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  1. Article ; Online: Life is really simple, but we insist on making it complicated. (Confucius).

    Shimosawa, Tatsuo

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 4, Page(s) 1051–1053

    MeSH term(s) Humans ; Cross-Sectional Studies ; Prevalence ; Nutrition Surveys ; Inflammation ; Hypertension
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01212-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Quality is not an act, it is a habit-Aristotle.

    Shimosawa, Tatsuo

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 5, Page(s) 1221–1226

    Abstract: To measure blood pressure precisely and make the data comparable among facilities, measurement methods and devices must be standardized. Since the Minamata Convention on Mercury, there is no metrological standard for sphygmomanometers. The current ... ...

    Abstract To measure blood pressure precisely and make the data comparable among facilities, measurement methods and devices must be standardized. Since the Minamata Convention on Mercury, there is no metrological standard for sphygmomanometers. The current validation methods recommended by non-profit organizations in Japan, the US, and European Union countries are not necessarily applicable to the clinical setting, and no protocol for daily or routine performance of quality control has been defined. In addition, recent rapid technological advances have enabled monitoring blood pressure at home with wearable devices or without a cuff by using a smartphone app. A clinically relevant validation method for this recent technology is not available. The importance of out-of-office blood pressure measurement is highlighted by guidelines for the diagnosis and treatment of hypertension, but an appropriate protocol for validating a device is required.
    MeSH term(s) Humans ; Reproducibility of Results ; Blood Pressure Determination/methods ; Blood Pressure ; Sphygmomanometers ; Hypertension
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01234-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
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  3. Article ; Online: How animal models can be utilized to find new biomarkers for cardiovascular diseases.

    Shimosawa, Tatsuo

    Clinical science (London, England : 1979)

    2023  Volume 137, Issue 6, Page(s) 527–535

    Abstract: It has been more than 60 years since the colonized genetic model of hypertension was first established. Model animals contribute greatly to the advance of understanding of the pathophysiology and development of effective therapy. In this review, the ... ...

    Abstract It has been more than 60 years since the colonized genetic model of hypertension was first established. Model animals contribute greatly to the advance of understanding of the pathophysiology and development of effective therapy. In this review, the author focuses on two points: gene-related biomarkers and the use of humanized mice to search for biomarkers. First, the author provides an overview of the history of the establishment of hypertension and salt-sensitivity model rats, as well as advances in genetic analysis of causative genes of hypertension and the theory of renal causes of salt-sensitive hypertension. The recent animal model analysis adds the notion of the importance of epigenetic alterations in addition to the genetic causes of hypertension. Both germline mutations and epigenetic analysis of congenic animal models are complementary and should carry out furtherly. Among epigenetic factors, non-coding RNA is a promising new 'liquid biopsy' which is originally applied to diagnose cancers by detecting cancer cell-derived DNA, RNA, or other molecules in a person's body fluid and now it can be applied to any pathophysiological conditions. Then, the author reviews the usefulness of humanized mice. Few studies have used such mice in cardiovascular research, but the present study highlights a study of immune-related disease and the search for biomarkers in such mice. Perspectives on using humanized mice in cardiovascular research are discussed.
    MeSH term(s) Rats ; Mice ; Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/complications ; Hypertension ; Models, Animal ; Kidney ; Genetic Markers ; Disease Models, Animal
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Do not take a chance! We do not tell fortunes.

    Shimosawa, Tatsuo

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 3, Page(s) 541–542

    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-021-00848-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Targeting Inflammation is a Double-Edged Sword. Is PDIA1 A Key?

    Shimosawa, Tatsuo

    Journal of atherosclerosis and thrombosis

    2022  Volume 29, Issue 9, Page(s) 1273–1274

    MeSH term(s) Humans ; Inflammation
    Language English
    Publishing date 2022-02-09
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Is the cut off point proper in screening of primary aldosteronism by urinary Na/K ratio. Japanese are still high in Na/K ratio.

    Shimosawa, Tatsuo

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 3, Page(s) 551

    MeSH term(s) Humans ; Hyperaldosteronism/diagnosis ; Japan ; Sodium
    Chemical Substances Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-021-00787-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: There are Doubtless Many Different Languages in the World, and None is without Meaning (1 Corinthians 14:10).

    Shimosawa, Tatsuo

    Journal of atherosclerosis and thrombosis

    2021  Volume 29, Issue 5, Page(s) 573–574

    MeSH term(s) Humans ; Language
    Language English
    Publishing date 2021-05-29
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Editorial: Endocrine consequences of sleep disorders.

    Uchima Koecklin, Karin Harumi / Shimosawa, Tatsuo / Li, Peng

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1238950

    MeSH term(s) Humans ; Endocrine System ; Sleep ; Sleep Wake Disorders/complications
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1238950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Never give up correcting your lifestyle! The beginning is always the hardest!

    Shimosawa, Tatsuo

    Hypertension research : official journal of the Japanese Society of Hypertension

    2018  Volume 41, Issue 10, Page(s) 783

    MeSH term(s) Feeding Behavior ; Life Style ; Sodium Chloride ; Sodium Chloride, Dietary
    Chemical Substances Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2018-08-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-018-0084-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
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  10. Article: Sex differences in the evaluation of proteinuria using the urine dipstick test.

    Kojima, Chiari / Umemura, Hiroshi / Shimosawa, Tatsuo / Nakayama, Tomohiro

    Frontiers in medicine

    2023  Volume 10, Page(s) 1148698

    Abstract: Background: The urine protein dipstick test is widely used, but false-positive and false-negative results may occur. This study aimed to compare the urine protein dipstick test with a urine protein quantification method.: Methods: The data were ... ...

    Abstract Background: The urine protein dipstick test is widely used, but false-positive and false-negative results may occur. This study aimed to compare the urine protein dipstick test with a urine protein quantification method.
    Methods: The data were extracted using the Abbott Diagnostic Support System, which analyzes the inspection results using multiple parameters. This study included 41,058 specimens tested using the urine dipstick test and protein creatinine ratio from patients aged ≥18 years. The proteinuria creatinine ratio was classified according to the Kidney Disease Outcomes Quality Initiative guidelines.
    Results: Urine protein on the dipstick test was negative in 15,548 samples (37.9%), trace in 6,422 samples (15.6%), and ≥1+ in 19,088 samples (46.5%). Among the trace proteinuria samples, A1 (<0.15 g/gCr), A2 (0.15-0.49 g/gCr), and A3 (≥0.5 g/gCr) category proteinuria accounted for 31.2, 44.8, and 24.0% of samples, respectively. All trace proteinuria specimens with a specific gravity of <1.010 were classified as A2 and A3 category proteinuria. In the trace proteinuria cases, women had a lower specific gravity and a higher percentage of A2 or A3 category proteinuria than men. The sensitivity in the "dipstick proteinuria" ≥ trace" group was higher than that in the "dipstick proteinuria ≥ 1+" group within the lower specific gravity group. The sensitivity in the "dipstick proteinuria ≥ 1+" group was higher for men than for women, and the sensitivity in the "dipstick proteinuria ≥ trace" group was higher than that in the "dipstick proteinuria ≥ 1+" group for women.
    Conclusion: Pathological proteinuria assessment requires caution; this study suggests that evaluating the specific gravity of urine specimens with trace proteinuria is essential. Particularly for women, the sensitivity of the urine dipstick test is low, and caution is needed even with trace specimens.
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1148698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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