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  1. Article ; Online: Cyclic stretch-induced exosomes from periodontal ligament cells promote osteoblasts osteogenic differentiation via the miR-181d-5p/TNF signaling pathway.

    Qu, Fang / Zhang, Yi-Fan / Wang, Ying-Ying / Cao, Xi-Meng / Shen, Ying-Yi / Wu, Zi-Ang / Wu, Ya-Qin / Xu, Chun

    Archives of oral biology

    2023  Volume 157, Page(s) 105843

    Abstract: Objective: To investigate the effects of cyclic stretch-induced periodontal ligament cell (PDLC) exosomes on osteoblast differentiation, and to explore their regulatory role in mechanical force-related periodontal tissue remodeling.: Design: After ... ...

    Abstract Objective: To investigate the effects of cyclic stretch-induced periodontal ligament cell (PDLC) exosomes on osteoblast differentiation, and to explore their regulatory role in mechanical force-related periodontal tissue remodeling.
    Design: After applying 20 % cyclic stretch loading to PDLCs, exosomes were extracted from the supernatant and co-cultured with osteoblasts to detect their effects on osteogenic differentiation. Meanwhile, the exosomes were sequenced by high-throughput microRNA sequencing for bioinformatic analysis and validation to explore exosome signaling pathways through miRNAs.
    Results: Cyclic stretch-induced PDLC exosomes could be taken up by osteoblasts and promoted osteogenic differentiation of osteoblasts, as demonstrated by the increased expression levels of osteogenesis-related factors and enhanced alkaline phosphatase (Alp) staining. Among the differentially expressed miRNAs between exosomes from cyclic stretch group and control group, miRNA-181d-5p was up-regulated significantly. The expression levels of osteogenesis-related factors and Alp staining were also increased in osteoblasts transfected with miR-181d-5p, and this effect might be related to the inhibitory role of exosomal miR-181d-5p on tumor necrosis factor (TNF).
    Conclusions: Cyclic stretch-induced PDLC exosomes exhibited a promoting effect on osteogenic differentiation, which might result from the inhibition of TNF via exosomal miR-181d-5p.
    MeSH term(s) Osteogenesis/genetics ; Periodontal Ligament ; Exosomes/metabolism ; Cells, Cultured ; Cell Differentiation ; MicroRNAs/genetics ; Signal Transduction ; Osteoblasts
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2023.105843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Chemical constituents from Abrus cantoniensis and their cytotoxic effects on cancer cells

    Bao, Ze-Qing / Bao, Ying-Yi / Qin, Xiao-Cui / Wu, Wei-Bin / Zhang, Xia

    Phytochemical Society of Europe Phytochemistry letters. 2022 June, v. 49

    2022  

    Abstract: Two new compounds named 4-(4-hydroxybenzyl)-isofraxidin (1) and 1''-methoxyl-bavacoumestan B (2), along with five known compounds (3–7) were isolated from the EtOAc-soluble extract of Abrus cantoniensis. Their structures were elucidated with ... ...

    Abstract Two new compounds named 4-(4-hydroxybenzyl)-isofraxidin (1) and 1''-methoxyl-bavacoumestan B (2), along with five known compounds (3–7) were isolated from the EtOAc-soluble extract of Abrus cantoniensis. Their structures were elucidated with spectroscopic and physico-chemical analyses. All isolates were evaluated for their cytotoxic activities against four cancer cell lines including HepG2, SMMC-7721, A549 and MCF-7. Among them, compounds 1 and 5 exhibited significant cytotoxic activity on the above four cell lines. In particular, 1 showed the potent cytotoxic activity on HepG2 and SMMC-7721 cells with IC₅₀ values of 4.31 ± 0.5 and 3.24 ± 0.9 μM, respectively.
    Keywords Abrus cantoniensis ; cytotoxicity ; neoplasm cells ; plant biochemistry ; spectroscopy
    Language English
    Dates of publication 2022-06
    Size p. 1-4.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2022.02.005
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Domestication Gene

    Qin, Xiaoxuan / Jiang, Liang / Zhao, Ping / Lin, Ying / Zhang, Yi / Xia, Qingyou

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: ... Bombyx ... ...

    Abstract Bombyx mori
    MeSH term(s) Animals ; Bombyx/metabolism ; Larva/genetics ; Domestication ; Glutamine/metabolism ; Body Size
    Chemical Substances Glutamine (0RH81L854J)
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063427
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  4. Article: Relationship between

    Liu, Yi-Ying / Wan, Qin

    World journal of diabetes

    2023  Volume 14, Issue 12, Page(s) 1803–1812

    Abstract: Background: Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment ... ...

    Abstract Background: Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment is difficult and the prognosis is poor. At present, the pathogenesis of diabetic kidney disease is still unclear, and it is believed that it is associated with genetic and environmental factors.
    Aim: To explore the relationship between the glucokinase regulatory protein (
    Methods: We selected 252 patients (126 males and 126 females) with T2D admitted to our hospital from January 2020 to October 2020, and 66 healthy people (44 females and 22 males). According to the urinary albumin/creatinine ratio, the subjects were divided into group I (control), group II (T2D with normoalbuminuria), group III (T2D with microalbuminuria), and group IV (T2D with macroalbuminuria). Additionly, the subjects were divided into group M (normal group) or group N (albuminuria group) according to whether they developed albuminuria. We detected the
    Results: Gene distribution and genotype distribution among groups I-IV accorded with the Hardy-Weinberg equilibrium. Genotype frequency was significantly different among the four groups (
    Conclusion: CT + TT genotype is a risk factor for T2D with albuminuria. In the future, we can assess the risk of individuals carrying susceptible genes to delay the onset of T2D.
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Clinical Trial
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v14.i12.1803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A systematic review and meta-analysis of observational studies of the association between the use of incretin-based therapies and the risk of pancreatic cancer.

    Hidayat, Khemayanto / Zhou, Ying-Yi / Du, Hong-Zhen / Qin, Li-Qiang / Shi, Bi-Min / Li, Zeng-Ning

    Pharmacoepidemiology and drug safety

    2022  Volume 32, Issue 2, Page(s) 107–125

    Abstract: Background: Some early reports in the medical literature have raised concern about a possible increased risk of pancreatic cancer associated with the use of two broad classes of incretin-based therapies, dipeptidyl peptidase-4 inhibitors, and glucagon- ... ...

    Abstract Background: Some early reports in the medical literature have raised concern about a possible increased risk of pancreatic cancer associated with the use of two broad classes of incretin-based therapies, dipeptidyl peptidase-4 inhibitors, and glucagon-like peptide-1 receptor agonists. This possibility has been somewhat mitigated by the null findings meta-analyses of randomized controlled trials, but the usefulness of their findings was hampered by serious shortcomings of lack of power and representativeness. These shortcomings can typically be addressed by observational studies, but observational studies on the topic have yielded conflicting findings. A systematic review and meta-analysis of observational studies was performed to qualitatively and quantitatively appraise the totality of evidence on the association between the use of incretin-based therapies and the risk of pancreatic cancer in routine clinical practice.
    Methods: The PubMed, Web of Science, Embase, and Google Scholar databases were searched. The study quality was appraised using the ROBINS-I tool and based on the presence of pharmacoepidemiology biases. A random-effects model was used to estimate the summary relative risks with corresponding CIs.
    Results: A total of 14 studies were included. The qualitative assessment revealed that all studies had inadequate follow-up (≤5 years), 12 studies were suspected to suffer from time-lag bias (due to inappropriate choice of comparator group) to varying extent, five studies included prevalent users, five studies did not implement exposure lag period, five studies had a serious risk of bias due to confounding, and one study had a time-window bias. The quantitative assessment showed no indication of an increased risk when all studies were pooled together (RR 1.04, 95% CI 0.87, 1.24) and when the analysis was restricted to the studies with the least bias (RR 0.77, 95% CI 0.51, 1.17). However, the pooled RRs were more frequently higher in the studies with less rigorous design and analysis. Specifically, a tendency toward an increased risk was observed in the studies with (RR 1.34, 95% CI 1.04, 1.72) or possibly with (RR 1.10, 95% CI 0.89, 1.36) time-lag bias, in the studies that did not apply (RR 1.23, 95% CI 0.93, 1.63) or with potentially inadequate exposure lag period of 6 months (RR 1.13, 95% CI 0.66, 1.94), in the studies that inappropriate comparator group of a combination of unspecified (RR 1.49, 95% CI 1.25, 1.78) or non-insulin (RR 1.15, 95% CI 0.93, 1.42) antidiabetic drugs, and in the studies with serious risk of bias due to confounding (RR 1.18, 95% CI 0.56, 2.49).
    Conclusions: In summary, the totality of evidence from observational studies does not support the claim that the use of incretin-based therapies is associated with an increased risk of pancreatic cancer in routine clinical practice. The increased risk of pancreatic cancer observed in observational studies reflects bias resulting from suboptimal methodological approaches, which need to be avoided by future studies.
    MeSH term(s) Humans ; Incretins/adverse effects ; Hypoglycemic Agents/adverse effects ; Pancreatic Neoplasms/chemically induced ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Pancreatic Neoplasms
    Chemical Substances Incretins ; Hypoglycemic Agents ; Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2022-12-11
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.5550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3395: Show issues Location:
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  6. Article ; Online: ALDH3A1 upregulation inhibits neutrophils N2 polarization and halts oral cancer growth.

    He, Ying / Qu, Yi / Jin, Shan / Zhang, Yongfeng / Qin, Lizheng

    Oral diseases

    2024  

    Abstract: Objectives: Tumor-associated neutrophils (TANs) are among the most abundant inflammatory cells in tumor microenvironment (TME). Aldehyde dehydrogenase 3A1 (ALDH3A1) is significantly reduced in oral squamous cell carcinoma (OSCC), ALDH3A1 overexpression ... ...

    Abstract Objectives: Tumor-associated neutrophils (TANs) are among the most abundant inflammatory cells in tumor microenvironment (TME). Aldehyde dehydrogenase 3A1 (ALDH3A1) is significantly reduced in oral squamous cell carcinoma (OSCC), ALDH3A1 overexpression suppresses tumorigenesis by inhibiting inflammation. This study investigated the relationship and mechanisms underlying the crosstalk between ALDH3A1 and TANs in OSCC.
    Materials and methods: Immunohistochemistry and immunofluorescence were performed to investigate the abundance of TANs and the expression of ALDH3A1. dHL-60 were induced with tumor-conditioned media and recombinant IL-6/IL-8. The expression of key proteins in PI3K/AKT/NF-κB pathway were detected by RT-PCR and western blot. A xenograft model was utilized to examine the effect of ALDH3A1 on tumorigenicity and polarization of TANs.
    Results: In patients with OSCC, TANs significantly increased and were associated with a worse prognosis. Additionally, ALDH3A1 negatively correlated with TANs infiltration and especially the N2 phenotype which was the prominent part in OSCC. Furthermore, our study demonstrated that tumor-derived IL-8 drives ALDH3A1-mediated TANs N2 polarization in the TME through PI3K/AKT/NF-κB pathway in vitro and in vivo.
    Conclusion: Our results indicate that TANs can serve as a prognostic biomarker and ALDH3A1 could be a promising therapeutic target for regulating TANs N2 polarization in antitumor therapy.
    Language English
    Publishing date 2024-01-15
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14863
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    Zs.A 4427: Show issues Location:
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  7. Article ; Online: Chiral Cp

    Wang, Juanjuan / Luo, Mu-Peng / Gu, Yi-Jie / Liu, Yu-Ying / Yin, Qin / Wang, Shou-Guo

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 12, Page(s) e202400502

    Abstract: Chiral cyclopentadienyl-rhodium(III) ... ...

    Abstract Chiral cyclopentadienyl-rhodium(III) Cp
    Language English
    Publishing date 2024-02-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202400502
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  8. Article ; Online: Multifunctional Metal-Organic Framework (MOF)-Based Nanoplatforms for Crop Protection and Growth Promotion.

    Wang, Chao-Yi / Qin, Jian-Chun / Yang, Ying-Wei

    Journal of agricultural and food chemistry

    2023  

    Abstract: Phytopathogen, pest, weed, and nutrient deficiency cause severe losses to global crop yields every year. As the core engine, agrochemicals drive the continuous development of modern agriculture to meet the demand for agricultural productivity and ... ...

    Abstract Phytopathogen, pest, weed, and nutrient deficiency cause severe losses to global crop yields every year. As the core engine, agrochemicals drive the continuous development of modern agriculture to meet the demand for agricultural productivity and increase the environmental burden due to inefficient use. With new advances in nanotechnology, introducing nanomaterials into agriculture to realize agrochemical accurate and targeted delivery has brought new opportunities to support the sustainable development of green agriculture. Metal-Organic frameworks (MOFs), which weave metal ions/clusters and organic ligands into porous frameworks, have exhibited significant advantages in constructing biotic/abiotic stimuli-responsive nanoplatforms for controlled agrochemical delivery. This review emphasizes the recent developments of MOF-based nanoplatforms for crop protection, including phytopathogen, pest, and weed control, and crop growth promotion, including fertilizer/plant hormone delivery. Finally, forward-looking perspectives and challenges on MOF-based nanoplatforms for future applications in crop protection and growth promotion are also discussed.
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c01094
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    Zs.A 1172: Show issues Location:
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  9. Article: Meroterpenoid Dimers from

    Qin, Fu-Ying / Chen, Yan-Yi / Zhang, Jiao-Jiao / Cheng, Yong-Xian

    Frontiers in chemistry

    2022  Volume 10, Page(s) 888371

    Abstract: Dimercochlearlactones A-J ( ...

    Abstract (±)-Dimercochlearlactones A-J (
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.888371
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  10. Article ; Online: Assessing Dietary Consumption of Sodium and Potassium in China through Wastewater Analysis.

    Tan, Dong Qin / Liang, Yi / Guo, Ting / Li, Yan Ying / Song, Yong Xin / Wang, De Gao

    Biomedical and environmental sciences : BES

    2024  Volume 37, Issue 1, Page(s) 127–131

    MeSH term(s) Sodium ; Wastewater ; Potassium ; Diet ; Blood Pressure ; China ; Sodium, Dietary ; Sodium Chloride, Dietary
    Chemical Substances Sodium (9NEZ333N27) ; Wastewater ; Potassium (RWP5GA015D) ; Sodium, Dietary ; Sodium Chloride, Dietary
    Language English
    Publishing date 2024-02-07
    Publishing country China
    Document type Letter
    ZDB-ID 645083-0
    ISSN 2214-0190 ; 0895-3988
    ISSN (online) 2214-0190
    ISSN 0895-3988
    DOI 10.3967/bes2024.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2459: Show issues Location:
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