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Article ; Online: Accelerated decline in motor suppression in patients with cerebrovascular disorders: A kinetic analysis using the square-tracing task.

Kimoto, Shoko / Naito, Yasuo / Nishikawa, Takashi

2024 Volume 54, Issue 3, Page(s) 383–390

Abstract: Background: Patients with cerebrovascular disorders (CVDs) tend to exhibit impulsive behaviour without controlling their movements, leading to difficulty in performing activities of daily living and an increased risk of accidents. This hastiness, termed ...

Abstract	Background: Patients with cerebrovascular disorders (CVDs) tend to exhibit impulsive behaviour without controlling their movements, leading to difficulty in performing activities of daily living and an increased risk of accidents. This hastiness, termed 'pacing impairment', has been studied but is not fully understood. Objective: To experimentally examine the kinetic features of pacing impairment by focusing on changes in speed and investigating neuropsychological substrates. Methods: We instructed 53 inpatients with CVDs, 20 orthopaedic inpatients, and 20 healthy participants to trace a 200 mm-sided square as slowly as possible for 120 seconds. We measured the tracing length and mean acceleration and examined the relationship between these measurements, neuropsychological symptoms, and lesion sites. Results: Gradual acceleration in drawing, i.e., decline in motor suppression, was observed more frequently in the CVD group than in the control groups. Excessive acceleration was associated with unilateral spatial neglect, frontal lobe signs, and attention disorders but not with motor impersistence. Additionally, the incidence of excessive acceleration did not differ between left and right hemisphere lesion subgroups and was not associated with any specific lesion site. Conclusion: Pacing impairment can manifest as general or holistic deficits in attentional function widely distributed throughout the cerebral hemispheres.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Aged ; Cerebrovascular Disorders/physiopathology ; Cerebrovascular Disorders/complications ; Neuropsychological Tests ; Psychomotor Performance/physiology ; Adult ; Aged, 80 and over
Language	English
Publishing date	2024-04-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1087912-2
ISSN	1878-6448 ; 1053-8135
ISSN (online)	1878-6448
ISSN	1053-8135
DOI	10.3233/NRE-230375
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Article: [Light and Shadow by Standardization of Gastrointestinal Examination (Radiological Technology)].

Nishikawa, Takashi

Nihon Hoshasen Gijutsu Gakkai zasshi

2018 Volume 74, Issue 2, Page(s) 191–195

MeSH term(s)	Gastrointestinal Tract/diagnostic imaging ; Humans ; Stomach Neoplasms/diagnostic imaging ; Technology, Radiologic/standards
Language	Japanese
Publishing date	2018
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2269092-X
ISSN	1881-4883 ; 0369-4305
ISSN (online)	1881-4883
ISSN	0369-4305
DOI	10.6009/jjrt.2018_JSRT_74.2.191
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Article ; Online: Corrigendum to Participation of the descending noradrenergic inhibitory system in the anti-hyperalgesic effect of acetaminophen in a rat model of inflammation. Life Sci. 286 (2021) 120030.

Juri, Takashi / Fujimoto, Yohei / Suehiro, Koichi / Nishikawa, Kiyonobu / Mori, Takashi

Life sciences

2022 Volume 295, Page(s) 120429

Language	English
Publishing date	2022-02-28
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.120429
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Article ; Online: Betamethasone use and risk factors for pulmonary edema during the perinatal period: a single-center retrospective cohort study in Japan.

Nishikawa, Takashi / Fukuhara, Ken

BMC pregnancy and childbirth

2022 Volume 22, Issue 1, Page(s) 636

Abstract: Background: A few studies have reported that maternal administration of antenatal corticosteroids increased the risk of pulmonary edema (PE). However, despite the increasing usage rate of betamethasone as antenatal corticosteroid, maternal ... ...

Abstract	Background: A few studies have reported that maternal administration of antenatal corticosteroids increased the risk of pulmonary edema (PE). However, despite the increasing usage rate of betamethasone as antenatal corticosteroid, maternal administration of betamethasone as a risk factor for PE has not been well studied. This study aimed to evaluate how maternal backgrounds and complications, tocolytic agents, and betamethasone affect the incidence of PE during the perinatal period and determine the risk factor for PE. Methods: This was a single-center retrospective cohort study in Kurashiki, Japan. The study subjects were patients who had been admitted to our hospital for perinatal management including pregnancy, delivery and puerperium between 2017 and 2020. The primary outcome measure was defined as the incidence of PE during hospitalization. First, in all study subjects, Cox proportional hazards model was used to determine the risk factor for PE during the perinatal period. Next, using propensity score matching, we divided the patients into the betamethasone and betamethasone-free groups and examined the association between betamethasone use and the incidence of PE with Cox proportional hazards model. Results: During the study period, 4919 cases were hospitalized, and there were 16 PE cases (0.3%). In all analyzed subjects, the occurrence of PE was significantly associated with preeclampsia (hazard ratio 16.8, 95% confidence intervals (CI) 5.39-52.7, P < 0.001) and the combined use of the tocolytic agents such as ritodrine hydrochloride and magnesium sulfate, and betamethasone (hazard ratio 11.3, 95% CI 2.66-48.1, P = 0.001). In contrast, after propensity score matching, no statistically significant difference was found between the betamethasone and betamethasone-free groups in the incidence of PE (hazard ratio 3.19, 95% CI 0.67-15.3, P = 0.145). Conclusions: A combined use of tocolytic agents and antenatal corticosteroids such as betamethasone may be an independent risk factor for PE during the perinatal period. On the other hand, betamethasone use alone may not be associated with the incidence of PE. When tocolytic agents and betamethasone are administrated to pregnant women, it is important to pay attention to the appearance of maternal respiratory symptoms.
MeSH term(s)	Adrenal Cortex Hormones/adverse effects ; Betamethasone/adverse effects ; Female ; Humans ; Japan/epidemiology ; Pregnancy ; Premature Birth/chemically induced ; Pulmonary Edema/chemically induced ; Pulmonary Edema/epidemiology ; Retrospective Studies ; Risk Factors ; Tocolytic Agents/adverse effects
Chemical Substances	Adrenal Cortex Hormones ; Tocolytic Agents ; Betamethasone (9842X06Q6M)
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-022-04918-2
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Article ; Online: Prevalence and scalable control of localized networks.

Duan, Chao / Nishikawa, Takashi / Motter, Adilson E

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 32, Page(s) e2122566119

Abstract: The ability to control network dynamics is essential for ensuring desirable functionality of many technological, biological, and social systems. Such systems often consist of a large number of network elements, and controlling large-scale networks ... ...

Abstract	The ability to control network dynamics is essential for ensuring desirable functionality of many technological, biological, and social systems. Such systems often consist of a large number of network elements, and controlling large-scale networks remains challenging because the computation and communication requirements increase prohibitively fast with network size. Here, we introduce a notion of
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2122566119
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Article: Refractory ovarian squamous cell carcinoma arising from a seromucinous borderline tumor with squamous overgrowth: A case report.

Tamura, Ryo / Kushiya, Naohisa / Yamaguchi, Masayuki / Nishikawa, Nobumichi / Motoyama, Teiichi / Kawasaki, Takashi / Kikuchi, Akira

Gynecologic oncology reports

2024 Volume 51, Page(s) 101323

Abstract: Ovarian squamous cell carcinoma (SCC) is rare, and most cases arise from ovarian teratomas. Herein, we present a case of ovarian SCC arising from an ovarian seromucinous borderline tumor (SMBT) with squamous overgrowth. A 71-year-old woman an underwent ... ...

Abstract	Ovarian squamous cell carcinoma (SCC) is rare, and most cases arise from ovarian teratomas. Herein, we present a case of ovarian SCC arising from an ovarian seromucinous borderline tumor (SMBT) with squamous overgrowth. A 71-year-old woman an underwent emergency laparotomy due to the rupture of a right ovarian tumor suspected to be a borderline or malignant tumor. We performed a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and partial omentectomy. The postoperative diagnosis was stage IC3 ovarian SCC arising from the SMBT with a squamous overgrowth. Subsequently, she underwent six cycles of combination therapy comprising paclitaxel and carboplatin. Two months after the last chemotherapy treatment, she presented with back pain. A CT scan showed a 14 mm pelvic tumor affecting the ureter, leading to right hydronephrosis. The patient underwent tumor resection and ureteroureterostomy. The pathological diagnosis was keratinizing SCC, representing ovarian cancer recurrence. Eight months after the removal of the recurrent tumor, we found a 35 mm recurrent pelvic tumor causing right hydronephrosis. Additionally, a 20 mm pleural dissemination was identified. Comprehensive genome profiling of recurrent tumor revealed genomic abnormalities in
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2024.101323
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Article ; Online: The Lower the Physical Function, the Higher the Quality of Life in Japanese Adolescents with Cerebral Palsy.

Kato, Masako / Arai, Hiroshi / Komatsu, Koyu / Tateyama, Kiyomi / Nishikawa, Takashi

Physical & occupational therapy in pediatrics

2023 Volume 43, Issue 6, Page(s) 713–724

Abstract: Aims: To investigate the factors that contribute to subjective quality of life (QOL) in adolescents with cerebral palsy (CP).: Methods: We evaluated the subjective QOL in 51 adolescents with CP through interviews using the Japanese version of ... ...

Abstract	Aims: To investigate the factors that contribute to subjective quality of life (QOL) in adolescents with cerebral palsy (CP). Methods: We evaluated the subjective QOL in 51 adolescents with CP through interviews using the Japanese version of KIDSCREEN-27 (J-KIDSCREEN-27) and compared the scores with those of 60 typically developing adolescents. Correlations of subjective QOL with age, sex, the levels of functions (gross motor, manipulation, and communication), intelligence, the level of activity of daily living (ADL), and the type of educational support were examined. Thereafter, we investigated the predictors of the subjective QOL by multiple regression analysis. Results: The total QOL scores and individual J-KIDSCREEN-27 domains were not significantly different from those of typically developing adolescents. Sex, manipulation and communication functions, and intelligence had no relationship with subjective QOL. Gross motor function and ADL level negatively correlated with satisfaction with the school environment. Multiple regression analysis revealed that higher age predicts lower psychological well-being, lower gross motor function predicts higher satisfaction with the school environment, and attending schools or classes for special needs predicts higher physical well-being. Conclusions: Seeking adequate support for mildly affected adolescents attending regular classes will be the key to further improving subjective QOL in adolescents with CP.
MeSH term(s)	Humans ; Adolescent ; Quality of Life/psychology ; Cerebral Palsy ; East Asian People ; Parents/psychology ; Psychological Well-Being ; Surveys and Questionnaires
Language	English
Publishing date	2023-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	783998-4
ISSN	1541-3144 ; 0194-2638
ISSN (online)	1541-3144
ISSN	0194-2638
DOI	10.1080/01942638.2023.2186197
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Zs.B 2678: Show issues

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Article ; Online: Additive effect of factor X on the structure and stability of activated factor VII-induced fibrin clot in hemophilic plasma with inhibitor.

Takami, Eisuke / Hashimoto, Kohei / Kitano, Ryoichi / Nishikawa, Kazumi / Fuchigami, Takashi / Nakano, Hirotoshi

Thrombosis research

2023 Volume 223, Page(s) 127–130

MeSH term(s)	Humans ; Factor VIIa/pharmacology ; Fibrin ; Factor X/pharmacology ; Fibrinolysis ; Blood Coagulation ; Thrombin/pharmacology ; Carboxypeptidase B2
Chemical Substances	Factor VIIa (EC 3.4.21.21) ; Fibrin (9001-31-4) ; Factor X (9001-29-0) ; Thrombin (EC 3.4.21.5) ; Carboxypeptidase B2 (EC 3.4.17.20)
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Letter
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2023.01.020
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Article ; Online: Participation of the descending noradrenergic inhibitory system in the anti-hyperalgesic effect of acetaminophen in a rat model of inflammation.

Juri, Takashi / Fujimoto, Yohei / Suehiro, Koichi / Nishikawa, Kiyonobu / Mori, Takashi

Life sciences

2021 Volume 286, Page(s) 120030

Abstract: Aims: This study investigated the relationship between the analgesic efficacy of acetaminophen and the descending noradrenergic systems using rodent models of inflammatory pain.: Main methods: Inflammatory pain models were established by carrageenan ... ...

Abstract	Aims: This study investigated the relationship between the analgesic efficacy of acetaminophen and the descending noradrenergic systems using rodent models of inflammatory pain. Main methods: Inflammatory pain models were established by carrageenan injection into rats' paws. The models were defined as acute (4 h after carrageenan injection), subacute (24 h after carrageenan injection), and late (1 week after carrageenan injection) phase. To evaluate intravenous acetaminophen treatment, the withdrawal threshold to mechanical stimuli was assessed simultaneously with in vivo microdialysis assay of noradrenaline levels in the locus coeruleus (LC). Further analyses were performed to observe the effect of yohimbine on the treatment and the impact of AM404 treatment, a metabolite of acetaminophen, on noradrenaline levels in the LC. Key findings: In all phases, intravenous acetaminophen had a significant anti-hyperalgesic effect (p < 0.05). There was a significant time-dependent increase in the noradrenaline concentration within the LC (acetaminophen versus saline treatment; at 30 min, p < 0.001; 60 min, p < 0.01) in the subacute pain model, but not in the acute and late phase pain models. Intrathecal pre-injection of yohimbine attenuated the anti-hyperalgesic effect after acetaminophen injection only in the subacute model (p < 0.05). In the subacute pain model, intracerebroventricular administration of AM404 showed the same trend in noradrenaline levels as acetaminophen administration (AM404 versus vehicle group at 30 min, p < 0.001). Significance: We found the descending noradrenergic inhibitory system is involved in the antinociceptive action of acetaminophen in the subacute phase of inflammatory pain.
MeSH term(s)	Acetaminophen/pharmacology ; Acetaminophen/therapeutic use ; Animals ; Carrageenan/administration & dosage ; Disease Models, Animal ; Hyperalgesia/drug therapy ; Inflammation/chemically induced ; Inflammation/drug therapy ; Locus Coeruleus/drug effects ; Locus Coeruleus/metabolism ; Male ; Norepinephrine/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Yohimbine/pharmacology
Chemical Substances	Yohimbine (2Y49VWD90Q) ; Acetaminophen (362O9ITL9D) ; Carrageenan (9000-07-1) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2021-10-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.120030
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Article: Incidence of menstrual cycle abnormalities and polycystic ovary syndrome in female Japanese patients with type 1 diabetes mellitus. The role of androgens.

Nakamichi, Tatsuya / Kawamura, Tomoyuki / Nishigaki, Satsuki / Odagiri, Shino / Yuyama, Yoshihiko / Nishikawa-Nakamura, Naoko / Hotta, Yuko / Hamazaki, Takashi

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology

2024 Volume 33, Issue 2, Page(s) 59–65

Abstract: Type 1 diabetes mellitus (T1DM) adversely affects gonadal function. This study aimed to define the characteristics and factors associated with menstrual cycle abnormalities and polycystic ovary syndrome (PCOS) in Japanese patients with T1DM. Our study ... ...

Abstract	Type 1 diabetes mellitus (T1DM) adversely affects gonadal function. This study aimed to define the characteristics and factors associated with menstrual cycle abnormalities and polycystic ovary syndrome (PCOS) in Japanese patients with T1DM. Our study enrolled 157 patients, including 55 with oligomenorrhea (prolonged menstrual cycle) and 102 without oligomenorrhea. LH/FSH ratio (p = 0.04) and total testosterone levels (p = 0.03) were significantly higher in the oligomenorrhea group than in the non-oligomenorrhea group. No significant differences were found between the two groups regarding age at menarche, age at T1DM diagnosis, treatment, glycated hemoglobin, or total daily insulin dose. Of the 55 patients in the oligomenorrhea group, 27 were diagnosed with PCOS based on the Rotterdam criteria. We concluded that female patients with T1DM, as well as abnormal menstrual cycles and hyperandrogenism, may suffer from undiagnosed PCOS and should be referred to a gynecologist for full assessment, diagnosis, and treatment.
Language	English
Publishing date	2024-02-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2079760-6
ISSN	0918-5739
ISSN	0918-5739
DOI	10.1297/cpe.2024-0011
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