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  1. Article ; Online: Invited Commentary: A Phase 2, Multicenter Study of Nevanimibe for the Treatment of Congenital Adrenal Hyperplasia.

    Speiser, Phyllis W

    The Journal of clinical endocrinology and metabolism

    2020  Volume 105, Issue 10

    MeSH term(s) 17-alpha-Hydroxyprogesterone ; Adrenal Hyperplasia, Congenital/drug therapy ; Humans ; Urea/analogs & derivatives
    Chemical Substances 17-alpha-Hydroxyprogesterone (68-96-2) ; Urea (8W8T17847W) ; nevanimibe (VK9OS8R205)
    Language English
    Publishing date 2020-08-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  2. Article ; Online: Emerging medical therapies for congenital adrenal hyperplasia.

    Speiser, Phyllis W

    F1000Research

    2019  Volume 8, Page(s) 363

    Abstract: Congenital adrenal hyperplasia has traditionally been treated with daily oral doses of glucocorticoids and mineralocorticoid supplements. Such therapy does not precisely replicate the adrenal cortex's circadian pattern. As a consequence, patients are ... ...

    Abstract Congenital adrenal hyperplasia has traditionally been treated with daily oral doses of glucocorticoids and mineralocorticoid supplements. Such therapy does not precisely replicate the adrenal cortex's circadian pattern. As a consequence, patients are intermittently overtreated or undertreated leading to growth suppression in children, excess weight gain and altered metabolism. Several new treatments are on the horizon. This article will summarize some new potential therapies as adjuncts to, or replacement for, standard therapy.
    MeSH term(s) Adrenal Hyperplasia, Congenital/drug therapy ; Child ; Glucocorticoids/therapeutic use ; Humans
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2019-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.17778.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Congenital adrenal hyperplasia

    Speiser, Phyllis W.

    (Endocrinology and metabolism clinics of North America ; 30,1)

    2001  

    Author's details Phyllis W. Speiser, guest ed
    Series title Endocrinology and metabolism clinics of North America ; 30,1
    Collection
    Language English
    Size XII, 244 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013047925
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 148 -30,1- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Emerging medical therapies for congenital adrenal hyperplasia [version 1; peer review

    Phyllis W. Speiser

    F1000Research, Vol

    4 approved]

    2019  Volume 8

    Abstract: Congenital adrenal hyperplasia has traditionally been treated with daily oral doses of glucocorticoids and mineralocorticoid supplements. Such therapy does not precisely replicate the adrenal cortex's circadian pattern. As a consequence, patients are ... ...

    Abstract Congenital adrenal hyperplasia has traditionally been treated with daily oral doses of glucocorticoids and mineralocorticoid supplements. Such therapy does not precisely replicate the adrenal cortex's circadian pattern. As a consequence, patients are intermittently overtreated or undertreated leading to growth suppression in children, excess weight gain and altered metabolism. Several new treatments are on the horizon. This article will summarize some new potential therapies as adjuncts to, or replacement for, standard therapy.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: A Rationale for Mineralocorticoid Supplementation in Classic Congenital Adrenal Hyperplasia.

    Speiser, Phyllis W

    Hormone research in paediatrics

    2015  

    Language English
    Publishing date 2015-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2537278-6
    ISSN 1663-2826 ; 1663-2818
    ISSN (online) 1663-2826
    ISSN 1663-2818
    DOI 10.1159/000375531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 414: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Adrenal Dysfunction.

    Speiser, Phyllis W

    Adolescent medicine: state of the art reviews

    2015  Volume 26, Issue 2, Page(s) 343–363

    MeSH term(s) Adolescent ; Adrenal Gland Diseases/diagnosis ; Adrenal Gland Diseases/etiology ; Adrenal Gland Diseases/therapy ; Diagnostic Imaging ; Humans ; Risk Factors
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2398471-5
    ISSN 1934-4287
    ISSN 1934-4287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Congenital Adrenal Hyperplasia.

    Speiser, Phyllis W

    F1000Research

    2015  Volume 4, Issue F1000 Faculty Rev, Page(s) 601

    Abstract: Congenital adrenal hyperplasia associated with deficiency of steroid 21-hydroxylase is the most common inborn error in adrenal function and the most common cause of adrenal insufficiency in the pediatric age group. As patients now survive into adulthood, ...

    Abstract Congenital adrenal hyperplasia associated with deficiency of steroid 21-hydroxylase is the most common inborn error in adrenal function and the most common cause of adrenal insufficiency in the pediatric age group. As patients now survive into adulthood, adult health-care providers must also be familiar with this condition. Over the past several years, F1000 has published numerous commentaries updating research and practical guidelines for this condition. The purposes of this review are to summarize basic information defining congenital adrenal hyperplasia and to highlight current knowledge and controversies in management.
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.6543.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diagnosis and management of congenital adrenal hyperplasia.

    Speiser, Phyllis W

    Expert review of endocrinology & metabolism

    2014  Volume 1, Issue 1, Page(s) 103–110

    Abstract: Congenital adrenal hyperplasia is the name applied to a class of autosomal recessive disorders resulting from deficiency of one of five enzymes necessary for cortisol synthesis by the adrenal cortex. Congenital adrenal hyperplasia is most often ... ...

    Abstract Congenital adrenal hyperplasia is the name applied to a class of autosomal recessive disorders resulting from deficiency of one of five enzymes necessary for cortisol synthesis by the adrenal cortex. Congenital adrenal hyperplasia is most often attributable to steroid 21-hydroxylase deficiency, accounting for more than 90% of cases. This discussion will be limited to the most common form of the disease, highlighting methods of diagnostic screening and challenges in disease management.
    Language English
    Publishing date 2014-01-23
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/17446651.1.1.103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Premature Adrenarche.

    Novello, Laura / Speiser, Phyllis W

    Pediatric annals

    2018  Volume 47, Issue 1, Page(s) e7–e11

    Abstract: Adrenarche is when a child's adrenal cortex starts to secrete adrenal androgen precursors. Dehydroepiandrosterone (DHEA) is the most abundant product of the adrenal cortex, and is a weak androgen agonist thought to be responsible for the clinical signs ... ...

    Abstract Adrenarche is when a child's adrenal cortex starts to secrete adrenal androgen precursors. Dehydroepiandrosterone (DHEA) is the most abundant product of the adrenal cortex, and is a weak androgen agonist thought to be responsible for the clinical signs of pubarche by conversion to more potent androgens, testosterone, and dihydrotestosterone. DHEA's extra-adrenal sulfation product, dehydroepiandrosterone sulfate, is a stable marker for adrenal androgenic activity. Pubarche is the physical manifestation of androgenic hormone production, and includes the development of pubic and axillary hair, adult body odor, and acne. This stage is usually considered premature if it commences before age 8 years in girls or age 9 years in boys. Premature adrenarche is a diagnosis of exclusion, as true centrally mediated precocious puberty, congenital adrenal hyperplasia, exogenous androgen exposure, and androgen-secreting tumors must be ruled out. Premature adrenarche may be associated with a history of an infant who was small for gestational age at birth who then gained weight rapidly thereafter or became obese. In some instances, premature adrenarche may predict functional ovarian hyperandrogenism in adolescence. Management of premature adrenarche is largely aimed at observation, lifestyle adjustments for weight concerns, and monitoring for future possible persistent androgen excess and insulin resistance. [Pediatr Ann. 2018;47(1):e7-e11.].
    MeSH term(s) Adrenarche ; Child ; Diagnosis, Differential ; Female ; Humans ; Male ; Prognosis ; Puberty, Precocious/diagnosis ; Puberty, Precocious/etiology ; Puberty, Precocious/therapy
    Language English
    Publishing date 2018-01-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20171214-04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1347: Show issues Location:
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  10. Article: A Rationale for Mineralocorticoid Supplementation in Classic Congenital Adrenal Hyperplasia

    Speiser, Phyllis W.

    Hormone Research in Paediatrics

    2015  Volume 83, Issue 6, Page(s) 422–423

    Institution Division of Pediatric Endocrinology, Cohen Children's Medical Center of New York, Hofstra-North Shore LIJ School of Medicine, Lake Success, N.Y., USA
    Language English
    Publishing date 2015-04-25
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Commentary
    ZDB-ID 2537278-6
    ISSN 1663-2826 ; 1663-2818
    ISSN (online) 1663-2826
    ISSN 1663-2818
    DOI 10.1159/000375531
    Database Karger publisher's database

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