LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1512

Search options

  1. Article: Commentary: Inhibitors of mitochondrial respiratory chain in the treatment of type 2 diabetes.

    Ye, Jianping

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 6, Page(s) 2807–2808

    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Commentary: Gut microbiota reduce the risk of hyperuricemia and gout in the human body.

    Wang, Lin / Ye, Jianping

    Acta pharmaceutica Sinica. B

    2023  Volume 14, Issue 1, Page(s) 433–435

    Language English
    Publishing date 2023-11-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Commentary: Mammokine directs beige adipocytes to reserve energy for milk production in breast.

    Tang, Lina / Ye, Jianping

    Acta pharmaceutica Sinica. B

    2023  Volume 14, Issue 3, Page(s) 1472–1476

    Language English
    Publishing date 2023-12-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.11.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Mechanism of insulin resistance in obesity: a role of ATP.

    Ye, Jianping

    Frontiers of medicine

    2021  Volume 15, Issue 3, Page(s) 372–382

    Abstract: Obesity increases the risk of type 2 diabetes through the induction of insulin resistance. The mechanism of insulin resistance has been extensively investigated for more than 60 years, but the essential pathogenic signal remains missing. Existing ... ...

    Abstract Obesity increases the risk of type 2 diabetes through the induction of insulin resistance. The mechanism of insulin resistance has been extensively investigated for more than 60 years, but the essential pathogenic signal remains missing. Existing hypotheses include inflammation, mitochondrial dysfunction, hyperinsulinemia, hyperglucagonemia, glucotoxicity, and lipotoxicity. Drug discoveries based on these hypotheses are unsuccessful in the development of new medicines. In this review, multidisciplinary literature is integrated to evaluate ATP as a primary signal for insulin resistance. The ATP production is elevated in insulin-sensitive cells under obese conditions independent of energy demand, which we have named "mitochondrial overheating." Overheating occurs because of substrate oversupply to mitochondria, leading to extra ATP production. The ATP overproduction contributes to the systemic insulin resistance through several mechanisms, such as inhibition of AMPK, induction of mTOR, hyperinsulinemia, hyperglucagonemia, and mitochondrial dysfunction. Insulin resistance represents a feedback regulation of energy oversupply in cells to control mitochondrial overloading by substrates. Insulin resistance cuts down the substrate uptake to attenuate mitochondrial overloading. The downregulation of the mitochondrial overloading by medicines, bypass surgeries, calorie restriction, and physical exercise leads to insulin sensitization in patients. Therefore, ATP may represent the primary signal of insulin resistance in the cellular protective response to the substrate oversupply. The prevention of ATP overproduction represents a key strategy for insulin sensitization.
    MeSH term(s) Adenosine Triphosphate ; Diabetes Mellitus, Type 2 ; Humans ; Insulin ; Insulin Resistance ; Obesity
    Chemical Substances Insulin ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2021-05-28
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-021-0862-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Discriminatively Constrained Semi-Supervised Multi-View Nonnegative Matrix Factorization with Graph Regularization

    Guosheng Cui / Ye Li / Jianzhong Li / Jianping Fan

    Big Data Mining and Analytics, Vol 7, Iss 1, Pp 55-

    2024  Volume 74

    Abstract: Nonnegative Matrix Factorization (NMF) is one of the most popular feature learning technologies in the field of machine learning and pattern recognition. It has been widely used and studied in the multi-view clustering tasks because of its effectiveness. ...

    Abstract Nonnegative Matrix Factorization (NMF) is one of the most popular feature learning technologies in the field of machine learning and pattern recognition. It has been widely used and studied in the multi-view clustering tasks because of its effectiveness. This study proposes a general semi-supervised multi-view nonnegative matrix factorization algorithm. This algorithm incorporates discriminative and geometric information on data to learn a better-fused representation, and adopts a feature normalizing strategy to align the different views. Two specific implementations of this algorithm are developed to validate the effectiveness of the proposed framework: Graph regularization based Discriminatively Constrained Multi-View Nonnegative Matrix Factorization (GDCMVNMF) and Extended Multi-View Constrained Nonnegative Matrix Factorization (ExMVCNMF). The intrinsic connection between these two specific implementations is discussed, and the optimization based on multiply update rules is presented. Experiments on six datasets show that the effectiveness of GDCMVNMF and ExMVCNMF outperforms several representative unsupervised and semi-supervised multi-view NMF approaches.
    Keywords multi-view ; semi-supervised clustering ; discriminative information ; geometric information ; feature normalizing strategy ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Tsinghua University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Response to Letter to the Editor From Asadipooya: "Obesity and COVID-19: Mechanistic Insights From Adipose Tissue".

    Yu, Lili / Ye, Jianping

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 10, Page(s) e4274–e4275

    MeSH term(s) Adipose Tissue ; COVID-19 ; Humans ; Obesity/complications
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac451
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Real-Time Tracking Method for Sports Targets in Smart Cities under the Internet+ Background.

    Hu, Jianping / Ye, Xinjiang

    publication RETRACTED

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 7481160

    Abstract: Real-time tracking of video sports targets has been widely used in the sports industry. In order to further improve the accuracy of real-time tracking of sports targets, this paper proposes a real-time tracking method for sports targets in smart cities ... ...

    Abstract Real-time tracking of video sports targets has been widely used in the sports industry. In order to further improve the accuracy of real-time tracking of sports targets, this paper proposes a real-time tracking method for sports targets in smart cities in the context of Internet+. This method collects data and information on the targets in the sports process, fully considers the diversity of the sports process, and performs real-time tracking and detection of the upgraded sports targets. Finally, the experimental research shows that the method in this paper can track the target accurately and quickly in real time during the movement process, and the accuracy and real-time tracking are relatively better than other tracking methods, which can be used as a powerful tool for subsequent moving target tracking.
    MeSH term(s) Cities ; Internet ; Sports
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/7481160
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Real-Time Tracking Method for Sports Targets in Smart Cities under the Internet+ Background

    Jianping Hu / Xinjiang Ye

    Computational Intelligence and Neuroscience, Vol

    2022  Volume 2022

    Abstract: Real-time tracking of video sports targets has been widely used in the sports industry. In order to further improve the accuracy of real-time tracking of sports targets, this paper proposes a real-time tracking method for sports targets in smart cities ... ...

    Abstract Real-time tracking of video sports targets has been widely used in the sports industry. In order to further improve the accuracy of real-time tracking of sports targets, this paper proposes a real-time tracking method for sports targets in smart cities in the context of Internet+. This method collects data and information on the targets in the sports process, fully considers the diversity of the sports process, and performs real-time tracking and detection of the upgraded sports targets. Finally, the experimental research shows that the method in this paper can track the target accurately and quickly in real time during the movement process, and the accuracy and real-time tracking are relatively better than other tracking methods, which can be used as a powerful tool for subsequent moving target tracking.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Subject code 796
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Function and mechanism of exogenous AGR2 in colorectal cancer cells.

    Zheng, Chao / Mao, Yu / Ye, Jianping / Zhang, Miaolong / Chen, Yongfeng

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28175

    Abstract: Background: Anterior gradient 2 (AGR2) is highly enriched in several malignant tumors and can boost tumor metastasis. Whereas, AGR2 role in colorectal cancer (CRC) is not clear.: Methods: AGR2 expression in the GEPIA database was studied, and the ... ...

    Abstract Background: Anterior gradient 2 (AGR2) is highly enriched in several malignant tumors and can boost tumor metastasis. Whereas, AGR2 role in colorectal cancer (CRC) is not clear.
    Methods: AGR2 expression in the GEPIA database was studied, and the results were confirmed by Western blot in CRC cell lines (SW480, SW620, and HT-29). The impact of AGR2 on the multiplication, migration, invasion and EMT of CRC cells were studied by CCK-8 assay, as well as clone formation, wound healing and transwell assays. The protein concent related to the AKT/β-catenin signaling pathway were accessed via Western blot.
    Results: AGR2 concent in CRC tissues was notablely boosted versus normal colorectal tissues. Exogenous AGR2 boosted the multiplication of CRC cells. In addition, exogenous AGR2 induced EMT, which demonstrated that ZEB1, N-cadherin, Vimentin, Slug, Snail protein concent boosted and E-cadherin protein abated in CRC cells. In terms of mechanism, exogenous AGR2 upgulated
    Conclusion: Exogenous AGR2 enhances the multiplication of CRC cells and induces EMT process, the mechanism of which is related to AKT/β-catenin signal pathway.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28175
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Peroxisome-based metabolic engineering for biomanufacturing and agriculture.

    Song, Shuyan / Ye, Cuifang / Jin, Yijun / Dai, Huaxin / Hu, Jianping / Lian, Jiazhang / Pan, Ronghui

    Trends in biotechnology

    2024  

    Abstract: Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic engineering. The peroxisome has emerged as a highly valuable and promising compartment for organelle engineering, particularly in the fields of biological ... ...

    Abstract Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic engineering. The peroxisome has emerged as a highly valuable and promising compartment for organelle engineering, particularly in the fields of biological manufacturing and agriculture. In this review, we summarize the remarkable achievements in peroxisome engineering in yeast, the industrially popular biomanufacturing chassis host, to produce various biocompounds. We also review progress in plant peroxisome engineering, a field that has already exhibited high potential in both biomanufacturing and agriculture. Moreover, we outline various experimentally validated strategies to improve the efficiency of engineered pathways in peroxisomes, as well as prospects of peroxisome engineering.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2024.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top