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  1. Article ; Online: Liver Surface Nodularity as a Biomarker for Detection and Evaluation of Cirrhosis.

    Goshima, Satoshi / Bae, Kyongtae T

    Radiology

    2017  Volume 283, Issue 3, Page(s) 921–922

    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2017170112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Importance of Better Human-Computer Interaction in the Era of Deep Learning: Mammography Computer-Aided Diagnosis as a Use Case.

    Nishikawa, Robert M / Bae, Kyongtae T

    Journal of the American College of Radiology : JACR

    2017  Volume 15, Issue 1 Pt A, Page(s) 49–52

    MeSH term(s) Algorithms ; Breast Neoplasms/diagnostic imaging ; Diagnosis, Computer-Assisted/methods ; Female ; Humans ; Machine Learning ; Mammography ; Radiographic Image Interpretation, Computer-Assisted/methods ; Sensitivity and Specificity
    Language English
    Publishing date 2017-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2017.08.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Deep Learning Approach for Automated Segmentation of Kidneys and Exophytic Cysts in Individuals with Autosomal Dominant Polycystic Kidney Disease.

    Kim, Youngwoo / Tao, Cheng / Kim, Hyungchan / Oh, Geum-Yoon / Ko, Jeongbeom / Bae, Kyongtae T

    Journal of the American Society of Nephrology : JASN

    2022  Volume 33, Issue 8, Page(s) 1581–1589

    Abstract: Background: Total kidney volume (TKV) is an important imaging biomarker in autosomal dominant polycystic kidney disease (ADPKD). Manual computation of TKV, particularly with the exclusion of exophytic cysts, is laborious and time consuming.: Methods: ...

    Abstract Background: Total kidney volume (TKV) is an important imaging biomarker in autosomal dominant polycystic kidney disease (ADPKD). Manual computation of TKV, particularly with the exclusion of exophytic cysts, is laborious and time consuming.
    Methods: We developed a fully automated segmentation method for TKV using a deep learning network to selectively segment kidney regions while excluding exophytic cysts. We used abdominal
    Results: The automated and manual reference methods exhibited excellent geometric concordance (Dice similarity coefficient: mean±SD, 0.962±0.018) on the test datasets, with kidney volumes ranging from 178.9 to 2776.0 ml (mean±SD, 1058.5±706.8 ml) and exophytic cysts ranging from 113.4 to 2497.6 ml (mean±SD, 549.0±559.1 ml). The intraclass correlation coefficient was 0.9994 (95% confidence interval, 0.9991 to 0.9996;
    Conclusions: We developed a fully automated segmentation method to measure TKV that excludes exophytic cysts and has an accuracy similar to that of a human expert. This technique may be useful in clinical studies that require automated computation of TKV to evaluate progression of ADPKD and response to treatment.
    MeSH term(s) Cysts/diagnostic imaging ; Cysts/pathology ; Deep Learning ; Disease Progression ; Humans ; Image Processing, Computer-Assisted/methods ; Kidney/diagnostic imaging ; Kidney/pathology ; Magnetic Resonance Imaging/methods ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnostic imaging ; Polycystic Kidney, Autosomal Dominant/pathology
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021111400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genomic Analysis to Avoid Misdiagnosis of Adults With Bilateral Renal Cysts.

    Gulati, Ashima / Bae, Kyongtae T / Somlo, Stefan / Watnick, Terry

    Annals of internal medicine

    2018  Volume 169, Issue 2, Page(s) 130–131

    MeSH term(s) Aged ; Diagnosis, Differential ; Genetic Testing/methods ; Humans ; Kidney Diseases, Cystic/diagnosis ; Kidney Diseases, Cystic/diagnostic imaging ; Kidney Diseases, Cystic/genetics ; Magnetic Resonance Imaging ; Male ; Muscle Cramp/diagnosis ; Muscle Cramp/diagnostic imaging ; Muscle Cramp/genetics ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Polycystic Kidney, Autosomal Dominant/diagnostic imaging ; Polycystic Kidney, Autosomal Dominant/genetics ; Raynaud Disease/diagnosis ; Raynaud Disease/diagnostic imaging ; Raynaud Disease/genetics
    Language English
    Publishing date 2018-03-27
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L17-0644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel 3D capsule device to restrict kidney volume expansion on polycystic kidney progression: feasibility study in a rat model.

    Bae, Kyongtae T / Kumamoto, Kanako / Yoshimura, Aya / Kugita, Masanori / Horie, Shigeo / Yamaguchi, Tamio / Bae, Junu T / Nagao, Shizuko

    Journal of nephrology

    2021  Volume 35, Issue 3, Page(s) 1033–1040

    Abstract: Background: Cystogenesis in polycystic kidney disease (PKD) is likely accelerated by various renal insults, including crystal deposition, that activate renal tubule obstruction and dilation. We developed a capsule-based device that can be applied to ... ...

    Abstract Background: Cystogenesis in polycystic kidney disease (PKD) is likely accelerated by various renal insults, including crystal deposition, that activate renal tubule obstruction and dilation. We developed a capsule-based device that can be applied to cystic kidneys to restrict tubular lumen dilatation and cyst expansion.
    Methods: Kidney capsule devices were designed from computed tomography images of wild-type and Cy/+ rats. Capsule devices were surgically implanted on kidneys in six surgical sessions over a period of 14 months in 7 wild-type rats of 6.5-8 weeks (3 sham operations, 2 right, 2 left) and 6 Cy/+ rats of 6.5 weeks (2 sham, 3 left, 1 bilateral). After surgery, the rats were followed for 5.4-12.4 weeks' growth and sacrificed to retrieve the kidneys. During the follow-up, serum creatinine was measured and retrieved kidneys were weighed. Histological analysis including cystic area measurement and immunohistochemistry was performed.
    Results: Morphometric capsule devices were configured and developed by an image processing technique and produced using a 3D printer. Encapsulated Cy/+ kidneys (n = 5; mean weight 3.64 g) were consistently smaller in size (by 21-36%; p < 0.001) than unencapsulated Cy/+ kidneys (n = 7; mean weight 5.52 g). Encapsulated Cy/+ kidneys (mean %cyst area: 29.4%) showed smaller histological cystic area (by 28-58%; p < 0.001) than unencapsulated Cy/+ kidneys (mean %cyst area 48.6%). Cell proliferation and macrophages were also markedly reduced in encapsulated Cy/+ kidneys, compared to unencapsulated Cy/+ kidneys.
    Conclusions: We report a pilot feasibility study for the application of a novel morphometric 3D capsule device to the Cy/+ rat model showing restricted kidney volume expansion on polycystic kidney disease progression.
    MeSH term(s) Animals ; Cell Proliferation ; Cysts/pathology ; Disease Models, Animal ; Feasibility Studies ; Humans ; Kidney/pathology ; Polycystic Kidney Diseases/pathology ; Rats
    Language English
    Publishing date 2021-11-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-021-01160-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Optimization of contrast enhancement in thoracic MDCT.

    Bae, Kyongtae T

    Radiologic clinics of North America

    2010  Volume 48, Issue 1, Page(s) 9–29

    Abstract: Many clinical applications of thoracic computed tomography (CT) require contrast medium to enhance and delineate vascular, mediastinal, hilar, and cardiac structures, and differentiate normal and pathologic vascular or tumoral conditions. Multidetector ... ...

    Abstract Many clinical applications of thoracic computed tomography (CT) require contrast medium to enhance and delineate vascular, mediastinal, hilar, and cardiac structures, and differentiate normal and pathologic vascular or tumoral conditions. Multidetector row computed tomography (MDCT) is superior to single-detector row CT (SDCT) because MDCT permits more efficient and flexible use of intravenous contrast medium to achieve enhancement. However, to fully reap the benefits of MDCT contrast enhancement, the technical challenges associated with optimizing enhancement and scan timing in MDCT need to be solved. This article reviews the basic principles of CT contrast enhancement and discusses common clinical considerations and the protocol design modifications that are necessary to achieve optimal contrast enhancement in thoracic MDCT.
    MeSH term(s) Angiography/methods ; Contrast Media/administration & dosage ; Contrast Media/pharmacokinetics ; Humans ; Injections, Intravenous ; Radiographic Image Enhancement/methods ; Radiography, Thoracic/methods ; Radiography, Thoracic/trends ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/trends
    Chemical Substances Contrast Media
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2009.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intravenous contrast medium administration and scan timing at CT: considerations and approaches.

    Bae, Kyongtae T

    Radiology

    2010  Volume 256, Issue 1, Page(s) 32–61

    Abstract: The continuing advances in computed tomographic (CT) technology in the past decades have provided ongoing opportunities to improve CT image quality and clinical practice and discover new clinical CT imaging applications. New CT technology, however, has ... ...

    Abstract The continuing advances in computed tomographic (CT) technology in the past decades have provided ongoing opportunities to improve CT image quality and clinical practice and discover new clinical CT imaging applications. New CT technology, however, has introduced new challenges in clinical radiology practice. One of the challenges is with intravenous contrast medium administration and scan timing. In this article, contrast medium pharmacokinetics and patient, contrast medium, and CT scanning factors associated with contrast enhancement and scan timing are presented and discussed. Published data from clinical studies of contrast medium and physiology are reviewed and interpreted. Computer simulation data are analyzed to provide an in-depth analysis of various factors associated with contrast enhancement and scan timing. On the basis of basic principles and analysis of the factors, clinical considerations and modifications to protocol design that are necessary to optimize contrast enhancement for common clinical CT applications are proposed.
    MeSH term(s) Anthropometry ; Clinical Protocols/standards ; Computer Simulation ; Contrast Media/administration & dosage ; Contrast Media/pharmacokinetics ; Humans ; Infusions, Intravenous ; Injections, Intravenous ; Radiation Dosage ; Radiographic Image Enhancement/methods ; Radiographic Image Interpretation, Computer-Assisted ; Time Factors ; Tomography, X-Ray Computed
    Chemical Substances Contrast Media
    Keywords covid19
    Language English
    Publishing date 2010-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.10090908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Utility of new image-derived biomarkers for autosomal dominant polycystic kidney disease prognosis using automated instance cyst segmentation.

    Gregory, Adriana V / Chebib, Fouad T / Poudyal, Bhavya / Holmes, Heather L / Yu, Alan S L / Landsittel, Douglas P / Bae, Kyongtae T / Chapman, Arlene B / Frederic, Rahbari-Oskoui / Mrug, Michal / Bennett, William M / Harris, Peter C / Erickson, Bradley J / Torres, Vicente E / Kline, Timothy L

    Kidney international

    2023  Volume 104, Issue 2, Page(s) 334–342

    Abstract: New image-derived biomarkers for patients affected by autosomal dominant polycystic kidney disease are needed to improve current clinical management. The measurement of total kidney volume (TKV) provides critical information for clinicians to drive care ... ...

    Abstract New image-derived biomarkers for patients affected by autosomal dominant polycystic kidney disease are needed to improve current clinical management. The measurement of total kidney volume (TKV) provides critical information for clinicians to drive care decisions. However, patients with similar TKV may present with very different phenotypes, often requiring subjective decisions based on other factors (e.g., appearance of healthy kidney parenchyma, a few cysts contributing significantly to overall TKV, etc.). In this study, we describe a new technique to individually segment cysts and quantify biometric parameters including cyst volume, cyst number, parenchyma volume, and cyst parenchyma surface area. Using data from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) study the utility of these new parameters was explored, both quantitatively as well as visually. Total cyst number and cyst parenchyma surface area showed superior prediction of the slope of estimated glomerular filtration rate decline, kidney failure and chronic kidney disease stages 3A, 3B, and 4, compared to TKV. In addition, presentations such as a few large cysts contributing significantly to overall kidney volume were shown to be much better stratified in terms of outcome predictions. Thus, these new image biomarkers, which can be obtained automatically, will have great utility in future studies and clinical care for patients affected by autosomal dominant polycystic kidney disease.
    MeSH term(s) Humans ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnostic imaging ; Disease Progression ; Magnetic Resonance Imaging/methods ; Prognosis ; Kidney/diagnostic imaging ; Biomarkers ; Glomerular Filtration Rate
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.01.010
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  9. Article ; Online: Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial.

    Seliger, Stephen L / Watnick, Terry / Althouse, Andrew D / Perrone, Ronald D / Abebe, Kaleab Z / Hallows, Kenneth R / Miskulin, Dana C / Bae, Kyongtae T

    Kidney360

    2021  Volume 1, Issue 12, Page(s) 1363–1372

    Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) has been associated with metabolic disturbances characterized by downregulation of AMP-activated protein kinase (AMPK), a critical sensor of the cellular energy status. Therapeutic ... ...

    Abstract Background: Autosomal dominant polycystic kidney disease (ADPKD) has been associated with metabolic disturbances characterized by downregulation of AMP-activated protein kinase (AMPK), a critical sensor of the cellular energy status. Therapeutic activation of AMPK by metformin could inhibit cyst enlargement by inhibition of both the mammalian target of rapamycin pathway and fluid secretion
    Methods: We designed a phase-2, randomized, placebo-controlled, clinical trial to assess the safety, tolerability, and efficacy of metformin on total kidney volume in adults without diabetes (age 18-60 years) with ADPKD and eGFR of ≥50 ml/min per 1.73 m
    Results: We successfully randomized 97 participants recruited from two university-based clinical sites in Baltimore and Boston. The mean age of participants was 41.9 years, 72% were female, and 94% of participants were White. The majority of study participants had early stage disease, with a mean eGFR of 86.8±19.0 ml/min per 1.73 m
    Conclusions: We report successful recruitment in this ongoing, novel, clinical trial of metformin in ADPKD, with a study sample comprising patients with early stage disease and nearly a half of participants considered at high estimated risk for progression. Participants reported a low gastrointestinal symptom burden at baseline, and HRQoL similar to that of the general population, with no differences in symptoms or HRQoL related to organomegaly.
    Clinical trial registry name and registration number: Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease (TAME), NCT02656017.
    MeSH term(s) Adolescent ; Adult ; Disease Progression ; Female ; Glomerular Filtration Rate ; Humans ; Middle Aged ; Patient Reported Outcome Measures ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Quality of Life ; Young Adult
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0004002020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Enhancement of functional MRI signal at high-susceptibility regions of brain using simultaneous multiecho multithin-slice summation imaging technique.

    Kim, Tae / Zhao, Tiejun / Bae, Kyongtae T

    Journal of magnetic resonance imaging : JMRI

    2016  Volume 44, Issue 2, Page(s) 478–485

    Abstract: ... t-test, P < 0.05). SMSME-thin further increased values as compared with SMSME (∼45% for tSNR and ∼20 ...

    Abstract Purpose: To increase temporal-signal-to-noise ratio (tSNR) and blood oxygen level-dependent (BOLD) sensitivity at high-susceptibility regions of the brain by means of a simultaneous multiecho multithin-slice summation imaging technique.
    Materials and methods: The simultaneous multislice (SMS) technique was implemented with multiecho (SMSME) and multiecho with thin-slice summation (SMSME-thin) at 3T. Multiecho data were summated based on the local apparent T2* weighting factor. Ten healthy subjects were studied for the whole brain activation by breath-holding. The tSNR values and the number of activated pixels acquired with SMSME and SMSME-thin were compared with those acquired with the conventional gradient-echo EPI in multiple brain regions
    Results: SMS methods accelerated imaging time by 5-fold as compared with the conventional method, resulting in the acquisition of three echoes and four thin-slices during the same TR of 2.5 seconds. At high-susceptibility regions, including the amygdala, inferior and middle temporal, and anterior frontal lobes, SMSME increased tSNR values by up to ∼80% and BOLD activation by up to ∼20% (paired t-test, P < 0.05). SMSME-thin further increased values as compared with SMSME (∼45% for tSNR and ∼20% for activation, P < 0.05).
    Conclusion: The SMSME-thin imaging technique enhanced the temporal-signal-to-noise ratio and functional activation at high susceptibility regions of the brain. J. Magn. Reson. Imaging 2016;44:478-485.
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.25170
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