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  1. Article ; Online: Adrenomedullin in COVID-19 induced endotheliitis.

    Wilson, Darius Cameron / Schefold, Joerg C / Baldirà, Jaume / Spinetti, Thibaud / Saeed, Kordo / Elke, Gunnar

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 411

    MeSH term(s) Adrenomedullin/therapeutic use ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/physiopathology ; Endothelium/virology ; Humans ; Inflammation/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/physiopathology
    Chemical Substances Adrenomedullin (148498-78-6)
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Letter
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03151-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early sepsis identification following cytoreductive surgery for peritoneal malignancy.

    Wilson, Darius Cameron / Yershov, Danylo / Kandiah, Chandrakumaran / Cortes, Nicholas / Gordon, Kirsty / Saeed, Kordo

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 112

    MeSH term(s) Aged ; Cytoreduction Surgical Procedures/methods ; Cytoreduction Surgical Procedures/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/physiopathology ; Neoplasms/surgery ; Peritoneal Neoplasms/physiopathology ; Peritoneal Neoplasms/surgery ; Sepsis/diagnosis ; Sepsis/physiopathology
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-2831-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Adrenomedullin in COVID-19 induced endotheliitis

    Darius Cameron Wilson / Joerg C. Schefold / Jaume Baldirà / Thibaud Spinetti / Kordo Saeed / Gunnar Elke

    Critical Care, Vol 24, Iss 1, Pp 1-

    2020  Volume 2

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores.

    Elke, Gunnar / Bloos, Frank / Wilson, Darius Cameron / Meybohm, Patrick

    Critical care (London, England)

    2018  Volume 22, Issue 1, Page(s) 147

    MeSH term(s) Adrenomedullin/analysis ; Adrenomedullin/blood ; Area Under Curve ; Biomarkers/analysis ; Biomarkers/blood ; Hospital Mortality ; Humans ; Multiple Organ Failure/diagnosis ; Multiple Organ Failure/mortality ; Organ Dysfunction Scores ; Peptide Fragments/analysis ; Peptide Fragments/blood ; Proportional Hazards Models ; Protein Precursors/analysis ; Protein Precursors/blood ; ROC Curve ; Sepsis/classification ; Sepsis/complications
    Chemical Substances Biomarkers ; Peptide Fragments ; Protein Precursors ; mid-regional pro-adrenomedullin, human ; Adrenomedullin (148498-78-6)
    Language English
    Publishing date 2018-06-05
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-018-2084-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Adrenomedullin in COVID-19 induced endotheliitis

    Wilson, Darius Cameron / Schefold, Joerg C. / Baldirà, Jaume / Spinetti, Thibaud / Saeed, Kordo / Elke, Gunnar

    Critical Care

    2020  Volume 24, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2041406-7
    ISSN 1364-8535
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03151-7
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Adrenomedullin in COVID-19 induced endotheliitis.

    Wilson, Darius Cameron / Schefold, Joerg C. / Baldirà, Jaume / Spinetti, Thibaud / Saeed, Kordo / Elke, Gunnar

    Wilson, Darius Cameron; Schefold, Joerg C.; Baldirà, Jaume; Spinetti, Thibaud; Saeed, Kordo; Elke, Gunnar (2020). Adrenomedullin in COVID-19 induced endotheliitis. Critical care, 24(1), p. 411. BioMed Central 10.1186/s13054-020-03151-7

    2020  

    Keywords 610 Medicine & health ; covid19
    Language English
    Publishing date 2020-07-09
    Publisher BioMed Central
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Predicting the requirement for renal replacement therapy in intensive care patients with sepsis.

    Nierhaus, Axel / Bloos, Frank / Wilson, Darius Cameron / Elke, Gunnar / Meybohm, Patrick

    Critical care (London, England)

    2018  Volume 22, Issue 1, Page(s) 201

    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Humans ; Intensive Care Units/organization & administration ; Needs Assessment ; Renal Replacement Therapy/methods ; Sepsis/complications ; Sepsis/therapy
    Language English
    Publishing date 2018-08-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-018-2135-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department.

    Rosenqvist, Mari / Wilson, Darius Cameron / Tegnér, Lena / Bengtsson-Toni, Maria / Peyman, Marjaneh / Del Castillo, Juan Gonzalez / Saeed, Kordo / Melander, Olle

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 141

    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Biomarkers/analysis ; Biomarkers/blood ; Clinical Decision-Making ; Emergency Service, Hospital/organization & administration ; Humans ; Infections/drug therapy ; Time Factors
    Chemical Substances Anti-Bacterial Agents ; Biomarkers
    Language English
    Publishing date 2019-04-25
    Publishing country England
    Document type Letter
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-019-2422-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code.

    Baldirà, Jaume / Ruiz-Rodríguez, Juan Carlos / Wilson, Darius Cameron / Ruiz-Sanmartin, Adolf / Cortes, Alejandro / Chiscano, Luis / Ferrer-Costa, Roser / Comas, Inma / Larrosa, Nieves / Fàbrega, Anna / González-López, Juan José / Ferrer, Ricard

    Annals of intensive care

    2020  Volume 10, Issue 1, Page(s) 7

    Abstract: Background: Few validated biomarker or clinical score combinations exist which can discriminate between cases of infection and other non-infectious conditions following activation of an in-hospital sepsis code, as well as provide an accurate severity ... ...

    Abstract Background: Few validated biomarker or clinical score combinations exist which can discriminate between cases of infection and other non-infectious conditions following activation of an in-hospital sepsis code, as well as provide an accurate severity assessment of the corresponding host response. This study aimed to identify suitable blood biomarker (MR-proADM, PCT, CRP and lactate) or clinical score (SOFA and APACHE II) combinations to address this unmet clinical need.
    Methods: A prospective, observational study of patients activating the Vall d'Hebron University Hospital sepsis code (ISC) within the emergency department (ED), hospital wards and intensive care unit (ICU). Area under the receiver operating characteristic (AUROC) curves, logistic and Cox regression analysis were used to assess performance.
    Results: 148 patients fulfilled the Vall d'Hebron ISC criteria, of which 130 (87.8%) were retrospectively found to have a confirmed diagnosis of infection. Both PCT and MR-proADM had a moderate-to-high performance in discriminating between infected and non-infected patients following ISC activation, although the optimal PCT cut-off varied significantly across departments. Similarly, MR-proADM and SOFA performed well in predicting 28- and 90-day mortality within the total infected patient population, as well as within patients presenting with a community-acquired infection or following a medical emergency or prior surgical procedure. Importantly, MR-proADM also showed a high association with the requirement for ICU admission after ED presentation [OR (95% CI) 8.18 (1.75-28.33)] or during treatment on the ward [OR (95% CI) 3.64 (1.43-9.29)], although the predictive performance of all biomarkers and clinical scores diminished between both settings.
    Conclusions: Results suggest that the individual use of PCT and MR-proADM might help to accurately identify patients with infection and assess the overall severity of the host response, respectively. In addition, the use of MR-proADM could accurately identify patients requiring admission onto the ICU, irrespective of whether patients presented to the ED or were undergoing treatment on the ward. Initial measurement of both biomarkers might therefore facilitate early treatment strategies following activation of an in-hospital sepsis code.
    Language English
    Publishing date 2020-01-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-020-0625-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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