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  1. Article ; Online: A Socially Assistive Robot for Stroke Patients: Acceptance, Needs, and Concerns of Patients and Informal Caregivers.

    Dembovski, Ayelet / Amitai, Yael / Levy-Tzedek, Shelly

    Frontiers in rehabilitation sciences

    2022  Volume 2, Page(s) 793233

    Abstract: Stroke patients often contend with long-term physical challenges that require treatment and support from both formal and informal caregivers. Socially Assistive Robots (SARs) can assist patients in their physical rehabilitation process and relieve some ... ...

    Abstract Stroke patients often contend with long-term physical challenges that require treatment and support from both formal and informal caregivers. Socially Assistive Robots (SARs) can assist patients in their physical rehabilitation process and relieve some of the burden on the informal caregivers, such as spouses and family members. We collected and analyzed information from 23 participants (11 stroke patients and 12 informal caregivers) who participated in a total of six focus-group discussions. The participants responded to questions regarding using a SAR to promote physical exercises during the rehabilitation process: (a) the advantages and disadvantages of doing so; (b) specific needs that they wish a SAR would address; (c) patient-specific adaptations they would propose to include; and (d) concerns they had regarding the use of such technology in stroke rehabilitation. We found that the majority of the participants in both groups were interested in experiencing the use of a SAR for rehabilitation, in the clinic and at home. Both groups noted the advantage of having the constant presence of a motivating entity with whom they can practice their rehabilitative exercises. The patients noted how such a device can assist
    Language English
    Publishing date 2022-01-25
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6861
    ISSN (online) 2673-6861
    DOI 10.3389/fresc.2021.793233
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  2. Article ; Online: A Socially Assistive Robot for Stroke Patients

    Ayelet Dembovski / Yael Amitai / Shelly Levy-Tzedek

    Frontiers in Rehabilitation Sciences, Vol

    Acceptance, Needs, and Concerns of Patients and Informal Caregivers

    2022  Volume 2

    Abstract: Stroke patients often contend with long-term physical challenges that require treatment and support from both formal and informal caregivers. Socially Assistive Robots (SARs) can assist patients in their physical rehabilitation process and relieve some ... ...

    Abstract Stroke patients often contend with long-term physical challenges that require treatment and support from both formal and informal caregivers. Socially Assistive Robots (SARs) can assist patients in their physical rehabilitation process and relieve some of the burden on the informal caregivers, such as spouses and family members. We collected and analyzed information from 23 participants (11 stroke patients and 12 informal caregivers) who participated in a total of six focus-group discussions. The participants responded to questions regarding using a SAR to promote physical exercises during the rehabilitation process: (a) the advantages and disadvantages of doing so; (b) specific needs that they wish a SAR would address; (c) patient-specific adaptations they would propose to include; and (d) concerns they had regarding the use of such technology in stroke rehabilitation. We found that the majority of the participants in both groups were interested in experiencing the use of a SAR for rehabilitation, in the clinic and at home. Both groups noted the advantage of having the constant presence of a motivating entity with whom they can practice their rehabilitative exercises. The patients noted how such a device can assist formal caregivers in managing their workload, while the informal caregivers indicated that such a system could ease their own workload and sense of burden. The main disadvantages that participants noted related to the robot not possessing human abilities, such as the ability to hold a conversation, to physically guide the patient's movements, and to express or understand emotions. We anticipate that the data collected in this study—input from the patients and their family members, including the similarities and differences between their points of view—will aid in improving the development of SARs for rehabilitation, so that they can better suit people who have had a stroke, and meet their individual needs.
    Keywords socially assistive robots ; stroke ; rehabilitation ; focus groups ; informal caregivers ; patients ; Other systems of medicine ; RZ201-999 ; Medical technology ; R855-855.5
    Subject code 300 ; 360
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Rapid Induction of Protective Immunity against Pneumonic Plague by

    Aftalion, Moshe / Tidhar, Avital / Vagima, Yaron / Gur, David / Zauberman, Ayelet / Holtzman, Tzvi / Makovitzki, Arik / Chitlaru, Theodor / Mamroud, Emanuelle / Levy, Yinon

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: In a recent study, we demonstrated that vaccination with the polymeric F1 capsule antigen of the plague ... ...

    Abstract In a recent study, we demonstrated that vaccination with the polymeric F1 capsule antigen of the plague pathogen
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030581
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  4. Article ; Online: Purification of Extracellular Microvesicles Secreted by Dermal Fibroblasts.

    Petit, Isabelle / Levy, Ayelet / Aberdam, Daniel

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2154, Page(s) 63–72

    Abstract: Extracellular vesicles (EVs) secreted by all cells are key players in information transfer within a tissue or organism. With their highly cell-specific protein and RNA content, EVs can propagate cellular signals and modulate distant cells' behavior. ... ...

    Abstract Extracellular vesicles (EVs) secreted by all cells are key players in information transfer within a tissue or organism. With their highly cell-specific protein and RNA content, EVs can propagate cellular signals and modulate distant cells' behavior. Dermal fibroblasts are supportive cells for all skin cells and the roles of their EVs start to come to light only recently. In this chapter, we describe a protocol to isolate small EVs from primary human fibroblast culture using classical differential centrifugation methodology.
    MeSH term(s) Cell Fractionation/methods ; Cell-Derived Microparticles/metabolism ; Exosomes/metabolism ; Extracellular Vesicles/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; Skin/cytology ; Ultracentrifugation
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0648-3_6
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  5. Article ; Online: A Community Social Work Paradigm: Thoughts and Reflections.

    Weiss-Dagan, Shlomit / Aviv, Inbal / Eliyahou, Ayala / Levy, Drorit / Makaros, Ayelet / Freiberg, Smadar / Zriker, Amit

    Social work

    2023  Volume 69, Issue 1, Page(s) 35–42

    Abstract: Community social work (CSW) is often regarded as a practice with a variety of intervention models. The objectives of the present article are to examine CSW's philosophical and theoretical roots and to bridge the gap in the literature regarding the ... ...

    Abstract Community social work (CSW) is often regarded as a practice with a variety of intervention models. The objectives of the present article are to examine CSW's philosophical and theoretical roots and to bridge the gap in the literature regarding the theoretical and philosophical origins of CSW and to conceptualize these theoretical bases as a paradigm with ontological, epistemological, axiological, and methodological aspects. The ontology of the proposed CSW paradigm relies on ecological theory, critical theory, and community psychology. The paradigm's epistemology relies on the basic assumption that community members are autonomous subjective human beings with important and valid knowledge who make decisions concerning their lives. Axiologically, the most prominent value of the paradigm is participation, from which other central values derive. The paradigm's methodology derives from its three abovementioned components. The conceptualization of a CSW paradigm provides a theoretical foundation for community interventions and refining the goals of these interventions. The paradigm can be used as a pedagogical and identity-building tool with students and social workers who focus on CSW.
    MeSH term(s) Humans ; Social Work
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410783-4
    ISSN 1545-6846 ; 0037-8046
    ISSN (online) 1545-6846
    ISSN 0037-8046
    DOI 10.1093/sw/swad051
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    Zs.B 2951: Show issues Location:
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  6. Article ; Online: Multiple Forms of Neural Cell Death in the Cyclical Brain Degeneration of A Colonial Chordate.

    Anselmi, Chiara / Caicci, Federico / Bocci, Tommaso / Guidetti, Matteo / Priori, Alberto / Giusti, Veronica / Levy, Tom / Raveh, Tal / Voskoboynik, Ayelet / Weissman, Irving L / Manni, Lucia

    Cells

    2023  Volume 12, Issue 7

    Abstract: Human neuronal loss occurs through different cellular mechanisms, mainly studied in vitro. Here, we characterized neuronal death ... ...

    Abstract Human neuronal loss occurs through different cellular mechanisms, mainly studied in vitro. Here, we characterized neuronal death in
    MeSH term(s) Animals ; Humans ; Chordata ; Cell Death ; Apoptosis/genetics ; Urochordata/genetics ; Neurodegenerative Diseases/genetics ; Mammals
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12071041
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  7. Article ; Online: Rapid Induction of Protective Immunity against Pneumonic Plague by Yersinia pestis Polymeric F1 and LcrV Antigens

    Moshe Aftalion / Avital Tidhar / Yaron Vagima / David Gur / Ayelet Zauberman / Tzvi Holtzman / Arik Makovitzki / Theodor Chitlaru / Emanuelle Mamroud / Yinon Levy

    Vaccines, Vol 11, Iss 581, p

    2023  Volume 581

    Abstract: In a recent study, we demonstrated that vaccination with the polymeric F1 capsule antigen of the plague pathogen Yersinia pestis led to the rapid induction of a protective humoral immune response via the pivotal activation of innate-like B1b cells. ... ...

    Abstract In a recent study, we demonstrated that vaccination with the polymeric F1 capsule antigen of the plague pathogen Yersinia pestis led to the rapid induction of a protective humoral immune response via the pivotal activation of innate-like B1b cells. Conversely, the monomeric version of F1 failed to promptly protect vaccinated animals in this model of the bubonic plague. In this study, we examined the ability of F1 to confer the rapid onset of protective immunity in the more challenging mouse model of the pneumonic plague. Vaccination with one dose of F1 adsorbed on aluminum hydroxide elicited effective protection against subsequent lethal intranasal exposure to a fully virulent Y. pestis strain within a week. Interestingly, the addition of the LcrV antigen shortened the time required for achieving such rapid protective immunity to 4–5 days after vaccination. As found previously, the polymeric structure of F1 was essential in affording the accelerated protective response observed by covaccination with LcrV. Finally, in a longevity study, a single vaccination with polymeric F1 induced a higher and more uniform humoral response than a similar vaccination with monomeric F1. However, in this setting, the dominant contribution of LcrV to long-lasting immunity against a lethal pulmonary challenge was reiterated.
    Keywords vaccination ; pneumonic plague ; rapid protection ; polymeric F1 ; monomeric F1 ; LcrV ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Electron transport

    Guo, Cunlan / Gavrilov, Yulian / Gupta, Satyajit / Bendikov, Tatyana / Levy, Yaakov / Vilan, Ayelet / Pecht, Israel / Sheves, Mordechai / Cahen, David

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 47, Page(s) 28878–28885

    Abstract: A way of modulating the solid-state electron transport (ETp) properties of oligopeptide junctions is presented by charges and internal hydrogen bonding, which affect this process markedly. The ETp properties of a series of tyrosine (Tyr)-containing hexa- ... ...

    Abstract A way of modulating the solid-state electron transport (ETp) properties of oligopeptide junctions is presented by charges and internal hydrogen bonding, which affect this process markedly. The ETp properties of a series of tyrosine (Tyr)-containing hexa-alanine peptides, self-assembled in monolayers and sandwiched between gold electrodes, are investigated in response to their protonation state. Inserting a Tyr residue into these peptides enhances the ETp carried
    MeSH term(s) Hydrogen Bonding ; Alanine ; Tyrosine ; Electron Transport ; Peptides
    Chemical Substances Alanine (OF5P57N2ZX) ; Tyrosine (42HK56048U) ; Peptides
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp02807g
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  9. Article ; Online: Assessment of the Biomechanical Effects of Prophylactic Sacral Dressings on Tissue Loads: A Computational Modeling Analysis.

    Levy, Ayelet / Gefen, Amit

    Ostomy/wound management

    2017  Volume 63, Issue 10, Page(s) 48–55

    Abstract: The sacrum is the most susceptible anatomical site for developing pressure injuries, including deep tissue injuries, during supine lying. Prophylactic dressings generally are designed to reduce friction, alleviate internal tissue shear, manage the ... ...

    Abstract The sacrum is the most susceptible anatomical site for developing pressure injuries, including deep tissue injuries, during supine lying. Prophylactic dressings generally are designed to reduce friction, alleviate internal tissue shear, manage the microclimate, and overall cushion the soft tissues subjected to sustained deformations under the sacrum. Using computational modeling, the authors developed a set of 8 magnetic resonance imaging-based, 3-dimensional finite element models of the buttocks of a healthy 28-year-old woman for comparing the biomechanical effects of different prophylactic sacral dressing designs when used during supine lying on a standard hospital foam mattress. Computer simulation data from model variants incorporating an isotropic (same stiffness in every direction) multilayer compliant dressing, an anisotropic (directionally dependent stiffness properties) multilayer compliant dressing, and a completely stiff dressing were compared to control (no dressing). Specific outcome measures that were compared across these simulation cases were strain energy density (SED) and maximal shear stresses in a volume of interest (VOI) of soft tissues surrounding the sacrum. The SED and shear stress measurements were obtained in pure compression loading of the buttocks (ie, simulating a horizontal supine bed rest) and in combined compression-and-shear loads applied to the buttocks (ie, 45˚ Fowler position causing frictional and shear forces) on a standard foam mattress. Compared to the isotropic dressing design, the anisotropic dressing facilitated more soft tissue protection through an additional 11% reduction in exposure to SED at the VOI. In this model, use of the anisotropic compliant dressing resulted in the lowest exposures to internal tissue SED and shear stresses. Research to examine the clinical inference of this modeling technique and studies to compare the effects of prophylactic dressings on healthy volunteers and patients in different positions are warranted.
    MeSH term(s) Bandages/standards ; Biomechanical Phenomena ; Computer Simulation ; Humans ; Patient Simulation ; Pre-Exposure Prophylaxis/methods ; Pressure/adverse effects ; Pressure Ulcer/prevention & control ; Sacrococcygeal Region/injuries ; Sacrococcygeal Region/physiopathology ; Stress, Mechanical
    Language English
    Publishing date 2017-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089112-2
    ISSN 1943-2720 ; 0889-5899
    ISSN (online) 1943-2720
    ISSN 0889-5899
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3333: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Phage Therapy Potentiates Second-Line Antibiotic Treatment against Pneumonic Plague.

    Vagima, Yaron / Gur, David / Aftalion, Moshe / Moses, Sarit / Levy, Yinon / Makovitzki, Arik / Holtzman, Tzvi / Oren, Ziv / Segula, Yaniv / Fatelevich, Ella / Tidhar, Avital / Zauberman, Ayelet / Rotem, Shahar / Mamroud, Emanuelle / Steinberger-Levy, Ida

    Viruses

    2022  Volume 14, Issue 4

    Abstract: Plague pandemics and outbreaks have killed millions of people during the history of humankind. The disease, caused by the ... ...

    Abstract Plague pandemics and outbreaks have killed millions of people during the history of humankind. The disease, caused by the bacteria
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteriophages ; Disease Models, Animal ; Humans ; Mice ; Phage Therapy ; Plague/drug therapy ; Yersinia pestis
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-03-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14040688
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