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  1. Book ; Thesis: Bestimmung des Renal- Resistive- Index (RRI) mittels farbkodierter Doppler-Sonographie zur Detektion eines akuten Nierenversagens nach Transkatheter-Aortenklappen-Implantation (TAVI)

    Kasisada, Fawad / Rudolph, Tanja / Brinkkötter, Paul-Thomas

    2019  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Kardiologie, Pneumologie, Angiologie und Internistische Intensivmedizin
    Author's details vorgelegt von Fawad Kasisada ; 1. Gutachterin: Professorin Dr. med. T. Rudolph, 2. Gutachter: Professor Dr. med. P. Brinkkötter ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin III Kardiologie
    Subject code 610
    Language German
    Size 121 Blätter, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2019
    HBZ-ID HT020348192
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 67 order for loan Magazin

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  2. Book ; Thesis: Stellenwert von Troponin I zur Risikostratifizierung von Patienten mit Brustschmerz in der Notfallversorgung

    Paul, Tanja

    2001  

    Author's details vorgelegt von Tanja Paul
    Language German
    Size 109 S. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2001
    HBZ-ID HT013388639
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 MB 3401 order for loan Magazin

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  3. Book ; Online: Mammakarzinom der Frau

    Wörmann, Bernhard / Aebi, Stefan / Balic, Marija / Decker, Thomas / Fehm, Tanja / Greil, Richard / Harbeck, Nadia / Krug, Barbara / Overkamp, Friedrich / Rick, Oliver / Wenz, Frederik / Lüftner, Diana

    Leitlinie - ICD-10: C50.0 - 50.9 : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

    (Onkopedia Leitlinien)

    2018  

    Abstract: Das Mammakarzinom ist der häufigste maligne Tumor der Frau. Das mittlere Erkrankungsalter liegt bei etwa 64 Jahren. Durch das Mammographie-Screening wird die tumorspezifische Mortalität gesenkt. Die Prognose der Patientinnen wird vor allem vom Stadium ... ...

    Institution Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
    Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie
    Schweizerische Gesellschaft für Medizinische Onkologie
    Schweizerische Gesellschaft für Hämatologie
    Author's details DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V., OeGHO - Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SSMO/SSOM/SGMO - Schweizerische Gesellschaft für Medizinische Onkologie, SGH-SSH - Schweizerische Gesellschaft für Hämatologie/Société Suisse d'Hématologie ; Autoren: Bernhard Wörmann, Stefan Aebi, Marija Balic, Thomas Decker, Tanja Fehm, Richard Greil, Nadia Harbeck, Barbara Krug, Friedrich Overkamp, Oliver Rick, Frederik Wenz, Diana Lüftner ; Autoren früherer Versionen: Kurt Possinger, Hellmut Samonigg
    Series title Onkopedia Leitlinien
    Abstract Das Mammakarzinom ist der häufigste maligne Tumor der Frau. Das mittlere Erkrankungsalter liegt bei etwa 64 Jahren. Durch das Mammographie-Screening wird die tumorspezifische Mortalität gesenkt. Die Prognose der Patientinnen wird vor allem vom Stadium und von der Biologie der Erkrankung bestimmt. Der Therapieanspruch ist kurativ im lokal begrenzten, im lokal fortgeschrittenen und im lokal rezidivierten Stadium. Die Therapie ist in diesen Krankheitsstadien multimodal. Neben der Operation umfasst sie die Bestrahlung sowie die medikamentöse Therapie mit Einsatz von antihormonell, zytostatisch, gezielt und osteoprotektiv wirksamen Arzneimitteln. Im metastasierten Stadium ist der Therapieanspruch palliativ mit dem Ziel der Linderung von Symptomen und Verlängerung der Überlebenszeit. Durch die Fortschritte in der Diagnostik und der Therapie ist die krebsspezifische Mortalität in den letzten Jahren kontinuierlich gesunken. Die relative 5-Jahres-Überlebensrate aller Patientinnen liegt bei 87%, bei Patientinnen mit lokal begrenzten Stadien deutlich höher.
    Subject code 610
    Language German
    Size 1 Online-Ressource (51 Seiten), Diagramme
    Edition Stand: Januar 2018
    Publisher DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020356912
    DOI 10.4126/FRL01-006418826
    Database Repository for Life Sciences

    Full text online

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  4. Article ; Online: Patient-reported outcomes with anifrolumab in patients with systemic lupus erythematosus.

    Stamm, Tanja / Parodis, Ioannis / Studenic, Paul

    The Lancet. Rheumatology

    2022  Volume 4, Issue 3, Page(s) e157–e159

    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00029-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Mammakarzinom der Frau

    Wörmann, Bernhard / Aebi, Stefan / Balic, Marija / Decker, Thomas / Fehm, Tanja / Greil, Richard / Harbeck, Nadia / Krug, Barbara / Overkamp, Friedrich / Rick, Oliver / Wenz, Frederik / Lüftner, Diana

    Leitlinie - ICD-10: C50.0 - 50.9 : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

    (Onkopedia Leitlinien)

    2017  

    Abstract: Das Mammakarzinom ist der häufigste maligne Tumor der Frau. Das mittlere Erkrankungsalter liegt bei etwa 64 Jahren. Durch das Mammographie-Screening wird die tumorspezifische Mortalität gesenkt. Die Prognose der Patientinnen wird vor allem vom Stadium ... ...

    Institution Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
    Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie
    Schweizerische Gesellschaft für Medizinische Onkologie
    Author's details DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V., OeGHO - Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SSMO/SSOM/SGMO - Schweizerische Gesellschaft für Medizinische Onkologie ; Autoren: Bernhard Wörmann, Stefan Aebi, Marija Balic, Thomas Decker, Tanja Fehm, Richard Greil, Nadia Harbeck, Barbara Krug, Friedrich Overkamp, Oliver Rick, Frederik Wenz, Diana Lüftner
    Series title Onkopedia Leitlinien
    Abstract Das Mammakarzinom ist der häufigste maligne Tumor der Frau. Das mittlere Erkrankungsalter liegt bei etwa 64 Jahren. Durch das Mammographie-Screening wird die tumorspezifische Mortalität gesenkt. Die Prognose der Patientinnen wird vor allem vom Stadium und von der Biologie der Erkrankung bestimmt. Der Therapieanspruch ist kurativ im lokal begrenzten, im lokal fortgeschrittenen und im lokal rezidivierten Stadium. Die Therapie ist in diesen Krankheitsstadien multimodal. Neben der Operation umfasst sie die Bestrahlung sowie die medikamentöse Therapie mit Einsatz von antihormonell, zytostatisch, gezielt und osteoprotektiv wirksamen Arzneimitteln. Im metastasierten Stadium ist der Therapieanspruch palliativ mit dem Ziel der Linderung von Symptomen und Verlängerung der Überlebenszeit. Durch die Fortschritte in der Diagnostik und der Therapie ist die krebsspezifische Mortalität in den letzten Jahren kontinuierlich gesunken. Die relative 5-Jahres-Überlebensrate aller Patientinnen liegt bei 87%, bei Patientinnen mit lokal begrenzten Stadien deutlich höher
    Subject code 610
    Language German
    Size 1 Online-Ressource (50 Seiten), Diagramme
    Edition Stand: April 2017
    Publisher DGHO - Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online
    Note Autoren früherer Versionen: Kurt Possinger, Hellmut Samonigg ; Open Access
    HBZ-ID HT020614106
    DOI 10.4126/FRL01-006423572
    Database Repository for Life Sciences

    Full text online

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  6. Book ; Online: Education Studies in South Africa : The Quest for Relevance, Rigour and Restructuring

    Wolhuter, Charl C. / Ankiah-Gangadeen, Aruna / Botha, Carolina / Khanare, Fumane P. / Kruger, Corné / Kwatubana, Siphokazi / Munje, Paul N. / Muthusamy, Nirashnee / Nadal, Pascal S. / Rens, Julialet / Schoonen, Andri / Spamer, Tanja / Wessels, Elsabé / Whalen, Catherine / Wood, Lesley

    2020  

    Keywords Education ; Educational strategies & policy ; Education research ; Relevance ; Rigour ; Restructuring ; Structure ; Classroom management ; Teaching and learning
    Size 1 electronic resource (408 pages)
    Publisher AOSIS
    Publishing place Durbanville
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047847
    ISBN 9781928523598 ; 1928523595
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article: Schuldvorwürfe in der Palliativversorgung neu verstehen

    Brinkmann, Tanja M. / Möllers, Jan / Paul, Chris

    Zeitschrift für Palliativmedizin

    2021  Volume 22, Issue 03, Page(s) 139–145

    Language German
    Publishing date 2021-04-28
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072361-1
    ISSN 1615-293X ; 1615-2921
    ISSN (online) 1615-293X
    ISSN 1615-2921
    DOI 10.1055/a-1363-6356
    Database Thieme publisher's database

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  8. Article: Superficial white matter integrity in neuromyelitis optica spectrum disorder and multiple sclerosis.

    Komnenić, Darko / Phillips, Owen Robert / Joshi, Shantanu H / Chien, Claudia / Schmitz-Hübsch, Tanja / Asseyer, Susanna / Paul, Friedemann / Finke, Carsten

    Multiple sclerosis journal - experimental, translational and clinical

    2024  Volume 10, Issue 1, Page(s) 20552173231226107

    Abstract: Background: Superficial white matter (SWM) is a particularly vulnerable area of white matter adjacent to cerebral cortex that was shown to be a sensitive marker of disease severity in several neurological and psychiatric disorders, including multiple ... ...

    Abstract Background: Superficial white matter (SWM) is a particularly vulnerable area of white matter adjacent to cerebral cortex that was shown to be a sensitive marker of disease severity in several neurological and psychiatric disorders, including multiple sclerosis (MS), but has not been studied in neuromyelitis optica spectrum disorder (NMOSD).
    Objective: To compare the integrity of SWM between MS patients, NMOSD patients and healthy controls, and explore the correlation of SWM integrity with cognitive performance and overall disability.
    Methods: Forty NMOSD patients, 48 MS patients and 52 healthy controls were included in the study. Mean diffusivity (MD) values obtained by diffusion tensor imaging were used as a measure of SWM integrity. Cognitive performance and overall disability were assessed with standardized tests.
    Results: Superficial white matter MD was increased in MS patients compared to healthy controls. Higher MD was associated with poorer spatial memory (most prominently in right temporal and right limbic lobe) and poorer information processing speed in MS patients. After adjusting for age, no significant differences of SWM MD were observed between NMOSD patients and healthy controls.
    Conclusion: Integrity of SWM is compromised in MS, but not in NMOSD, and can serve as a sensitive marker of disease severity.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2841884-0
    ISSN 2055-2173 ; 2055-2173
    ISSN (online) 2055-2173
    ISSN 2055-2173
    DOI 10.1177/20552173231226107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interventions targeting psychological well-being for motor neuron disease carers: A systematic review.

    Cafarella, Paul / Effing, Tanja / Chur-Hansen, Anna

    Palliative & supportive care

    2022  , Page(s) 1–17

    Abstract: Objectives: This systematic review considers interventions designed to improve the psychological well-being (PWB) of carers of people with motor neuron disease (MND) using quantitative, qualitative, or mixed-methods studies, and aimed to (1) summarize ... ...

    Abstract Objectives: This systematic review considers interventions designed to improve the psychological well-being (PWB) of carers of people with motor neuron disease (MND) using quantitative, qualitative, or mixed-methods studies, and aimed to (1) summarize current research, (2) assess the quality of evidence, and (3) evaluate the effectiveness of interventions.
    Method: Mixed-methods systematic review (MMSR) was conducted based on Joanna Briggs Institute methodology for quantitative, qualitative, and mixed-methods reviews and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
    Results: Thirteen papers met the inclusion criteria, including 12 studies (six mixed-methods, four quantitative, and two qualitative). Four studies described randomized controlled trials, seven detailed uncontrolled longitudinal studies with a single treatment group and a pre-post design, and one was an observational survey. Critical appraisal of the studies revealed a wide range of weaknesses in the quantitative and/or qualitative methodologies. Due to the heterogeneity of interventions, outcomes, and measurements, a narrative and convergent approach to data synthesis was employed. While a minority of studies demonstrated some benefits to hedonic and eudaimonic aspects of PWB, the interpretability of these data was limited by methodological problems.
    Significance of results: This MMSR highlighted a paucity of quality research regarding interventions for the PWB of MND carers. Although some benefits to PWB were demonstrated, most studies suffered from substantial methodological problems, rendering the overall evidence base low. High-quality and carefully designed studies are a priority to enable effective development and testing of much-needed interventions targeting the PWB for MND carers.
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2454009-2
    ISSN 1478-9523 ; 1478-9515
    ISSN (online) 1478-9523
    ISSN 1478-9515
    DOI 10.1017/S1478951522000311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6697: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Metastable condensates suppress conversion to amyloid fibrils.

    Das, Tapojyoti / Zaidi, Fatima / Farag, Mina / Ruff, Kiersten M / Messing, James / Taylor, J Paul / Pappu, Rohit V / Mittag, Tanja

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Stress granules form via co-condensation of RNA binding proteins with prion-like low complexity domains (PLCDs) and RNA molecules released by stress-induced polysomal runoff. Homotypic interactions among PLCDs can drive amyloid fibril formation and this ... ...

    Abstract Stress granules form via co-condensation of RNA binding proteins with prion-like low complexity domains (PLCDs) and RNA molecules released by stress-induced polysomal runoff. Homotypic interactions among PLCDs can drive amyloid fibril formation and this is enhanced by ALS-associated mutations. We find that homotypic interactions that drive condensation versus fibril formation are separable for A1-LCD, the PLCD of hnRNPA1. These separable interactions lead to condensates that are metastable versus fibrils that are globally stable. Metastable condensates suppress fibril formation, and ALS-associated mutations enhance fibril formation by weakening condensate metastability. Mutations designed to enhance A1-LCD condensate metastability restore wild-type behaviors of stress granules in cells even when ALS-associated mutations are present. This suggests that fibril formation can be suppressed by enhancing condensate metastability through condensate-driving interactions.
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.28.582569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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