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  1. Article ; Online: Chemistry, information and Frank: a tribute to Frank Brown.

    Agrafiotis, Dimitris K / Holloway, M Katharine / Johnson, Scott Arne / Reynolds, Charles H / Stouch, Terry Richard / Tropsha, Alexander / Waller, Chris L

    Journal of computer-aided molecular design

    2018  Volume 32, Issue 7, Page(s) 723–729

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Informatics/history ; Models, Chemical ; United States
    Language English
    Publishing date 2018-07-23
    Publishing country Netherlands
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 808166-9
    ISSN 1573-4951 ; 0920-654X
    ISSN (online) 1573-4951
    ISSN 0920-654X
    DOI 10.1007/s10822-018-0135-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2625: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: What we have learned from the Infant Aphakia Treatment Study: The 49th Annual Frank D. Costenbader Lecture.

    Lambert, Scott R

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2023  Volume 27, Issue 5, Page(s) 253–258

    Abstract: Unilateral congenital cataracts lead to deprivation amblyopia, which can be severe. Until the 1970s, they were believed to be always associated with poor visual outcomes. However, advances in our understanding of the plasticity of the infant brain and ... ...

    Abstract Unilateral congenital cataracts lead to deprivation amblyopia, which can be severe. Until the 1970s, they were believed to be always associated with poor visual outcomes. However, advances in our understanding of the plasticity of the infant brain and the development of better surgical techniques allowed good visual outcomes to be obtained in a few of these patients. The Infant Aphakia Treatment Study (IATS) was conducted to provide empirical evidence regarding the best type of optical correction to be used following surgical extraction of the cataract. Specifically, infants were randomly assigned to either be left aphakic and to wear contact lenses or an intraocular lens (IOL) was implanted and the residual refractive error was corrected with spectacles. The study found that good visual acuity and stereopsis could be achieved in some patients in both treatment groups. Early cataract surgery, consistent optical correction and part-time patching of the fellow eye are important elements needed to achieve good visual outcomes. However, excess patching of the fellow eye may interfere with the development of stereopsis. More adverse events occurred after IOL implantation, particularly visual axis opacification, compared with the infants who were left aphakic. Glaucoma-related adverse events occurred in 40% of eyes after a 10-year follow-up and were not associated with IOL implantation. Further research is needed to increase the percentage of children with unilateral congenital cataracts who achieve good visual outcomes.
    MeSH term(s) Child ; Infant ; Humans ; Aphakia, Postcataract/surgery ; Lens Implantation, Intraocular ; Visual Acuity ; Follow-Up Studies ; Cataract Extraction ; Lenses, Intraocular ; Cataract/congenital ; Postoperative Complications
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2023.08.001
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    Zs.A 5188: Show issues Location:
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  3. Article ; Online: Frank Horan (1933 to 2015).

    Scott, J

    The bone & joint journal

    2016  Volume 98-B, Issue 1, Page(s) 144

    MeSH term(s) England ; History, 20th Century ; History, 21st Century ; Orthopedics/history ; Periodicals as Topic/history
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.98B1.37633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6989: Show issues Location:
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  4. Article ; Online: Predictive validity of conversion from the clinical high risk syndrome to frank psychosis.

    Yoviene Sykes, Laura A / Ferrara, Maria / Addington, Jean / Bearden, Carrie E / Cadenhead, Kristin S / Cannon, Tyrone D / Cornblatt, Barbara A / Perkins, Diana O / Mathalon, Daniel H / Seidman, Larry J / Tsuang, Ming T / Walker, Elaine F / McGlashan, Thomas H / Woodberry, Kristen A / Powers, Albert R / Ponce, Allison N / Cahill, John D / Pollard, Jessica M / Srihari, Vinod H /
    Woods, Scott W

    Schizophrenia research

    2019  Volume 216, Page(s) 184–191

    Abstract: ... the predictive validity of the criteria for conversion or transition to frank psychosis. The current study ...

    Abstract Although the clinical high risk for psychosis (CHR) paradigm has become well-established over the past two decades, one key component has received surprisingly little investigative attention: the predictive validity of the criteria for conversion or transition to frank psychosis. The current study evaluates the predictive validity of the transition to psychosis as measured by the Structured Interview for Psychosis-Risk Syndromes (SIPS) in CHR individuals. Participants included 33 SIPS converters and 399 CHR non-converters both from the North American Prodromal Longitudinal Study (NAPLS-2), as well as a sample of 67 separately ascertained first-episode psychosis (FEP) patients from the STEP program. Comparisons were made at baseline and one-year follow-up on demographic, diagnostic stability (SCID), and available measurement domains relating to severity of illness (psychotropic medication, psychosocial treatment, and resource utilization). Principal findings are: 1) a large majority of cases in both SIPS converters (n = 27/33, 81.8%) and FEP (n = 57/67, 85.1%) samples met criteria for continued psychosis at one-year follow-up; 2) follow-up prescription rates for current antipsychotic medication were higher in SIPS converters (n = 17/32, 53.1%) compared to SIPS non-converters (n = 81/397, 20.4%), and similar as compared to FEP cases (n = 39/65, 60%); and 3) at follow-up, SIPS converters had higher rates of resource utilization (psychiatric hospitalizations, day hospital admissions, and ER visits) than SIPS non-converters and were similar to FEP in most categories. The results suggest that the SIPS definition of psychosis onset carries substantial predictive validity. Limitations and future directions are discussed.
    MeSH term(s) Humans ; Longitudinal Studies ; Prodromal Symptoms ; Psychotic Disorders/diagnosis ; Psychotic Disorders/epidemiology ; Syndrome
    Language English
    Publishing date 2019-12-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2019.12.002
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    Zs.A 2351: Show issues Location:
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    Zs.MO 543: Show issues

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  5. Book ; Online: My Father, Frank

    Smythe, Tony / Scott, Doug

    2013  

    Abstract: Frank Smythe's mountaineering achievements in the decade before the Second World War became a part ...

    Abstract Frank Smythe's mountaineering achievements in the decade before the Second World War became a part of climbing history. His intensive Alpine climbing, followed by two Himalayan expeditions ? to Kangchenjunga in 1930 and success the following year on Kamet, the highest summit then reached ? became the prelude to Everest. And in 1933 on that great mountain, climbing alone and without supplementary oxygen he got to within 820 feet of the top, a record height before efforts were resumed post-war and Everest was climbed in 1953. And as a superb Himalayan finale, in 1937 he returned to the Indian Ga
    Language English
    Size Online-Ressource (519 p)
    Publisher Vertebrate Publishing
    Publishing place New York
    Document type Book ; Online
    Note Description based upon print version of record
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article ; Online: The Frank Horan essay prize.

    Scott, J

    The Journal of bone and joint surgery. British volume

    2010  Volume 92, Issue 9, Page(s) 1185

    MeSH term(s) Awards and Prizes ; Humans ; Joints/surgery ; Orthopedics
    Language English
    Publishing date 2010-09
    Publishing country England
    Document type Editorial
    ZDB-ID 220626-2
    ISSN 2044-5377 ; 0301-620X ; 0447-9076
    ISSN (online) 2044-5377
    ISSN 0301-620X ; 0447-9076
    DOI 10.1302/0301-620X.92B9.25620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia.

    Graham, Naida L / Leonard, Carol / Tang-Wai, David F / Black, Sandra / Chow, Tiffany W / Scott, Chris J M / McNeely, Alicia A / Masellis, Mario / Rochon, Elizabeth

    Dementia and geriatric cognitive disorders extra

    2016  Volume 6, Issue 3, Page(s) 407–423

    Abstract: Background/aims: Frank agrammatism, defined as the omission and/or substitution of grammatical ... primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients ... Results: The majority of cases exhibited neither frank agrammatism nor AOS.: Conclusion: There are ...

    Abstract Background/aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis.
    Method: We assessed grammatical production in 9 patients who satisfied current diagnostic criteria. Although the focus was agrammatism, motor speech skills were also evaluated to determine whether dysfluency arose primarily from apraxia of speech (AOS), instead of, or in addition to, agrammatism. Volumetric MRI analyses provided impartial imaging-supported diagnosis.
    Results: The majority of cases exhibited neither frank agrammatism nor AOS.
    Conclusion: There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant.
    Language English
    Publishing date 2016-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2621464-7
    ISSN 1664-5464
    ISSN 1664-5464
    DOI 10.1159/000448944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia

    Graham, Naida L. / Leonard, Carol / Tang-Wai, David F. / Black, Sandra / Chow, Tiffany W. / Scott, Chris J.M. / McNeely, Alicia A. / Masellis, Mario / Rochon, Elizabeth

    Dementia and Geriatric Cognitive Disorders Extra

    2016  Volume 6, Issue 3, Page(s) 407–423

    Abstract: Background/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical ... primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients ... The majority of cases exhibited neither frank agrammatism nor AOS. Conclusion: There are nfPPA patients ...

    Institution Department of Speech-Language Pathology, Faculty of Medicine, University of Toronto Toronto Rehabilitation Institute, Toronto, Ont Department of Audiology and Speech-Language Pathology, University of Ottawa, Ottawa, Ont University Health Network Memory Clinic, Toronto Western Hospital Department of Medicine (Neurology), University of Toronto L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre Rotman Research Institute, and Department of Psychiatry (Geriatric Psychiatry), University of Toronto, Toronto, Ont., Canada
    Abstract Background/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. Method: We assessed grammatical production in 9 patients who satisfied current diagnostic criteria. Although the focus was agrammatism, motor speech skills were also evaluated to determine whether dysfluency arose primarily from apraxia of speech (AOS), instead of, or in addition to, agrammatism. Volumetric MRI analyses provided impartial imaging-supported diagnosis. Results: The majority of cases exhibited neither frank agrammatism nor AOS. Conclusion: There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant.
    Keywords Diagnostic criteria ; Frontotemporal dementia ; Apraxia of speech ; Differential diagnosis
    Language English
    Publishing date 2016-09-23
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Research Article ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
    ZDB-ID 2621464-7
    ISSN 1664-5464 ; 1664-5464
    ISSN (online) 1664-5464
    ISSN 1664-5464
    DOI 10.1159/000448944
    Database Karger publisher's database

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  9. Article: A virtual roundtable. Providers in the spotlight hold a frank discussion on the state of the profession today.

    Hillier, Robin / Scott, Shawn / Francis, Charles / Wright, Chris / Coble, Tom

    Provider (Washington, D.C.)

    2012  Volume 38, Issue 6, Page(s) 22–3, 26–9, 31–2

    MeSH term(s) Biomedical Technology ; Forecasting ; Health Care Reform ; Humans ; Long-Term Care/organization & administration ; Medicaid ; Medicare ; Organizational Objectives ; Personnel Selection ; Quality Assurance, Health Care ; United States
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632795-3
    ISSN 0888-0352
    ISSN 0888-0352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2185: Show issues Location:
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  10. Book ; Online: Insurance regulation and the Dodd-Frank Act

    Harrington, Scott E

    (Working papers / Wharton School, University of Pennsylvania)

    2011  

    Author's details Scott E. Harrington
    Series title Working papers / Wharton School, University of Pennsylvania
    Keywords Finanzsektor ; Systemrisiko ; Regulierung ; Versicherung ; Versicherungsökonomik ; USA
    Language English
    Size Online-Ressource (PDF-Datei: 23 S., 204,23 KB)
    Publisher Wharton School, University of Pennsylvania
    Publishing place Philadelphia, Pa
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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