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  1. Article ; Online: Spring Update From New ACMQ President Dan M. Westphal.

    Westphal, Dan M

    American journal of medical quality : the official journal of the American College of Medical Quality

    2021  Volume 36, Issue 3, Page(s) 208

    Language English
    Publishing date 2021-05-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1131772-3
    ISSN 1555-824X ; 1062-8606
    ISSN (online) 1555-824X
    ISSN 1062-8606
    DOI 10.1097/01.JMQ.0000751256.21182.2b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.

    Brand, Frank / Förster, Alisa / Christians, Anne / Bucher, Martin / Thomé, Carina M / Raab, Marc S / Westphal, Manfred / Pietsch, Torsten / von Deimling, Andreas / Reifenberger, Guido / Claus, Peter / Hentschel, Bettina / Weller, Michael / Weber, Ruthild G

    Acta neuropathologica

    2019  Volume 139, Issue 1, Page(s) 175–192

    Abstract: ... migration. During the cell cycle, focadhesin levels peaked in G2/M phase and influenced time-dependent G2/M ... accelerating G2/M phase progression. ...

    Abstract In search of novel genes associated with glioma pathogenesis, we have previously shown frequent deletions of the KIAA1797/FOCAD gene in malignant gliomas, and a tumor suppressor function of the encoded focadhesin impacting proliferation and migration of glioma cells in vitro and in vivo. Here, we examined an association of reduced FOCAD gene copy number with overall survival of patients with astrocytic gliomas, and addressed the molecular mechanisms that govern the suppressive effect of focadhesin on glioma growth. FOCAD loss was associated with inferior outcome in patients with isocitrate dehydrogenase 1 or 2 (IDH)-mutant astrocytic gliomas of WHO grades II-IV. Multivariate analysis considering age at diagnosis as well as IDH mutation, MGMT promoter methylation, and CDKN2A/B homozygous deletion status confirmed reduced FOCAD gene copy number as a prognostic factor for overall survival. Using a yeast two-hybrid screen and pull-down assays, tubulin beta-6 and other tubulin family members were identified as novel focadhesin-interacting partners. Tubulins and focadhesin co-localized to centrosomes where focadhesin was enriched in proximity to centrioles. Focadhesin was recruited to microtubules via its interaction partner SLAIN motif family member 2 and reduced microtubule assembly rates, possibly explaining the focadhesin-dependent decrease in cell migration. During the cell cycle, focadhesin levels peaked in G2/M phase and influenced time-dependent G2/M progression potentially via polo like kinase 1 phosphorylation, providing a possible explanation for focadhesin-dependent cell growth reduction. We conclude that FOCAD loss may promote biological aggressiveness and worsen clinical outcome of diffuse astrocytic gliomas by enhancing microtubule assembly and accelerating G2/M phase progression.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Astrocytoma/genetics ; Astrocytoma/mortality ; Astrocytoma/pathology ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Cell Division/genetics ; Female ; G2 Phase/genetics ; Humans ; Male ; Microtubules/genetics ; Middle Aged ; Sequence Deletion ; Tumor Suppressor Proteins/genetics ; Young Adult
    Chemical Substances FOCAD protein, human ; Tumor Suppressor Proteins
    Language English
    Publishing date 2019-08-31
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-019-02067-z
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  3. Book ; Online ; E-Book: Die Nachhaltigkeit von Hanf

    Westphal, Jonas Michael Wilhelm

    ein Überblick über Produkt und Nutzung in der Wirtschaft

    (Essentials ; Springer eBook collection)

    2022  

    Abstract: ... l auch in Deutschland realisieren könnte. Der Inhalt Die Pflanze Cannabis Sativa L. Der nachhaltige Nutzen von Han ...

    Author's details Jonas Michael Wilhelm Westphal
    Series title Essentials
    Springer eBook collection
    Abstract Einleitung – Worum es geht -- Nachhaltigkeit -- Kulturpflanze Hanf -- UN- Ziele (SDG) einer Nachhaltigen Entwicklung -- Was ist zu tun?.

    Die Cannabispflanze könnte als Nutzhanf besser als bisher gedacht dazu beitragen, die Ziele des UN-Nachhaltigkeits-Reports, der sog. Agenda 2030 und deren 17 SDGs (Sustainable Development Goals), zu erreichen. Unter dem Gesundheitsaspekt steht ihre medizinische Verwendung im Vordergrund, doch wird sie auch in kosmetischen Produkten und in Nahrungsangeboten für Mensch und Tier eingesetzt. Im Rahmen der zunehmenden Klimakrise hilft Nutzhanf vor allem bei der Bewältigung des CO2 Problems: in der Landwirtschaft durch Bindung des CO2 ähnlich wie bei der Aufforstung, in der Industrie als recyclebarer Rohstoff-Ersatz etwa als Plastik-Ersatz, bei der Kleidung, in der Technik oder im Bauwesen. Momentan zeigen die immensen Preise und die hohe Nachfrage leider ein anderes Bild, vom Bürger, der möchte, aber nicht kann oder darf, von Bauern, die immense bürokratische Hürden zu überwinden haben, bis hin zu einer Industrie, die durch komplexe Regeln und Gesetze abgeschreckt wird zu investieren. Das essential zeigt, wie man dieses Potential auch in Deutschland realisieren könnte. Der Inhalt Die Pflanze Cannabis Sativa L. Der nachhaltige Nutzen von Hanf Die möglichen Folgen wirtschaftlicher Nutzung Die vier Grundbedingungen für eine Legalisierung Der Autor Jonas M. Westphal hat bereits während seines Logistik-Studiums Vorträge über die Sinnhaftigkeit der Legalisierung von Cannabis in Deutschland und Europa gehalten. Durch die geweckte Neugierde an der Pflanze Cannabis Sativa L. vernetzte er sich mit dem pensionierten Cannabis-Experten Prof. Stephan Quensel von der Universität Bremen, Autor von „Das Elend der Suchtprävention“, der auch das Geleitwort schrieb.
    Keywords Economics ; Industries ; Sustainability ; Cannabis ; Hanf ; Nachhaltigkeit ; Kreislaufwirtschaft ; Legalisierug ; Sustainable Development Goals ; Co2-Reduktion ; Prof. Stephan Quensel ; Phytosanierung ; Hanf Ökologie ; Hanf Ökonomie ; Hanf Textilien ; Hanf Beton ; Hanf Dämmung ; Hanf urban Mining
    Language German
    Size 1 Online-Ressource (XIII, 69 Seiten)
    Publisher Springer Fachmedien Wiesbaden
    Publishing place Wiesbaden
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer ; Zugriff für angemeldete ZB MED-Nutzer und -Nutzerinnen
    HBZ-ID HT021722238
    ISBN 978-3-658-39335-9 ; 9783658393342 ; 3-658-39335-1 ; 3658393343
    DOI 10.1007/978-3-658-39335-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online ; Thesis: Radon als Tracer in der Luftqualitätsüberwachung

    Westphal, Michael

    (Tharandter Klimaprotokolle ; 24)

    2019  

    Author's details Michael Westphal ; Gutachter: Christian Bernhofer, Jörg Matschullat, Gerald Spindler
    Series title Tharandter Klimaprotokolle ; 24
    Collection
    Keywords Radon ; Meteorologie ; Luftreinhaltung ; Luftverschmutzung ; Stickstoffdioxid ; Feinstaub ; air pollution ; meteorology ; monitoring ; nitrogen dioxide ; particulate matter
    Subject code 630
    Language German
    Size 1 Online-Ressource
    Publisher Sächsische Landesbibliothek – Staats- und Universitätsbibliothek Dresden
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Dresden, Technische Universität Dresden, 2018
    Note Open Access
    Remark Elektronischer Volltext
    HBZ-ID HT021473270
    ISBN 9783867805902 ; 3867805903
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: Commentary on the Article of M. N. Pamir, S. Peker, S. Özgen, T. Kılıç, U. Türe, M. M. Özek: Anterior Transcallosal Approach to the Colloid Cysts of the Third Ventricle: Case Series and Review of the Literature

    Westphal, M.

    Zentralblatt für Neurochirurgie

    2004  Volume 65, Issue 03, Page(s) 116–116

    Language English
    Publishing date 2004-08-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2443459-0
    ISSN 1438-9746 ; 0044-4251 ; 1868-4904
    ISSN (online) 1438-9746
    ISSN 0044-4251 ; 1868-4904
    DOI 10.1055/s-2004-820312
    Database Thieme publisher's database

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  6. Article: Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo.

    Westphal, Sabine / Lügering, Andreas / von Wedel, Julia / von Eiff, Christof / Maaser, Christian / Spahn, Thomas / Heusipp, Gerhard / Schmidt, M Alexander / Herbst, Hermann / Williams, Ifor R / Domschke, Wolfram / Kucharzik, Torsten

    The American journal of pathology

    2008  Volume 172, Issue 3, Page(s) 671–680

    Abstract: M cells, specialized cells within Peyer's patches (PPs), are reduced in number in chemokine ... receptor 6 (CCR6)-deficient mice. The pathogenic microorganism Yersinia enterocolitica exploits M cells ... as an in vivo model to determine M-cell function. After oral challenge with Y. enterocolitica, control mice ...

    Abstract M cells, specialized cells within Peyer's patches (PPs), are reduced in number in chemokine receptor 6 (CCR6)-deficient mice. The pathogenic microorganism Yersinia enterocolitica exploits M cells for the purpose of mucosal tissue invasion exclusively through PPs. The aim of this study was to evaluate the course of yersiniosis in CCR6-deficient mice and to investigate whether these mice might be used as an in vivo model to determine M-cell function. After oral challenge with Y. enterocolitica, control mice suffered from lethal septic infection whereas CCR6-deficient mice showed very limited symptoms of infection. Immunohistochemical analysis demonstrated PP invasion by Y. enterocolitica in control mice whereas no bacteria could be found in CCR6-deficient mice. In addition, a significant induction of proinflammatory cytokines could be found in control mice whereas proinflammatory cytokine levels in CCR6-deficient mice remained unchanged. In contrast, intraperitoneal infection resulted in severe systemic yersiniosis in both mouse groups. Abrogated oral Y. enterocolitica infection in CCR6-deficient mice demonstrates the importance of CCR6 expression in the physiological and pathological immune responses generated within PPs by influencing M-cell differentiation, underscoring the important role of M cells in the process of microbial uptake. CCR6-deficient mice may therefore represent a suitable model for the study of M-cell function in vivo.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Citrobacter rodentium ; Colitis/microbiology ; Enterobacteriaceae Infections/genetics ; Enterobacteriaceae Infections/pathology ; Immunity, Innate/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Peyer's Patches/abnormalities ; Peyer's Patches/cytology ; Peyer's Patches/physiology ; Receptors, CCR6/genetics ; Spleen/microbiology ; Spleen/pathology ; Yersinia Infections/genetics ; Yersinia Infections/immunology ; Yersinia Infections/pathology ; Yersinia enterocolitica
    Chemical Substances CCR6 protein, mouse ; Receptors, CCR6
    Language English
    Publishing date 2008-02-07
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.2353/ajpath.2008.070393
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  7. Article: Absence of CCR6 inhibits CD4+ regulatory T-cell development and M-cell formation inside Peyer's patches.

    Lügering, Andreas / Floer, Martin / Westphal, Sabine / Maaser, Christian / Spahn, Thomas W / Schmidt, M Alexander / Domschke, Wolfram / Williams, Ifor R / Kucharzik, Torsten

    The American journal of pathology

    2005  Volume 166, Issue 6, Page(s) 1647–1654

    Abstract: ... of UEA-1+ cells inside the FAE showed reduced M-cell numbers in CCR6-deficient mice. These results ... for the formation of M cells. ...

    Abstract The chemokine Mip3alpha is specifically expressed by the follicle-associated epithelia (FAE) covering intestinal Peyer's patches (PPs) and is the only known chemokine ligand for the chemokine receptor CCR6. Although CCR6-deficient mice are known to have a perturbed intestinal immune system, little is known about the specific impact of this interaction for Peyer's patch formation. To elucidate the effect of Mip3alpha on PP lymphocyte development, we used a CCR6/enhanced green fluorescent protein (EGFP) knock-in mouse model and analyzed lymphocyte development by immunohistochemistry and flow cytometry. PPs of CCR6-/- mice were significantly size-reduced with a proportional loss of B cells and T cells, whereas T-cell subsets were disturbed with a decreased CD4/CD8 ratio paralleled with a loss of regulatory CD4+ CD45Rb(low) T cells. The analysis of cytokine production by CCR6-expressing cells could demonstrate that CCR6 is involved in the regulation of cytokine secretion such as interleukin-12 by dendritic cells. Quantification of UEA-1+ cells inside the FAE showed reduced M-cell numbers in CCR6-deficient mice. These results suggest that the interaction of CCR6 with its ligand Mip3alpha is important for immune responses generated inside the PPs, particularly for the generation of regulatory CD4+ T cells residing inside PPs and for the formation of M cells.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; Cell Movement/immunology ; Cytokines/biosynthesis ; Cytokines/immunology ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells ; Flow Cytometry ; Green Fluorescent Proteins ; Immunohistochemistry ; Mice ; Mice, Knockout ; Microscopy, Electron, Transmission ; Peyer's Patches/cytology ; Peyer's Patches/immunology ; Peyer's Patches/ultrastructure ; Receptors, CCR6 ; Receptors, Chemokine/deficiency ; Receptors, Chemokine/immunology ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology
    Chemical Substances CCR6 protein, mouse ; Cytokines ; Receptors, CCR6 ; Receptors, Chemokine ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2005-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/S0002-9440(10)62475-3
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  8. Article ; Online: Announcing Exciting New Developments at ACMQ.

    Westphal, Dan M

    American journal of medical quality : the official journal of the American College of Medical Quality

    2022  Volume 37, Issue 2, Page(s) 189

    Language English
    Publishing date 2022-03-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1131772-3
    ISSN 1555-824X ; 1062-8606
    ISSN (online) 1555-824X
    ISSN 1062-8606
    DOI 10.1097/JMQ.0000000000000043
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  9. Article ; Online: What's New at ACMQ for 2022?

    Westphal, Dan M

    American journal of medical quality : the official journal of the American College of Medical Quality

    2022  Volume 37, Issue 1, Page(s) 93

    Language English
    Publishing date 2022-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1131772-3
    ISSN 1555-824X ; 1062-8606
    ISSN (online) 1555-824X
    ISSN 1062-8606
    DOI 10.1097/JMQ.0000000000000031
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  10. Article ; Online: Thank You for Joining Us for "Care After Covid".

    Westphal, Dan M

    American journal of medical quality : the official journal of the American College of Medical Quality

    2022  Volume 37, Issue 6, Page(s) 560

    MeSH term(s) Humans ; COVID-19 ; Congresses as Topic
    Language English
    Publishing date 2022-10-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1131772-3
    ISSN 1555-824X ; 1062-8606
    ISSN (online) 1555-824X
    ISSN 1062-8606
    DOI 10.1097/JMQ.0000000000000082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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