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  1. Article ; Online: Basically, nucleophilicity matters little: towards unravelling the supramolecular driving forces in enzyme-like CO

    Esteve, Ferran / Altava, Belén / Luis, Santiago V / García-Verdugo, Eduardo

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 33, Page(s) 6637–6645

    Abstract: The reaction mechanism for the cycloaddition of ... ...

    Abstract The reaction mechanism for the cycloaddition of CO
    MeSH term(s) Carbon Dioxide/chemistry ; Carbonates/chemistry ; Catalysis ; Cycloaddition Reaction ; Peptidomimetics
    Chemical Substances Carbonates ; Peptidomimetics ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob00948j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unravelling the Supramolecular Driving Forces in the Formation of CO

    Esteve, Ferran / Villanueva-Antolí, Alexis / Altava, Belén / García-Verdugo, Eduardo / Luis, Santiago V

    Gels (Basel, Switzerland)

    2022  Volume 8, Issue 6

    Abstract: A new family of ... ...

    Abstract A new family of C
    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels8060390
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  3. Article ; Online: Continuous Flow Processes as an Enabling Tool for the Synthesis of Constrained Pseudopeptidic Macrocycles.

    Esteve, Ferran / Porcar, Raul / Luis, Santiago V / Altava, Belen / García-Verdugo, Eduardo

    The Journal of organic chemistry

    2022  Volume 87, Issue 5, Page(s) 3519–3528

    Abstract: Herein we report our efforts to develop a continuous flow methodology for the efficient preparation of pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo-[3,4- ...

    Abstract Herein we report our efforts to develop a continuous flow methodology for the efficient preparation of pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo-[3,4-
    MeSH term(s) Anions ; Cyclization ; Macrocyclic Compounds ; Molecular Structure
    Chemical Substances Anions ; Macrocyclic Compounds
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c03081
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  4. Article: Continuous Flow Processes as an Enabling Tool for the Synthesis of Constrained Pseudopeptidic Macrocycles

    Esteve, Ferran / Porcar, Raul / Luis, Santiago V. / Altava, Belen / García-Verdugo, Eduardo

    Journal of organic chemistry. 2022 Feb. 15, v. 87, no. 5

    2022  

    Abstract: Herein we report our efforts to develop a continuous flow methodology for the efficient preparation of pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo-[3,4-f]-isoindolocyclophane scaffold and involving four coupled substitution ... ...

    Abstract Herein we report our efforts to develop a continuous flow methodology for the efficient preparation of pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo-[3,4-f]-isoindolocyclophane scaffold and involving four coupled substitution reactions in the macrocyclization process. Appropriate design of a supported base permitted the continuous production of the macrocycles even at large scales, taking advantage of the positive template effect promoted by the bromide anions. In addition, the use of flow protocols allowed a ca. 20-fold increase in productivity as well as reducing the environmental impact almost 2 orders of magnitude, in comparison with the related batch macrocyclization process.
    Keywords environmental impact ; macrocyclization reactions ; organic chemistry
    Language English
    Dates of publication 2022-0215
    Size p. 3519-3528.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c03081
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Successful ustekinumab treatment in a patient with psoriasis and subacute cutaneous lupus erythematosus.

    Mazgaj, Magdalena / Picard-Dahan, Catherine / Deschamps, Lydia / Marinho, Eduardo / Estève, Eric / Descamps, Vincent

    International journal of dermatology

    2020  Volume 59, Issue 4, Page(s) e118–e120

    MeSH term(s) Aged ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Lupus Erythematosus, Cutaneous/complications ; Lupus Erythematosus, Cutaneous/drug therapy ; Lupus Erythematosus, Cutaneous/pathology ; Psoriasis/complications ; Psoriasis/drug therapy ; Psoriasis/pathology ; Skin/pathology ; Treatment Outcome ; Ustekinumab/therapeutic use
    Chemical Substances Dermatologic Agents ; Ustekinumab (FU77B4U5Z0)
    Language English
    Publishing date 2020-01-20
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.14773
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  6. Article ; Online: Unravelling the Supramolecular Driving Forces in the Formation of CO 2 -Responsive Pseudopeptidic Low-Molecular-Weight Hydrogelators

    Ferran Esteve / Alexis Villanueva-Antolí / Belén Altava / Eduardo García-Verdugo / Santiago V. Luis

    Gels, Vol 8, Iss 390, p

    2022  Volume 390

    Abstract: A new family of C 2 -symmetric pseudopeptides with a high functional density for supramolecular interactions has been synthetized through the attachment of four amino acid subunits to a diamino aliphatic spacer. The resulting open-chain compounds present ...

    Abstract A new family of C 2 -symmetric pseudopeptides with a high functional density for supramolecular interactions has been synthetized through the attachment of four amino acid subunits to a diamino aliphatic spacer. The resulting open-chain compounds present remarkable properties as low-molecular-weight hydrogelators. The self-assembled 3D networks were characterized by SEM analyses, observing regular nanofibres with 80–100 nm diameters. Spectroscopic and molecular modelling experiments revealed the presence of strong synergic effects between the H-bonding and π–π interactions, with the best results obtained for the homoleptic tetra-pseudopeptide derived from l -Phe. In addition, these bioinspired hydrogels possessed pH- and CO 2 -responsive sol–gel transitions. The formation of ammonium carbamate derivatives in the presence of carbon dioxide led to a detrimental change in its adequate self-assembly. CO 2 desorption temperatures of ca. 70 °C were assigned to the thermodynamically favoured recovery of the supramolecular gel.
    Keywords pseudopeptides ; hydrogels ; LMWG ; supramolecular chemistry ; responsive materials ; CO 2 absorption ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
    Subject code 540
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Highly Selective Anion Template Effect in the Synthesis of Constrained Pseudopeptidic Macrocyclic Cyclophanes.

    Esteve, Ferran / Altava, Belen / Bolte, Michael / Burguete, M Isabel / García-Verdugo, Eduardo / Luis, Santiago V

    The Journal of organic chemistry

    2020  Volume 85, Issue 2, Page(s) 1138–1145

    Abstract: Herein, we report the synthesis of a novel family of constrained pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo[3,4- ...

    Abstract Herein, we report the synthesis of a novel family of constrained pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo[3,4-
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.9b03048
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  8. Article ; Online: Quantification of H

    Martí-Bonmatí, Luis / Rodríguez-Ortega, Alejandro / Ten-Esteve, Amadeo / Alberich-Bayarri, Ángel / Celda, Bernardo / Ferrer, Eduardo

    European radiology experimental

    2021  Volume 5, Issue 1, Page(s) 56

    Abstract: Background: Indirect : Methods: MR images were used to calculate the R1, R2, and R2* relaxation rates in phantoms (19 vials with different H: Results: There were no significant changes on the R1 and R2* values from phantoms. The R2 obtained with ... ...

    Abstract Background: Indirect
    Methods: MR images were used to calculate the R1, R2, and R2* relaxation rates in phantoms (19 vials with different H
    Results: There were no significant changes on the R1 and R2* values from phantoms. The R2 obtained with the turbo spin-echo T2-weighted sequence with 20-ms echo time interval had the higher statistical difference (0.67 s
    Conclusions: Indirect
    MeSH term(s) Animals ; Brain/diagnostic imaging ; Feasibility Studies ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Pilot Projects ; Rats
    Language English
    Publishing date 2021-12-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2509-9280
    ISSN (online) 2509-9280
    DOI 10.1186/s41747-021-00246-w
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  9. Article: Protocol for a multi-phase, multi-center, real-world, hybrid effectiveness-implementation study of a digital intervention for pediatric chronic pain co-designed with patients (Digital SPA).

    de la Vega, Rocío / Serrano-Ibáñez, Elena R / Ruiz-Párraga, Gema T / Palermo, Tonya M / Wicksell, Rikard / Fernández-Jiménez, Eduardo / Oliva, Silvia / Roldán, Susana / Monfort, Laura / Peláez, María José / Leyva Carmona, Moisés / Ramírez-Maestre, Carmen / López-Martínez, Alicia E / Miró, Jordi / Esteve, Rosa

    Digital health

    2023  Volume 9, Page(s) 20552076231219490

    Abstract: Background: Children and adolescents with chronic pain are a vulnerable population who often lack the resources to manage their condition. Due to high personal, social, and economic consequences, proper management in its early stages is key to reducing ... ...

    Abstract Background: Children and adolescents with chronic pain are a vulnerable population who often lack the resources to manage their condition. Due to high personal, social, and economic consequences, proper management in its early stages is key to reducing disability. The aim of this project is to co-develop a digital intervention for pediatric chronic pain (Digital SPA) with end-users and to evaluate its effectiveness and implementation outcomes in Spain.
    Methods: (Phase 1) Focus groups with patients, parents, and clinicians (
    Discussion: This study is expected to produce a co-created evidence-based digital intervention for pediatric chronic pain and a roadmap for successful implementation.
    Trial registration number trn and date of registration: ClinicalTrials.gov (registered on 26 June 2023: https://clinicaltrials.gov/study/NCT05917626).
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819396-9
    ISSN 2055-2076
    ISSN 2055-2076
    DOI 10.1177/20552076231219490
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  10. Article ; Online: Environmental footprint of critical agro-export products in the Peruvian hyper-arid coast: A case study for green asparagus and avocado.

    Esteve-Llorens, Xavier / Ita-Nagy, Diana / Parodi, Eduardo / González-García, Sara / Moreira, María Teresa / Feijoo, Gumersindo / Vázquez-Rowe, Ian

    The Science of the total environment

    2021  Volume 818, Page(s) 151686

    Abstract: Peru has become one of the world's main agricultural hubs for a wide range of fruits and vegetables. Two of these products, avocado and green asparagus, have raised attention in recent years in the international scene from an environmental perspective ... ...

    Abstract Peru has become one of the world's main agricultural hubs for a wide range of fruits and vegetables. Two of these products, avocado and green asparagus, have raised attention in recent years in the international scene from an environmental perspective due to the high amounts of water they require, as well as the long air and marine freighting distances to export these products to Europe, Asia or the US. Consequently, the aim of the current study was to perform an environmental assessment of these two products using two life-cycle methods: carbon and water footprint. For the latter, water scarcity, acidification, eco-toxicity and eutrophication impact categories have been selected for assessment. Inventory data were gathered from six different companies located in different regions of the hyper-arid Peruvian coast. The results report that the products are not carbon intensive and are in line with other similar plant-based products. Conversely, the hyper-arid conditions of the cultivation sites require a large volume of groundwater to fulfill the needs of the crops. Interestingly, even though this may lead to overexploitation of groundwater resources in the absence of appropriate management policies, the low mobility of pollutants, namely pesticides, constitutes a natural barrier to protect the degradation of natural water bodies. Similarly, highly technified irrigation systems have allowed minimizing the amounts of water used per hectare. In conclusion, results from this study may be useful in more concise environmental assessment studies on food products and diets, considering the consumption of these Peruvian products in many countries in the world. Furthermore, results are also important at regional level since they depict the carbon and water performance of these products and can also be accompanied by cross-cutting certification schemes, including Product Environmental Footprint Category Rules Guidance.
    MeSH term(s) Agriculture/methods ; Asparagus Plant/growth & development ; Environment ; Environmental Monitoring ; Eutrophication ; Persea ; Peru ; Vegetables
    Language English
    Publishing date 2021-11-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.151686
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