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Article ; Online: Liver fat as risk factor of hepatic and cardiometabolic diseases.

Demir, Münevver / Bornstein, Stefan R / Mantzoros, Christos S / Perakakis, Nikolaos

Obesity reviews : an official journal of the International Association for the Study of Obesity

2023 Volume 24, Issue 10, Page(s) e13612

Abstract: Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive accumulation of fat in the liver that can progress to liver inflammation (non-alcoholic steatohepatitis [NASH]), liver fibrosis, and cirrhosis. Although most efforts for ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive accumulation of fat in the liver that can progress to liver inflammation (non-alcoholic steatohepatitis [NASH]), liver fibrosis, and cirrhosis. Although most efforts for drug development are focusing on the treatment of the latest stages of NAFLD, where significant fibrosis and NASH are present, findings from studies suggest that the amount of liver fat may be an important independent risk factor and/or predictor of development and progression of NAFLD and metabolic diseases. In this review, we first describe the current tools available for quantification of liver fat in humans and then present the clinical and pathophysiological evidence that link liver fat with NAFLD progression as well as with cardiometabolic diseases. Finally, we discuss current pharmacological and non-pharmacological approaches to reduce liver fat and present open questions that have to be addressed in future studies.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Risk Factors ; Liver Cirrhosis ; Cardiovascular Diseases/etiology
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13612
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Zs.A 5908: Show issues

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Article ; Online: Intergenerational Trauma, Dependency, and Detachment.

Spiel, Shira / Szymanski, Kate / Bornstein, Robert

The Journal of nervous and mental disease

2023 Volume 211, Issue 9, Page(s) 679–685

Abstract: Abstract: The literature on intergenerational transmission of trauma is predominantly focused on the mental health functioning of children and grandchildren of trauma survivors. Research shows that having a traumatized parent is related to increased ... ...

Abstract	Abstract: The literature on intergenerational transmission of trauma is predominantly focused on the mental health functioning of children and grandchildren of trauma survivors. Research shows that having a traumatized parent is related to increased psychopathology and dysfunctional attachment patterns in the next generation, but little is known about the effects of parental trauma on other aspects of interpersonal relating. The current study addresses this gap. Participants were young adult students from an urban college; individual and parental trauma histories, and indices of unhealthy dependency, dysfunctional detachment, and healthy dependency, were obtained. Results indicated that a wide range of parental traumas were positively correlated with dysfunctional detachment, but not related to destructive overdependence or healthy dependency. These results suggest that a wide range of parental traumas have a negative impact on the next generation's interpersonal dependency by fostering a tendency to distance themselves from close relationships.
MeSH term(s)	Child ; Young Adult ; Humans ; Interpersonal Relations ; Historical Trauma ; Dependency, Psychological ; Psychopathology ; Parents/psychology
Language	English
Publishing date	2023-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3020-x
ISSN	1539-736X ; 0022-3018
ISSN (online)	1539-736X
ISSN	0022-3018
DOI	10.1097/NMD.0000000000001682
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Article: Triage implementation in resource-limited emergency departments: sharing tools and experience from the Pacific region.

Mitchell, Rob / White, Libby / Elton, Leigh / Luke, Cliff / Bornstein, Sarah / Atua, Vincent

International journal of emergency medicine

2024 Volume 17, Issue 1, Page(s) 21

Abstract: According to the World Health Organization's (WHO) Emergency Care Systems Framework, triage is an essential function of emergency departments (EDs). This practice innovation article describes four strategies that have been used to support implementation ... ...

Abstract	According to the World Health Organization's (WHO) Emergency Care Systems Framework, triage is an essential function of emergency departments (EDs). This practice innovation article describes four strategies that have been used to support implementation of the WHO-endorsed Interagency Integrated Triage Tool (IITT) in the Pacific region, namely needs assessment, digital learning, public communications and electronic data management.Using a case study from Vila Central Hospital in Vanuatu, a Pacific Small Island Developing State, we reflect on lessons learned from IITT implementation in a resource-limited ED. In particular, we describe the value of a bespoke needs assessment tool for documenting triage and patient flow requirements; the challenges and opportunities presented by digital learning; the benefits of locally designed, public-facing communications materials; and the feasibility and impact of a low-cost electronic data registry system.Our experience of using these tools in Vanuatu and across the Pacific region will be of interest to other resource-limited EDs seeking to improve their triage practice and performance. Although the resources and strategies presented in this article are focussed on the IITT, the principles are equally relevant to other triage systems.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2411462-5
ISSN	1865-1380 ; 1865-1372
ISSN (online)	1865-1380
ISSN	1865-1372
DOI	10.1186/s12245-024-00583-8
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Article ; Online: A retrospective cohort analysis of treatment outcomes of patients with tuberculosis who used substances in Tel Aviv, Israel.

Kaliner, Ehud / Bornstein, Sandy / Kabha, Doaa / Lidji, Moshe / Sheffer, Rivka / Mor, Zohar

Alcohol and alcoholism (Oxford, Oxfordshire)

2024 Volume 59, Issue 2

Abstract: Aims: To outline the demographic, clinical, laboratory characteristics, and treatment outcomes of tuberculosis (TB) patients who used substances.: Methods: This retrospective cohort study compared 50 TB patients who used substances with a matched ... ...

Abstract	Aims: To outline the demographic, clinical, laboratory characteristics, and treatment outcomes of tuberculosis (TB) patients who used substances. Methods: This retrospective cohort study compared 50 TB patients who used substances with a matched random sample of 100 TB patients who did not use substances between 2007 and 2017. Treatment failure was defined as a sputum smear or culture that tested positive after 5 months of treatment, loss to follow-up, unevaluated patients, or death. Results: TB patients who used substances were typically younger, experienced homelessness, smokers, and had fewer chronic diseases than those who did not use substances. They also were hospitalized for longer periods, their treatment durations were longer, had higher rates of multidrug resistant strains, increased rates of treatment failure, and higher mortality. Individuals whose treatment failed predominantly originated from the former Soviet Union, experienced homelessness, and had chronic diseases compared with those whose treatment was successful. In the multivariate analysis, homelessness [odds ratios (OR) = 6.7], chronic diseases (OR = 12.4), and substance use (OR = 4.0) were predictors of treatment failures. Conclusions: TB patients who used substances were more likely to have treatment failure. Targeted interventions, including early diagnosis and enhanced support during treatment, are essential to achieve treatment success in this vulnerable population, in addition to TB-alcohol/drug collaborative activities.
MeSH term(s)	Humans ; Retrospective Studies ; Israel/epidemiology ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Treatment Outcome ; Cohort Studies ; Chronic Disease
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	604956-4
ISSN	1464-3502 ; 0309-1635 ; 0735-0414
ISSN (online)	1464-3502
ISSN	0309-1635 ; 0735-0414
DOI	10.1093/alcalc/agad073
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Zs.B 798: Show issues

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Article ; Online: The Adrenal Gland and Pancreatic Islets - A Beneficial Endocrine Alliance.

Schubert, Undine / Lehmann, Susann / Schmid, Janine / Morawietz, Henning / Bornstein, Stefan R / Ludwig, Barbara

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

2024 Volume 56, Issue 4, Page(s) 286–293

Abstract: Intraportal islet transplantation in patients with type 1 diabetes enables restoration of glucose-regulated insulin secretion. However, several factors hamper a widespread application and long-term success: chronic hypoxia, an inappropriate ... ...

Abstract	Intraportal islet transplantation in patients with type 1 diabetes enables restoration of glucose-regulated insulin secretion. However, several factors hamper a widespread application and long-term success: chronic hypoxia, an inappropriate microenvironment and suppression of regenerative and proliferative potential by high local levels of immunosuppressive agents. Therefore, the identification of alternative and superior transplant sites is of major scientific and clinical interest. Here, we aim to evaluate the adrenal as an alternative transplantation site. The adrenal features a particular microenvironment with extensive vascularization, anti-apoptotic and pro-proliferative, anti-inflammatory and immunosuppressive effects. To validate this novel transplantation site, an in vitro co-culture system of adrenal cells and pancreatic islets was established and viability, islet survival, functional potency and antioxidative defense capacity were evaluated. For in vivo validation, an immune-deficient diabetic mouse model for intra-adrenal islet transplantation was applied. The functional capacity of intra-adrenally grafted islets to reverse diabetes was compared to a standard islet transplant model and measures of engraftment such as vascular integration were evaluated. The presence of adrenal cells positively impacted on cell metabolism and oxidative stress. Following transplantation, we could demonstrate enhanced islet function in comparison to standard models with improved engraftment and superior re-vascularization. This experimental approach allows for novel insights into the interaction of endocrine systems and may open up novel strategies for islet transplantation augmented through the bystander effect of other endocrine cells or the active factors secreted by adrenal cells modulating the microenvironment.
MeSH term(s)	Mice ; Animals ; Humans ; Islets of Langerhans ; Islets of Langerhans Transplantation ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 1/metabolism ; Adrenal Glands ; Insulin Secretion
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80125-2
ISSN	1439-4286 ; 0018-5043
ISSN (online)	1439-4286
ISSN	0018-5043
DOI	10.1055/a-2256-6344
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Zs.A 681: Show issues

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Article: Metabolic Syndrome and its Correlates among Hypertensive Patients in Abuja, North Central Nigeria.

Onyegbutulem, H C / Henry-Onyegbutulem, P I / Dogo, D / Schwarz, P E H / Bornstein, S R

West African journal of medicine

2023 Volume 40, Issue 11, Page(s) 1164–1172

Abstract: Background: Metabolic syndrome is a constellation of abnormalities which includes central obesity, dyslipidaemia, elevated blood pressure and hyperglycemia. Hypertension, (which is a very common component of metabolic syndrome), and diabetes mellitus, ... ...

Abstract	Background: Metabolic syndrome is a constellation of abnormalities which includes central obesity, dyslipidaemia, elevated blood pressure and hyperglycemia. Hypertension, (which is a very common component of metabolic syndrome), and diabetes mellitus, are independently associated. Also, studies examining metabolic syndrome inAbuja, a city with affluence-driven lifestyle, are not available. This study aimed to investigate the prevalence of metabolic syndrome among hypertensive patients in Abuja, Nigeria, as well as to examine the associations between metabolic syndrome and certain factors in that cohort of hypertensive patients. Methods: This was a retrospective study that used data from hypertensive patients who attended clinic over a period of five years. Eight hundred and fifty-eight, (858-combined), case files of pre-treated, (previously known hypertensive patients) and newly diagnosed hypertensive participants were used for the study. The student t-tests were used to compare continuous variables, while Chi-square (χ2) tests were used for relationship between qualitative variables. The likelihood ratio test was employed to further confirm the statistical significance of certain independent variables relating with metabolic syndrome. A P-value of < 0.05 was considered statistically significant. Results: The mean ages were 48.70±12.18, 49.19±11.06 and 48.2±13.3 years for combined group, the pre-treated and the newly-diagnosed groups respectively. The pre-treated, group consists of those previously known hypertensive patients, while the new group consists of those who were newly diagnosed hypertensive patients and were treatment naïve. The prevalence of metabolic syndrome in this study was 45.5% in the combined group, 47.23% in the pre-treated group and 37.3% in the newly diagnosed group. The commonest component of metabolic syndrome was reduced high density lipoprotein cholesterol, HDL-C. Conclusion: Metabolic syndrome is prevalent among hypertensive patients in Abuja, Nigeria. Some correlates of metabolic syndrome include; elevated BMI, truncal obesity, elevated total cholesterol, the use of thiazide diuretics and beta blockers as antihypertensives.
MeSH term(s)	Humans ; Metabolic Syndrome/epidemiology ; Nigeria/epidemiology ; Retrospective Studies ; Hypertension/epidemiology ; Hypertension/complications ; Obesity/epidemiology ; Obesity/complications ; Prevalence ; Risk Factors
Language	English
Publishing date	2023-12-13
Publishing country	Nigeria
Document type	Journal Article
ZDB-ID	1132088-6
ISSN	0189-160X
ISSN	0189-160X
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Zs.A 3527: Show issues

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Article ; Online: Cochlear Implantation in Children With a Long Average Duration of Single Sided Deafness.

Colasacco, Christine J / Morgan, Samantha / Bornstein, Rivka / Drugge, Elizabeth / Stidham, Katrina R

The Annals of otology, rhinology, and laryngology

2023 Volume 133, Issue 3, Page(s) 345–350

Abstract: Objectives: Previous research has shown the positive effects of cochlear implantation in children with a short duration of single sided deafness (SSD). This case series assessed the impact of cochlear implantation in a cohort of children with a longer ... ...

Abstract	Objectives: Previous research has shown the positive effects of cochlear implantation in children with a short duration of single sided deafness (SSD). This case series assessed the impact of cochlear implantation in a cohort of children with a longer average duration of SSD. Methods: A retrospective chart review of 6 children who received a cochlear implant for SSD. The mean age at time of cochlear implantation was 14.7 years old (median = 15.5, interquartile range (IQR) = 2.5) and mean duration of hearing loss before cochlear implantation was 10.8 years (median = 11.5, IQR = 5.3). Pre- and post-operative audiometric data for aided speech perception testing, sentence recognition in quiet, sentence recognition in noise, and word recognition scores were analyzed. Results: When compared to preoperative hearing aid scores a 24% significant increase in median word score and a 64% significant increase in median sentence recognition score in quiet was observed at 12 months post-op. Conclusion: Cochlear implantation in children with a longer duration of SSD can provide benefit to speech recognition. Lay summary: This retrospective case series of children with prolonged single sided deafness demonstrated an improvement in word and sentence recognition within 12 months of receiving a cochlear implant.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Cochlear Implantation ; Retrospective Studies ; Speech Perception ; Treatment Outcome ; Cochlear Implants ; Deafness/surgery ; Hearing Loss, Unilateral/surgery
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894231216288
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Article: [No title information]

Cozma, Diana / Siatra, Panagiota / Bornstein, Stefan R. / Steenblock, Charlotte

Hormone and Metabolic Research

(The Adrenal Gland)

2024 Volume 56, Issue 01, Page(s) 65–77

Abstract: ... in the neuroendocrine stress axis, the critical regulator of the body’s stress response ...

Series title	The Adrenal Gland
Abstract	Metabolic diseases are prevalent in modern society and have reached pandemic proportions. Metabolic diseases have systemic effects on the body and can lead to changes in the neuroendocrine stress axis, the critical regulator of the body’s stress response. These changes may be attributed to rising insulin levels and the release of adipokines and inflammatory cytokines by adipose tissue, which affect hormone production by the neuroendocrine stress axis. Chronic stress due to inflammation may exacerbate these effects. The increased sensitivity of the neuroendocrine stress axis may be responsible for the development of metabolic syndrome, providing a possible explanation for the high prevalence of severe comorbidities such as heart disease and stroke associated with metabolic disease. In this review, we address current knowledge of the neuroendocrine stress axis in response to metabolic disease and discuss its role in developing metabolic syndrome.
Keywords	HPA axis ; adipose tissue ; obesity ; metabolic diseases ; obesity
Language	English
Publishing date	2024-01-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80125-2
ISSN	1439-4286 ; 0018-5043
ISSN (online)	1439-4286
ISSN	0018-5043
DOI	10.1055/a-2201-6641
Database	Thieme publisher's database

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Zs.A 681: Show issues

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Article: Titin-Truncating variants Predispose to Dilated Cardiomyopathy in Diverse Populations.

DePaolo, John / Bornstein, Marc / Judy, Renae / Abramowitz, Sarah / Verma, Shefali S / Levin, Michael G / Arany, Zoltan / Damrauer, Scott M

medRxiv : the preprint server for health sciences

2024

Abstract: Importance: The effect of high percentage spliced in (hiPSI) : Objective: To determine the effect of TTNtvs on risk of DCM in diverse population as measured by genetic distance (GD) in principal component (PC) space.: Design: Cohort study.: ... ...

Abstract	Importance: The effect of high percentage spliced in (hiPSI) Objective: To determine the effect of TTNtvs on risk of DCM in diverse population as measured by genetic distance (GD) in principal component (PC) space. Design: Cohort study. Setting: Penn Medicine Biobank (PMBB) is a large, diverse biobank. Participants: Participants were recruited from across the Penn Medicine healthcare system and volunteered to have their electronic health records linked to biospecimen data including DNA which has undergone whole exome sequencing. Main outcomes and measures: Risk of DCM among individuals carrying a hiPSI TTNtv. Results: Carrying a hiPSI TTNtv was associated with DCM among PMBB participants across a range of GD deciles from the 1000G European centroid; the effect estimates ranged from odds ratio (OR) = 3.29 (95% confidence interval [CI] 1.26 to 8.56) to OR = 9.39 (95% CI 3.82 to 23.13). When individuals were assigned to population subgroups based on genetic similarity to the 1000G reference populations, hiPSI TTNtvs conferred significant risk of DCM among those genetically similar to the 1000G European reference population (OR = 7.55, 95% CI 4.99 to 11.42, Conclusions and relevance: TTNtvs are associated with increased risk of DCM among a diverse cohort. There is no significant difference in effect of TTNtvs on DCM risk across deciles of GD from the 1000G European centroid, suggesting genetic background should not be considered when screening individuals for titin-related DCM.
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.17.24301405
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Article ; Online: Exploring Localized Provoked Vulvodynia: Insights from Animal Model Research.

Nakhleh-Francis, Yara / Awad-Igbaria, Yaseen / Sakas, Reem / Bang, Sarina / Abu-Ata, Saher / Palzur, Eilam / Lowenstein, Lior / Bornstein, Jacob

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: Provoked vulvodynia represents a challenging chronic pain condition, characterized by its multifactorial origins. The inherent complexities of human-based studies have necessitated the use of animal models to enrich our understanding of vulvodynia's ... ...

Abstract	Provoked vulvodynia represents a challenging chronic pain condition, characterized by its multifactorial origins. The inherent complexities of human-based studies have necessitated the use of animal models to enrich our understanding of vulvodynia's pathophysiology. This review aims to provide an exhaustive examination of the various animal models employed in this research domain. A comprehensive search was conducted on PubMed, utilizing keywords such as "vulvodynia", "chronic vulvar pain", "vulvodynia induction", and "animal models of vulvodynia" to identify pertinent studies. The search yielded three primary animal models for vulvodynia: inflammation-induced, allergy-induced, and hormone-induced. Additionally, six agents capable of triggering the condition through diverse pathways were identified, including factors contributing to hyperinnervation, mast cell proliferation, involvement of other immune cells, inflammatory cytokines, and neurotransmitters. This review systematically outlines the various animal models developed to study the pathogenesis of provoked vulvodynia. Understanding these models is crucial for the exploration of preventative measures, the development of novel treatments, and the overall advancement of research within the field.
MeSH term(s)	Animals ; Vulvodynia/etiology ; Vulvodynia/pathology ; Female ; Disease Models, Animal ; Humans ; Inflammation/pathology
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084261
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