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  1. Article ; Online: A future treatment horizon for migraine?

    Hay, Debbie L

    The Lancet. Neurology

    2024  Volume 23, Issue 3, Page(s) 226–227

    MeSH term(s) Humans ; Migraine Disorders/drug therapy ; Forecasting
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(24)00032-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
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  2. Book: The calcitonin gene-related peptide family

    Hay, Debbie L.

    form, function and future perspectives

    2010  

    Author's details Debbie L. Hay ... (ed.)
    Language English
    Size VIII, 236 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016107162
    ISBN 978-90-481-2908-9 ; 9789048129096 ; 90-481-2908-7 ; 9048129095
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 5277 order for loan Magazin

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  3. Article ; Online: Comment on Yoo et al. Amylin Protein Expression in the Rat Brain and Neuro-2a Cells.

    Rees, Tayla A / Hay, Debbie L / Walker, Christopher S

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: We read with great interest the recent article by Yoo and colleagues [ ... ]. ...

    Abstract We read with great interest the recent article by Yoo and colleagues [...].
    MeSH term(s) Animals ; Rats ; Islet Amyloid Polypeptide ; Neurology ; Peptide Hormones ; Brain
    Chemical Substances Islet Amyloid Polypeptide ; Peptide Hormones
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.

    Russo, Andrew F / Hay, Debbie L

    Physiological reviews

    2022  Volume 103, Issue 2, Page(s) 1565–1644

    Abstract: Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory neurons as well as in other cell types, such as motor neurons and neuroendocrine ...

    Abstract Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory neurons as well as in other cell types, such as motor neurons and neuroendocrine cells. CGRP acts via at least two G protein-coupled receptors that form unusual complexes with receptor activity-modifying proteins. These are the CGRP receptor and the AMY
    MeSH term(s) Humans ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Gene-Related Peptide/therapeutic use ; Receptors, Calcitonin Gene-Related Peptide/metabolism ; Migraine Disorders/drug therapy ; Migraine Disorders/metabolism ; Central Nervous System/metabolism ; Motor Neurons
    Chemical Substances Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Receptors, Calcitonin Gene-Related Peptide
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00059.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond.

    Garelja, Michael L / Hay, Debbie L

    Headache

    2022  Volume 62, Issue 9, Page(s) 1093–1104

    Abstract: Objective: To summarize the pharmacology of the calcitonin peptide family of receptors and explore their relationship to migraine and current migraine therapies.: Background: Therapeutics that dampen calcitonin gene-related peptide (CGRP) signaling ... ...

    Abstract Objective: To summarize the pharmacology of the calcitonin peptide family of receptors and explore their relationship to migraine and current migraine therapies.
    Background: Therapeutics that dampen calcitonin gene-related peptide (CGRP) signaling are now in clinical use to prevent or treat migraine. However, CGRP belongs to a broader peptide family, including the peptides amylin and adrenomedullin. Receptors for this family are complex, displaying overlapping pharmacologic profiles. Despite the focus on CGRP and the CGRP receptor in migraine research, recent evidence implicates related peptides and receptors in migraine.
    Methods: This narrative review summarizes literature encompassing the current pharmacologic understanding of the calcitonin peptide family, and the evidence that links specific members of this family to migraine and migraine-like behaviors.
    Results: Recent work links amylin and adrenomedullin to migraine-like behavior in rodent models and migraine-like attacks in individuals with migraine. We collate novel information that suggests females may be more sensitive to amylin and CGRP in the context of migraine-like behaviors. We report that drugs designed to antagonize the canonical CGRP receptor also antagonize a second CGRP-responsive receptor and speculate as to whether this influences therapeutic efficacy. We also discuss the specificity of current drugs with regards to CGRP isoforms and how this may influence therapeutic profiles. Lastly, we emphasize that receptors related to, but distinct from, the canonical CGRP receptor may represent underappreciated and novel drug targets.
    Conclusion: Multiple peptides within the calcitonin family have been linked to migraine. The current focus on CGRP and its canonical receptor may be obscuring pathways to further therapeutics. Drug discovery schemes that take a wider view of the receptor family may lead to the development of new anti-migraine drugs with favorable clinical profiles. We also propose that understanding these related peptides and receptors may improve our interpretation regarding the mechanism of action of current drugs.
    MeSH term(s) Female ; Humans ; Calcitonin Gene-Related Peptide/metabolism ; Receptors, Calcitonin Gene-Related Peptide/metabolism ; Adrenomedullin/therapeutic use ; Calcitonin/therapeutic use ; Islet Amyloid Polypeptide ; Migraine Disorders/drug therapy ; Migraine Disorders/metabolism
    Chemical Substances Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Receptors, Calcitonin Gene-Related Peptide ; Adrenomedullin (148498-78-6) ; Calcitonin (9007-12-9) ; Islet Amyloid Polypeptide
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 539: Show issues Location:
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  6. Article: Editorial: Calcitonin Gene-Related Peptide: Novel Biology and Treatments.

    Brain, Susan D / Russo, Andrew F / Hay, Debbie L

    Frontiers in physiology

    2022  Volume 13, Page(s) 964568

    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.964568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Novel Genetic Variant of a Class B G Protein-Coupled Receptor Reveals a Role for Adrenomedullin in Human Fertility.

    Hay, Debbie L

    ACS pharmacology & translational science

    2018  Volume 1, Issue 2, Page(s) 138–139

    Language English
    Publishing date 2018-09-21
    Publishing country United States
    Document type Editorial
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.8b00038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Atogepant (Qulipta®) for migraine prevention.

    Hay, Debbie L / Walker, Christopher S / Harris, Paul W R

    Trends in pharmacological sciences

    2022  Volume 43, Issue 8, Page(s) 701–702

    MeSH term(s) Analgesics ; Calcitonin Gene-Related Peptide ; Calcitonin Gene-Related Peptide Receptor Antagonists ; Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Piperidines ; Pyridines ; Pyrroles ; Spiro Compounds
    Chemical Substances Analgesics ; Calcitonin Gene-Related Peptide Receptor Antagonists ; Piperidines ; Pyridines ; Pyrroles ; Spiro Compounds ; atogepant (7CRV8RR151) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2022.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1513: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 6: Show issues

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  9. Article: CGRP Receptor Biology: Is There More Than One Receptor?

    Hay, Debbie L

    Handbook of experimental pharmacology

    2018  Volume 255, Page(s) 13–22

    Abstract: Calcitonin gene-related peptide (CGRP) has many reported pharmacological actions. Can a single receptor explain all of these? This chapter outlines the molecular nature of reported CGRP binding proteins and their pharmacology. Consideration of whether ... ...

    Abstract Calcitonin gene-related peptide (CGRP) has many reported pharmacological actions. Can a single receptor explain all of these? This chapter outlines the molecular nature of reported CGRP binding proteins and their pharmacology. Consideration of whether CGRP has only one or has more receptors is important because of the key role that this peptide plays in migraine. It is widely thought that the calcitonin receptor-like receptor together with receptor activity-modifying protein 1 (RAMP1) is the only relevant receptor for CGRP. However, some closely related receptors also have high affinity for CGRP and it is still plausible that these play a role in CGRP biology, and in migraine. The calcitonin receptor/RAMP1 complex, which is currently called the AMY
    MeSH term(s) Calcitonin ; Calcitonin Receptor-Like Protein/genetics ; Humans ; Migraine Disorders ; Receptors, Calcitonin Gene-Related Peptide/genetics
    Chemical Substances Calcitonin Receptor-Like Protein ; Receptors, Calcitonin Gene-Related Peptide ; Calcitonin (9007-12-9)
    Language English
    Publishing date 2018-05-23
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2018_131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  10. Article ; Online: Amylin.

    Hay, Debbie L

    Headache

    2017  Volume 57 Suppl 2, Page(s) 89–96

    Abstract: Amylin is a 37 amino acid peptide hormone that is closely related to calcitonin gene-related peptide (CGRP). Amylin and CGRP share a receptor and are reported to have several similar biological actions. Given the important role of CGRP in migraine and ... ...

    Abstract Amylin is a 37 amino acid peptide hormone that is closely related to calcitonin gene-related peptide (CGRP). Amylin and CGRP share a receptor and are reported to have several similar biological actions. Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider potential areas of overlap between the amylin and CGRP systems. This short review provides a brief introduction to amylin biology, the use of an amylin analog to treat diabetes, and consideration of whether amylin could have any role in headache disorders. Finally, this review informs readers about the AMY
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.13077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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