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  1. Article ; Online: An Escape From Diabetes.

    Rasouli, Neda

    The Journal of clinical endocrinology and metabolism

    2020  Volume 105, Issue 9

    MeSH term(s) Benzhydryl Compounds ; Diabetes Mellitus, Type 2 ; Glucosides ; Humans ; Insulin Glargine ; Metformin
    Chemical Substances Benzhydryl Compounds ; Glucosides ; dapagliflozin (1ULL0QJ8UC) ; Insulin Glargine (2ZM8CX04RZ) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2020-06-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response to Letter to the Editor From Chang Villacreses et al: "Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes".

    Rasouli, Neda / Pittas, Anastassios G

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 7, Page(s) e3095–e3096

    MeSH term(s) Dietary Supplements ; Humans ; Insulin Resistance/physiology ; Prediabetic State/drug therapy ; Vitamin D ; Vitamin D Deficiency/drug therapy
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Serum lipid profile as a tool to predict incident diabetes: Is it a wishful thinking?

    Young, Kendra A / Rasouli, Neda

    Journal of diabetes and its complications

    2020  Volume 34, Issue 12, Page(s) 107755

    MeSH term(s) Asian Continental Ancestry Group ; China ; Cohort Studies ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2020.107755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Adipose tissue hypoxia and insulin resistance.

    Rasouli, Neda

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2016  Volume 64, Issue 4, Page(s) 830–832

    Abstract: Despite the well-established association of obesity with insulin resistance and inflammation, the underlying mechanisms and sequence of events leading to inflammation and insulin resistance remain unknown. Adipose tissue hypoxia has been proposed as one ... ...

    Abstract Despite the well-established association of obesity with insulin resistance and inflammation, the underlying mechanisms and sequence of events leading to inflammation and insulin resistance remain unknown. Adipose tissue hypoxia has been proposed as one of the possible key events during the process of fat expansion that leads to adipose tissue dysfunction. The focus of this paper is reviewing the evidence on adipose tissue hypoxia in obesity and its relation to insulin resistance.
    MeSH term(s) Adipose Tissue/pathology ; Animals ; Disease Models, Animal ; Humans ; Hypoxia/pathology ; Insulin Resistance ; Obesity/pathology
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1136/jim-2016-000106
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  5. Article: Design and rationale for the SIB trial: a randomized parallel comparison of semaglutide

    Rella, Steven / Onyiah, Joseph / Baker, Chelsea / Singh, Vatsala / Her, Andrew / Rasouli, Neda

    Therapeutic advances in endocrinology and metabolism

    2023  Volume 14, Page(s) 20420188231207348

    Abstract: Objective: To describe the rationale and design of the SIB trial, an interventional clinical trial testing the hypothesis that subcutaneous (s.c.) once-weekly semaglutide can improve intestinal permeability and reduce systemic inflammation in ... ...

    Abstract Objective: To describe the rationale and design of the SIB trial, an interventional clinical trial testing the hypothesis that subcutaneous (s.c.) once-weekly semaglutide can improve intestinal permeability and reduce systemic inflammation in participants with type 2 diabetes (T2D) and obesity.
    Methods: SIB (NCT04979130) is an investigator-initiated, single-center randomized, double-blinded, placebo-controlled clinical study being conducted at the University of Colorado Anschutz Medical Campus. The primary objective of this novel trial is to test the hypothesis that subcutaneous (s.c.) once-weekly semaglutide could improve intestinal permeability and reduce systemic inflammation in participants with T2D and obesity. Eligible participants had a diagnosis of type 2 diabetes, elevated body mass index, and evidence of systemic inflammation. Participants were randomized 1:1 to s.c. semaglutide or placebo. Participants were assessed for intestinal permeability and markers of inflammation at baseline, mid-study, and at the end of the study. Efficacy assessments were based on the analysis of the following: lactulose:mannitol ratio test, serum lipopolysaccharide-binding protein (LBP), fecal calprotectin, inflammatory biomarkers (IL-6, TNF, IL-1, IL-8, hs-CRP), and HbA1c. All participants who enrolled in the trial provided written informed consent after having received written and oral information on the trial. The risks of semaglutide use were minimized by administration according to FDA-labeled use and close monitoring for adverse events.
    Discussion: SIB is the first study to examine the effects of GLP-1 receptor agonists on intestinal permeability in humans and will provide important data on their impact on systemic inflammation and intestinal permeability in the setting of T2D and obesity.
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2554822-0
    ISSN 2042-0196 ; 2042-0188
    ISSN (online) 2042-0196
    ISSN 2042-0188
    DOI 10.1177/20420188231207348
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  6. Article ; Conference proceedings: Tirzepatide Induces Weight Loss in participants with Type 2 Diabetes Regardless of Baseline BMI: A Post Hoc Analysis of SURPASS-1 through -5 Studies

    Kwan, Anita YM / Maldonado, Juan M. / Wang, Hui / Rasouli, Neda / Wilding, John P.H. / Aberle, Jens

    Diabetologie und Stoffwechsel

    2023  Volume 18, Issue S 01

    Event/congress Diabetes Kongress 2023 - 57. Jahrestagung der DDG, CityCube Berlin, 2023-05-17
    Language German
    Publishing date 2023-04-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0043-1767995
    Database Thieme publisher's database

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  7. Article ; Online: Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial.

    LeBlanc, Erin S / Pittas, Anastassios G / Nelson, Jason / Chatterjee, Ranee / Rasouli, Neda / Rhee, Mary K / Pratley, Richard E / Desouza, Cyrus V / Neff, Lisa M / Peters, Anne M / Dagogo-Jack, Samuel / Hsia, Daniel S

    BMJ open diabetes research & care

    2024  Volume 12, Issue 1

    Abstract: Introduction: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by ... ...

    Abstract Introduction: Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race.
    Research design and methods: From data collected at 22 US clinical sites, we conducted a cross-sectional study of concurrently measured A1c and OGTT and observational longitudinal follow-up of the subset with high-risk pre-diabetes. Numerical integration methods were used to calculate area under the glycemic curve (AUC
    Results: 1016 black, 2658 white, and 193 Asian persons at risk of diabetes were included in cross-sectional analysis. Of these, 2154 with high-risk pre-diabetes were followed for 2.5 years. For a given A1c level, AUC
    Conclusions: Use of additional testing beyond A1c to screen for diabetes may better stratify diabetes risk in the diverse US population.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Prediabetic State/epidemiology ; Prediabetic State/diagnosis ; Vitamin D ; Cross-Sectional Studies ; Glycated Hemoglobin ; Blood Glucose/analysis ; Race Factors ; Vitamins ; White
    Chemical Substances Vitamin D (1406-16-2) ; Glycated Hemoglobin ; Blood Glucose ; Vitamins
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2732918-5
    ISSN 2052-4897 ; 2052-4897
    ISSN (online) 2052-4897
    ISSN 2052-4897
    DOI 10.1136/bmjdrc-2023-003613
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  8. Article: The Impact of Diabetes Mellitus on Clinical Outcomes after Percutaneous Coronary Intervention with Different Stent Sizes.

    Zibaeenezhad, Mohammad Javad / Sayadi, Mehrab / Mohammadi, Seyyed Saeed / Khorshidi, Soorena / Hadiyan, Ehsan / Rasouli, Neda / Karimi-Akhormeh, Ali / Razeghian-Jahromi, Iman

    The journal of Tehran Heart Center

    2023  Volume 17, Issue 4, Page(s) 207–214

    Abstract: Background: This study aimed to investigate the possible relationship between different stent sizes and clinical outcomes after percutaneous coronary intervention (PCI) in patients with diabetes treated with drug-eluting stents (DESs) and dual ... ...

    Abstract Background: This study aimed to investigate the possible relationship between different stent sizes and clinical outcomes after percutaneous coronary intervention (PCI) in patients with diabetes treated with drug-eluting stents (DESs) and dual antiplatelet therapy (DAPT).
    Methods: Patients with stable coronary artery disease undergoing elective PCI with the DES were entered into a retrospective cohort between 2003 and 2019. Major adverse cardiac events (MACE), defined as the combined endpoint of revascularization, myocardial infarction, and cardiovascular death, were recorded. The participants were categorized according to the stent size: 27 mm for length and 3 mm for diameter. DAPT (aspirin and clopidogrel) was used for at least 2 years for diabetics and 1 year for nondiabetics. The median duration of follow-up was 74.7 months.
    Results: Out of 1630 participants, 29.0% had diabetes. The diabetics constituted 37.8% of those with MACE. The mean diameter of the stents in the diabetics and nondiabetics was 2.81±0.29 mm and 2.90±0.35 mm, respectively (P>0.05). The mean stent length was 19.48±7.58 mm and 18.92±6.64 mm in the diabetics and nondiabetics, respectively (P>0.05). After adjustments for confounding variables, MACE was not significantly different between the patients with and without diabetes. Although MACE incidence was not affected by stent dimensions in the patients with diabetes, the nondiabetic patients implanted with a stent length exceeding 27 mm experienced MACE less frequently.
    Conclusion: Diabetes did not influence MACE in our population. Additionally, stents of different sizes were not associated with MACE in patients with diabetes. We propose that using the DES supplemented by long-term DAPT and tight control of glycemic status after PCI could decrease the adverse consequences of diabetes.
    Language English
    Publishing date 2023-04-18
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2476998-8
    ISSN 2008-2371 ; 1735-5370 ; 1735-8620
    ISSN (online) 2008-2371
    ISSN 1735-5370 ; 1735-8620
    DOI 10.18502/jthc.v17i4.11609
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  9. Article: Should metformin remain the first-line therapy for treatment of type 2 diabetes?

    Baker, Chelsea / Retzik-Stahr, Cimmaron / Singh, Vatsala / Plomondon, Renee / Anderson, Victoria / Rasouli, Neda

    Therapeutic advances in endocrinology and metabolism

    2021  Volume 12, Page(s) 2042018820980225

    Abstract: Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications. It is generally well-tolerated with minimal side effects and is ... ...

    Abstract Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications. It is generally well-tolerated with minimal side effects and is affordable. Although the safety and efficacy of metformin have been well-established, there is discussion regarding whether metformin should continue to be the first choice for therapy as other anti-hyperglycemic medications exhibit additional advantages in certain populations. Despite a long-standing history of metformin use, there are limited cardiovascular outcomes data for metformin. Furthermore, the available studies fail to provide strong evidence due to either small sample size or short duration. Recent data from glucagon-like peptide-1 receptor agonist and sodium-glucose cotransporter-2 inhibitor cardiovascular and renal outcomes trials demonstrated additional protection from diabetes complications for some high-risk patients, which has impacted the guidelines for diabetes management. Post-hoc analyses comparing hazard ratios for participants taking metformin at baseline
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554822-0
    ISSN 2042-0196 ; 2042-0188
    ISSN (online) 2042-0196
    ISSN 2042-0188
    DOI 10.1177/2042018820980225
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  10. Article ; Online: Dietary inflammatory index is associated with pain intensity and some components of quality of life in patients with knee osteoarthritis.

    Toopchizadeh, Vahideh / Dolatkhah, Neda / Aghamohammadi, Dawood / Rasouli, Mahrokh / Hashemian, Maryam

    BMC research notes

    2020  Volume 13, Issue 1, Page(s) 448

    Abstract: Objectives: We aim to measure dietary inflammatory index (DII) and its association with functional status, pain intensity and quality of life (QOL) in patients with knee osteoarthritis (KOA). Dietary information from 220 qualified patients with KOA was ... ...

    Abstract Objectives: We aim to measure dietary inflammatory index (DII) and its association with functional status, pain intensity and quality of life (QOL) in patients with knee osteoarthritis (KOA). Dietary information from 220 qualified patients with KOA was collected by a 168-item food frequency questionnaire. The functional status, pain intensity and QOL were evaluated by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, Visual Analogue Scale (VAS) and SF36 questionnaire respectively.
    Results: Linear regression analysis showed that the DII was significantly associated with VAS (p = 0.040; β = 0.151), and physical function (p = 0.039; β = - 0.184), emotional wellbeing (p = 0.048; β = - 0.158) and pain (p = 0.020; β = 0.161) scales and physical health (p = 0.047; β = 0.110) subscale of QOL after adjusting for age, sex, body mass index, and physical activity. There was no significant differences concerning WOMAC across the DII tertiles with and without adjustment to probable confounders (P
    MeSH term(s) Humans ; Osteoarthritis, Knee ; Pain/etiology ; Pain Measurement ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2020-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-020-05277-x
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