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Article ; Online: Heterotopic Potential of Darkness

Akira Suwa

Humanities, Vol 11, Iss 5, p

Exploration and Experimentation of Queer Space in Sarah Waters’s Neo-Victorian Trilogy

2022 Volume 5

Abstract: This article argues that darkness contributes to the creation of, and expands the concept of, heterotopias. In Sarah Waters’s neo-Victorian trilogy, consisting of Tipping the Velvet (1998), Affinity (1999), and Fingersmith (2002), her characters utilize ... ...

Abstract	This article argues that darkness contributes to the creation of, and expands the concept of, heterotopias. In Sarah Waters’s neo-Victorian trilogy, consisting of Tipping the Velvet (1998), Affinity (1999), and Fingersmith (2002), her characters utilize darkness as their queer heterotopic space in order to call into question dominant heteronormative ideologies. Darkness plays an important role at the inception of the characters’ romantic relationships by facilitating space that allows their non-normative feelings to be expressed, thereby bringing queer desire to the forefront of each narrative. Darkness is a critical factor that renders a space heterotopic, as it blurs the boundary between heteronormative and queer, hence allowing transgression of the characters within Waters’s novels. Within queer heterotopic space created out of the darkness, there is a confluence of opposing values that enables the characters to examine the possibility of transcending heteronormativity and envisioning queer futures.
Keywords	Sarah Waters ; heterotopia ; darkness ; queer spatiality ; Tipping the Velvet ; Affinity ; History of scholarship and learning. The humanities ; AZ20-999
Subject code	820
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Heterotopic and Neo-Victorian Affinities

Marie-Luise Kohlke / Elizabeth Ho / Akira Suwa

Humanities, Vol 11, Iss 8, p

Introducing the Special Issue on Neo-Victorian Heterotopias

2022 Volume 8

Abstract: The introduction to this special issue on Neo-Victorian Heterotopias investigates the affinities between the spaces designated by Michel Foucault’s ambivalent and protean concept of ‘heterotopia’ and the similarly equivocal, shifting, and adaptable ... ...

Abstract	The introduction to this special issue on Neo-Victorian Heterotopias investigates the affinities between the spaces designated by Michel Foucault’s ambivalent and protean concept of ‘heterotopia’ and the similarly equivocal, shifting, and adaptable cultural phenomenon of ‘neo-Victorianism’. In both cases, cultural spaces and/or artefacts prove deeply intertwined with chronicity, at once juxtaposing and blending different temporal moments, past and present. Socially produced sites of distinct emplacement are exposed not just as culturally and historically contingent constructs, but simultaneously enable forms of resistance to the prevailing ideologies that call them into being. The fertile exercise of considering heterotopias and neo-Victorianism in conjunction opens up new explorations of the Long Nineteenth Century and its impact on today’s cultural imaginary, memory and identity politics, contestations of systemic historical iniquities, and engagements with forms of difference, non-normativity, and Otherness.
Keywords	compensation ; crisis ; cultural memory ; deviation ; Michel Foucault ; heterotopia ; History of scholarship and learning. The humanities ; AZ20-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Orientational Dynamics of Magnetic Iron Oxide Nanoparticles in a Hydrogel: Observation by Magnetic Linear Dichroism under Oscillating Field.

Suwa, Masayori / Uotani, Akira / Tojo, Yuki / Onodera, Reisho / Tsukahara, Satoshi

Langmuir : the ACS journal of surfaces and colloids

2022 Volume 38, Issue 31, Page(s) 9708–9719

Abstract: For the success of biomedical applications of magnetic iron oxide nanoparticles (MION), such as magnetic hyperthermia and magnetic particle imaging, it is essential to understand the orientational dynamics of MION in a complex fluid under an alternating ... ...

Abstract	For the success of biomedical applications of magnetic iron oxide nanoparticles (MION), such as magnetic hyperthermia and magnetic particle imaging, it is essential to understand the orientational dynamics of MION in a complex fluid under an alternating field. Here, using the magnetic linear dichroism (MLD) measurement, we directly observed the orientational behavior of MION in a hydrogel under a damped oscillating magnetic field (DOMF) of 33 kHz in frequency. Hydrophobically modified ethoxylated urethane (HEUR) is examined as the network polymer because the mesh size of the network is controllable with its concentration. We used two MIONs: a bare MION (MION1) and a MION coated with an amphiphilic polymer (MION2). Where the mesh size of the gel network is larger than the particle's hydrodynamic diameter, MION1 in the hydrogel rotates in the same manner in a simple solution, although the macroscopic rheological property of the medium is quite different. Meanwhile, the orientational behavior of MION2 is dramatically changed by the addition of HEUR molecules even below the minimum gelation concentration, indicating that MION2 is associated with the flower micelles of HEUR. By analyzing the MLD waveform, the orientational behavior of MION1 in the HEUR gel under a DOMF can be explained with single-mode relaxation, whereas that of MION2 is complicated; a rapid partial rotation near the particle and a whole slow rotation of the particle-flower micelle associate are superimposed. It is hard to distinguish this difference in orientational behaviors from the dynamic magnetization curve because the dominant magnetization reversal process is Néel rotation, the rotation of the magnetic moment in the particle. The MLD measurement is a potential tool for optimizing biomedical techniques utilizing MIONs and for nanorheology or colloid science in a complex matrix such as a hydrogel or cytoplasmic matrix.
MeSH term(s)	Hydrogels ; Magnetic Iron Oxide Nanoparticles ; Magnetic Phenomena ; Magnetics ; Micelles ; Polymers
Chemical Substances	Hydrogels ; Micelles ; Polymers
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.2c01593
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Article: Orientational Dynamics of Magnetic Iron Oxide Nanoparticles in a Hydrogel: Observation by Magnetic Linear Dichroism under Oscillating Field

Suwa, Masayori / Uotani, Akira / Tojo, Yuki / Onodera, Reisho / Tsukahara, Satoshi

Langmuir. 2022 July 26, v. 38, no. 31

2022

Abstract	For the success of biomedical applications of magnetic iron oxide nanoparticles (MION), such as magnetic hyperthermia and magnetic particle imaging, it is essential to understand the orientational dynamics of MION in a complex fluid under an alternating field. Here, using the magnetic linear dichroism (MLD) measurement, we directly observed the orientational behavior of MION in a hydrogel under a damped oscillating magnetic field (DOMF) of 33 kHz in frequency. Hydrophobically modified ethoxylated urethane (HEUR) is examined as the network polymer because the mesh size of the network is controllable with its concentration. We used two MIONs: a bare MION (MION1) and a MION coated with an amphiphilic polymer (MION2). Where the mesh size of the gel network is larger than the particle’s hydrodynamic diameter, MION1 in the hydrogel rotates in the same manner in a simple solution, although the macroscopic rheological property of the medium is quite different. Meanwhile, the orientational behavior of MION2 is dramatically changed by the addition of HEUR molecules even below the minimum gelation concentration, indicating that MION2 is associated with the flower micelles of HEUR. By analyzing the MLD waveform, the orientational behavior of MION1 in the HEUR gel under a DOMF can be explained with single-mode relaxation, whereas that of MION2 is complicated; a rapid partial rotation near the particle and a whole slow rotation of the particle-flower micelle associate are superimposed. It is hard to distinguish this difference in orientational behaviors from the dynamic magnetization curve because the dominant magnetization reversal process is Néel rotation, the rotation of the magnetic moment in the particle. The MLD measurement is a potential tool for optimizing biomedical techniques utilizing MIONs and for nanorheology or colloid science in a complex matrix such as a hydrogel or cytoplasmic matrix.
Keywords	fever ; gelation ; hydrodynamics ; hydrogels ; iron oxides ; magnetic fields ; micelles ; polymers ; rheological properties ; urethane
Language	English
Dates of publication	2022-0726
Size	p. 9708-9719.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.2c01593
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Article ; Online: Preclinical Development and Validation of ASP5354: A Near-Infrared Fluorescent Agent for Intraoperative Ureter Visualization.

Fushiki, Hiroshi / Yoshikawa, Tomoaki / Matsuda, Toshihiro / Sato, Takeshi / Suwa, Akira

Molecular imaging and biology

2021 Volume 25, Issue 1, Page(s) 74–84

Abstract: Purpose: Iatrogenic ureteral injury (IUI) can complicate minimally invasive and open abdominopelvic surgery. The incidence of IUI is low and dependent on the type of surgery (< 10 %), but it is associated with high morbidity. Therefore, intraoperative ... ...

Abstract	Purpose: Iatrogenic ureteral injury (IUI) can complicate minimally invasive and open abdominopelvic surgery. The incidence of IUI is low and dependent on the type of surgery (< 10 %), but it is associated with high morbidity. Therefore, intraoperative visualization of the ureter is critical to reduce the incidence of IUI, and some methodologies for ureter visualization have been developed. Amongst these, near-infrared fluorescence (NIRF) visualization is thought to bring an advantage with real-time retroperitoneal visualization through the retroperitoneum. We investigated an indocyanine green (ICG) derivative, ASP5354, which emits NIRF at 820 nm when exposed to near-infrared light at a wavelength of 780 nm, in a rodent and porcine model. Procedures: Wistar rats and Göttingen minipigs under anesthesia were laparotomized and then administered ASP5354 chloride intravenously at dose of 0.03 and 0.3 mg/kg for rats and 0.001 and 0.01 mg/kg for minipigs, respectively. Videos of the abdominal cavity in minipigs were taken using a near-infrared fluorescent camera (pde-neo) and assessed visually by three independent clinicians. Toxicological evaluation was demonstrated with cynomolgus monkeys. Results: The proportion of animals whose ureters were visible up to 3 h after administration of ASP5354 chloride were 33 % at 0.001 mg/kg and 100 % at 0.01 mg/kg, respectively. In a toxicological study in cynomolgus monkeys, ASP5354 chloride demonstrated no significant toxicity, suggesting that 0.01 mg/kg provides an optimal dose when used clinically and could allow for ureter visualization during routine surgical procedures. Conclusions: The dose of 0.01 mg/kg provided an optimal dose for ureter visualization up to 3 h after administration. ASP5354 shows promise for ureter visualization during abdominopelvic surgery, which may potentially lower the risk of IUI.
MeSH term(s)	Swine ; Animals ; Rats ; Ureter/diagnostic imaging ; Ureter/injuries ; Laparoscopy/methods ; Fluorescent Dyes ; Swine, Miniature ; Chlorides ; Macaca fascicularis ; Rats, Wistar ; Indocyanine Green ; Optical Imaging/methods
Chemical Substances	Fluorescent Dyes ; Chlorides ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-021-01613-0
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Article ; Online: Randomized, Double-Blind, Controlled Study to Evaluate Safety and Pharmacokinetics of Single Ascending Doses of ASP5354, an Investigational Imaging Product, in Healthy Adult Volunteers.

Murase, Tosei / Takizawa, Masaomi / Galitz, Lawrence / Flach, Stephen / Murray, Valene / Gufford, Brandon / Suwa, Akira

Clinical pharmacology in drug development

2021 Volume 10, Issue 12, Page(s) 1460–1468

Abstract: Intraoperative ureter identification helps reduce the risk of ureteral injury. Currently, no suitable agents for real-time ureter visualization are approved. ASP5354 (TK-1) is a novel indocyanine green derivative. In this first-in-human phase 1, double- ... ...

Abstract	Intraoperative ureter identification helps reduce the risk of ureteral injury. Currently, no suitable agents for real-time ureter visualization are approved. ASP5354 (TK-1) is a novel indocyanine green derivative. In this first-in-human phase 1, double-blind, sequential ascending-dose study, urethral catheters were placed in 6 healthy volunteers who were randomized to single-dose, intravenous ASP5354 0.1 mg (n = 4) or placebo (n = 2). Sequential dose escalations to 0.5-, 2-, 8-, and 24-mg ASP5354 in new cohorts were contingent upon Dose-Escalation Committee approval after review of pharmacokinetic (PK) and safety data. Blood and urine samples were collected over 24 hours following dose administration. Objectives were to assess the safety/tolerability and PK of ASP5354. Treatment-emergent adverse events (TEAEs) were reported in 3 (15%) and 2 (20%) participants in the ASP5354 and placebo groups, respectively. In the former, there were 6 TEAEs (5/6 grade 1-2). One ASP5354 participant experienced grade 3 pyelonephritis, attributed to the catheter. No TEAEs were related to ASP5354. Mean plasma terminal elimination half-life ranged from 2.1 to 3.6 hours, with near complete urinary excretion of unchanged ASP5354 within 24 hours after administration. Linear and dose-proportional PK were observed. These results support further evaluation of ASP5354 at doses up to 24 mg for intraoperative near-infrared fluorescence ureter visualization.
MeSH term(s)	Adult ; Area Under Curve ; Double-Blind Method ; Healthy Volunteers ; Humans
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2649010-9
ISSN	2160-7648 ; 2160-763X
ISSN (online)	2160-7648
ISSN	2160-763X
DOI	10.1002/cpdd.1013
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Article ; Online: Localized colorectal cancer database integrating 4 randomized controlled trials; (JCOG2310A).

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2024 Volume 50, Issue 6, Page(s) 108354

Abstract: Although phase III randomized controlled trials (RCTs) represent the most robust statistical approach for answering clinical questions, they require massive expenditures in terms of time, labor, and funding. Ancillary and supplementary analyses using ... ...

Abstract	Although phase III randomized controlled trials (RCTs) represent the most robust statistical approach for answering clinical questions, they require massive expenditures in terms of time, labor, and funding. Ancillary and supplementary analyses using RCTs are sometimes conducted as alternative approaches to answering clinical questions, but the available integrated databases of RCTs are limited. In this background, the Colorectal Cancer Study Group (CCSG) of the Japan Clinical Oncology Group (JCOG) established a database of ancillary studies integrating four phase III RCTs (JCOG0212, JCOG0404, JCOG0910 and JCOG1006) conducted by the CCSG to investigate specific clinicopathological factors in pStage II/III colorectal cancer (JCOG2310A). This database will be updated by adding another clinical trial data and accelerating several analyses that are clinically relevant in the management of localized colorectal cancer. This study describes the details of this database and planned and ongoing analyses as an initiative of JCOG cOlorectal Young investigators (JOY).
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2024.108354
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Article ; Online: Daprodustat for anaemia in patients with heart failure and chronic kidney disease: A randomized controlled study.

Iso, Takashi / Matsue, Yuya / Mizukami, Akira / Tokano, Takashi / Isoda, Kikuo / Suwa, Satoru / Miyauchi, Katsumi / Yanagisawa, Naotake / Okumura, Yasuo / Minamino, Tohru

ESC heart failure

2022

Abstract: Aims: Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have been developed for the treatment of renal anaemia; however, no study has evaluated the safety and efficacy of HIF-PH inhibitors in patients with heart failure (HF). This study ... ...

Abstract	Aims: Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have been developed for the treatment of renal anaemia; however, no study has evaluated the safety and efficacy of HIF-PH inhibitors in patients with heart failure (HF). This study was designed to evaluate the safety and efficacy of daprodustat, a HIF-PH inhibitor, in patients with HF and renal anaemia. Methods and results: We designed a pilot, multi-centre, open-label, randomized controlled study, in which 50 patients with HF complicated with chronic kidney disease and anaemia will be randomized 1:1 to either the daprodustat or control group at seven sites in Japan. Study entry requires New York Heart Association Class II HF symptoms or a history of hospitalization due to HF, an estimated glomerular filtration rate of <60 mL/min/1.73 m Conclusion: Considering the hypothetical upside and downside of using HIF-PH inhibitors in anaemic patients with HF and chronic kidney disease, and because there are virtually no safe and effective treatments for patients with anaemia not caused by iron deficiency, our study results will contribute significantly to this field.
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14109
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Article: [Diagnosis and recently developed treatment modalities for pulmonary artery hypertension associated with collagen disease].

Suwa, Akira

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2007 Volume 96, Issue 12, Page(s) 2804–2811

MeSH term(s)	Collagen Diseases/complications ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/drug therapy
Language	Japanese
Publishing date	2007-05-01
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.96.2804
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Article: [A Case of Laparoscopic Total Gastrectomy for Juvenile Polyposis of Stomach with Synchronous Multiple Intramucosal Carcinomas].

Sakai, Jun / Ono, Hidetaka / Otsubo, Kana / Tsuura, Yukio / Imanishi, Kota / Takeshita, Yusuke / Takenouchi, Akira / Shimozawa, Motoharu / Kobayashi, Kei / Suwa, Hirokazu / Minami, Yuta / Nojiri, Kazunori / Yoshida, Kenichi / Masui, Hidenobu / Nagahori, Kaoru

Gan to kagaku ryoho. Cancer & chemotherapy

2023 Volume 49, Issue 13, Page(s) 1699–1701

Abstract: The patient was a 57-year-old woman. She was referred to our hospital because severe anemia. Upper gastrointestinal endoscopy revealed polyposis throughout the stomach and lobulated polyps in cardia, greater curve of middle body of the stomach, and ... ...

Abstract	The patient was a 57-year-old woman. She was referred to our hospital because severe anemia. Upper gastrointestinal endoscopy revealed polyposis throughout the stomach and lobulated polyps in cardia, greater curve of middle body of the stomach, and angulus. Colonoscopy and small bowel endoscopy showed no obvious abnormal findings. Based on these findings, a laparoscopic total gastrectomy with D1 lymph node dissection was performed for suspected juvenile polyposis of stomach with severe anemia. The gross examination of the resection specimen revealed diffuse polyposis throughout the stomach, and histopathological examination revealed hyperplasia of the orbital epithelium throughout the stomach and lack of edema in lamina propria of mucous and eosinophil leukocytic infiltration, leading to the diagnosis of juvenile polyposis of stomach. Two well differentiated adenocarcinomas were found in 2 locations, which remained within the mucosa. We report a case of laparoscopic total gastrectomy for juvenile polyposis of the stomach with gastric cancer, with some discussion of the literature.
MeSH term(s)	Female ; Humans ; Middle Aged ; Stomach/pathology ; Gastrectomy ; Stomach Neoplasms/pathology ; Endoscopy, Gastrointestinal ; Adenocarcinoma/surgery ; Laparoscopy
Language	Japanese
Publishing date	2023-01-24
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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