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Article: Interleukins in adipose tissue: Keeping the balance

Antuna-Puente, Barbara / Fellahi, Soraya / McAvoy, Chloé / Fève, Bruno / Bastard, Jean-Philippe

Elsevier B.V. Molecular and cellular endocrinology. 2022 Feb. 15, v. 542

2022

Abstract: The role of the immune system is to defend the host and preserve the functionality in response to stress. This function is not limited to infection or injury as it also plays a role in the response to overnutrition. Indeed, low-grade chronic activation ... ...

Abstract	The role of the immune system is to defend the host and preserve the functionality in response to stress. This function is not limited to infection or injury as it also plays a role in the response to overnutrition. Indeed, low-grade chronic activation of the immune system associated with overnutrition may be deleterious, contributing importantly to diabetes and long-term complications, such as cardiovascular disorders. Increasing evidence shows that adipose tissue participates in the obesity-related inflammatory response and that interleukins are one of the key players, either as a pro-inflammatory response to the metabolic dysregulation or to restore homeostasis. The crosstalk between adipocytes and immune cells through some important interleukins and their role in metabolic disruption is the topic of this review.
Keywords	adipocytes ; adipose tissue ; diabetes ; endocrinology ; homeostasis ; immune system ; inflammation ; interleukins ; overnutrition ; stress response
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2021.111531
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Interleukins in adipose tissue: Keeping the balance.

Antuna-Puente, Barbara / Fellahi, Soraya / McAvoy, Chloé / Fève, Bruno / Bastard, Jean-Philippe

Molecular and cellular endocrinology

2021 Volume 542, Page(s) 111531

Abstract	The role of the immune system is to defend the host and preserve the functionality in response to stress. This function is not limited to infection or injury as it also plays a role in the response to overnutrition. Indeed, low-grade chronic activation of the immune system associated with overnutrition may be deleterious, contributing importantly to diabetes and long-term complications, such as cardiovascular disorders. Increasing evidence shows that adipose tissue participates in the obesity-related inflammatory response and that interleukins are one of the key players, either as a pro-inflammatory response to the metabolic dysregulation or to restore homeostasis. The crosstalk between adipocytes and immune cells through some important interleukins and their role in metabolic disruption is the topic of this review.
MeSH term(s)	Adipocytes/metabolism ; Adipose Tissue/metabolism ; Humans ; Inflammation/metabolism ; Insulin Resistance ; Interleukins/metabolism
Chemical Substances	Interleukins
Language	English
Publishing date	2021-12-12
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2021.111531
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Article ; Online: Le rapport adiponectine sur leptine, un biomarqueur d’insulino-résistance et de risque cardiométabolique encore méconnu.

Vatier, Camille / Antuna-Puente, Barbara / Fellahi, Soraya / Vigouroux, Corinne / Capeau, Jacqueline / Bastard, Jean-Philippe

Annales de biologie clinique

2020 Volume 78, Issue 3, Page(s) 265–268

Abstract: Leptin and adiponectin are two adipokines. Their circulating concentrations, high for leptin and low for adiponectin, are predictive of insulin resistance and of an unfavorable cardiometabolic evolution in patients with obesity, metabolic syndrome or ... ...

Title translation	The adiponectin to leptin ratio, a still unrecognized biomarker of insulin resistance and cardiometabolic risk.
Abstract	Leptin and adiponectin are two adipokines. Their circulating concentrations, high for leptin and low for adiponectin, are predictive of insulin resistance and of an unfavorable cardiometabolic evolution in patients with obesity, metabolic syndrome or type 2 diabetes. In addition, recently, the adiponectin/leptin ratio has been proposed as an index of adipose tissue dysfunction together with threshold values for cardiometabolic risk for this index. The relevance and potential applications of the adiponectin/leptin and leptin/adiponectin ratios are discussed in the light of recent literature in this brief update.
MeSH term(s)	Adiponectin/analysis ; Adiponectin/blood ; Biomarkers/analysis ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/metabolism ; Diagnostic Techniques, Endocrine ; Humans ; Insulin Resistance ; Leptin/analysis ; Leptin/blood ; Metabolic Syndrome/complications ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/metabolism ; Obesity/complications ; Obesity/diagnosis ; Obesity/metabolism ; Prognosis ; Risk Factors
Chemical Substances	Adiponectin ; Biomarkers ; Leptin
Language	French
Publishing date	2020-05-18
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	418098-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2020.1559
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Article ; Online: Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population.

Rivera-Paredez, Berenice / Hidalgo-Bravo, Alberto / León-Reyes, Guadalupe / Antuna-Puente, Bárbara / Flores, Yvonne N / Salmerón, Jorge / Velázquez-Cruz, Rafael

Genes

2021 Volume 12, Issue 8

Abstract: Vitamin D-binding protein (VDBP) is encoded by ... ...

Abstract	Vitamin D-binding protein (VDBP) is encoded by the
MeSH term(s)	Bone Density ; Female ; Haplotypes ; Homozygote ; Humans ; Male ; Mexico ; Polymorphism, Single Nucleotide ; Vitamin D-Binding Protein/blood ; Vitamin D-Binding Protein/genetics
Chemical Substances	GC protein, human ; Vitamin D-Binding Protein
Language	English
Publishing date	2021-07-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12081176
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Article ; Online: Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study.

Morán-Ramos, Sofía / Soriano-Cortés, Ruth / Soto-Fuentes, Valeria / Tenorio-Quiroz, Amyris / Gervasio-Ortiz, Emmanuel / Rico-Amador, Dulce / Herrera, Miguel / Sierra-Salazar, Mauricio / Aguilar-Salinas, Carlos A / Antuna-Puente, Bárbara / Rodríguez-Flores, Marcela

Lifestyle genomics

2023 Volume 17, Issue 1, Page(s) 12–21

Abstract: Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, ...

Abstract	Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = -0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10-4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.
MeSH term(s)	Adult ; Humans ; Gastric Bypass/methods ; Gastrointestinal Microbiome ; Obesity, Morbid/surgery ; Obesity, Morbid/microbiology ; Cohort Studies ; Diabetes Mellitus, Type 2 ; RNA, Ribosomal, 16S/genetics ; Feces/microbiology ; Bacteria/genetics ; Weight Loss
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2946059-1
ISSN	2504-3188 ; 2504-3161
ISSN (online)	2504-3188
ISSN	2504-3161
DOI	10.1159/000535397
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Article: Hepatic mir-122-3p, mir-140-5p and mir-148b-5p expressions are correlated with cytokeratin-18 serum levels in MAFLD.

López-Sánchez, Guillermo N / Montalvo-Javé, Eduardo / Domínguez-Perez, Mayra / Antuna-Puente, Barbara / Beltrán-Anaya, Fredy O / Hidalgo-Miranda, Alfredo / Chávez-Tapia, Norberto C / Uribe, Misael / Nuño-Lámbarri, Natalia

Annals of hepatology

2022 Volume 27, Issue 6, Page(s) 100756

Abstract: Introduction and objectives: Metabolic-associated fatty liver disease (MAFLD) is defined by steatosis in more than 5% of hepatocytes without other liver diseases. Patients with this disease can progress to multiple stages like liver fibrosis, cirrhosis, ...

Abstract	Introduction and objectives: Metabolic-associated fatty liver disease (MAFLD) is defined by steatosis in more than 5% of hepatocytes without other liver diseases. Patients with this disease can progress to multiple stages like liver fibrosis, cirrhosis, and hepatocellular carcinoma. miRNAs are single-stranded molecules that regulate metabolic homeostasis; their differential expression postulates them as potential circulating biomarkers for MAFLD. Previous research reported that hsa-miR-140-5p, hsa-miR-148-5p, and hsa-miR-122-3p have a differential expression in patients with MAFLD. This study aimed to investigate the correlation between liver hsa-miR-140-5p, hsa-miR-148-5p, and hsa-miR-122-3p and serum biomarkers CK-18, APOB, IL-6, IL-32, and TNF-α in patients with MAFLD compared with control patients. Materials and methods: A cross-sectional study was carried out with 16 patients of both sexes, aged between 18-60 years, to determine the association between the levels of hsa-miR-140-5p, hsa-miR-148-5p, and hsa-miR-122-3p with MAFLD in liver biopsies of patients who underwent laparoscopic cholecystectomy. Results: Twelve patients presented MAFLD, four without hepatic steatosis. Circulating levels of CK-18 showed a significant difference in patients with MAFLD, and a strong correlation was found between hsa-miR-122-3p, hsa-miR-140-5p, and hsa-miR-148b-5p versus the CAP value. Conclusion: There is a correlation between elevated tissue expression of hsa-miR-122-3p, hsa-miR-140-5p, and hsa-miR-148b-3p with plasma levels of CK-18 in patients with simple steatosis compared with patients without the disease.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Biomarkers ; Cross-Sectional Studies ; Keratin-18/genetics ; Liver/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Non-alcoholic Fatty Liver Disease/genetics
Chemical Substances	Biomarkers ; Keratin-18 ; MicroRNAs ; MIRN122 microRNA, human ; Mirn140 microRNA, human ; MIRN148 microRNA, human
Language	English
Publishing date	2022-09-10
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
DOI	10.1016/j.aohep.2022.100756
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Article ; Online: Association of Gut Microbiota with Atherogenic Dyslipidemia, and Its Impact on Serum Lipid Levels after Bariatric Surgery.

López-Montoya, Priscilla / Cerqueda-García, Daniel / Rodríguez-Flores, Marcela / López-Contreras, Blanca / Villamil-Ramírez, Hugo / Morán-Ramos, Sofía / Molina-Cruz, Selene / Rivera-Paredez, Berenice / Antuna-Puente, Bárbara / Velázquez-Cruz, Rafael / Villarreal-Molina, Teresa / Canizales-Quinteros, Samuel

Nutrients

2022 Volume 14, Issue 17

Abstract: Gut microbiota has been suggested to modulate circulating lipids. However, the relationship between the gut microbiota and atherogenic dyslipidemia (AD), defined as the presence of both low HDL-C and hypertriglyceridemia, is not fully understood. ... ...

Abstract	Gut microbiota has been suggested to modulate circulating lipids. However, the relationship between the gut microbiota and atherogenic dyslipidemia (AD), defined as the presence of both low HDL-C and hypertriglyceridemia, is not fully understood. Moreover, because obesity is among the main causes of secondary AD, it is important to analyze the effect of gut microbiota composition on lipid profiles after a weight loss intervention. We compared the microbial diversity and taxonomic composition in patients with AD (n = 41) and controls (n = 38) and sought correlations of genera abundance with serum lipid levels in 20 patients after weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery. Gut microbiota composition was profiled using next-generation sequencing of 16S rRNA. Gut microbiota diversity was significantly lower in atherogenic dyslipidemia. Moreover, relative abundance of two genera with LDA score >3.5 (Megasphaera and LPS-producing Escherichia-Shigella), was significantly higher in AD subjects, while the abundance of four short chain fatty acids (SCFA) producing-genera (Christensenellaceae R-7, Ruminococcaceae UCG-014; Akkermansia and [Eubacterium] eligens group) was significantly higher in controls. Notably, [Eubacterium] eligens group abundance was also significantly associated with higher HDL-C levels in RYGB patients one year after surgery. Although dietary polyunsaturated fatty acid/saturated fatty acid (PUFA/SFA) ratio and PUFA intake were higher in controls than in AD subjects, of the four genera differentiated in cases and controls, only Akkermansia abundance showed a positive and significant correlation with PUFA/SFA ratio. Our results suggest that SCFA-producing bacteria promote a healthy lipid homeostasis, while the presence of LPS-producing bacteria such Escherichia-Shigella may contribute to the development of atherogenic dyslipidemia.
MeSH term(s)	Bariatric Surgery ; Dyslipidemias ; Fatty Acids, Volatile ; Gastrointestinal Microbiome ; Humans ; Lipopolysaccharides ; RNA, Ribosomal, 16S/genetics ; Weight Loss
Chemical Substances	Fatty Acids, Volatile ; Lipopolysaccharides ; RNA, Ribosomal, 16S
Language	English
Publishing date	2022-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14173545
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Article ; Online: The expression of adiponectin in human's results: a major source of errors and need for consensus.

Bastard, Claire / Antuna-Puente, Barbara / Fellahi, Soraya / Capeau, Jacqueline / Bastard, Jean-Philippe

Annales de biologie clinique

2017 Volume 75, Issue 2, Page(s) 233–235

Title translation	L’expression des résultats d’adiponectinémie chez l’homme : une source importante d’erreurs et une nécessité de consensus.
MeSH term(s)	Adiponectin/analysis ; Adiponectin/blood ; Blood Chemical Analysis/standards ; Clinical Laboratory Services/standards ; Consensus ; Data Aggregation ; Health Services Needs and Demand ; Humans ; Predictive Value of Tests ; Reference Values ; Reproducibility of Results ; Research Design
Chemical Substances	ADIPOQ protein, human ; Adiponectin
Language	English
Publishing date	2017-04-01
Publishing country	France
Document type	Letter
ZDB-ID	2023584-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2017.1223
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Article ; Online: Adiponectin: anti-inflammatory and cardioprotective effects.

Villarreal-Molina, M T / Antuna-Puente, B

Biochimie

2012 Volume 94, Issue 10, Page(s) 2143–2149

Abstract: Adipose tissue is an endocrine organ that plays an essential role in regulating several metabolic functions through the secretion of biological mediators called "adipokines". Dysregulation of adipokines plays a crucial role in obesity-related diseases. ... ...

Abstract	Adipose tissue is an endocrine organ that plays an essential role in regulating several metabolic functions through the secretion of biological mediators called "adipokines". Dysregulation of adipokines plays a crucial role in obesity-related diseases. Adiponectin (APN) is the most abundant adipokine accounting for the 0.01% of total serum protein, and is involved in a wide variety of physiological processes including energy metabolism, inflammation, and vascular physiology. APN plasma levels are reduced in individuals with obesity, type 2 diabetes and coronary artery disease, all traits with low-grade chronic inflammation. It is has been suggested that the absence of APN anti-inflammatory effects may be a contributing factor to this inflammation. APN inhibits the expression of tumor necrosis factor-α-induced endothelial adhesion molecules, macrophage-to-foam cell transformation, tumor necrosis factor-α expression in macrophages and adipose tissue, and smooth muscle cell proliferation. It also has anti-apoptotic and anti-oxidant effects, which play a role in its cardioprotective action. This review will focus on APN as an anti-inflammatory, anti-atherogenic and cardioprotective plasma protein.
MeSH term(s)	Adiponectin/chemistry ; Adiponectin/metabolism ; Adiponectin/secretion ; Animals ; Humans ; Immunity ; Inflammation/metabolism ; Myocardium/metabolism ; Myocardium/pathology
Chemical Substances	Adiponectin
Language	English
Publishing date	2012-10
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2012.06.030
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Article ; Online: Systemic Adiponectin Values in Humans Require Standardized Units.

Bastard, Claire / Antuna-Puente, Barbara / Fellahi, Soraya / Capeau, Jacqueline / Bastard, Jean-Philippe

Obesity surgery

2016 Volume 26, Issue 2, Page(s) 381–382

MeSH term(s)	Adiponectin/blood ; Female ; Gastric Bypass ; Humans ; Intercellular Adhesion Molecule-1/blood ; Interleukin-10/blood ; Leptin/blood ; Male ; Obesity/surgery ; Plasminogen Activator Inhibitor 1/blood
Chemical Substances	Adiponectin ; Leptin ; Plasminogen Activator Inhibitor 1 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-015-1960-8
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