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  1. Book ; Online ; E-Book: Epicardial adipose tissue

    Iacobellis, Gianluca

    from cell to clinic

    (Contemporary cardiology)

    2020  

    Author's details Gianluca Iacobellis editor
    Series title Contemporary cardiology
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xiv, 191 Seiten), Illustrationen
    Publisher Humana Press
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020436052
    ISBN 978-3-030-40570-0 ; 9783030405694 ; 3-030-40570-2 ; 3030405699
    DOI 10.1007/978-3-030-40570-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Epicardial fat links obesity to cardiovascular diseases.

    Iacobellis, Gianluca

    Progress in cardiovascular diseases

    2023  Volume 78, Page(s) 27–33

    Abstract: Patients with obesity have been historically associated with higher risk to develop cardiovascular diseases (CVD). However, regional, visceral, organ specific adiposity seems to play a stronger role in the development of those cardiovascular diseases ... ...

    Abstract Patients with obesity have been historically associated with higher risk to develop cardiovascular diseases (CVD). However, regional, visceral, organ specific adiposity seems to play a stronger role in the development of those cardiovascular diseases than obesity by itself. Epicardial adipose tissue is the visceral fat depot of the heart with peculiar anatomy, regional differences, genetic profile and functions. Due to its unobstructed contiguity with heart and intense pro inflammatory and pro arrhythmogenic activities, epicardial fat is directly involved in major obesity-related CVD complications, such as coronary artery disease (CAD), atrial fibrillation (AF) and heart failure (HF). Current and developing imaging techniques can measure epicardial fat thickness, volume, density and inflammatory status for the prediction and stratification of the cardiovascular risk in both symptomatic and asymptomatic obese individuals. Pharmacological modulation of the epicardial fat with glucagon like peptide-1 receptor (GLP1R) analogs, sodium glucose transporter-2 inhibitors, and potentially dual (glucose-dependent insulinotropic polypeptide -GLP1R) agonists, can reduce epicardial fat mass, resume its original cardio-protective functions and therefore reduce the cardiovascular risk. Epicardial fat assessment is poised to change the traditional paradigm that links obesity to the heart.
    MeSH term(s) Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Adipose Tissue/diagnostic imaging ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Pericardium/diagnostic imaging ; Heart Failure
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209312-1
    ISSN 1873-1740 ; 1532-8643 ; 0033-0620
    ISSN (online) 1873-1740 ; 1532-8643
    ISSN 0033-0620
    DOI 10.1016/j.pcad.2023.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epicardial adipose tissue in contemporary cardiology.

    Iacobellis, Gianluca

    Nature reviews. Cardiology

    2022  Volume 19, Issue 9, Page(s) 593–606

    Abstract: Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and unobstructed proximity to the heart and has a transcriptome and secretome very ... ...

    Abstract Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and unobstructed proximity to the heart and has a transcriptome and secretome very different from that of other fat depots. EAT has physiological and pathological properties that vary depending on its location. It can be highly protective for the adjacent myocardium through dynamic brown fat-like thermogenic function and harmful via paracrine or vasocrine secretion of pro-inflammatory and profibrotic cytokines. EAT is a modifiable risk factor that can be assessed with traditional and novel imaging techniques. Coronary and left atrial EAT are involved in the pathogenesis of coronary artery disease and atrial fibrillation, respectively, and it also contributes to the development and progression of heart failure. In addition, EAT might have a role in coronavirus disease 2019 (COVID-19)-related cardiac syndrome. EAT is a reliable potential therapeutic target for drugs with cardiovascular benefits such as glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter 2 inhibitors. This Review provides a comprehensive and up-to-date overview of the role of EAT in cardiovascular disease and highlights the translational nature of EAT research and its applications in contemporary cardiology.
    MeSH term(s) Adipose Tissue/diagnostic imaging ; Atrial Fibrillation ; COVID-19 ; Cardiology ; Humans ; Pericardium/diagnostic imaging ; Pericardium/pathology
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-022-00679-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Can epicardial fat glucagon-like peptide-1 receptor open up to the cardiovascular benefits of glucagon-like peptide-1 analogues?

    Iacobellis, Gianluca

    Polish archives of internal medicine

    2021  Volume 131, Issue 3, Page(s) 224–225

    MeSH term(s) Coronary Artery Disease/metabolism ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; Humans ; Pericardium ; Renin-Angiotensin System
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2021-03-30
    Publishing country Poland
    Document type Editorial ; Comment
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.15904
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  5. Article ; Online: Aging Effects on Epicardial Adipose Tissue.

    Iacobellis, Gianluca

    Frontiers in aging

    2021  Volume 2, Page(s) 666260

    Abstract: Epicardial fat is the visceral fat of the heart. Epicardial fat is a white adipose tissue, but it displays also brown-fat like or beige fat features. Under physiological conditions, epicardial fat has cardioprotective functions such as free fatty acids ... ...

    Abstract Epicardial fat is the visceral fat of the heart. Epicardial fat is a white adipose tissue, but it displays also brown-fat like or beige fat features. Under physiological conditions, epicardial fat has cardioprotective functions such as free fatty acids supply and thermoregulation of the adjacent myocardium. Epicardial adipose tissue encounters changes in the transition from embryological to childhood and then to adult life. Aging can affect the function and morphology of epicardial fat, more likely in women than in men. The effect of aging on the brown fat properties of the epicardial fat is the most prominent and with the greatest clinical implications. It is promising to know that epicardial fat responds to newer pharmaceutical drugs modulating the adipose tissue and potentially restoring its browning effects. Epicardial fat pro-inflammatory secretome is down-regulated in end-stage coronary artery disease. Chronic ischemia and adverse hemodynamic conditions can also affect the regulatory component of the epicardial fat. Epicardial fat may incur in apoptotic and fibrotic changes that alter its transcriptome and proteasome. In conclusion, aging and advanced stage of chronic diseases are likely to influence and affect epicardial fat genes and function
    Language English
    Publishing date 2021-05-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 3076785-4
    ISSN 2673-6217 ; 2673-6217
    ISSN (online) 2673-6217
    ISSN 2673-6217
    DOI 10.3389/fragi.2021.666260
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  6. Book: Obesity and cardiovascular disease

    Iacobellis, Gianluca

    2009  

    Author's details Gianluca Iacobellis
    Keywords Obesity / complications ; Cardiovascular Diseases / etiology ; Cardiovascular system/Diseases ; Cardiovascular system/Diseases/Treatment ; Cardiovascular system/Diseases/Diagnosis ; Obesity/Complications ; Obesity/Risk factors
    Subject code 616.1
    Language English
    Size XV, 272 S., [2] Bl. : Ill., Kt.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016102277
    ISBN 978-0-19-954932-0 ; 0-19-954932-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 5160 order for loan Magazin

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  7. Article ; Online: COVID-19 and diabetes: Can DPP4 inhibition play a role?

    Iacobellis, Gianluca

    Diabetes research and clinical practice

    2020  Volume 162, Page(s) 108125

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Diabetes Complications/drug therapy ; Diabetes Mellitus/drug therapy ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2020.108125
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  8. Book: Drug drug interactions in the metabolic syndrome

    Iacobellis, Gianluca

    2006  

    Title variant Drug-drug interactions in the metabolic syndrome
    Author's details Gianluca Iacobellis
    Keywords Metabolic Syndrome X / drug therapy ; Drug Interactions ; Anti-Obesity Agents / pharmacokinetics ; Hypoglycemic Agents / pharmacokinetics ; Antilipemic Agents / pharmacokinetics
    Language English
    Size X, 121 S. : Ill., graph. Darst.
    Publisher Nova Science Publ
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT014817327
    ISBN 1-59454-952-4 ; 978-1-59454-952-6
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Treating the Bone to Protect the Heart: Potential Newer Mechanisms and Targets.

    Iacobellis, Gianluca

    The American journal of the medical sciences

    2019  Volume 357, Issue 6, Page(s) 451–452

    MeSH term(s) Animals ; Diabetes Mellitus, Experimental ; Fibrosis ; Heart ; Ibandronic Acid ; Polyisoprenyl Phosphates ; Rats ; Sesquiterpenes
    Chemical Substances Polyisoprenyl Phosphates ; Sesquiterpenes ; farnesyl pyrophosphate (79W6B01D07) ; Ibandronic Acid (UMD7G2653W)
    Language English
    Publishing date 2019-02-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2019.02.001
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  10. Article ; Online: Letter to the Editor: "GLP-1 Receptor Expression Within the Human Heart".

    Iacobellis, Gianluca

    Endocrinology

    2018  Volume 159, Issue 5, Page(s) 1964–1965

    MeSH term(s) Glucagon-Like Peptide-1 Receptor ; Heart ; Humans ; Receptors, Glucagon
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Receptors, Glucagon
    Language English
    Publishing date 2018-03-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2018-00196
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