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  1. Article ; Online: Artistic movements as pitfalls in iconodiagnosis.

    Lefrère, Bertrand / Libé, Rossella / Groussin, Lionel

    Annales d'endocrinologie

    2023  Volume 85, Issue 2, Page(s) 163–165

    MeSH term(s) Humans ; Art
    Language English
    Publishing date 2023-12-13
    Publishing country France
    Document type Letter
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thyroid swellings in Renaissance illuminations.

    Lefrère, Bertrand / Libé, Rossella / Groussin, Lionel

    Annales d'endocrinologie

    2023  Volume 84, Issue 2, Page(s) 322–324

    MeSH term(s) Humans ; Lighting ; Goiter ; Thyroid Neoplasms
    Language English
    Publishing date 2023-01-12
    Publishing country France
    Document type Letter
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2023.01.001
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  3. Article ; Online: More on Anti-Insulin Receptor Antibody in Malignant Insulinoma and Refractory Hypoglycemia.

    Schubert, Louis / Groussin, Lionel / Bouys, Lucas

    The New England journal of medicine

    2023  Volume 389, Issue 17, Page(s) 1634–1635

    MeSH term(s) Humans ; Insulinoma/complications ; Hypoglycemia/etiology ; Pancreatic Neoplasms/complications
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2311041
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  4. Article: MAPK Pathway Inhibitors in Thyroid Cancer: Preclinical and Clinical Data.

    Schubert, Louis / Mariko, Mohamed Lamine / Clerc, Jérôme / Huillard, Olivier / Groussin, Lionel

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Thyroid cancer is the most common endocrine cancer, with a good prognosis in most cases. However, some cancers of follicular origin are metastatic or recurrent and eventually become radioiodine refractory thyroid cancers (RAIR-TC). These more aggressive ... ...

    Abstract Thyroid cancer is the most common endocrine cancer, with a good prognosis in most cases. However, some cancers of follicular origin are metastatic or recurrent and eventually become radioiodine refractory thyroid cancers (RAIR-TC). These more aggressive cancers are a clinical concern for which the therapeutic arsenal remains limited. Molecular biology of these tumors has highlighted a hyper-activation of the Mitogen-Activated Protein Kinases (MAPK) pathway (RAS-RAF-MEK-ERK), mostly secondary to the
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030710
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  5. Article ; Online: Authors' Reply: 18F-fluorocholine PET/CT in MEN1 Patients with Primary Hyperparathyroidism.

    Gaujoux, Sébastien / Gauthé, Mathieu / Groussin, Lionel

    World journal of surgery

    2021  Volume 45, Issue 4, Page(s) 1256

    MeSH term(s) Choline/analogs & derivatives ; Humans ; Hyperparathyroidism, Primary/diagnostic imaging ; Hyperparathyroidism, Primary/surgery ; Positron Emission Tomography Computed Tomography
    Chemical Substances fluorocholine (6029HGL0QP) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2021-01-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05896-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Amiodarone-induced thyrotoxicosis.

    Schubert, Louis / Bricaire, Léopoldine / Groussin, Lionel

    Annales d'endocrinologie

    2020  Volume 82, Issue 3-4, Page(s) 163–166

    Abstract: Amiodarone-induced thyrotoxicosis (AIT) are not uncommon endocrinopathies. Clinicians are sometimes faced with difficult diagnostic and therapeutic situations. The disease pathophysiology is partially understood, explaining the lack of predictive factors ...

    Abstract Amiodarone-induced thyrotoxicosis (AIT) are not uncommon endocrinopathies. Clinicians are sometimes faced with difficult diagnostic and therapeutic situations. The disease pathophysiology is partially understood, explaining the lack of predictive factors for occurrence. Different international recommendations for their management have been published: the most recent in 2018 by the European Thyroid Association (ETA) (Ross et al., 2016; Bartalena et al., 2018). The purpose of this paper is to present the essential concepts for their management and to review the literature since 2018.
    MeSH term(s) Amiodarone/adverse effects ; Anti-Arrhythmia Agents/adverse effects ; History, 21st Century ; Hypothyroidism/chemically induced ; Hypothyroidism/therapy ; Practice Guidelines as Topic ; Thyroid Function Tests ; Thyrotoxicosis/chemically induced ; Thyrotoxicosis/diagnosis ; Thyrotoxicosis/therapy
    Chemical Substances Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2020-04-29
    Publishing country France
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2020.04.009
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  7. Article ; Online: Larotrectinib-Enhanced Radioactive Iodine Uptake in Advanced Thyroid Cancer.

    Groussin, Lionel / Clerc, Jérôme / Huillard, Olivier

    The New England journal of medicine

    2020  Volume 383, Issue 17, Page(s) 1686–1687

    MeSH term(s) Humans ; Iodine Radioisotopes/metabolism ; Iodine Radioisotopes/therapeutic use ; Lung/diagnostic imaging ; Lung/metabolism ; Middle Aged ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/drug effects ; Thyroid Cancer, Papillary/metabolism ; Thyroid Cancer, Papillary/radiotherapy ; Thyroid Cancer, Papillary/secondary ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/metabolism ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/radiotherapy
    Chemical Substances Iodine Radioisotopes ; Iodine-131 ; Pyrazoles ; Pyrimidines ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; larotrectinib (PF9462I9HX)
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2023094
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    Ua VI Zs.34: Show issues Location:
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  8. Article: NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK.

    Cormier, Françoise / Housni, Selma / Dumont, Florent / Villard, Mélodie / Cochand-Priollet, Béatrix / Mercier-Nomé, Françoise / Perlemoine, Karine / Bertherat, Jérôme / Groussin, Lionel

    Oncogenesis

    2023  Volume 12, Issue 1, Page(s) 55

    Abstract: Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display poor prognosis. NF-κB signaling pathways are involved in tumor progression of various cancers. Here, we finely characterize the NF- ... ...

    Abstract Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display poor prognosis. NF-κB signaling pathways are involved in tumor progression of various cancers. Here, we finely characterize the NF-κB pathways and their involvement in TC. By using immunoblot and gel shift assays, we demonstrated that both classical and alternative NF-κB pathways are activated in ten TC-derived cell lines, leading to activated RelA/p50 and RelB/p50 NF-κB dimers. By analyzing the RNAseq data of the large papillary thyroid carcinoma (PTC) cohort from The Cancer Genome Atlas (TCGA) project, we identified a tumor progression-related NF-κB signature in BRAF
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674437-5
    ISSN 2157-9024
    ISSN 2157-9024
    DOI 10.1038/s41389-023-00496-w
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  9. Article: Genetics of Human Thyroid Cancer Cell Lines-Letter.

    Garcia, Cyril / Cormier, Françoise / Groussin, Lionel

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2019  Volume 25, Issue 22, Page(s) 6882

    MeSH term(s) Cell Line, Tumor ; Humans ; Thyroid Neoplasms
    Language English
    Publishing date 2019-11-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-2107
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    Zs.A 4223: Show issues Location:
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  10. Article ; Online: Differentiation between adrenocortical carcinoma and lipid-poor adrenal adenoma using a multiparametric MRI-based diagnostic algorithm.

    Oloukoi, Carmelia / Dohan, Anthony / Gaillard, Martin / Hoeffel, Christine / Groussin-Rouiller, Lionel / Bertherat, Jérome / Jouinot, Anne / Assié, Guillaume / Fuks, David / Sibony, Mathilde / Soyer, Philippe / Jannot, Anne-Sophie / Barat, Maxime

    Diagnostic and interventional imaging

    2024  

    Abstract: Purpose: The purpose of this study was to evaluate the capabilities of multiparametric magnetic resonance imaging (MRI) in differentiating between lipid-poor adrenal adenoma (LPAA) and adrenocortical carcinoma (ACC).: Materials and methods: Patients ... ...

    Abstract Purpose: The purpose of this study was to evaluate the capabilities of multiparametric magnetic resonance imaging (MRI) in differentiating between lipid-poor adrenal adenoma (LPAA) and adrenocortical carcinoma (ACC).
    Materials and methods: Patients of two centers who underwent surgical resection of LPAA or ACC after multiparametric MRI were retrospectively included. A training cohort was used to build a diagnostic algorithm obtained through recursive partitioning based on multiparametric MRI variables, including apparent diffusion coefficient and chemical shift signal ratio (i.e., tumor signal intensity index). The diagnostic performances of the multiparametric MRI-based algorithm were evaluated using a validation cohort, alone first and then in association with adrenal tumor size using a cut-off of 4 cm. Performances of the diagnostic algorithm for the diagnosis of ACC vs. LPAA were calculated using pathology as the reference standard.
    Results: Fifty-four patients (27 with LPAA and 27 with ACC; 37 women; mean age, 48.5 ± 13.3 [standard deviation (SD)] years) were used as the training cohort and 61 patients (24 with LPAA and 37 with ACC; 47 women; mean age, 49 ± 11.7 [SD] years) were used as the validation cohort. In the validation cohort, the diagnostic algorithm yielded best accuracy for the diagnosis of ACC vs. LPAA (75%; 46/61; 95% CI: 55-88) when used without lesion size. Best sensitivity was obtained with the association of the diagnostic algorithm with tumor size (96%; 23/24; 95% CI: 80-99). Best specificity was obtained with the diagnostic algorithm used alone (76%; 28/37; 95% CI: 60-87).
    Conclusion: A multiparametric MRI-based diagnostic algorithm that includes apparent diffusion coefficient and tumor signal intensity index helps discriminate between ACC and LPAA with high degrees of specificity and accuracy. The association of the multiparametric MRI-based diagnostic algorithm with adrenal lesion size helps maximize the sensitivity of multiparametric MRI for the diagnosis of ACC.
    Language English
    Publishing date 2024-04-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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