusing on GPT-4 and its potential impact on mental health care delivery. We first introduce key concepts and terminology describing how the technology works and various novel uses of it. We then dive into key considerations for GPT-4 and other large language models (LLMs) and wrap up with suggested future directions and initial guidance to the field.
MeSH term(s)	Humans ; Artificial Intelligence ; Mental Health
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055376-6
ISSN	1535-1645 ; 1523-3812
ISSN (online)	1535-1645
ISSN	1523-3812
DOI	10.1007/s11920-023-01477-x
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Article ; Online: Greater complexity and monitoring of the new Kidney Allocation System: Implications and unintended consequences of concentric circle kidney allocation on network complexity.

Adler, Joel T / Husain, Syed A / King, Kristen L / Mohan, Sumit

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2021 Volume 21, Issue 6, Page(s) 2007–2013

Abstract: The deceased donor kidney allocation system in the United States has undergone several rounds of iterative changes, but these changes were not explicitly designed to address the geographic variation in access to transplantation. The new allocation system, ...

Abstract	The deceased donor kidney allocation system in the United States has undergone several rounds of iterative changes, but these changes were not explicitly designed to address the geographic variation in access to transplantation. The new allocation system, expected to start in December 2020, changes the definition of "local allocation" from the Donation Service Area to 250 nautical mile circles originating from the donor hospital. While other solid organs have adopted a similar approach, the larger number of both kidney transplant centers and transplant candidates is likely to have different consequences. Here, we discuss the incredible increase in complexity in allocation, discuss some of the likely intended and unintended consequences, and propose metrics to monitor the new system.
MeSH term(s)	Humans ; Kidney ; Kidney Transplantation ; Tissue Donors ; Tissue and Organ Procurement ; United States ; Waiting Lists
Language	English
Publishing date	2021-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16441
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Article ; Online: The psychiatric impact of COVID-19 on healthcare workers.

Cabarkapa, Sonja / King, Joel A / Ng, Chee H

Australian journal of general practice

2020 Volume 49, Issue 12, Page(s) 791–795

Abstract: Background: Healthcare workers (HCWs) are a vulnerable population who have been exposed to high work-related stress during the COVID-19 pandemic because of the high risk of infection and excessive workloads. HCWs are at greater risk of mental illness, ... ...

Abstract	Background: Healthcare workers (HCWs) are a vulnerable population who have been exposed to high work-related stress during the COVID-19 pandemic because of the high risk of infection and excessive workloads. HCWs are at greater risk of mental illness, particularly sleep disturbances, post-trauma stress syndromes, depression and anxiety. Objective: The aim of this article is to highlight the psychiatric impact of the COVID-19 pandemic on frontline HCWs, the need for screening and early diagnosis by general practitioners (GPs), and the appropriate psychosocial strategies and treatments to address this. Discussion: Opportunistic screening for mental health issues among HCWs is especially important during the current pandemic. Various tools and strategies can be used for efficient assessment and treatment of the common mental health issues HCWs are likely to face.
MeSH term(s)	Anxiety/complications ; Anxiety/etiology ; Anxiety/psychology ; Australia/epidemiology ; COVID-19/complications ; COVID-19/psychology ; Depression/complications ; Depression/etiology ; Depression/psychology ; Health Personnel/psychology ; Humans ; Mental Health/standards ; Mental Health/trends ; Surveys and Questionnaires
Language	English
Publishing date	2020-11-16
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2924889-9
ISSN	2208-7958 ; 2208-794X
ISSN (online)	2208-7958
ISSN	2208-794X
DOI	10.31128/AJGP-07-20-5531
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Article ; Online: What's race got to do with it? Factors contributing to self-change from cocaine use disorder among Black adults.

Sypher, Isaiah / Pavlo, Anthony / King, Jaelen / Youins, Richard / Shumake, Amina / Lopez, Joel / Haeny, Angela M

Journal of substance use and addiction treatment

2023 Volume 153, Page(s) 208945

Abstract: Introduction: A substantial number of people with substance use disorders recover without formal treatment, though we know little about the process of self-change among Black adults with cocaine use disorder (CUD) and whether racism contributes to the ... ...

Abstract	Introduction: A substantial number of people with substance use disorders recover without formal treatment, though we know little about the process of self-change among Black adults with cocaine use disorder (CUD) and whether racism contributes to the development of CUD and these adults' process of self-change. Methods: The study team conducted qualitative interviews with 29 Black adults using a narrative and phenomenological approach. At the time of the interview, all participants met criteria for DSM-5 CUD prior to the past year but did not meet criteria for CUD in the past year and reported that they reduced their cocaine use without formal treatment. Participants completed a qualitative interview followed by the UConn Racial/Ethnic Stress & Trauma Survey. Thematic analyses informed key themes from the qualitative interviews. Results: Qualitative analyses indicated several major factors that contributed to self-change from CUD: racial identity, responsibility to family, social regard, spirituality, turning point for change, and changing one's environment. These results highlight that self-change from CUD is a complex, ongoing, and multifaceted process. The identified themes align with several theories of recovery, including social control theory and the theory of stress and coping. Furthermore, the results suggest that experiences of racism are common among Black adults recovering from CUD, and that the multiple strategies employed for coping with racism may be consistent with the process of self-change. Conclusions: This study shows that multiple race-related factors contribute to the development of, maintenance of, and self-change from CUD among Black adults. Better understanding these factors can help to inform drug treatment.
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2949-8759
ISSN (online)	2949-8759
DOI	10.1016/j.josat.2022.208945
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