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  1. Article ; Online: Is IGF-1 a useful inhibitor of Na

    Baartscheer, Antonius / Veldkamp, Marieke W

    Acta physiologica (Oxford, England)

    2018  Volume 224, Issue 2, Page(s) e13164

    MeSH term(s) Hydrogen-Ion Concentration ; Insulin-Like Growth Factor I ; Sodium-Hydrogen Exchangers
    Chemical Substances Sodium-Hydrogen Exchangers ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2018-08-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13164
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  2. Article ; Online: Sodium-glucose co-transporter 2 inhibitor empagliflozin inhibits the cardiac Na+/H+ exchanger 1: persistent inhibition under various experimental conditions.

    Zuurbier, Coert J / Baartscheer, Antonius / Schumacher, Cees A / Fiolet, Jan W T / Coronel, Ruben

    Cardiovascular research

    2022  Volume 117, Issue 14, Page(s) 2699–2701

    MeSH term(s) Action Potentials/drug effects ; Animals ; Benzhydryl Compounds/pharmacology ; Buffers ; Glucosides/pharmacology ; Hydrogen-Ion Concentration ; Male ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Rabbits ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Hydrogen Exchanger 1/antagonists & inhibitors ; Sodium-Hydrogen Exchanger 1/metabolism
    Chemical Substances Benzhydryl Compounds ; Buffers ; Glucosides ; Sodium-Glucose Transporter 2 Inhibitors ; Sodium-Hydrogen Exchanger 1 ; empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Letter
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab129
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  3. Article: Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells.

    Chen, Sha / Schumacher, Cees A / Van Amersfoorth, Shirley C M / Fiolet, Jan W T / Baartscheer, Antonius / Veldkamp, Marieke W / Coronel, Ruben / Zuurbier, Coert J

    Frontiers in physiology

    2023  Volume 14, Page(s) 1179131

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1179131
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  4. Article ; Online: Letter by Baartscheer et al Regarding Editorial, "Matter of Fat: Are Lipids Antiarrhythmic?".

    Baartscheer, Antonius / Veldkamp, Marieke W / Coronel, Ruben

    Circulation. Arrhythmia and electrophysiology

    2016  Volume 9, Issue 3, Page(s) e003933

    MeSH term(s) Animals ; Female ; Hypercholesterolemia/complications ; Male ; Myocardial Ischemia/complications ; Myocytes, Cardiac/metabolism ; Tachycardia, Ventricular/prevention & control ; Ventricular Fibrillation/prevention & control
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.116.003933
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  5. Article: Adenovirus gene transfer of SERCA in heart failure. A promising therapeutic approach ?

    Baartscheer, A

    Cardiovascular research

    2001  Volume 49, Issue 2, Page(s) 249–252

    MeSH term(s) Action Potentials ; Adenoviridae/genetics ; Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium-Transporting ATPases/genetics ; Gene Transfer Techniques ; Genetic Therapy/methods ; Genetic Vectors/administration & dosage ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Myocardial Contraction ; Sarcoplasmic Reticulum Calcium-Transporting ATPases ; Sodium Channels/metabolism
    Chemical Substances Calcium Channels ; Sodium Channels ; Calcium-Transporting ATPases (EC 3.6.3.8) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2001-02-01
    Publishing country England
    Document type Comment ; Editorial ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1016/s0008-6363(00)00275-3
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  6. Article: Chronic inhibition of na(+)/h(+)-exchanger in the heart.

    Baartscheer, Antonius

    Current vascular pharmacology

    2001  Volume 4, Issue 1, Page(s) 23–29

    Abstract: The incidence and prevalence of heart failure (HF) has increased over the last decades. The main reasons for this increase are the ageing population and an increase in survival rate after myocardial infarction and other cardiovascular diseases. Although, ...

    Abstract The incidence and prevalence of heart failure (HF) has increased over the last decades. The main reasons for this increase are the ageing population and an increase in survival rate after myocardial infarction and other cardiovascular diseases. Although, pharmacotherapy has significantly improved survival, the prognosis of HF is still rather poor. Total mortality is high and approximately half of the deaths are sudden and unexpected. Angiotensin-converting-enzyme (ACE)-inhibitors generally given with diuretic and digoxin are the standard treatment for patients with HF. Despite the established benefits of ACE-inhibitors there is a need for new pharmacological tools for the treatment of HF. Recent experimental evidence has shown that activity of the Na(+)/H(+)-exchanger in the heart (NHE-1) is increased in HF. Because NHE-1 exchanges intracellular H(+) for extracellular Na(+) in a one by one stoichiometry, the intracellular ionic changes resulting from increased activity, will be a increased pH(i) and intracellular sodium ([Na(+)](i)). Activation of NHE-1 results only in a small increase in pH(i), under physiological conditions where bicarbonate-dependent mechanisms are active. However, a considerable increase in [Na(+)](i) was always present. The elevation of [Na(+)](i) might be responsible for the increase of intracellular calcium ([Ca(2+)](i)) levels mediated by the Na(+)/Ca(2+)-exchanger (NCX). Increases in [Na(+)](i), pH(i) and [Ca(2+)](i), features of cardiac myocytes isolated from failing hearts, are recognized as a cell growth signal And thus may play a role in the hypertrophic response, cellular remodeling and finally the development of HF. Acute application of cariporide, an inhibitor of NHE-1, on failing myocytes not only normalized [Na(+)](i) but also cytoplasmic and sarcoplasmic reticulum calcium handling and the propensity to develop delayed after depolarizations (DAD's). In several animal models of HF it has been shown the chronic inhibition of NHE-1 attenuates the development of hypertrophy and whole heart remodeling. Recently, in a volume and pressure overload model of HF in rabbits it has been demonstrated that chronic treatment also prevents the development of HF and cellular ionic and electrophysiological remodeling. Therefore, chronic treatment with an inhibitor of NHE-1 might prove beneficial in patients at risk of developing HF, especially when given at an early stage.
    MeSH term(s) Animals ; Anti-Arrhythmia Agents/therapeutic use ; Female ; Guanidines/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/enzymology ; Heart Failure/physiopathology ; Humans ; Hydrogen-Ion Concentration ; Male ; Models, Cardiovascular ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Sodium/metabolism ; Sodium-Hydrogen Exchangers/antagonists & inhibitors ; Sodium-Hydrogen Exchangers/metabolism ; Sodium-Hydrogen Exchangers/physiology ; Sulfones/therapeutic use ; Ventricular Remodeling/drug effects
    Chemical Substances Anti-Arrhythmia Agents ; Guanidines ; Sodium-Hydrogen Exchangers ; Sulfones ; growth factor-activatable Na-H exchanger NHE-1 ; cariporide (7E3392891K) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2001-11-15
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192362-0
    ISSN 1570-1611
    ISSN 1570-1611
    DOI 10.2174/157016106775203117
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  7. Article ; Online: Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na

    Uthman, Laween / Li, Xiaoling / Baartscheer, Antonius / Schumacher, Cees A / Baumgart, Patricia / Hermanides, Jeroen / Preckel, Benedikt / Hollmann, Markus W / Coronel, Ruben / Zuurbier, Coert J / Weber, Nina C

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Volume 146, Page(s) 112515

    Abstract: Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i's) were shown to reduce heart failure hospitalization and oxidative stress. However, how inflammation ... ...

    Abstract Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i's) were shown to reduce heart failure hospitalization and oxidative stress. However, how inflammation causes oxidative stress in endothelial cells, and how SGLT2i's can reduce this is unknown. Here we hypothesized that 1) TNF-α activates the Na
    MeSH term(s) Benzhydryl Compounds/pharmacology ; Endothelial Cells/drug effects ; Glucosides/pharmacology ; Humans ; Inflammation Mediators/metabolism ; Ouabain/pharmacology ; Reactive Oxygen Species/metabolism ; Sodium/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Hydrogen Exchangers/drug effects ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Benzhydryl Compounds ; Glucosides ; Inflammation Mediators ; Reactive Oxygen Species ; Sodium-Glucose Transporter 2 Inhibitors ; Sodium-Hydrogen Exchangers ; Tumor Necrosis Factor-alpha ; Ouabain (5ACL011P69) ; Sodium (9NEZ333N27) ; empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2021-12-09
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.112515
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  8. Article: Limited role of Ca

    Verkerk, A O / Tan, H L / Baartscheer, T / Ravesloot, J H

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2015  Volume 10, Issue 12, Page(s) 506–511

    Abstract: Objectives: The proarrhythmic, early afterdepolarisations during phase two of the action potential (phase-2 EADs) are associated with secondary Ca: Methods: The contribution of I: Results: The I: Conclusion: In sheep ventricular myocytes, ... ...

    Abstract Objectives: The proarrhythmic, early afterdepolarisations during phase two of the action potential (phase-2 EADs) are associated with secondary Ca
    Methods: The contribution of I
    Results: The I
    Conclusion: In sheep ventricular myocytes, I
    Language English
    Publishing date 2015-02-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
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  9. Article ; Online: Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy.

    Rivaud, Mathilde R / Baartscheer, Antonius / Verkerk, Arie O / Beekman, Leander / Rajamani, Sridharan / Belardinelli, Luiz / Bezzina, Connie R / Remme, Carol Ann

    International journal of cardiology

    2018  Volume 263, Page(s) 54–62

    Abstract: Background: Long QT syndrome mutations in the SCN5A gene are associated with an enhanced late sodium current (I: Methods and results: Wild-type (WT) and Scn5a: Conclusions: In this study we established a causal link between the magnitude of ... ...

    Abstract Background: Long QT syndrome mutations in the SCN5A gene are associated with an enhanced late sodium current (I
    Methods and results: Wild-type (WT) and Scn5a
    Conclusions: In this study we established a causal link between the magnitude of I
    MeSH term(s) Animals ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/physiopathology ; Calcium/physiology ; Cells, Cultured ; Intracellular Fluid/drug effects ; Intracellular Fluid/physiology ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; NAV1.5 Voltage-Gated Sodium Channel/physiology ; Sodium/physiology ; Sodium Channel Blockers/pharmacology ; Sodium Channel Blockers/therapeutic use ; Sodium-Calcium Exchanger/drug effects ; Sodium-Calcium Exchanger/physiology
    Chemical Substances NAV1.5 Voltage-Gated Sodium Channel ; Scn5a protein, mouse ; Sodium Channel Blockers ; Sodium-Calcium Exchanger ; Sodium (9NEZ333N27) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2018.03.044
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  10. Article ; Online: Arrhythmogenic pulmonary vein myocardium in heart failure.

    Boukens, Bastiaan J / Baartscheer, Antonius / Higa, Satoshi

    Clinical and experimental pharmacology & physiology

    2011  Volume 38, Issue 10, Page(s) 654–655

    MeSH term(s) Animals ; Atrial Fibrillation/physiopathology ; Electrophysiologic Techniques, Cardiac/statistics & numerical data ; Heart Failure/physiopathology ; Membrane Potentials/physiology ; Pulmonary Veins/physiopathology
    Language English
    Publishing date 2011-10
    Publishing country Australia
    Document type Comment ; Editorial
    ZDB-ID 189277-0
    ISSN 1440-1681 ; 0305-1870 ; 0143-9294
    ISSN (online) 1440-1681
    ISSN 0305-1870 ; 0143-9294
    DOI 10.1111/j.1440-1681.2011.05577.x
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