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Article ; Online: Genetic variants associated with inflammatory bowel disease and gut graft-versus-host disease.

Martin, Paul J / Storer, Barry E / Levine, David M / Hansen, John A

2021 Volume 5, Issue 21, Page(s) 4456–4464

Abstract: Previous studies have identified genetic variants associated with inflammatory bowel disease (IBD). We tested the hypothesis that some of these variants are also associated with the risk of moderate to severe gut graft-versus-host disease (GVHD) after ... ...

Abstract	Previous studies have identified genetic variants associated with inflammatory bowel disease (IBD). We tested the hypothesis that some of these variants are also associated with the risk of moderate to severe gut graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). Associations were evaluated initially in a discovery cohort of 1980 HCT recipients of European ancestry with HLA-matched related or unrelated donors. Associations discovered in this cohort were tested for replication in a separate cohort of 1294 HCT recipients. Among the 296 single-nucleotide polymorphisms and 26 HLA alleles tested, we found that the recipient rs1260326 homozygous T allele in GCKR was associated with a higher risk of stage 2 to 4 gut GVHD. No other candidate variants were associated with stage 2 to 4 gut GVHD. The rs1260326 variant resides in an IBD-associated locus containing FNDC4, a gene that encodes a secreted anti-inflammatory factor that dampens macrophage activity and improves colitis in mice. Our results suggest that targeting inflammatory macrophages with recombinant FNDC4 offers an attractive avenue of clinical investigation for management of IBD and gut GVHD.
MeSH term(s)	Animals ; Colitis ; Graft vs Host Disease/genetics ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Inflammatory Bowel Diseases/genetics ; Mice ; Proteins ; Unrelated Donors
Chemical Substances	FNDC4 protein, human ; Proteins
Language	English
Publishing date	2021-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021004959
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Article ; Online: Response.

Bhatia, Shailender / Storer, Barry E / Nghiem, Paul

Journal of the National Cancer Institute

2017 Volume 109, Issue 10

Language	English
Publishing date	2017-07-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djx053
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Article ; Online: Incorporating Physical Function and Cognition Into Mortality Risk Assessment for Acute Myeloid Leukemia-Reply.

Sorror, Mohamed L / Storer, Barry E / Estey, Elihu H

JAMA oncology

2018 Volume 4, Issue 7, Page(s) 1014–1015

MeSH term(s)	Cognition ; Humans ; Leukemia, Myeloid, Acute ; Risk Assessment
Language	English
Publishing date	2018-07-18
Publishing country	United States
Document type	Letter ; Comment
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2018.0677
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Article ; Online: Revised Acute Myeloid Leukemia Composite Model Using the 2017 European LeukemiaNet Risk Classification.

Sorror, Mohamed L / Storer, Barry E / Nyland, Jennifer / Estey, Elihu H

JAMA oncology

2019 Volume 5, Issue 7, Page(s) 1062–1064

MeSH term(s)	Humans ; Leukemia, Myeloid, Acute/classification ; Models, Biological ; Platelet Count ; Risk
Language	English
Publishing date	2019-05-16
Publishing country	United States
Document type	Journal Article
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2019.0902
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Article ; Online: Genetic associations with immune-mediated outcomes after allogeneic hematopoietic cell transplantation.

Martin, Paul J / Levine, David M / Storer, Barry E / Sather, Cassandra L / Spellman, Stephen R / Hansen, John A

Blood advances

2022 Volume 6, Issue 8, Page(s) 2608–2617

Abstract: Previous studies have identified more than 200 genetic variants associated with acute or chronic graft-versus-host disease (aGVHD; cGVHD) or recurrent malignancy after allogeneic hematopoietic cell transplantation (HCT). We tested these candidate donor ... ...

Abstract	Previous studies have identified more than 200 genetic variants associated with acute or chronic graft-versus-host disease (aGVHD; cGVHD) or recurrent malignancy after allogeneic hematopoietic cell transplantation (HCT). We tested these candidate donor and recipient variants in a cohort of 4270 HCT recipients of European ancestry and in subcohorts of 1827 sibling and 1447 unrelated recipients who had 10/10 HLA-A, B, C, DRB1, and DQB1-matched donors. We also carried out a genome-wide association study (GWAS) for these same outcomes. The discovery and replication analysis of candidate variants identified a group of closely linked recipient HLA-DPB1 single-nucleotide polymorphisms (SNPs) associated with an increased risk of aGVHD and a corresponding decreased risk of recurrent malignancy after unrelated HCT. These results reflect a correlation with the level of HLA-DPB1 expression previously shown to affect the risks of aGVHD and relapse in unrelated recipients. Our GWAS identified an association of cGVHD with a locus of X-linked recipient intron variants in NHS, a gene that regulates actin remodeling and cell morphology. Evaluation of this association in a second replication cohort did not confirm the original replication results, and we did not reach any definitive conclusion regarding the validity of this discovery. The cohort used for our study is larger than those used in most previous HCT studies but is smaller than those typically used for other genotype-phenotype association studies. Genomic and disease data from our study are available for further analysis in combination with data from other cohorts.
MeSH term(s)	Chronic Disease ; Genome-Wide Association Study ; Graft vs Host Disease/genetics ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Recurrence ; Siblings ; Tissue Donors
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021005620
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Article ; Online: Statistical considerations in studies of late effects in HCT.

Storer, Barry E

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

2009 Volume 15, Issue 1 Suppl, Page(s) 25–28

MeSH term(s)	Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/mortality ; Hematopoietic Stem Cell Transplantation/statistics & numerical data ; Humans ; Survival Analysis ; Transplantation, Autologous
Language	English
Publishing date	2009-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1474865-4
ISSN	1523-6536 ; 1083-8791
ISSN (online)	1523-6536
ISSN	1083-8791
DOI	10.1016/j.bbmt.2008.10.003
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Zs.A 5082: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Genetic variants associated with cytomegalovirus infection after allogeneic hematopoietic cell transplantation.

Casto, Amanda M / Seo, Sachiko / Levine, David M / Storer, Barry E / Dong, Xinyuan / Hansen, John A / Boeckh, Michael / Martin, Paul J

Blood

2021 Volume 138, Issue 17, Page(s) 1628–1636

Abstract: Human cytomegalovirus (CMV) reactivation is a frequent complication of allogeneic hematopoietic cell transplantation (HCT). Despite routine screening for CMV reactivation and early antiviral treatment, the rates of CMV-related complications after HCT ... ...

Abstract	Human cytomegalovirus (CMV) reactivation is a frequent complication of allogeneic hematopoietic cell transplantation (HCT). Despite routine screening for CMV reactivation and early antiviral treatment, the rates of CMV-related complications after HCT remain high. Genetic variants in both the donor and recipient have been associated with the risk of CMV reactivation and disease after HCT, but these associations have not been validated, and their clinical importance remains unclear. In this study, we assessed 117 candidate variants previously associated with CMV-related phenotypes for association with CMV reactivation and disease in a cohort of 2169 CMV-seropositive HCT recipients. We also carried out a genome-wide association study (GWAS) for CMV reactivation and disease in the same cohort. Both analyses used a prespecified discovery and replication approach to control the risk of false-positive results. Among the 117 candidate variants, our analysis implicates only the donor ABCB1 rs1045642 genotype as a risk factor for CMV reactivation. This synonymous variant in P-glycoprotein may influence the risk of CMV reactivation by altering the efflux of cyclosporine and tacrolimus from donor lymphocytes. In the GWAS analysis, the donor CDC42EP3 rs11686168 genotype approached the significance threshold for association with CMV reactivation, although we could not identify a mechanism to explain this association. The results of this study suggest that most genomic variants previously associated with CMV phenotypes do not significantly alter the risk for CMV reactivation or disease after HCT.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/genetics ; Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cytomegalovirus/isolation & purification ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/etiology ; Cytomegalovirus Infections/genetics ; Female ; GTP-Binding Protein Regulators/genetics ; Genome-Wide Association Study ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Transplantation, Homologous/adverse effects ; Virus Activation ; Young Adult
Chemical Substances	ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; CDC42EP3 protein, human ; GTP-Binding Protein Regulators
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2021012153
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Article ; Online: Allogeneic Hematopoietic Cell Transplantation in the Outpatient Setting.

Granot, Noa / Storer, Barry E / Cooper, Jason P / Flowers, Mary E / Sandmaier, Brenda M / Storb, Rainer

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

2019 Volume 25, Issue 11, Page(s) 2152–2159

Abstract: Conditioning with fludarabine and low-dose total-body irradiation before allogeneic hematopoietic cell transplantation (HCT) enabled treating older or medically infirm patients with advanced hematologic malignancies in the outpatient setting. Between ... ...

Abstract	Conditioning with fludarabine and low-dose total-body irradiation before allogeneic hematopoietic cell transplantation (HCT) enabled treating older or medically infirm patients with advanced hematologic malignancies in the outpatient setting. Between December 1997 and June 2017, 1037 patients with hematologic malignancies received peripheral blood stem cell (PBSC) grafts from HLA-matched or 1 HLA antigen/allele-mismatched related or unrelated donors. Median age was 58 (range, 18 to 80) years. Serious comorbidities with Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) scores ≥3 were present in 52% of patients. We found that 47% of patients were either never hospitalized or only had an overnight hospital stay for infusion of late-arriving PBSCs while 53% were admitted for a median of 6 days. Main reasons for admission were infection, fever, graft-versus-host disease, and regimen-related toxicity. Two thirds of admissions occurred within 3 weeks of HCT. The 5-year risk of nonrelapse mortality (NRM) was 26% among hospitalized patients and 13% among nonhospitalized patients. Significant risk factors for hospitalization included unrelated transplants, 1 HLA antigen-mismatched transplant, high HCT-CI scores, and diagnosis of nonmyeloma malignancies. Significant risk factors for NRM were hospitalization, older age, unrelated transplants, and high HCT-CI scores. Ambulatory allogeneic HCT is feasible and safe.
MeSH term(s)	Adolescent ; Adult ; Aged ; Allografts ; Ambulatory Care ; Disease-Free Survival ; Female ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/therapy ; Humans ; Male ; Middle Aged ; Peripheral Blood Stem Cell Transplantation ; Prospective Studies ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2019-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1474865-4
ISSN	1523-6536 ; 1083-8791
ISSN (online)	1523-6536
ISSN	1083-8791
DOI	10.1016/j.bbmt.2019.06.025
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Article ; Online: Second allogeneic hematopoietic cell transplantation for relapse after first allografts.

Gyurkocza, Boglarka / Storb, Rainer / Chauncey, Thomas R / Maloney, David G / Storer, Barry E / Sandmaier, Brenda M

Leukemia & lymphoma

2019 Volume 60, Issue 7, Page(s) 1758–1766

Abstract: We analyzed outcomes of 126 patients with hematologic malignancies, who relapsed after first allogeneic hematopoietic cell transplantation (HCT) and received subsequent allografts. In 17 cases, the original donors were utilized, while in 109 cases ... ...

Abstract	We analyzed outcomes of 126 patients with hematologic malignancies, who relapsed after first allogeneic hematopoietic cell transplantation (HCT) and received subsequent allografts. In 17 cases, the original donors were utilized, while in 109 cases different donors were identified. The 2-year overall survival (OS), relapse, and non-relapse mortality (NRM) rates were 33%, 42%, and 33%, respectively. Patients with early relapse after first allogeneic HCT (within 100 days vs. 100 days to 12 months vs. >12 months) had higher relapse rates (50% vs. 47% vs. 34%, respectively;
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Graft vs Host Disease/epidemiology ; Graft vs Host Disease/mortality ; Graft vs Host Disease/pathology ; Graft vs Host Disease/therapy ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/pathology ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; New York/epidemiology ; Prognosis ; Retrospective Studies ; Survival Rate ; Transplantation Conditioning ; Transplantation, Homologous ; Unrelated Donors ; Young Adult
Language	English
Publishing date	2019-01-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2018.1542149
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Article ; Online: Impact of Rituximab and Host/Donor Fc Receptor Polymorphisms after Allogeneic Hematopoietic Cell Transplantation for CD20

Granot, Noa / Rezvani, Andrew R / Pender, Barbara S / Storer, Barry E / Sandmaier, Brenda M / Storb, Rainer / Maloney, David G

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

2020 Volume 26, Issue 10, Page(s) 1811–1818

Abstract: We previously reported a 24% 1-year relapse rate in 93 older or medically unfit patients with ... ...

Abstract	We previously reported a 24% 1-year relapse rate in 93 older or medically unfit patients with CD20
MeSH term(s)	B-Lymphocytes ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation ; Humans ; Neoplasm Recurrence, Local ; Prospective Studies ; Receptors, Fc/genetics ; Rituximab/therapeutic use ; Transplantation Conditioning ; Transplantation, Homologous
Chemical Substances	Receptors, Fc ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2020-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1474865-4
ISSN	1523-6536 ; 1083-8791
ISSN (online)	1523-6536
ISSN	1083-8791
DOI	10.1016/j.bbmt.2020.07.014
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