LIVIVO - Search results -

Search results

Result 1 - 10 of total 266

Search options

Article ; Online: Long-term home parenteral nutrition in systemic sclerosis-related intestinal failure is feasible but unveils occult cardiac disease.

Suzon, Benoit / Rivière, Sophie / Schiffmann, Auelie / Rivet, Valérian / Flori, Nicolas / Guilpain, Philippe / Maria, Alexandre Thibault Jacques

Nutrition (Burbank, Los Angeles County, Calif.)

2023 Volume 110, Page(s) 112009

Abstract: Objective: The aim of this study was to compare safety and efficacy of long-term home parenteral nutrition between patients with systemic sclerosis and intestinal failure (IF) and controls with IF from another etiology.: Methods: A retrospective ... ...

Abstract	Objective: The aim of this study was to compare safety and efficacy of long-term home parenteral nutrition between patients with systemic sclerosis and intestinal failure (IF) and controls with IF from another etiology. Methods: A retrospective study was conducted in a referral center for systemic sclerosis (SSc) in Montpellier, France. Patients followed between 1985 and 2020 with SSc-related IF were included and compared with control patients with IF from another etiology. The patients included had to be treated for ≥4 wk by home parenteral nutrition (HPN). Primary outcome was occurrence of HPN-related complications. Secondary outcomes included duration of parenteral nutrition, body mass index at 12 mo, and survival. Results: Cumulative duration of HPN was 23 397 catheter days. HPN resulted in body mass index increase in both groups. There was no statistical difference regarding catheter-related bloodstream infections and thrombosis between the groups, despite use of immunosuppressive drugs and autologous hematopoietic stem cell transplantation in patients with SSc. However, the patients with SSc had significantly more HPN-related cardiac overload than the controls (P < 0.0001). Overloads occurred in SSc patients with and without cardiac disease, arguing for comprehensive hemodynamic screening in this condition. Conclusion: Long-term HPN in SSc-related IF is feasible but unveils occult cardiac disease.
MeSH term(s)	Humans ; Retrospective Studies ; Intestinal Failure ; Parenteral Nutrition, Home/adverse effects ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/therapy ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/etiology ; Heart Diseases/etiology ; Heart Diseases/therapy ; Intestinal Diseases/etiology ; Intestinal Diseases/therapy
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2290: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Modifications des réseaux neuronaux par transgénèse conditionnelle: une clé pour notre compréhension des pathologies neuro- psychiatriques du système des noyaux de la base.

Schiffmann, S N

Bulletin et memoires de l'Academie royale de medecine de Belgique

2009 Volume 164, Issue 7-9, Page(s) 171–8; discussion 178–80

Abstract: The striatum, the first relay of the basal ganglia system, is critically involved in motor functions and motivational processes. The dorsal striatum is central to the motor control and motor learning and the ventral striatum or nucleus accumbens is ... ...

Title translation	Changes in neural networks by conditional transgenic approach: a key to our comprehension of neuro-psychiatric disorders in the basal ganglia system.
Abstract	The striatum, the first relay of the basal ganglia system, is critically involved in motor functions and motivational processes. The dorsal striatum is central to the motor control and motor learning and the ventral striatum or nucleus accumbens is essential for motivation, the reward system and reinforcement by drugs. This system is dysfunctional in movement disorders such as Parkinson's disease and Huntington's disease and in psychiatric disorders including drug addiction. The striatum consists of two populations of neurons projecting at the origin of two distinct paths in the circuit of basal ganglia, and of different populations of interneurons. These two populations of efferent neurons, striatopallidal and striatonigral neurons, are characterized by their projection sites and their differential expression in dopamine receptors and neuropeptides. Their roles in motor control and motivational processes and in the mechanisms of neuroadaptation in the system's pathologies remain mostly unknown. To identify these specific functions, we have developed new animal models wearing molecular or cell "lesions" by a conditional transgenic approach to target a specific population of neurons. By this approach, we demonstrated the inhibitory role of the population of striatopallidal neurons in the motor control and in the process of drug addiction, identified new genes selectively expressed by striatopallidal neurons that could be the target for future therapies and identified the potential role of this population of neurons disturbances in attention-deficit hyperactivity disorder (ADHD).
MeSH term(s)	Animals ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Basal Ganglia/physiopathology ; Corpus Striatum/physiopathology ; Humans ; Huntington Disease/physiopathology ; Mental Disorders/physiopathology ; Mice ; Mice, Knockout ; Models, Animal ; Movement Disorders/physiopathology ; Nerve Net/physiopathology ; Nervous System Diseases/physiopathology ; Neural Pathways/physiopathology ; Neurons, Efferent/metabolism ; Neuropeptides/metabolism ; Nucleus Accumbens/physiopathology ; Parkinson Disease/physiopathology ; Rats ; Rats, Transgenic ; Receptors, Dopamine/metabolism ; Substance-Related Disorders/physiopathology
Chemical Substances	Neuropeptides ; Receptors, Dopamine
Language	French
Publishing date	2009
Publishing country	Belgium
Document type	English Abstract ; Lectures
ZDB-ID	1445946-2
ISSN	0377-8231
ISSN	0377-8231
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.7: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum.

Pommer, Stefan / Akamine, Yumiko / Schiffmann, Serge N / de Kerchove d'Exaerde, Alban / Wickens, Jeffery R

The Journal of neuroscience : the official journal of the Society for Neuroscience

2021 Volume 41, Issue 37, Page(s) 7831–7847

Abstract: The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main axon, forming a local lateral inhibition network. Serotonin, acting via the 5-HT1B receptor, ... ...

Abstract	The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main axon, forming a local lateral inhibition network. Serotonin, acting via the 5-HT1B receptor, modulates neurotransmitter release from SPN terminals in striatal output nuclei, but the role of 5-HT1B receptors in lateral inhibition among SPNs in the striatum is unknown. Here, we report the effects of 5-HT1B receptor activation on lateral inhibition in the mouse striatum. Whole-cell recordings were made from SPNs in acute brain slices of either sex, while optogenetically activating presynaptic SPNs or fast-spiking interneurons (FSIs). Activation of 5-HT1B receptors significantly reduced the amplitude of IPSCs evoked by optical stimulation of both direct and indirect pathway SPNs. This reduction was blocked by application of a 5-HT1B receptor antagonist. Activation of 5-HT1B receptors did not reduce the amplitude of IPSCs evoked from FSIs. These results suggest a new role for serotonin as a modulator of lateral inhibition among striatal SPNs. The 5-HT1B receptor may, therefore, be a suitable target for future behavioral experiments investigating the currently unknown role of lateral inhibition in the function of the striatum.
MeSH term(s)	Action Potentials/drug effects ; Animals ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Interneurons/drug effects ; Interneurons/metabolism ; Mice ; Neural Inhibition/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Patch-Clamp Techniques ; Receptor, Serotonin, 5-HT1B/metabolism ; Serotonin/metabolism ; Serotonin 5-HT1 Receptor Agonists/pharmacology ; Synaptic Transmission/drug effects ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Receptor, Serotonin, 5-HT1B ; Serotonin 5-HT1 Receptor Agonists ; Serotonin (333DO1RDJY) ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1037-20.2021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1668: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Immuno-inflammatory

Roser, Luise A / Luckhardt, Sonja / Ziegler, Nicole / Thomas, Dominique / Wagner, Pia Viktoria / Damm, Georg / Scheffschick, Andrea / Hewitt, Philip / Parnham, Michael J / Schiffmann, Susanne

Frontiers in immunology

2023 Volume 14, Page(s) 1275368

Abstract: Introduction: Hepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to assess using current preclinical models and the incidence is too low to detect ... ...

Abstract	Introduction: Hepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to assess using current preclinical models and the incidence is too low to detect in clinical trials. As hepatotoxicity is a frequent reason for post-authorisation drug withdrawal, there is an urgent need for immuno-inflammatory Methods: Co-culture models of primary human CD8 Results: We identified CD8 Discussion: The
MeSH term(s)	Humans ; Interleukin-2/pharmacology ; Biological Products ; CD8-Positive T-Lymphocytes ; Drug-Related Side Effects and Adverse Reactions ; Chemical and Drug Induced Liver Injury/etiology
Chemical Substances	aldesleukin (M89N0Q7EQR) ; Interleukin-2 ; Biological Products
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1275368
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Conference proceedings: Das metastasierte Ösophaguskarzinom – eine chirurgisch therapierbare Erkrankung?

Knipper, K. / Krey, T. / Lyu, S. I. / Wirsik, N. M. / Schiffmann, L. M. / Fuchs, H. F. / Gebauer, F. / Schroeder, W. / Schloesser, H. A. / Popp, F. C. / Quaas, A. / Bruns, C. J. / Schmidt, T.

Zeitschrift für Gastroenterologie

2023 Volume 61, Issue 08

Event/congress	Viszeralmedizin 2023 77. Jahrestagung der DGVS mit Sektion Endoskopie Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie mit den Arbeitsgemeinschaften der DGAV und Jahrestagung der CACP, Erst online. Dann Hamburg., 2023-09-11
Language	German
Publishing date	2023-08-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/s-0043-1772038
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Zs.A 111: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 111/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model

El-Hindi, K. / Brachtendorf, S. / Hartel, J.C. / Oertel, S. / Birod, K. / Merz, N. / Trautmann, S. / Thomas, Dominique / Weigert, A. / Schäufele, T.J. / Scholich, K. / Schiffmann, Susanne / Ulshöfer, Thomas / Utermöhlen, O. / Grösch, Sabine

2022

Abstract: To better understand the role of sphingolipids in the multifactorial process of inflammatory bowel disease (IBD), we elucidated the role of CerS4 in colitis and colitis-associated cancer (CAC). For this, we utilized the azoxymethane/dextran sodium ... ...

Abstract	To better understand the role of sphingolipids in the multifactorial process of inflammatory bowel disease (IBD), we elucidated the role of CerS4 in colitis and colitis-associated cancer (CAC). For this, we utilized the azoxymethane/dextran sodium sulphate (AOM/DSS)- induced colitis model in global CerS4 knockout (CerS4 KO), intestinal epithelial (CerS4 Vil/Cre), or T-cell restricted knockout (CerS4 LCK/Cre) mice. CerS4 KO mice were highly sensitive to the toxic effect of AOM/DSS, leading to a high mortality rate. CerS4 Vil/Cre mice had smaller tumors than WT mice. In contrast, CerS4 LCK/Cre mice frequently suffered from pancolitis and developed more colon tumors. In vitro, CerS4-depleted CD8+ T-cells isolated from the thymi of CerS4 LCK/Cre mice showed impaired proliferation and prolonged cytokine production after stimulation in comparison with T-cells from WT mice. Depletion of CerS4 in human Jurkat T-cells led to a constitutively activated T-cell receptor and NF-κB signaling pathway. In conclusion, the deficiency of CerS4 in Tcells led to an enduring active status of these cells and prevents the resolution of inflammation, leading to a higher tumor burden in the CAC mouse model. In contrast, CerS4 deficiency in epithelial cells resulted in smaller colon tumors and seemed to be beneficial. The higher tumor incidence in CerS4 LCK/Cre mice and the toxic effect of AOM/DSS in CerS4 KO mice exhibited the importance of CerS4 in other tissues and revealed the complexity of general targeting CerS4. 23 3
Keywords	Ceramide synthase ; Colon ; Jurkat ; LASS ; T-cell ; Tumor
Subject code	570
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.

El-Hindi, Khadija / Brachtendorf, Sebastian / Hartel, Jennifer Christina / Oertel, Stephanie / Birod, Kerstin / Merz, Nadine / Trautmann, Sandra / Thomas, Dominique / Weigert, Andreas / Schäufele, Tim J / Scholich, Klaus / Schiffmann, Susanne / Ulshöfer, Thomas / Utermöhlen, Olaf / Grösch, Sabine

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract	To better understand the role of sphingolipids in the multifactorial process of inflammatory bowel disease (IBD), we elucidated the role of CerS4 in colitis and colitis-associated cancer (CAC). For this, we utilized the azoxymethane/dextran sodium sulphate (AOM/DSS)-induced colitis model in global CerS4 knockout (CerS4 KO), intestinal epithelial (CerS4 Vil/Cre), or T-cell restricted knockout (CerS4 LCK/Cre) mice. CerS4 KO mice were highly sensitive to the toxic effect of AOM/DSS, leading to a high mortality rate. CerS4 Vil/Cre mice had smaller tumors than WT mice. In contrast, CerS4 LCK/Cre mice frequently suffered from pancolitis and developed more colon tumors. In vitro, CerS4-depleted CD8+ T-cells isolated from the thymi of CerS4 LCK/Cre mice showed impaired proliferation and prolonged cytokine production after stimulation in comparison with T-cells from WT mice. Depletion of CerS4 in human Jurkat T-cells led to a constitutively activated T-cell receptor and NF-κB signaling pathway. In conclusion, the deficiency of CerS4 in T-cells led to an enduring active status of these cells and prevents the resolution of inflammation, leading to a higher tumor burden in the CAC mouse model. In contrast, CerS4 deficiency in epithelial cells resulted in smaller colon tumors and seemed to be beneficial. The higher tumor incidence in CerS4 LCK/Cre mice and the toxic effect of AOM/DSS in CerS4 KO mice exhibited the importance of CerS4 in other tissues and revealed the complexity of general targeting CerS4.
MeSH term(s)	Animals ; Azoxymethane/adverse effects ; Colitis-Associated Neoplasms/chemically induced ; Colitis-Associated Neoplasms/genetics ; Colitis-Associated Neoplasms/immunology ; Colitis-Associated Neoplasms/pathology ; Colonic Neoplasms/chemically induced ; Colonic Neoplasms/genetics ; Colonic Neoplasms/immunology ; Colonic Neoplasms/pathology ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; Humans ; Jurkat Cells ; Mice ; Mice, Knockout ; NF-kappa B/metabolism ; Organ Specificity ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Sphingosine N-Acyltransferase/genetics ; T-Lymphocytes/metabolism ; Tumor Burden
Chemical Substances	NF-kappa B ; Receptors, Antigen, T-Cell ; Dextran Sulfate (9042-14-2) ; CERS4 protein, mouse (EC 2.3.1.24) ; Sphingosine N-Acyltransferase (EC 2.3.1.24) ; Azoxymethane (MO0N1J0SEN)
Language	English
Publishing date	2022-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031866
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.

de Bruin, Natasja / Schneider, Ann-Kathrin / Reus, Philipp / Talmon, Sonja / Ciesek, Sandra / Bojkova, Denisa / Cinatl, Jindrich / Lodhi, Imran / Charlesworth, Bruce / Sinclair, Simon / Pennick, Graham / Laughey, William F / Gribbon, Philip / Kannt, Aimo / Schiffmann, Susanne

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: SARS-CoV-2 uses the human cell surface protein angiotensin converting enzyme 2 (ACE2) as the receptor by which it gains access into lung and other tissue. Early in the pandemic, there was speculation that a number of commonly used medications-including ... ...

Abstract	SARS-CoV-2 uses the human cell surface protein angiotensin converting enzyme 2 (ACE2) as the receptor by which it gains access into lung and other tissue. Early in the pandemic, there was speculation that a number of commonly used medications-including ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs)-have the potential to upregulate ACE2, thereby possibly facilitating viral entry and increasing the severity of COVID-19. We investigated the influence of the NSAIDS with a range of cyclooxygenase (COX)1 and COX2 selectivity (ibuprofen, flurbiprofen, etoricoxib) and paracetamol on the level of ACE2 mRNA/protein expression and activity as well as their influence on SARS-CoV-2 infection levels in a Caco-2 cell model. We also analysed the ACE2 mRNA/protein levels and activity in lung, heart and aorta in ibuprofen treated mice. The drugs had no effect on ACE2 mRNA/protein expression and activity in the Caco-2 cell model. There was no up-regulation of ACE2 mRNA/protein expression and activity in lung, heart and aorta tissue in ibuprofen-treated mice in comparison to untreated mice. Viral load was significantly reduced by both flurbiprofen and ibuprofen at high concentrations. Ibuprofen, flurbiprofen, etoricoxib and paracetamol demonstrated no effects on ACE2 expression or activity in vitro or in vivo. Higher concentrations of ibuprofen and flurbiprofen reduced SARS-CoV-2 replication in vitro.
MeSH term(s)	Acetaminophen/pharmacology ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; COVID-19/genetics ; COVID-19/metabolism ; COVID-19/pathology ; Caco-2 Cells ; Disease Progression ; Enzyme Activation/drug effects ; Etoricoxib/pharmacology ; Flurbiprofen/pharmacology ; Gene Expression Regulation, Enzymologic/drug effects ; Humans ; Ibuprofen/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Virus Internalization/drug effects
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Acetaminophen (362O9ITL9D) ; Flurbiprofen (5GRO578KLP) ; ACE2 protein, human (EC 3.4.17.23) ; Ace2 protein, mouse (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Ibuprofen (WK2XYI10QM) ; Etoricoxib (WRX4NFY03R)
Language	English
Publishing date	2022-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031049
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection

Bruin, N. de / Schneider, A.-K. / Reus, P. / Talmon, S. / Ciesek, S. / Bojkova, D. / Cinatl, J. / Lodhi, I. / Charlesworth, B. / Sinclair, S. / Pennick, G. / Laughey, W.F. / Gribbon, P. / Kannt, A. / Schiffmann, S.

2022

Abstract: Art. 1049, 14 S. ... SARS-CoV-2 uses the human cell surface protein angiotensin converting enzyme 2 ...

Abstract	Art. 1049, 14 S. SARS-CoV-2 uses the human cell surface protein angiotensin converting enzyme 2 (ACE2) as the receptor by which it gains access into lung and other tissue. Early in the pandemic, there was speculation that a number of commonly used medicationsâincluding ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs)âhave the potential to upregulate ACE2, thereby possibly facilitating viral entry and increasing the severity of COVID-19. We investigated the influence of the NSAIDS with a range of cyclooxygenase (COX)1 and COX2 selectivity (ibuprofen, flurbiprofen, etoricoxib) and paracetamol on the level of ACE2 mRNA/protein expression and activity as well as their influence on SARS-CoV-2 infection levels in a Caco-2 cell model. We also analysed the ACE2 mRNA/protein levels and activity in lung, heart and aorta in ibuprofen treated mice. The drugs had no effect on ACE2 mRNA/protein expression and activity in the Caco-2 cell model. There was no up-regulation of ACE2 mRNA/protein expression and activity in lung, heart and aorta tissue in ibuprofen-treated mice in comparison to untreated mice. Viral load was significantly reduced by both flurbiprofen and ibuprofen at high concentrations. Ibuprofen, flurbiprofen, etoricoxib and paracetamol demonstrated no effects on ACE2 expression or activity in vitro or in vivo. Higher concentrations of ibuprofen and flurbiprofen reduced SARS-CoV-2 replication in vitro. 23 Nr.3
Keywords	547
Subject code	570
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: High prevalence of malnutrition in systemic sclerosis: Results from a French monocentric cross-sectional study.

Rivet, Valérian / Riviere, Sophie / Goulabchand, Radjiv / Suzon, Benoît / Henneton, Pierrick / Partouche, Léo / Rullier, Patricia / Quellec, Alain Le / Konate, Amadou / Schiffmann, Aurélie / Vincent, Thierry / Ziane, Rahima / Flori, Nicolas / Picot, Marie Christine / Sultan, Ariane / Maria, Alexandre Thibaut Jacques / Guilpain, Philippe

Nutrition (Burbank, Los Angeles County, Calif.)

2023 Volume 116, Page(s) 112171

Abstract: Objectives: Systemic sclerosis (SSc) can cause malnutrition due to frequent gastrointestinal involvement. However, prevalence of malnutrition in SSc is poorly known. The aim of this study was to evaluate the prevalence of malnutrition in SSc and its ... ...

Abstract	Objectives: Systemic sclerosis (SSc) can cause malnutrition due to frequent gastrointestinal involvement. However, prevalence of malnutrition in SSc is poorly known. The aim of this study was to evaluate the prevalence of malnutrition in SSc and its potential associations with disease features in patients from a tertiary referral center. Methods: All patients meeting American College of Rheumatology/European Alliance of Associations for Rheumatology criteria for SSc followed between January 1, 1985, and January 1, 2019, at the Department of Internal Medicine, Saint Eloi University Hospital, were included. Malnutrition was assessed using the 2020 French recommendations for SSc and the malnutrition universal screening tool score. Severe malnutrition was defined via the French Haute Autorité de Santé (National Health Authority) 2007 criteria. Results: A total of 120 patients were included, with mean age 64 (± 15) y and a female-to-male sex ratio of 5:1. According to 2020 French recommendations, 71 patients (59.2%) were malnourished and 30 (25%) had at least one criterion of severe malnutrition. With the malnutrition universal screening tool score, 41.7%, 20%, and 38.3%, respectively, had low, medium, and high risk of malnutrition. Multivariate analysis revealed the following results: 1) malnutrition was associated with cardiac involvement (P < 0.01); 2) a high malnutrition universal screening tool score was also associated with specific cardiac involvement (P < 0.01); and 3) severe malnutrition was strongly correlated with interincisal distance <35 mm (P = 0.02). Conclusions: Malnutrition affects more than half of SSc patients and is associated with specific cardiac involvement. Interincisal distance <35 mm could be a red flag for severe malnutrition in SSc.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Prevalence ; Malnutrition/epidemiology ; Malnutrition/etiology ; Malnutrition/diagnosis ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/epidemiology ; Multivariate Analysis
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112171
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2290: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito