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Article ; Online: Respiratory syncytial virus hospitalisations among young children: a data linkage study - Erratum.

Prasad, Namrata / Newbern, E Claire / Trenholme, Adrian A / Wood, Tim / Thompson, Mark G / Aminisani, Nayyereh / Huang, Q Sue / Grant, Cameron C

Epidemiology and infection

2020 Volume 148, Page(s) e179

Language	English
Publishing date	2020-08-28
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268820001612
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Article ; Online: Respiratory Virus-related Emergency Department Visits and Hospitalizations Among Infants in New Zealand.

Prasad, Namrata / Trenholme, Adrian A / Huang, Q Sue / Duque, Jazmin / Grant, Cameron C / Newbern, E Claire

The Pediatric infectious disease journal

2020 Volume 39, Issue 8, Page(s) e176–e182

Abstract: Background: Estimates of the contribution of respiratory viruses to emergency department (ED) utilization remain limited.: Methods: We conducted surveillance of infants with acute respiratory infection (ARI) associated ED visits, which then resulted ... ...

Abstract	Background: Estimates of the contribution of respiratory viruses to emergency department (ED) utilization remain limited. Methods: We conducted surveillance of infants with acute respiratory infection (ARI) associated ED visits, which then resulted in either hospital admission or discharge home. Seasonal rates of specific viruses stratified by age, ethnicity, and socioeconomic status were estimated for both visits discharged directly from ED and hospitalizations using rates of positivity for each virus. Results: During the 2014-2016 winter seasons, 3585 (66%) of the 5412 ARI ED visits were discharged home directly and 1827 (34%) were admitted to hospital. Among visits tested for all respiratory viruses, 601/1111 (54.1%) of ED-only and 639/870 (73.4%) of the hospital-admission groups were positive for at least one respiratory virus. Overall, respiratory virus-associated ED visit rates were almost twice as high as hospitalizations. Respiratory syncytial virus was associated with the highest ED (34.4 per 1000) and hospitalization rates (24.6 per 1000) among infants. ED visit and hospitalization rates varied significantly by age and virus. Māori and Pacific children had significantly higher ED visit and hospitalization rates for all viruses compared with children of other ethnicities. Conclusions: Many infants with acute respiratory virus infections are managed in the ED rather than admitted to the hospital. Higher rates of ED-only versus admitted acute respiratory virus infections occur among infants living in lower socioeconomic households, older infants and infants of Māori or Pacific versus European ethnicity. Respiratory virus infections resulting in ED visits should be included in measurements of ARI disease burden.
MeSH term(s)	Acute Disease/epidemiology ; Emergency Service, Hospital/statistics & numerical data ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; New Zealand/epidemiology ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/etiology ; Respiratory Tract Infections/virology ; Retrospective Studies ; Seasons ; Virus Diseases/epidemiology ; Virus Diseases/etiology
Language	English
Publishing date	2020-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000002681
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Article ; Online: Failure to Test and Identify Perinatally Infected Children Born to Hepatitis C Virus-Infected Women.

Kuncio, Danica E / Newbern, E Claire / Johnson, Caroline C / Viner, Kendra M

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2016 Volume 62, Issue 8, Page(s) 980–985

Abstract: Background: Vertical transmission of hepatitis C virus (HCV) is the most common route of pediatric HCV infection. Approximately 5% of children born to HCV-infected mothers develop chronic infection. Recommendations employ risk-based HCV testing of ... ...

Abstract	Background: Vertical transmission of hepatitis C virus (HCV) is the most common route of pediatric HCV infection. Approximately 5% of children born to HCV-infected mothers develop chronic infection. Recommendations employ risk-based HCV testing of pregnant women, and screening children at a young age. This study assesses testing rates of children born to mothers tested HCV-positive in a major US city with a high burden of HCV infection. Methods: HCV surveillance data reported to the Philadelphia Department of Public Health are housed in the Hepatitis Registry. Additional tests, including negative results, were retrospectively collected. HCV data were matched with 2011-2013 birth certificates of children aged ≥20 months to identify mothers tested HCV-positive and screened children. The observed perinatal HCV seropositivity rate was compared to the expected rate (5%). Results: A total of 8119 females aged 12-54 years tested HCV-positive and in the Hepatitis Registry. Of these, 500 (5%) had delivered ≥1 child, accounting for 537 (1%) of the 55 623 children born in Philadelphia during the study period. Eighty-four (16%) of these children had HCV testing; 4 (1% of the total) were confirmed cases. Twenty-three additional children are expected to have chronic HCV infection, but were not identified by 20 months of age. Conclusions: These findings illustrate that a significant number of women giving birth in Philadelphia test positive for HCV and that most of their at-risk children remain untested. To successfully identify all HCV-infected children and integrate them into HCV-specific care, practices for HCV screening of pregnant women and their children should be improved.
MeSH term(s)	Adolescent ; Adult ; Child ; Female ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C/transmission ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/prevention & control ; Hepatitis C, Chronic/transmission ; Hepatitis C, Chronic/virology ; Humans ; Infant ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Middle Aged ; Philadelphia/epidemiology ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Prenatal Diagnosis ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2016-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciw026
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Article ; Online: Sensitivity and specificity of surveillance case definitions in detection of influenza and respiratory syncytial virus among hospitalized patients, New Zealand, 2012-2016.

Davis, William / Duque, Jazmin / Huang, Q Sue / Olson, Natalie / Grant, Cameron C / Newbern, E Claire / Thompson, Mark / Waite, Ben / Prasad, Namrata / Trenholme, Adrian / Azziz-Baumgartner, Eduardo

The Journal of infection

2021 Volume 84, Issue 2, Page(s) 216–226

Abstract: Background: The WHO is exploring the value of adding RSV testing to existing influenza surveillance systems to inform RSV control programs. We evaluate the usefulness of four commonly used influenza surveillance case-definitions for influenza and RSV ... ...

Abstract	Background: The WHO is exploring the value of adding RSV testing to existing influenza surveillance systems to inform RSV control programs. We evaluate the usefulness of four commonly used influenza surveillance case-definitions for influenza and RSV surveillance. Methods: SHIVERS, a multi-institutional collaboration, conducted surveillance for influenza and RSV in four New Zealand hospitals. Nurses reviewed admission logs, enrolled patients with suspected acute respiratory infections (ARI), and obtained nasopharyngeal swabs for RT-PCR. We compared the performance characteristics for identifying laboratory-confirmed influenza and RSV severe acute respiratory infection (SARI), defined as persons admitted with measured or reported fever and cough within 10 days of illness, to three other case definitions: 1. reported fever and cough or shortness of breath, 2. cough and shortness of breath, or 3. cough. Results: During April-September 2012-2016, SHIVERS identified 16,055 admissions with ARI; of 6374 cases consented and tested for influenza or RSV, 5437 (85%) had SARI and 937 (15%) did not. SARI had the highest specificity in detecting influenza (40.6%) and RSV (40.8%) but the lowest sensitivity (influenza 78.8%, RSV 60.3%) among patients of all ages. Cough or shortness of breath had the highest sensitivity (influenza 99.3%, RSV 99.9%) but the lowest specificity (influenza 1.6%, RSV 1.9%). SARI sensitivity among children aged <3 months was 60.8% for influenza and 43.6% for RSV-both lower than in other age groups. Conclusions: While SARI had the highest specificity, its sensitivity was limited, especially among children aged <3 months. Cough or shortness of breath was the most sensitive.
MeSH term(s)	Child ; Hospitalization ; Humans ; Infant ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; New Zealand/epidemiology ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Tract Infections
Language	English
Publishing date	2021-12-22
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2021.12.012
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Article ; Online: Modelling the impact of respiratory syncytial virus (RSV) vaccine and immunoprophylaxis strategies in New Zealand.

Prasad, Namrata / Read, Jonathan M / Jewell, Christopher / Waite, Ben / Trenholme, Adrian A / Huang, Q Sue / Grant, Cameron C / Newbern, E Claire / Hogan, Alexandra B

Vaccine

2021 Volume 39, Issue 31, Page(s) 4383–4390

Abstract: Background: Mathematical models of respiratory syncytial virus (RSV) transmission can help describe seasonal epidemics and assess the impact of potential vaccines and immunoprophylaxis with monoclonal antibodies (mAb).: Methods: We developed a ... ...

Abstract	Background: Mathematical models of respiratory syncytial virus (RSV) transmission can help describe seasonal epidemics and assess the impact of potential vaccines and immunoprophylaxis with monoclonal antibodies (mAb). Methods: We developed a deterministic, compartmental model for RSV transmission, which was fitted to population-based RSV hospital surveillance data from Auckland, New Zealand. The model simulated the introduction of either a maternal vaccine or a seasonal mAb among infants aged less than 6 months and estimated the reduction in RSV hospitalizations for a range of effectiveness and coverage values. Results: The model accurately reproduced the annual seasonality of RSV epidemics in Auckland. We found that a maternal vaccine with effectiveness of 30-40% in the first 90 days and 15-20% for the next 90 days could reduce RSV hospitalizations by 18-24% in children younger than 3 months, by 11-14% in children aged 3-5 months, and by 2-3% in children aged 6-23 months. A seasonal infant mAb with 40-60% effectiveness for 150 days could reduce RSV hospitalizations by 30-43%, 34-48% and by 14-21% in children aged 0-2 months, 3-5 months and 6-23 months, respectively. Conclusions: Our results suggest that either a maternal RSV vaccine or mAb would effectively reduce RSV hospitalization disease burden in New Zealand. Overall, a seasonal mAb resulted in a larger disease prevention impact than a maternal vaccine.
MeSH term(s)	Child ; Hospitalization ; Humans ; Immunization ; Infant ; New Zealand/epidemiology ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines ; Respiratory Syncytial Virus, Human
Chemical Substances	Respiratory Syncytial Virus Vaccines
Language	English
Publishing date	2021-06-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.05.100
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Article ; Online: Respiratory syncytial virus hospitalisations among young children: a data linkage study.

Prasad, Namrata / Newbern, E Claire / Trenholme, Adrian A / Wood, Tim / Thompson, Mark G / Aminisani, Nayyereh / Huang, Q Sue / Grant, Cameron C

Epidemiology and infection

2019 Volume 147, Page(s) e246

Abstract: We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was ... ...

Abstract	We aimed to provide comprehensive estimates of laboratory-confirmed respiratory syncytial virus (RSV)-associated hospitalisations. Between 2012 and 2015, active surveillance of acute respiratory infection (ARI) hospitalisations during winter seasons was used to estimate the seasonal incidence of laboratory-confirmed RSV hospitalisations in children aged <5 years in Auckland, New Zealand (NZ). Incidence rates were estimated by fine age group, ethnicity and socio-economic status (SES) strata. Additionally, RSV disease estimates determined through active surveillance were compared to rates estimated from hospital discharge codes. There were 5309 ARI hospitalisations among children during the study period, of which 3923 (73.9%) were tested for RSV and 1597 (40.7%) were RSV-positive. The seasonal incidence of RSV-associated ARI hospitalisations, once corrected for non-testing, was 6.1 (95% confidence intervals 5.8-6.4) per 1000 children <5 years old. The highest incidence was among children aged <3 months. Being of indigenous Māori or Pacific ethnicity or living in a neighbourhood with low SES independently increased the risk of an RSV-associated hospitalisation. RSV hospital discharge codes had a sensitivity of 71% for identifying laboratory-confirmed RSV cases. RSV infection is a leading cause of hospitalisation among children in NZ, with significant disparities by ethnicity and SES. Our findings highlight the need for effective RSV vaccines and therapies.
MeSH term(s)	Age Distribution ; Child ; Child, Preschool ; Cohort Studies ; Female ; Hospital Costs ; Hospitalization/economics ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Information Storage and Retrieval ; Male ; New Zealand/epidemiology ; Population Surveillance ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/economics ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human/isolation & purification ; Retrospective Studies ; Risk Assessment ; Seasons ; Sex Distribution
Language	English
Publishing date	2019-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268819001377
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Article ; Online: Evaluation of a community immunization outreach program--Philadelphia, Pennsylvania.

Drezner, Kate / Newbern, E Claire / Ossa, Alexandra / Johnson, Caroline

Journal of public health management and practice : JPHMP

2015 Volume 21, Issue 3, Page(s) 263–268

Abstract: Context: Every year the Philadelphia Department of Public Health selects roughly 5000 10-month olds not up-to-date (UTD) for their 6-month vaccinations for a community-based outreach program.: Objective: To evaluate the outreach program's ... ...

Abstract	Context: Every year the Philadelphia Department of Public Health selects roughly 5000 10-month olds not up-to-date (UTD) for their 6-month vaccinations for a community-based outreach program. Objective: To evaluate the outreach program's effectiveness from 2008 to 2012. Design: Outreach children from 2008 to 2012 were compared with children not selected for outreach on UTD rates and median UTD age in a retrospective cohort study. Setting: Philadelphia, Pennsylvania Participants: : 10- to 15-month olds from targeted Philadelphia ZIP codes. Intervention: Outreach workers investigated immunization status, educated families on the importance of timely immunizations, and assisted patients in securing health care services to bring children UTD on their 6-month vaccinations. Main outcome measures: Outcomes included UTD status for recommended vaccinations due by 6, 15, and 18 months and median age at which 15- and 18-month vaccinations were completed for outreach versus nonoutreach children. Results: Outreach children had significantly higher UTD rates for 6-month vaccinations than nonoutreach children. Outreach children also had significantly higher UTD rates for 15- and 18-month vaccinations, and therefore the effect of outreach is lasting. From 2008 to 2012, median UTD ages for 15- and 18-month vaccinations were significantly lower for outreach than for nonoutreach children. Conclusions: Outreach was effective in increasing immunization UTD rates and is a useful tool for improving childhood immunization rates in urban settings.
MeSH term(s)	Child ; Child, Preschool ; Community-Institutional Relations/standards ; Female ; Humans ; Immunization Programs/methods ; Immunization Programs/standards ; Immunization Schedule ; Infant ; Male ; Philadelphia ; Program Evaluation/methods ; Retrospective Studies
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2027860-3
ISSN	1550-5022 ; 1078-4659
ISSN (online)	1550-5022
ISSN	1078-4659
DOI	10.1097/PHH.0000000000000197
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Article ; Online: The continuum of hepatitis C testing and care.

Viner, Kendra / Kuncio, Danica / Newbern, E Claire / Johnson, Caroline C

Hepatology (Baltimore, Md.)

2015 Volume 61, Issue 3, Page(s) 783–789

Abstract: Unlabelled: A hepatitis C virus (HCV)-infected person will ideally have access to quality health care and move through the HCV continuum of care (CoC) from HCV antibody (Ab) screening, HCV-RNA confirmation, engagement and retention in medical care, and ... ...

Abstract	Unlabelled: A hepatitis C virus (HCV)-infected person will ideally have access to quality health care and move through the HCV continuum of care (CoC) from HCV antibody (Ab) screening, HCV-RNA confirmation, engagement and retention in medical care, and treatment. Unfortunately, studies show that many patients do not progress through this continuum. Because these studies may not be generalizable, we assessed the HCV CoC in Philadelphia from January 2010 to December 2013 at the population level. The expected HCV seroprevalence in Philadelphia during 2010-2013 was calculated by applying National Health and Nutrition Examination Survey prevalences to age-specific census data approximations and published estimates of homeless and incarcerated populations. HCV laboratory results reported to the Philadelphia Department of Public Health and enhanced surveillance data were used to determine where individuals fell on the continuum. HCV CoC was defined as follows: stage 1: HCV Ab screening; stage 2: HCV Ab and RNA testing; stage 3: RNA confirmation and continuing care; and stage 4: RNA confirmation, care, and HCV treatment. Of approximately 1,584,848 Philadelphia residents, 47,207 (2.9%) were estimated to have HCV. Positive HCV results were received for 13,596 individuals, of whom 6,383 (47%) had a positive HCV-RNA test. Of these, 1,745 (27%) were in care and 956 (15%) had or were currently receiving treatment. Conclusion: This continuum provides a real-life snapshot of how this disease is being managed in a major U.S. urban center. Many patients are lost at each stage, highlighting the need to raise awareness among health care professionals and at-risk populations about appropriate hepatitis testing, referral, support, and care.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Hepatitis C Antibodies/blood ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/virology ; Humans ; Infant ; Male ; Middle Aged ; RNA, Viral/analysis
Chemical Substances	Hepatitis C Antibodies ; RNA, Viral
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.27584
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Article: Modelling the impact of respiratory syncytial virus (RSV) vaccine and immunoprophylaxis strategies in New Zealand

Prasad, Namrata / Read, Jonathan M. / Jewell, Christopher / Waite, Ben / Trenholme, Adrian A. / Huang, Q. Sue / Grant, Cameron C. / Newbern, E. Claire / Hogan, Alexandra B.

Vaccine. 2021 July 13, v. 39, no. 31

2021

Abstract: Mathematical models of respiratory syncytial virus (RSV) transmission can help describe seasonal epidemics and assess the impact of potential vaccines and immunoprophylaxis with monoclonal antibodies (mAb).We developed a deterministic, compartmental ... ...

Abstract	Mathematical models of respiratory syncytial virus (RSV) transmission can help describe seasonal epidemics and assess the impact of potential vaccines and immunoprophylaxis with monoclonal antibodies (mAb).We developed a deterministic, compartmental model for RSV transmission, which was fitted to population-based RSV hospital surveillance data from Auckland, New Zealand. The model simulated the introduction of either a maternal vaccine or a seasonal mAb among infants aged less than 6 months and estimated the reduction in RSV hospitalizations for a range of effectiveness and coverage values.The model accurately reproduced the annual seasonality of RSV epidemics in Auckland. We found that a maternal vaccine with effectiveness of 30–40% in the first 90 days and 15–20% for the next 90 days could reduce RSV hospitalizations by 18–24% in children younger than 3 months, by 11–14% in children aged 3–5 months, and by 2–3% in children aged 6–23 months. A seasonal infant mAb with 40–60% effectiveness for 150 days could reduce RSV hospitalizations by 30–43%, 34–48% and by 14–21% in children aged 0–2 months, 3–5 months and 6–23 months, respectively.Our results suggest that either a maternal RSV vaccine or mAb would effectively reduce RSV hospitalization disease burden in New Zealand. Overall, a seasonal mAb resulted in a larger disease prevention impact than a maternal vaccine.
Keywords	Respiratory syncytial virus ; burden of disease ; disease prevention ; hospitals ; monitoring ; vaccines ; New Zealand
Language	English
Dates of publication	2021-0713
Size	p. 4383-4390.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.05.100
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Hemagglutinin and Neuraminidase Antibodies Are Induced in an Age- and Subtype-Dependent Manner after Influenza Virus Infection.

Wong, Sook-San / Waite, Ben / Ralston, Jacqui / Wood, Tim / Reynolds, G Edwin / Seeds, Ruth / Newbern, E Claire / Thompson, Mark G / Huang, Q Sue / Webby, Richard J

Journal of virology

2020 Volume 94, Issue 7

Abstract: Despite evidence that antibodies targeting the influenza virus neuraminidase (NA) protein can be protective and are broadly cross-reactive, the immune response to NA during infection is poorly understood compared to the response to hemagglutinin (HA) ... ...

Abstract	Despite evidence that antibodies targeting the influenza virus neuraminidase (NA) protein can be protective and are broadly cross-reactive, the immune response to NA during infection is poorly understood compared to the response to hemagglutinin (HA) protein. As such, we compared the antibody profile to HA and NA in two naturally infected human cohorts in Auckland, New Zealand: (i) a serosurvey cohort, consisting of pre- and post-influenza season sera from PCR-confirmed influenza cases (
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Antibodies, Viral/blood ; Child ; Child, Preschool ; Female ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Immunologic Memory ; Infant ; Infant, Newborn ; Influenza A virus/immunology ; Influenza B virus/immunology ; Influenza, Human/blood ; Influenza, Human/epidemiology ; Influenza, Human/immunology ; Male ; Neuraminidase/immunology ; New Zealand/epidemiology ; Polymerase Chain Reaction ; Seroepidemiologic Studies ; Young Adult
Chemical Substances	Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2020-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.01385-19
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