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  1. Article ; Online: Risky Play and Social Behaviors among Japanese Preschoolers: Direct Observation Method.

    Imai, Natsuko / Shikano, Akiko / Kidokoro, Tetsuhiro / Noi, Shingo

    International journal of environmental research and public health

    2022  Volume 19, Issue 13

    Abstract: While limited evidence is available, preliminary studies highlight the potential health benefits of risky play. However, most of the studies have used subjective methods (i.e., questionnaires) to evaluate children's risky play, which limits their ... ...

    Abstract While limited evidence is available, preliminary studies highlight the potential health benefits of risky play. However, most of the studies have used subjective methods (i.e., questionnaires) to evaluate children's risky play, which limits their validity and reliability. The purpose of the present study was to examine the relationship between the frequency of risky play and social behavior among Japanese preschoolers by using a valid and reliable method such as direct observation. A total of 32 Japanese preschoolers (71.4 ± 3.5 months old) participated in the study, and their social behaviors were measured by the Strength and Difficulties Questionnaire (SDQ). Data regarding the frequency of risky play was collected through direct observation. Results stated that, in a non-adjusted model, there was no significant association between children's risky play and prosocial behavior. However, the association became significant after adjusting for covariates such as gender, parental employment status, and physical activity. In contrast, there was no significant association between children's risky play and problem behavior (hyperactivity and aggression) after adjusting for covariates. In conclusion, covariates such as parental employment should be considered when examining the benefits of risky play.
    MeSH term(s) Child ; Child, Preschool ; Exercise ; Humans ; Japan ; Reproducibility of Results ; Social Behavior ; Surveys and Questionnaires
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19137889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Risky Play and Social Behaviors among Japanese Preschoolers

    Natsuko Imai / Akiko Shikano / Tetsuhiro Kidokoro / Shingo Noi

    International Journal of Environmental Research and Public Health, Vol 19, Iss 7889, p

    Direct Observation Method

    2022  Volume 7889

    Abstract: While limited evidence is available, preliminary studies highlight the potential health benefits of risky play. However, most of the studies have used subjective methods (i.e., questionnaires) to evaluate children’s risky play, which limits their ... ...

    Abstract While limited evidence is available, preliminary studies highlight the potential health benefits of risky play. However, most of the studies have used subjective methods (i.e., questionnaires) to evaluate children’s risky play, which limits their validity and reliability. The purpose of the present study was to examine the relationship between the frequency of risky play and social behavior among Japanese preschoolers by using a valid and reliable method such as direct observation. A total of 32 Japanese preschoolers (71.4 ± 3.5 months old) participated in the study, and their social behaviors were measured by the Strength and Difficulties Questionnaire (SDQ). Data regarding the frequency of risky play was collected through direct observation. Results stated that, in a non-adjusted model, there was no significant association between children’s risky play and prosocial behavior. However, the association became significant after adjusting for covariates such as gender, parental employment status, and physical activity. In contrast, there was no significant association between children’s risky play and problem behavior (hyperactivity and aggression) after adjusting for covariates. In conclusion, covariates such as parental employment should be considered when examining the benefits of risky play.
    Keywords risky play ; physical activity ; SDQ ; direct observation ; parental employment ; Japanese preschoolers ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A Case of Unresectable Combined Hepatocellular-cholangiocarcinoma Treated with Combination Therapy Consisting of Durvalumab Plus Tremelimumab.

    Unome, Shinji / Imai, Kenji / Miwa, Takao / Hanai, Tatsunori / Suetsugu, Atsushi / Takai, Koji / Suzui, Natsuko / Miyazaki, Tatsuhiko / Shimizu, Masahito

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: Combined hepatocellular cholangiocarcinoma is a rare and challenging primary liver malignancy that lacks any established standard treatments for unresectable cases. We herein present the first known case of a 49-year-old woman diagnosed with unresectable ...

    Abstract Combined hepatocellular cholangiocarcinoma is a rare and challenging primary liver malignancy that lacks any established standard treatments for unresectable cases. We herein present the first known case of a 49-year-old woman diagnosed with unresectable combined hepatocellular-cholangiocarcinoma, who underwent novel chemotherapy involving durvalumab plus tremelimumab combination therapy. The treatment was temporarily discontinued owing to immune-related adverse events, such as rash, and the patient was subsequently managed with systemic steroid therapy; however, the disease progressed after two courses of this treatment. Further studies are needed to validate the efficacy and safety of immune checkpoint inhibitors such as durvalumab and tremelimumab for the treatment of unresectable combined hepatocellular cholangiocarcinoma.
    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3071-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Frequency of hemorrhage after tooth extraction in patients treated with a direct oral anticoagulant: A multicenter cross-sectional study.

    Hiroshi, Iwabuchi / Natsuko, Sawai Y / Yutaka, Imai / Masayori, Shirakawa / Hiroyuki, Nakao / Hirohisa, Imai

    PloS one

    2022  Volume 17, Issue 4, Page(s) e0266011

    Abstract: Objective: Few studies have compared the frequency of hemorrhages after tooth extraction between patients taking direct oral anticoagulants (DOACs) and those taking warfarin or no anticoagulants. Further, the effects of the timing of DOAC administration ...

    Abstract Objective: Few studies have compared the frequency of hemorrhages after tooth extraction between patients taking direct oral anticoagulants (DOACs) and those taking warfarin or no anticoagulants. Further, the effects of the timing of DOAC administration and tooth extraction on the frequency of post-extraction hemorrhage have not been demonstrated. Therefore, we compared the frequency of post-extraction hemorrhages in patients in these different conditions and examined the effects of the timing of DOAC administration and tooth extraction on the frequency.
    Design: Prospective multicenter study.
    Setting: Eighty-six Japanese hospitals.
    Participants: In total, 182 teeth extracted from 145 individuals (119 teeth from adult males) receiving dabigatran and 88 teeth from individuals (62 teeth from adult males) receiving rivaroxaban were included.
    Intervention: Tooth extraction was followed by a 7-day observational period between November 1, 2008 and December 31, 2015. Dabigatran was administered twice daily; rivaroxaban was administered once a day.
    Primary outcome measure: Hemorrhage after tooth extraction.
    Results: The frequency of hemorrhage after tooth extraction was 1.65%, 3.41%, and 3.63% in those treated with dabigatran, rivaroxaban, and warfarin, respectively, and 0.39% in those who did not receive anticoagulants. Hemorrhages after tooth extraction were significantly higher in the rivaroxaban group than in patients who did not receive anticoagulants (P = 0.008). These frequencies did not differ significantly in the dabigatran and rivaroxaban groups compared to the warfarin group (P = 0.221 and P = 1.000, respectively).
    Conclusions: The frequency of hemorrhaging after tooth extraction appeared to be similar in patients receiving continuous dabigatran or rivaroxaban and in those receiving continuous warfarin.
    MeSH term(s) Administration, Oral ; Adult ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Cross-Sectional Studies ; Dabigatran/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/drug therapy ; Humans ; Male ; Prospective Studies ; Pyridones/therapeutic use ; Rivaroxaban/adverse effects ; Tooth Extraction/adverse effects ; Warfarin/adverse effects
    Chemical Substances Anticoagulants ; Pyridones ; Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC)
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0266011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Association between volume of patients undergoing stroke rehabilitation at acute care hospitals and improvement in activities of daily living.

    Tani, Takuaki / Imai, Shinobu / Inoue, Norihiko / Kanazawa, Natsuko / Fushimi, Kiyohide

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2022  Volume 32, Issue 2, Page(s) 106872

    Abstract: Background: This study aimed to determine the relationship between the annual volume of patients undergoing rehabilitation per hospital and the outcomes of patients admitted for acute stroke.: Methods: This observational study used nationwide ... ...

    Abstract Background: This study aimed to determine the relationship between the annual volume of patients undergoing rehabilitation per hospital and the outcomes of patients admitted for acute stroke.
    Methods: This observational study used nationwide administrative data. Data on stroke patients aged ≥ 20 years who underwent rehabilitation were extracted from 1,182 acute care hospitals in Japan. The exclusion criteria were extended hospital stay exceeding 180 days and death during hospitalization. Hospital volumes were divided into four quartiles of total patients per hospital. The primary outcome was an improvement in activities of daily living from admission to discharge measured using the Barthel index. Poisson regression analysis of activities of daily living improvement was performed using inverse probability of treatment weighting.
    Results: High rehabilitation volume was significantly correlated with improvements in activities of daily living using the "very low group" as a reference (risk ratio [95% confidence interval]): 1.06 [1.05-1.08], P<0.001). Low volume was also significantly associated with activities of daily living improvement (risk ratio [95% confidence interval]: 1.04 [1.03-1.06], P<0.001).
    Conclusions: The annual volume of stroke patients undergoing multidisciplinary rehabilitation at a specific hospital may be a factor in the degree of patient improvement in activities of daily living.
    Language English
    Publishing date 2022-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2022.106872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Immediate and Lasting Effects of Resident Summer Camp on Movement Behaviors Among Children.

    Kidokoro, Tetsuhiro / Minatoya, Yuji / Imai, Natsuko / Shikano, Akiko / Noi, Shingo

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 912221

    Abstract: This study aims to examine the immediate and lasting effects of resident summer camp on movement behaviors among children with repeated pre-, during-, and post-intervention measurements. In total, 21 children (aged 10.3 ± 1.2 years, 17 boys and 4 girls) ... ...

    Abstract This study aims to examine the immediate and lasting effects of resident summer camp on movement behaviors among children with repeated pre-, during-, and post-intervention measurements. In total, 21 children (aged 10.3 ± 1.2 years, 17 boys and 4 girls) participated in a 31-day nature-based resident summer camp in Japan. Daily children's movement behaviors (moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and sleep) were continuously monitored before, during, and after the summer camp (i.e., 75 continuous days). It was found that the children engaged more time in MVPA (9.6%), less time in SB (58.0%), had more steps (22,405 steps/day), and an earlier midpoint of sleep (0:24 a.m.) in the summer camp as compared to the other periods (before and after the camp). However, the children engaged in unfavorable behaviors [reduction in MVPA (3.6%), increased SB (67.3%), and a later midpoint of sleep (1:32 a.m.)] during the summer vacation after the camp. This study indicates that the resident summer camp was effective in improving children's movement behaviors during the camp. However, the lasting effects were negligible or at least limited after its completion.
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.912221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Frequency of hemorrhage after tooth extraction in patients treated with a direct oral anticoagulant

    Iwabuchi Hiroshi / Sawai Y Natsuko / Imai Yutaka / Shirakawa Masayori / Nakao Hiroyuki / Imai Hirohisa

    PLoS ONE, Vol 17, Iss 4, p e

    A multicenter cross-sectional study.

    2022  Volume 0266011

    Abstract: Objective Few studies have compared the frequency of hemorrhages after tooth extraction between patients taking direct oral anticoagulants (DOACs) and those taking warfarin or no anticoagulants. Further, the effects of the timing of DOAC administration ... ...

    Abstract Objective Few studies have compared the frequency of hemorrhages after tooth extraction between patients taking direct oral anticoagulants (DOACs) and those taking warfarin or no anticoagulants. Further, the effects of the timing of DOAC administration and tooth extraction on the frequency of post-extraction hemorrhage have not been demonstrated. Therefore, we compared the frequency of post-extraction hemorrhages in patients in these different conditions and examined the effects of the timing of DOAC administration and tooth extraction on the frequency. Design Prospective multicenter study. Setting Eighty-six Japanese hospitals. Participants In total, 182 teeth extracted from 145 individuals (119 teeth from adult males) receiving dabigatran and 88 teeth from individuals (62 teeth from adult males) receiving rivaroxaban were included. Intervention Tooth extraction was followed by a 7-day observational period between November 1, 2008 and December 31, 2015. Dabigatran was administered twice daily; rivaroxaban was administered once a day. Primary outcome measure Hemorrhage after tooth extraction. Results The frequency of hemorrhage after tooth extraction was 1.65%, 3.41%, and 3.63% in those treated with dabigatran, rivaroxaban, and warfarin, respectively, and 0.39% in those who did not receive anticoagulants. Hemorrhages after tooth extraction were significantly higher in the rivaroxaban group than in patients who did not receive anticoagulants (P = 0.008). These frequencies did not differ significantly in the dabigatran and rivaroxaban groups compared to the warfarin group (P = 0.221 and P = 1.000, respectively). Conclusions The frequency of hemorrhaging after tooth extraction appeared to be similar in patients receiving continuous dabigatran or rivaroxaban and in those receiving continuous warfarin.
    Keywords Medicine ; R ; Science ; Q
    Subject code 590 ; 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Accelerometer-Measured Physical Activity and Sedentary Time among Children in Japan before and during COVID-19: A Cross-Sectional and Longitudinal Analysis.

    Tanaka, Chiaki / Shikano, Akiko / Imai, Natsuko / Chong, Kar Hau / Howard, Steven J / Tanabe, Kosuke / Okely, Anthony D / Taylor, Ellie K / Noi, Shingo

    International journal of environmental research and public health

    2023  Volume 20, Issue 2

    Abstract: This study examined changes in physical activity (PA), sedentary behavior (SB), screen time, sleep, and executive function among Japanese preschoolers between COVID-19 pre-pandemic and pandemic periods, using cross-sectional and longitudinal data. ... ...

    Abstract This study examined changes in physical activity (PA), sedentary behavior (SB), screen time, sleep, and executive function among Japanese preschoolers between COVID-19 pre-pandemic and pandemic periods, using cross-sectional and longitudinal data. Accelerometer data from 63 children aged 5-6 years were collected from three kindergartens in Tokyo, Japan, in late 2019 (pre-COVID-19). This was compared to the data of 49 children aged 5-6 years from the same kindergartens, collected in late 2020 (during COVID-19). Sixteen children in the pre-COVID-19 cohort also participated in the 2020 survey and provided data for the longitudinal analysis. The mean minutes of PA, SB, screen time, and sleep duration, as well as executive function, were compared between the pre- and during COVID-19 cohorts. After adjusting for school, sex, and accelerometer wear time, there were no significant differences in any of the measured outcomes between the two cohorts. However, the analysis of longitudinal data revealed significant increases in time spent in SB and on screens, and a decrease in light-intensity PA and sleep duration during the pandemic compared to the pre-pandemic period. Results suggest that, despite the COVID-19 pandemic, young children's activity levels and SB did not significantly differ from pre-pandemic levels. However, school-aged children's SB, light PA, and sleep time were affected, although this cannot be disentangled from the effects of the transition to school.
    MeSH term(s) Humans ; Child ; Child, Preschool ; COVID-19/epidemiology ; Sedentary Behavior ; Japan/epidemiology ; Pandemics ; Cross-Sectional Studies ; Exercise ; Accelerometry/methods
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20021130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Different Types of Screen Behavior and Depression in Children and Adolescents.

    Kidokoro, Tetsuhiro / Shikano, Akiko / Tanaka, Ryo / Tanabe, Kosuke / Imai, Natsuko / Noi, Shingo

    Frontiers in pediatrics

    2022  Volume 9, Page(s) 822603

    Abstract: The purpose of this study was to examine the associations between different types of screen behavior and depression, taking into account exercise and sleep among children and adolescents. A total of 23,573 Japanese children and adolescents (aged 8-15 ... ...

    Abstract The purpose of this study was to examine the associations between different types of screen behavior and depression, taking into account exercise and sleep among children and adolescents. A total of 23,573 Japanese children and adolescents (aged 8-15 years) participated in this cross-sectional study. Different types of screen behavior, weekly exercise time, sleep duration, and prevalence of depression were assessed using a questionnaire. Independent associations between various types of screen behavior and prevalence of depression were examined using logistic regression analyses after adjusting for age, school, sleep duration, exercise time, and other screen behavior types. A two-way analysis of covariance was conducted to examine whether exercise and sleep can attenuate the negative effects of screen behavior. The associations between screen behavior and depression varied by screen behavior types and participant characteristics. More time spent engaging in newer types of screen behavior, including social media, online games, and online videos, was associated with a higher prevalence of depression. In contrast, more time spent on TV was associated with a lower prevalence of depression. Sufficient exercise can lower the prevalence of depression, regardless of the length of time and content of the screen, and its associations were particularly significant for junior high school girls. Sleep was not associated with the prevalence of depression among any participant group except elementary school boys. Our findings suggest that age- and sex-specific intervention strategies that also consider screen-based behavior can effectively lower the risk of depression in children and adolescents.
    Language English
    Publishing date 2022-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.822603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Existing Data Sources for Clinical Epidemiology: Database of the National Hospital Organization in Japan.

    Kanazawa, Natsuko / Tani, Takuaki / Imai, Shinobu / Horiguchi, Hiromasa / Fushimi, Kiyohide / Inoue, Norihiko

    Clinical epidemiology

    2022  Volume 14, Page(s) 689–698

    Abstract: This review introduces the National Hospital Organization (NHO) database in Japan. The NHO has maintained two databases through a system of data collection from 140 hospitals in the NHO. National Hospital Organization Clinical Data Archives (NCDA) is ... ...

    Abstract This review introduces the National Hospital Organization (NHO) database in Japan. The NHO has maintained two databases through a system of data collection from 140 hospitals in the NHO. National Hospital Organization Clinical Data Archives (NCDA) is collecting clinical information in real time from the electronic medical records since January 2016, and Medical Information Analysis (MIA) databank is collecting daily insurance claims data since April 2010. The NHO database covers more than 8 million patients in 140 hospitals throughout Japan. The database consists of the information of patient profiles, hospital admission and discharge, diagnosis with ICD-10 codes, text data from medical chart, daily health insurance claims such as medical procedures, medications or surgeries, vital signs and laboratory data, and so on. The NHO database includes a wide variety of diseases and settings, including acute, chronic and intractable diseases, emergency medical services, disaster medicine, response to emerging infectious disease outbreaks, medical care according to health policies such as psychiatry, tuberculosis, or muscular dystrophy, and health systems in sparsely populated non-urban areas. Among several common diseases, the database has representativeness in terms of age distribution compared with the Patient Survey 2017 by the Ministry of Health, Labour and Welfare. Interested researchers can contact (700-dbproject@mail.hosp.go.jp) the NHO database division to obtain more information about the NHO database for utilization.
    Language English
    Publishing date 2022-05-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494772-6
    ISSN 1179-1349
    ISSN 1179-1349
    DOI 10.2147/CLEP.S359072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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