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  1. Book: The renin angiotensin system and the heart

    Nicholls, M. Gary

    (Heart ; 76,3, Suppl. 3)

    1996  

    Title variant The renin-angiotensin system and the heart
    Author's details ed. by M. Gary Nicholls
    Series title Heart ; 76,3, Suppl. 3
    Collection
    Keywords Renin-Angiotensin System / physiology ; Heart Diseases / physiopathology ; Renin-Angiotensin-System ; Herz
    Subject Renin-Angiotensin-Aldosteron-System ; Renin angiotensin aldosterone system ; RAAS
    Language English
    Size 103 S. : Ill., graph. Darst.
    Publisher BMJ Publ. Group
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007370919
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui IV Zs 40 -76,3,Suppl.- verfügbar in Königswinter Königswinter

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  2. Article ; Online: James Ian Summers Robertson.

    Dominiczak, Anna / Fraser, Robert / Connell, John / Gary Nicholls, M

    Hypertension (Dallas, Tex. : 1979)

    2019  Volume 74, Issue 1, Page(s) 3–4

    MeSH term(s) Cardiology ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Physician's Role/history ; United Kingdom
    Language English
    Publishing date 2019-05-28
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.119.13195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  3. Article ; Online: Resurrecting New Zealand's public healthcare system or a charity hospital in every town?

    Nicholls, Michael Gary / Frampton, Christopher M / Bagshaw, Philip F

    Internal medicine journal

    2020  Volume 50, Issue 7, Page(s) 883–886

    Abstract: Radical market-oriented health reforms in New Zealand in the early 1990s failed to deliver key financial targets, resulted in unnecessary patient deaths, adversely affected public healthcare services, induced serious tensions between clinicians and ... ...

    Abstract Radical market-oriented health reforms in New Zealand in the early 1990s failed to deliver key financial targets, resulted in unnecessary patient deaths, adversely affected public healthcare services, induced serious tensions between clinicians and managers and encouraged a predisposition to private healthcare. A more co-operative health system was implemented in the late 1990s but remaining problems of inadequate patient access led to establishment of a charity hospital in Christchurch which, by November 2018, had registered over 18 000 patient visits. This is one indication of the need to resurrect our public healthcare system. In this paper, we discuss briefly the health reforms of the 1990s then, for discussion and debate, provide seven suggestions for how this resurrection might be achieved thereby avoiding the need for charity hospitals throughout the country.
    MeSH term(s) Charities ; Delivery of Health Care ; Health Care Reform ; Hospitals ; Humans ; New Zealand/epidemiology
    Language English
    Publishing date 2020-07-12
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.14903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  4. Article ; Online: Does the hormone "endogenous ouabain" exist in the human circulation?

    Kaaja, Risto J / Nicholls, M Gary

    BioFactors (Oxford, England)

    2018  Volume 44, Issue 3, Page(s) 219–221

    Abstract: Studies in the early 1990s suggested that a hormone identical to ouabain or an isomer of ouabain is secreted by the adrenal glands into the circulation and plays a role in the regulation of arterial pressure and cardiac and renal function. This hormone, ... ...

    Abstract Studies in the early 1990s suggested that a hormone identical to ouabain or an isomer of ouabain is secreted by the adrenal glands into the circulation and plays a role in the regulation of arterial pressure and cardiac and renal function. This hormone, known as endogenous ouabain (EO), was claimed to contribute to the pathophysiology of a number of disorders including heart failure, renal failure, pregnancy-induced, and essential hypertension. However, some research groups have been unable to confirm the presence of EO in the human circulation and the issue remains in dispute. In that the implications are of considerable importance to clinicians who, like the authors, lack biochemical expertise, it would be useful if the dispute could be addressed by disinterested scientists with long-standing and acknowledged expertise in analytical chemistry who could opine as to whether the evidence is, or is not, sufficient to state categorically that EO does (or does not) exist in the circulation in man. This brief review does not present new data but, rather, recommends that adjudication is needed regarding this important issue. © 2018 BioFactors, 44(3):219-221, 2018.
    MeSH term(s) Blood Pressure/physiology ; Cardiotonic Agents/blood ; Dissent and Disputes ; Female ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Ouabain/blood ; Pregnancy ; Quackery/ethics ; Renal Insufficiency/metabolism ; Renal Insufficiency/physiopathology ; Wedge Argument
    Chemical Substances Cardiotonic Agents ; Ouabain (5ACL011P69)
    Language English
    Publishing date 2018-03-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.1421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2473: Show issues Location:
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  5. Article ; Online: Assessment of unmet secondary elective healthcare need-itself in need of acute care in Aotearoa New Zealand.

    Bagshaw, Phil / Potter, John D / Hornblow, Andrew / Hudson, Ben / Toop, Les / Nicholls, M Gary / Frampton, Chris / Bagshaw, Sue / Gauld, Robin / Frizelle, Frank

    The New Zealand medical journal

    2023  Volume 136, Issue 1569, Page(s) 7–10

    MeSH term(s) Humans ; New Zealand ; Delivery of Health Care
    Language English
    Publishing date 2023-02-03
    Publishing country New Zealand
    Document type Editorial
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
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  6. Article ; Online: Population-wide dietary sodium restriction: a cautious view.

    Nicholls, M Gary

    Current hypertension reports

    2011  Volume 13, Issue 5, Page(s) 325–327

    Abstract: What I tell you three times is true"-Lewis Carroll. How many times have we been told that reducing dietary sodium intake will improve the health of whole populations? But is there adequate evidence to support this idea? Some recent studies have ... ...

    Abstract "What I tell you three times is true"-Lewis Carroll. How many times have we been told that reducing dietary sodium intake will improve the health of whole populations? But is there adequate evidence to support this idea? Some recent studies have indicated that caution is needed. Targeting those most likely to benefit should prevent inadvertent harm and free the rest of the population from yet another nagging plea to alter their lifestyle.
    MeSH term(s) Antihypertensive Agents/therapeutic use ; Humans ; Hypertension/prevention & control ; Renin-Angiotensin System ; Risk Factors ; Sodium Chloride, Dietary/administration & dosage
    Chemical Substances Antihypertensive Agents ; Sodium Chloride, Dietary
    Language English
    Publishing date 2011-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-011-0216-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5522: Show issues Location:
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  7. Book ; Conference proceedings: A new angiotensin-converting enzyme inhibitor

    Nicholls, M. Gary

    treatment of hypertension and congestive heart failure ; proc. of an Internat. Symp. on Enalapril, held in Sao Paulo, Brazil, on Nov. 10, 1984

    (Drugs ; 30, Suppl. 1)

    1985  

    Event/congress International Symposium on Enalapril (1984, SãoPaulo)
    Series title Drugs ; 30, Suppl. 1
    Collection
    Keywords HEART FAILURE, CONGESTIVE / DRUG THERAPY ; HYPERTENSION / DRUG THERAPY ; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
    Language English
    Size 96 S.
    Publisher ADIS Pr
    Publishing place Newton, Pa
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT002497357
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 762 -30,Suppl.1- verfügbar in Königswinter Königswinter

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  8. Article ; Online: Treating hypertension prevents heart failure.

    Nicholls, M Gary

    Current hypertension reports

    2008  Volume 10, Issue 6, Page(s) 424–425

    MeSH term(s) Antihypertensive Agents/administration & dosage ; Female ; Heart Failure/prevention & control ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Male ; Primary Prevention/methods ; Prognosis ; Sensitivity and Specificity ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2008-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-008-0079-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5522: Show issues Location:
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  9. Article: A call for screening for benign neutropenia in Arab populations.

    Denic, Srdjan / Nicholls, M Gary

    Saudi medical journal

    2011  Volume 32, Issue 7, Page(s) 738–739

    MeSH term(s) Adolescent ; Adult ; Aged ; Arabs ; Child ; Humans ; Middle Aged ; Neutropenia/diagnosis ; Young Adult
    Language English
    Publishing date 2011-07
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
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    Zs.B 2330: Show issues Location:
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    Zs.MB 6: Show issues

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  10. Article: Unilateral renal ischemia causing the hyponatremic hypertensive syndrome in children--more common than we think?

    Nicholls, M Gary

    Pediatric nephrology (Berlin, Germany)

    2006  Volume 21, Issue 7, Page(s) 887–890

    Abstract: A case report in the journal Pediatric Nephrology describes a 15-month-old girl with the syndrome of hypertension and hyponatremia (HH syndrome) due to underlying unilateral renal artery stenosis. This syndrome is typically associated with hypokalemia ... ...

    Abstract A case report in the journal Pediatric Nephrology describes a 15-month-old girl with the syndrome of hypertension and hyponatremia (HH syndrome) due to underlying unilateral renal artery stenosis. This syndrome is typically associated with hypokalemia and severe volume depletion and sometimes proteinuria, all of which, along with hypertension and hyponatremia, are usually corrected by resolution of the underlying renal ischemia. Gross and probably sudden activation of the renin-angiotensin system in response to renal ischemia is central to the pathophysiology although the cardiac atrial and B-type natriuretic peptides probably contribute also. Initial control of the severe hypertension may, in some cases, require careful volume repletion prior to introduction of blockade of the renin-angiotensin system in order to avoid first-dose hypotension, after which correction of the underlying renal ischemia is required. Whereas the syndrome has rarely been reported in children, it is possible that, as in adults, this reflects its lack of recognition by clinicians. The HH syndrome due to unilateral renal ischemia in children may be much more common than we think.
    MeSH term(s) Humans ; Hypertension, Renal/etiology ; Hyponatremia/etiology ; Infant ; Renal Artery Obstruction/complications ; Renal Artery Obstruction/pathology ; Renin-Angiotensin System/physiology ; Syndrome
    Language English
    Publishing date 2006-07
    Publishing country Germany
    Document type Editorial
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-006-0107-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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