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Article ; Online: Les mots du dépistage des cancers.

Mathoulin-Pélissier, Simone / Penel, Nicolas

2019 Volume 106, Issue 7-8, Page(s) 608–614

Title translation	Cancer screening words.
MeSH term(s)	Breast Neoplasms/diagnosis ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer ; Female ; Humans ; Neoplasms/diagnosis ; Neoplasms/prevention & control ; Population Surveillance ; Precancerous Conditions/diagnosis ; Secondary Prevention ; Uterine Cervical Neoplasms/diagnosis ; Vocabulary
Language	French
Publishing date	2019-04-16
Publishing country	France
Document type	Editorial
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2019.03.004
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Article ; Online: Evidence-based data and rare cancers: The need for a new methodological approach in research and investigation.

Mathoulin-Pélissier, S / Pritchard-Jones, K

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2018 Volume 45, Issue 1, Page(s) 22–30

Abstract: Rare cancers are not so rare, their incidence is increasing and, as a group, they have worse survival than the common cancers. These factors emphasise the societal need to ensure sufficient focus on research into their biological basis, aetiological ... ...

Abstract	Rare cancers are not so rare, their incidence is increasing and, as a group, they have worse survival than the common cancers. These factors emphasise the societal need to ensure sufficient focus on research into their biological basis, aetiological factors, new more effective therapies and organisation of healthcare to improve access to best practice and innovation. Accuracy of diagnosis is one of the first hurdles to be overcome, with around one third of tumours being reclassified - by type or risk group - when subject to a centralised pathology review process. Timely access to appropriate expert knowledge is a second challenge for patients - in Europe this is being addressed by the establishment of European Reference Networks (ERNs) as part of the EU cross border healthcare initiative. There are ERNs for adult solid and haematological cancers and childhood cancers, all of which are individually rare. These ERNs will facilitate creation of large databases of rare tumours that will incorporate knowledge of their molecular features and build an evidence base for the effectiveness of innovative, biology-directed therapies. With an increasing focus on 'real world' outcome data, research methodologies are evolving, to include randomised registry trials and data linkage approaches that exploit the ever-richer information held on patients in routine health care data. The inclusion of genomic analysis into cancer diagnosis, treatment and risk prediction raises many issues for the conduct of clinical research and cohort studies and personal data sharing. Sophisticated means of pseudonymisation, together with full involvement of affected and 'at risk' patients, are supporting novel research designs and access to data that will continue to build the evidence base to improve outcomes for patients with rare cancers.
MeSH term(s)	Biomedical Research ; Clinical Decision-Making ; Evidence-Based Medicine ; Humans ; Information Dissemination ; Neoplasms/diagnosis ; Neoplasms/pathology ; Neoplasms/therapy ; Randomized Controlled Trials as Topic ; Rare Diseases/diagnosis ; Rare Diseases/pathology ; Rare Diseases/therapy ; Registries ; Tissue Banks
Language	English
Publishing date	2018-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2018.02.015
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Article ; Online: Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative.

Galvin, Angéline / Soubeyran, Pierre / Brain, Etienne / Cheung, Kwok-Leung / Hamaker, Marije E / Kanesvaran, Ravindran / Mauer, Murielle / Mohile, Supriya / Montroni, Isacco / Puts, Martine / Rostoft, Siri / Wildiers, Hans / Mathoulin-Pélissier, Simone / Bellera, Carine

Journal of geriatric oncology

2023 Volume 15, Issue 1, Page(s) 101611

Abstract: As older adults with cancer are underrepresented in randomized clinical trials (RCT), there is limited evidence on which to rely for treatment decisions for this population. Commonly used RCT endpoints for the assessment of treatment efficacy are more ... ...

Abstract	As older adults with cancer are underrepresented in randomized clinical trials (RCT), there is limited evidence on which to rely for treatment decisions for this population. Commonly used RCT endpoints for the assessment of treatment efficacy are more often tumor-centered (e.g., progression-free survival). These endpoints may not be as relevant for the older patients who present more often with comorbidities, non-cancer-related deaths, and treatment toxicity. Moreover, their expectation and preferences are likely to differ from younger adults. The DATECAN-ELDERLY initiative combines a broad expertise, in geriatric oncology and clinical research, with interest in cancer RCT that include older patients with cancer. In order to guide researchers and clinicians coordinating cancer RCT involving older patients with cancer, the experts reviewed the literature on relevant domains to assess using patient-reported outcomes (PRO) and patient-related outcomes, as well as available tools related to these domains. Domains considered relevant by the panel of experts when assessing treatment efficacy in RCT for older patients with cancer included functional autonomy, cognition, depression and nutrition. These were based on published guidelines from international societies and from regulatory authorities as well as minimum datasets recommended to collect in RCT including older adults with cancer. In addition, health-related quality of life, patients' symptoms, and satisfaction were also considered by the panel. With regards to tools for the assessment of these domains, we highlighted that each tool has its own strengths and limitations, and very few had been validated in older adults with cancer. Further studies are thus needed to validate these tools in this specific population and define the minimum clinically important difference to use when developing RCTs in this population. The selection of the most relevant tool should thus be guided by the RCT research question, together with the specific properties of the tool.
MeSH term(s)	Humans ; Aged ; Neoplasms/therapy ; Treatment Outcome ; Patient Reported Outcome Measures
Language	English
Publishing date	2023-09-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2023.101611
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Article ; Online: Survival outcomes of patients with metastatic non-small cell lung cancer receiving chemotherapy or immunotherapy as first-line in a real-life setting.

Belaroussi, Yaniss / Bouteiller, Fanny / Bellera, Carine / Pasquier, David / Perol, Maurice / Debieuvre, Didier / Filleron, Thomas / Girard, Nicolas / Schott, Roland / Mathoulin-Pélissier, Simone / Martin, Anne-Laure / Cousin, Sophie

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9584

Abstract: Treatment of metastatic non-small cell lung cancer (mNSCLC) has been modified due to the development of immunotherapy. We assessed survival outcomes (overall [OS] and progression-free [rwPFS] survivals, time-to-next-treatment [TNT]) in mNSCLC patients ... ...

Abstract	Treatment of metastatic non-small cell lung cancer (mNSCLC) has been modified due to the development of immunotherapy. We assessed survival outcomes (overall [OS] and progression-free [rwPFS] survivals, time-to-next-treatment [TNT]) in mNSCLC patients after first-line immunotherapy and chemotherapy in real-life settings. Association between rwPFS and TNT, two candidate surrogate endpoints (SE), with OS was assessed. This retrospective multi-center study uses data from patients included in the Epidemio-Strategy Medico-Economic program with mNSCLC over 2015-2019. The impact of treatment on rwPFS/OS was evaluated with Cox models. Individual-level associations between SE and OS were estimated with an iterative multiple imputation approach and joint survival models. The population included 5294 patients (63 years median age). Median OS in immunotherapy group was 16.4 months (95%CI [14.1-NR]) and was higher than in chemotherapy group (11.6 months; 95%CI [11.0-12.2]). Improved OS was observed for the immunotherapy group after 3 months for subjects with performance status 0-1 (HR = 0.59; 95%CI [0.42-0.83], p < 0.01). The associations between rwPFS and TNT with OS were close ([Formula: see text]=0.57). Results emphasized a survival improvement with immunotherapy for patients in good health condition. There was moderate evidence of individual-level association between candidate SE and OS.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Immunotherapy ; Patients ; Time-to-Treatment
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36623-1
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Article ; Online: Association between pre-diagnosis geriatric syndromes and overall survival in older adults with cancer (the INCAPAC study).

Galvin, Angéline / Amadéo, Brice / Frasca, Matthieu / Soubeyran, Pierre / Rondeau, Virginie / Delva, Fleur / Pérès, Karine / Coureau, Gaëlle / Helmer, Catherine / Mathoulin-Pélissier, Simone

Journal of geriatric oncology

2023 Volume 14, Issue 6, Page(s) 101539

Abstract: Introduction: Several population-based studies have reported disparities in overall survival (OS) among older patients with cancer. However, geriatric syndromes, known to be associated with OS in the geriatric population, were rarely studied. Thus, our ... ...

Abstract	Introduction: Several population-based studies have reported disparities in overall survival (OS) among older patients with cancer. However, geriatric syndromes, known to be associated with OS in the geriatric population, were rarely studied. Thus, our aim was to identify the determinants of OS among French older adults with cancer, including geriatric syndromes before cancer diagnosis. Materials and methods: Using cancer registries, we identified older subjects (≥65 years) with cancer in three French prospective cohort studies on aging from the Gironde department. Survival time was calculated from the date of diagnosis to the date of all-cause death or to the date of last follow-up, whichever came first. Demographic and socioeconomic characteristics, smoking status, self-rated health, cancer-related factors (stage at diagnosis, treatment), as well as geriatric syndromes (polypharmacy, activity limitation, depressive symptomatology, and cognitive impairment or dementia) were studied. Analyses were performed using Cox proportional hazard models for the whole population, then by age group (65-84 and 85+). Results: Among the 607 subjects included in the study, the median age at cancer diagnosis was 84 years. Smoking habits, activity limitations, cognitive impairment or dementia, advanced cancer stage and absence of treatment were significantly associated with lower OS in the analysis including the whole population. Women presented higher OS. Factors associated with OS differed by age group. Polypharmacy was inversely associated with OS in older adults aged 65-84 and 85 + . Discussion: Our findings support that geriatric assessment is needed to identify patients at higher risk of death and that an evaluation of activity limitation in older adults is essential. Improving early detection could enable interventions to address factors (activity limitations, cognitive impairment) associated with OS, potentially reducing disparities and lead to earlier palliative care.
MeSH term(s)	Humans ; Aged ; Female ; Aged, 80 and over ; Prospective Studies ; Syndrome ; Aging ; Neoplasms/diagnosis ; Neoplasms/therapy ; Neoplasms/epidemiology ; Geriatric Assessment ; Dementia/diagnosis ; Dementia/epidemiology
Language	English
Publishing date	2023-06-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2023.101539
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Article ; Online: Hospital-based palliative care referrals: determinants in older adults with cancer.

Chanteclair, Alex / Duc, Sophie / Amadeo, Brice / Coureau, Gaelle / Soubeyran, Pierre / Mathoulin-Pelissier, Simone / Peres, Karine / Helmer, Catherine / Galvin, Angeline / Frasca, Matthieu

BMJ supportive & palliative care

2024

Abstract: Objectives: Early palliative care improves the quality of life of older patients with cancer. This work aimed to analyse the effect of sociodemographic, geriatric, and tumour-related determinants on hospital-based palliative care (HPC) referral in older ...

Abstract	Objectives: Early palliative care improves the quality of life of older patients with cancer. This work aimed to analyse the effect of sociodemographic, geriatric, and tumour-related determinants on hospital-based palliative care (HPC) referral in older patients with cancer, taking into account competing risk of death. Methods: Older adults with diagnosed cancer from 2014 to 2018 according to the general cancer registry of Gironde (French department) were identified in three population-based cohorts on ageing (PAQUID, 3C - Three City, AMI). Cause-specific Cox models focused on 10 usual determinants in geriatric oncology and palliative care: age, gender, living alone, place of residency, tumour prognosis, activities of daily living (ADL) and instrumental-ADL (IADL) limitations, cognitive impairment, depressive disorders, and polypharmacy. Results: 131 patients with incident cancer (mean age: 86.2 years, men: 62.6%, poor cancer prognosis: 32.8%) were included, HPC occurring for 26 of them. Unfavourable cancer prognosis was a key determinant for HPC referral (HR 7.02, 95% CI 2.86 to 17.23). An altered IADL score was associated with precocious (first year) referral (HR 3.21, 95% CI 1.20 to 8.64, respectively). Women had a higher rate immediately (first week) after diagnosis (HR 8.64, 95% CI 1.27 to 87.27). Conclusions: Cancer prognosis, functional decline and gender are independent factors of HPC referral in older patients with cancer. These findings may help for a better anticipation of the healthcare pathway.
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/spcare-2024-004787
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Article: Essais cliniques et personnes âgées cancéreuses, l’outil Geriatric Core Dataset (G-Code).

Paillaud, Elena / Cudennec, Tristan / Caillet, Philippe / Bellera, Carine / Mathoulin-Pélissier, Simone / Soubeyran, Pierre

Soins. Gerontologie

2019 Volume 24, Issue 137, Page(s) 35–37

Abstract: Faced with the lack of evidence-based medicine concerning the efficacy and tolerance of cancer treatments in the extremely heterogeneous elderly population, and with no standardised geriatric evaluation in geriatric oncology clinical trials, the ... ...

Title translation	Clinical trials and elderly patients with cancer, the Geriatric Core Dataset (G-Code) tool.
Abstract	Faced with the lack of evidence-based medicine concerning the efficacy and tolerance of cancer treatments in the extremely heterogeneous elderly population, and with no standardised geriatric evaluation in geriatric oncology clinical trials, the intergroup Dialog set itself the objective of establishing a minimal standardised geriatric evaluation for clinical trials. The evaluation must be simple, short and effective. It must comprise validated and reproducible measurement tools. The Geriatric Core Dataset, made up of seven items, has been formalised and validated by national and international experts.
MeSH term(s)	Aged ; Clinical Trials as Topic ; Datasets as Topic ; Geriatric Assessment ; Humans ; Neoplasms/therapy
Language	French
Publishing date	2019-05-23
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2246755-5
ISSN	1268-6034
ISSN	1268-6034
DOI	10.1016/j.sger.2019.03.010
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Article ; Online: One-Year Follow-Up of Seroprevalence of SARS-CoV-2 Infection and Anxiety among Health Workers of a French Cancer Center: The PRO-SERO-COV Study.

Richez, Brice / Cantarel, Coralie / Durrieu, Françoise / Soubeyran, Isabelle / Blanchi, Julie / Pernot, Simon / Chakiba Brugère, Camille / Roubaud, Guilhem / Cousin, Sophie / Etienne, Gabriel / Floquet, Anne / Babre, Florence / Rivalan, Julie / Lalet, Caroline / Narbonne, Marine / Belaroussi, Yaniss / Bellera, Carine / Mathoulin-Pélissier, Simone

International journal of environmental research and public health

2023 Volume 20, Issue 11

Abstract: Infection of SARS-CoV-2 among health workers (HWs) in contact with cancer patients has been a major issue since the beginning of the pandemic. We aimed to assess the serological immune status of SARS-CoV-2 infection among these HWs. A prospective cohort ... ...

Abstract	Infection of SARS-CoV-2 among health workers (HWs) in contact with cancer patients has been a major issue since the beginning of the pandemic. We aimed to assess the serological immune status of SARS-CoV-2 infection among these HWs. A prospective cohort study was initiated in the comprehensive cancer center of the Nouvelle-Aquitaine region (NA, France). Volunteer HWs working on March 2020 without active infection or symptoms of COVID-19 completed a self-questionnaire and had a blood test at inclusion, at 3 and 12 months. Positive serological status of SARS-CoV-2 infection was defined by anti-nucleocapsid antibodies and/or IgG anti-spike antibodies, except at 12 months due to vaccine. Half of the HWs were included (N = 517) and 89% were followed for three months (N = 500) and one year (N = 462). Seroprevalence of SARS-CoV-2 infection was 3.5% (95% CI: 1.9-5.1), 6.2% (95% CI: 4.1-8.3), and 10% (95% CI: 7.2-12.7) on June-September 2020, September 2020-January 2021, and June-October 2021, respectively. At 12 months, 93.3% had detectable antibodies with 80% vaccinated in the first three months of vaccine availability. The COVID-19-free policy of the institution, respect for barrier gestures, high and early vaccination of HWs, and low prevalence of SARS-CoV-2 in NA may explain the low rate of seropositivity among the HWs of the Institut Bergonié.
MeSH term(s)	Humans ; Seroepidemiologic Studies ; Follow-Up Studies ; Prospective Studies ; COVID-19/epidemiology ; SARS-CoV-2 ; Anxiety/epidemiology ; Health Personnel ; Immunoglobulin G ; Antibodies, Viral ; Neoplasms/epidemiology
Chemical Substances	Immunoglobulin G ; Antibodies, Viral
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20115949
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Article ; Online: Evaluating video-based consultations in routine clinical practice at a comprehensive cancer center.

Mottet, Thibaut / Hémar, Victor / Enfedaque, Sylvia / Mathoulin-Pélissier, Simone / Charitansky, Hélène / Godbert, Yann / Roubaud, Guilhem / Cabart, Mathilde / Chakiba, Camille / Chomy, François / Haik, Laura / Le Dantec, Nicolas / Bouleftour, Wafa / Magné, Nicolas / Quenel Tueux, Nathalie

Acta oncologica (Stockholm, Sweden)

2023 Volume 62, Issue 12, Page(s) 1905–1912

Abstract: Introduction: Integrating telemedicine into cancer care remains a major challenge. There are little clinical evidence for teleconsultation efficacy and safety in daily oncology practice. This study as a pioneering experience, aimed to analyze patient ... ...

Abstract	Introduction: Integrating telemedicine into cancer care remains a major challenge. There are little clinical evidence for teleconsultation efficacy and safety in daily oncology practice. This study as a pioneering experience, aimed to analyze patient and physician opinions regarding the implementation of telemedicine consultations, and to identify major limitations of telehealth spread in an oncology institute. Material and methods: During COVID-19 lockdown, patients and physicians who took part to at least one video-based teleconsultation between March and May 2020, were enrolled in this observational study. All eligible patients received an anonymous online questionnaire. On the other hand, all physicians eligible to participate were asked through email to complete a questionnaire. Results: In this study, 31 physicians and 304 patients consented to participate in this study by answering the questionnaire and were included. Regarding telemedicine satisfaction, 65.8% of patients were satisfied. The lack of clinical examination was the major limitation reported by 77% of patients. Patients belonging to a high socio-professional category were statistically more dissatisfied with the relationship with their doctor (OR = 2.31 and 95% CI [1.12; 4.74]). Conclusion: This study showed promising results of incorporating video-based teleconsultations into cancer patient management. Randomized clinical trials are needed in order to accelerate the digital implementation in clinical practice.
MeSH term(s)	Humans ; Telemedicine/methods ; Referral and Consultation ; COVID-19/epidemiology ; Physicians ; Personal Satisfaction ; Neoplasms/therapy
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2023.2278758
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Article ; Online: Prediction of survival after a lung transplant at 1 year (SALTO cohort) using information available at different key time points.

Belaroussi, Yaniss / Hustache-Castaing, Romain / Maury, Jean-Michel / Lehot, Laurent / Rodriguez, Arnaud / Demant, Xavier / Rozé, Hadrien / Brioude, Geoffrey / D'Journo, Xavier-Benoit / Drevet, Gabrielle / Tronc, Francois / Mathoulin-Pélissier, Simone / Jougon, Jacques / Thomas, Pascal-Alexandre / Thumerel, Matthieu

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2023 Volume 63, Issue 5

Abstract: Objectives: A lung transplant is the final treatment option for end-stage lung disease. We evaluated the individual risk of 1-year mortality at each stage of the lung transplant process.: Methods: This study was a retrospective analysis of patients ... ...

Abstract	Objectives: A lung transplant is the final treatment option for end-stage lung disease. We evaluated the individual risk of 1-year mortality at each stage of the lung transplant process. Methods: This study was a retrospective analysis of patients undergoing bilateral lung transplants between January 2014 and December 2019 in 3 French academic centres. Patients were randomly divided into development and validation cohorts. Three multivariable logistic regression models of 1-year mortality were applied (i) at recipient registration, (ii) the graft allocation and (iii) after the operation. The 1-year mortality was predicted for individual patients assigned to 3 risk groups at time points A to C. Results: The study population consisted of 478 patients with a mean (standard deviation) age of 49.0 (14.3) years. The 1-year mortality rate was 23.0%. There were no significant differences in patient characteristics between the development (n = 319) and validation (n = 159) cohorts. The models analysed recipient, donor and intraoperative variables. The discriminatory power (area under the receiver operating characteristic curve) was 0.67 (0.62-0.73), 0.70 (0.63-0.77) and 0.82 (0.77-0.88), respectively, in the development cohort and 0.74 (0.64-0.85), 0.76 (0.66-0.86) and 0.87 (0.79 - 0.95), respectively, in the validation cohort. Survival rates were significantly different among the low- (< 15%), intermediate- (15%-45%) and high-risk (> 45%) groups in both cohorts. Conclusions: Risk prediction models allow estimation of the 1-year mortality risk of individual patients during the lung transplant process. These models may help caregivers identify high-risk patients at times A to C and reduce the risk at subsequent time points.
MeSH term(s)	Humans ; Middle Aged ; Retrospective Studies ; Lung Transplantation ; Tissue Donors ; Lung ; Logistic Models ; Risk Factors
Language	English
Publishing date	2023-04-23
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezad167
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