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  1. Article: Suprapubic Cholecystectomy Improves Cosmetic Outcome Compared to Classic Cholecystectomy.

    Taha, Anas / Taha-Mehlitz, Stephanie / Sternkopf, Ulrich / Sorba, Elena / Enodien, Bassey / Vorburger, Stephan

    Journal of clinical medicine

    2022  Volume 11, Issue 15

    Abstract: Currently, cholecystectomy is performed laparoscopically. While the conventional approach (CA) with four access ports persists, other methods seek to reduce trauma or to optimize cosmetic results. In this study, the safety and cosmetic outcome of a ... ...

    Abstract Currently, cholecystectomy is performed laparoscopically. While the conventional approach (CA) with four access ports persists, other methods seek to reduce trauma or to optimize cosmetic results. In this study, the safety and cosmetic outcome of a suprapubic approach (SA) were evaluated. Between 2015 and 2016, patients undergoing elective cholecystectomy either by CA or by a suprapubic approach (SA) at our institution were included. The cosmetic outcome, postoperative morbidity, operative time and length of stay were evaluated. Pictures of the site of intervention were taken 6−12 months postoperatively and rated on a scale from 1 (unsatisfying aesthetic result) to 5 (excellent aesthetic result). Five “non-medical” and five “medical” raters as well as one board-certified plastic surgeon performed the ratings. A total of 70 patients were included (n = 28 SA, n = 42 CA). The two groups did not differ in baseline characteristics (age, gender, BMI). The SA group showed a significantly better aesthetic outcome compared to the CA group 4.8 (4.8−4.9) vs. 4.2 (3.8−4.4), (p > 0.001). Medical raters: 4.0 (3.8−4.2) vs. 4.8 (4.6−5.0), (p < 0.001); non-medical raters: 4.2 (3.8−4.6) vs. 5.0 (4.8−5.0), (p < 0.001); plastic surgeon: 4.0 (4.0−4.0) vs. 5.0 (5.0−5.0), (p < 0.001). Fair interrater consistency was demonstrated with an ICC of 0.47 (95% CI = 0.38−0.57). No significant difference in the complication rate (1 (3.5%) in SA vs. 6 (14%) in CA, (p = 0.3)), or the operating time 66 (50−86) vs. 70 (65−82) min, (p = 0.3), were observed. Patients stayed for a median of three (3−3) days in the SA group and 3 (3−4) days in the CA group (p = 0.08). This study demonstrated that the suprapubic approach is an appropriate alternative to conventional laparoscopic cholecystectomy, presenting a better cosmetic outcome with a similar complication rate.
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11154579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Gene Therapy for Cancer

    Hunt, Kelly K. / Swisher, Stephen G. / Vorburger, Stephan A.

    2007  

    Author's details edited by Kelly K. Hunt, Stephan A. Vorburger, Stephen G. Swisher
    Keywords Hematology ; Oncology
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387080
    ISBN 978-1-588-29472-2 ; 978-1-597-45222-9 ; 1-588-29472-2 ; 1-597-45222-X
    DOI 10.1007/978-1-59745-222-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Dreidimensionale Sicht in der laparoskopischen Chirurgie

    Vorburger, Stephan A.

    Swiss knife

    2010  Volume -, Issue 2, Page(s) 16

    Language German ; French
    Document type Article
    ZDB-ID 2270030-4
    ISSN 1661-1381
    Database Current Contents Medicine

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  4. Article ; Online: Suprapubic Cholecystectomy Improves Cosmetic Outcome Compared to Classic Cholecystectomy

    Anas Taha / Stephanie Taha-Mehlitz / Ulrich Sternkopf / Elena Sorba / Bassey Enodien / Stephan Vorburger

    Journal of Clinical Medicine, Vol 11, Iss 4579, p

    2022  Volume 4579

    Abstract: Currently, cholecystectomy is performed laparoscopically. While the conventional approach (CA) with four access ports persists, other methods seek to reduce trauma or to optimize cosmetic results. In this study, the safety and cosmetic outcome of a ... ...

    Abstract Currently, cholecystectomy is performed laparoscopically. While the conventional approach (CA) with four access ports persists, other methods seek to reduce trauma or to optimize cosmetic results. In this study, the safety and cosmetic outcome of a suprapubic approach (SA) were evaluated. Between 2015 and 2016, patients undergoing elective cholecystectomy either by CA or by a suprapubic approach (SA) at our institution were included. The cosmetic outcome, postoperative morbidity, operative time and length of stay were evaluated. Pictures of the site of intervention were taken 6–12 months postoperatively and rated on a scale from 1 (unsatisfying aesthetic result) to 5 (excellent aesthetic result). Five “non-medical” and five “medical” raters as well as one board-certified plastic surgeon performed the ratings. A total of 70 patients were included ( n = 28 SA, n = 42 CA). The two groups did not differ in baseline characteristics (age, gender, BMI). The SA group showed a significantly better aesthetic outcome compared to the CA group 4.8 (4.8–4.9) vs. 4.2 (3.8–4.4), ( p > 0.001). Medical raters: 4.0 (3.8–4.2) vs. 4.8 (4.6–5.0), ( p < 0.001); non-medical raters: 4.2 (3.8–4.6) vs. 5.0 (4.8–5.0), ( p < 0.001); plastic surgeon: 4.0 (4.0–4.0) vs. 5.0 (5.0–5.0), ( p < 0.001). Fair interrater consistency was demonstrated with an ICC of 0.47 (95% CI = 0.38–0.57). No significant difference in the complication rate (1 (3.5%) in SA vs. 6 (14%) in CA, ( p = 0.3)), or the operating time 66 (50–86) vs. 70 (65–82) min, ( p = 0.3), were observed. Patients stayed for a median of three (3–3) days in the SA group and 3 (3–4) days in the CA group ( p = 0.08). This study demonstrated that the suprapubic approach is an appropriate alternative to conventional laparoscopic cholecystectomy, presenting a better cosmetic outcome with a similar complication rate.
    Keywords suprapubic approach ; cholecystectomy ; laparoscopy ; minimally invasive surgery ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Tumornachsorge

    Vorburger, Stephan A. / Candinas, Daniel

    Therapeutische Umschau

    2008  Volume 65, Issue 6, Page(s) 313

    Language German
    Document type Article
    ZDB-ID 82044-1
    ISSN 0040-5930
    Database Current Contents Medicine

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  6. Article: Decision Analysis (cost-effectiveness analysis) for Surgeons

    Vorburger, Stephan

    Swiss knife

    2009  , Issue 4, Page(s) 18

    Language German ; French
    Document type Article
    ZDB-ID 2270030-4
    ISSN 1661-1381
    Database Current Contents Medicine

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  7. Article ; Online: Operation time and body mass index are significant risk factors for surgical site infection in laparoscopic sigmoid resection: a multicenter study.

    Kurmann, Anita / Vorburger, Stephan A / Candinas, Daniel / Beldi, Guido

    Surgical endoscopy

    2011  Volume 25, Issue 11, Page(s) 3531–3534

    Abstract: Background: Surgical site infection (SSI) in patients who underwent colorectal surgery is a common complication associated with increased morbidity and costs. The aim of this study was to assess risk factors for SSI in laparoscopic sigmoid resection for ...

    Abstract Background: Surgical site infection (SSI) in patients who underwent colorectal surgery is a common complication associated with increased morbidity and costs. The aim of this study was to assess risk factors for SSI in laparoscopic sigmoid resection for benign disease.
    Methods: Using a multicenter database of the Swiss Association of Laparoscopic and Thoracoscopic Surgery, we prospectively identified 4,488 patients who underwent laparoscopic colorectal surgery between 1995 and 2008; of these, 2,571 patients who underwent sigmoid resection for benign disease were included. Uni- and multivariate analyses were used to determine risk factors for SSI.
    Results: The incidence of SSI was 3.5% (90/2,571). Among SSI patients, incisional superficial infections were found in 71%, incisional deep infections in 22%, and organ-space infections in 7%. Patients' age, underlying disease, and surgeons' experience had no impact on SSI. Multivariate analyses showed that operation time >240 min (odds ratio [OR] 1.7; 95% confidence interval [CI] 1.0-2.8), BMI ≥ 27 kg/m(2) (OR 2.3 [1.3-4.5]), organ lesions (OR 7.9 [2.0-31.8]), and male gender (OR 2.3 [1.2-4.5]) were significant risk factors for SSI. Reoperations in the SSI group were significantly more frequent than in the Non-SSI group (30% vs. 3%; p < 0.001). SSI was associated with a significantly longer median hospital stay (15 days, range = 2-69 vs. 8 days, range = 1-69; p < 0.001) and higher mortality rate (2.2% vs. 0.4%; p = 0.019).
    Conclusion: Significant risk factors for SSI were operation time > 240 min, BMI ≥ 27 kg/m(2), organ lesions, and male gender. SSI was significantly associated with more reoperations, longer hospital stay, and higher mortality rate.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Colon, Sigmoid/surgery ; Female ; Humans ; Intraoperative Complications ; Laparoscopy ; Male ; Middle Aged ; Postoperative Complications ; Risk Factors ; Sigmoid Diseases/surgery ; Surgical Wound Infection/etiology ; Young Adult
    Language English
    Publishing date 2011-06-03
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-011-1753-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Tumornachsorge kolorektaler Karzinome.

    Vorburger, Stephan A / Gloor, Beat / Candinas, Daniel

    Therapeutische Umschau. Revue therapeutique

    2008  Volume 65, Issue 6, Page(s) 329–334

    Abstract: Because recurrent adenocarcinoma of the colon and rectum (CRC) can still be treated with acceptable 5-year survival rates, tumor surveillance plays an important role. Early detection of recurrent disease from CRC allows for effective treatment with ... ...

    Title translation Tumor surveillance after resection of colorectal cancer.
    Abstract Because recurrent adenocarcinoma of the colon and rectum (CRC) can still be treated with acceptable 5-year survival rates, tumor surveillance plays an important role. Early detection of recurrent disease from CRC allows for effective treatment with intention for cure. This is why, in 2007, an interdisciplinary group modified the popular "FAGAS" criteria, a proposition for surveillance after curative resection of colorectal cancer. Proposed are the 3-monthly follow-up of the tumor marker CEA (carcino embryonic antigen), which, in case of lower sigmoid or rectal cancer, would be completed by rectosigmoidoscopy and endosonography every 6 months. As a major change liver sonography is now proposed to be replaced by annual thoraco-abdominal CT scan. Colonoscopy within the first year after resection has its place in the surveillance due to a high rate of metachronous secondary tumors missed in the initial endoscopy. Once completed it needs not to be repeated for at least 3 years. Only in cases where early stage CRC was been completely resected no schematic surveillance must take place.
    MeSH term(s) Aftercare/methods ; Biomarkers, Tumor/blood ; Carcinoembryonic Antigen/blood ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Endosonography ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/therapy ; Neoplasm Staging ; Neoplasms, Second Primary/diagnosis ; Neoplasms, Second Primary/mortality ; Neoplasms, Second Primary/therapy ; Patient Care Team ; Postoperative Complications/diagnosis ; Postoperative Complications/mortality ; Postoperative Complications/therapy ; Prognosis ; Sigmoidoscopy ; Survival Analysis ; Tomography, X-Ray Computed
    Chemical Substances Biomarkers, Tumor ; Carcinoembryonic Antigen
    Language German
    Publishing date 2008-06
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930.65.6.329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chirurg und Forscher - Chirurg oder Forscher?

    Vorburger, Stephan

    Swiss knife

    2006  Volume -, Issue 2, Page(s) 19

    Language German
    Document type Article
    ZDB-ID 2270030-4
    ISSN 1661-1381
    Database Current Contents Medicine

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  10. Article: Adenoviral gene therapy.

    Vorburger, Stephan A / Hunt, Kelly K

    The oncologist

    2002  Volume 7, Issue 1, Page(s) 46–59

    Abstract: As of May 2001, 532 gene therapy protocols had been approved for evaluation in clinical trials; however, only five of those had been evaluated in phase III clinical trials. Among the most commonly used vectors for the delivery of genetic material into ... ...

    Abstract As of May 2001, 532 gene therapy protocols had been approved for evaluation in clinical trials; however, only five of those had been evaluated in phase III clinical trials. Among the most commonly used vectors for the delivery of genetic material into human cells are the adenoviruses. Remarkable progress has been made with these vectors in the last decade, but some shortcomings continue to challenge investigators. The newly acquired knowledge of the adenoviral life cycle and the positive outcomes from phase II clinical trials have led to the application of vectors engineered to selectively target tumor tissue under controlled promoters.
    MeSH term(s) Adenoviridae/genetics ; Clinical Trials as Topic ; Genetic Therapy/methods ; Genetic Vectors/therapeutic use ; Humans ; Neoplasms/therapy
    Language English
    Publishing date 2002-02-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1409038-7
    ISSN 1083-7159
    ISSN 1083-7159
    DOI 10.1634/theoncologist.7-1-46
    Database MEDical Literature Analysis and Retrieval System OnLINE

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