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Article ; Online: Yang et al. Reply.

Yang, Zhen-Qian / Shao, Zeng-Kai / Chen, Hua-Zhou / Mao, Xin-Rui / Ma, Ren-Min

2021 Volume 127, Issue 20, Page(s) 209402

Language	English
Publishing date	2021-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.209402
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Article ; Online: Restricted Phase Space Thermodynamics of Einstein-Power-Yang-Mills AdS Black Hole.

Du, Yun-Zhi / Li, Huai-Fan / Zhang, Yang / Zhou, Xiang-Nan / Zhao, Jun-Xin

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 4

Abstract: We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context ... of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated. ...

Abstract	We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context of the gauge-gravity duality. Under this framework, Newton's gravitational constant and the cosmological constant are varied in the system. We rewrite the thermodynamic first law in a more extended form containing both the pressure and the central charge of the dual conformal field theory, i.e., the restricted phase transition formula. A novel phenomena arises: the dual quantity of pressure is the effective volume, not the geometric one. That leads to a new behavior of the Van de Waals-like phase transition for this system with the fixed central charge: the supercritical phase transition. From the Ehrenfest's scheme perspective, we check out the second-order phase transition of the EPYM AdS black hole. Furthermore the effect of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated.
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25040687
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Article ; Online: MicroRNA-411-3p motivates methotrexate's cellular uptake and cytotoxicity via targeting Yin-yang 1 in leukemia cells.

Sun, HuiJing / Zhou, ShuGuang / Yang, ZhouSheng / Meng, MingYu / Dai, Yan / Li, XinYe / Chen, XiaoYu

Acta biochimica Polonica

2023 Volume 70, Issue 3, Page(s) 721–727

Abstract: ... uptake and cytotoxicity in acute lymphoblastic leukaemia (ALL) CEM-C1 cells by targeting Yin-yang 1 (YY1 ...

Abstract	This study aimed to figure out how microRNA (miR)-411-3p's impacts on methotrexate (MTX)'s cellular uptake and cytotoxicity in acute lymphoblastic leukaemia (ALL) CEM-C1 cells by targeting Yin-yang 1 (YY1). miR-411-3p and YY1 were detected by RT-qPCR or Western blot. Intracellular MTX concentration was measured by enzyme-linked immunosorbent assay. Cell viability and apoptosis were evaluated by CCK-8, clonal formation assay, and flow cytometry. Verification of miR-411-3p and YY1's targeting link was manifested. It came out that miR-411-3p mimic or si-YY1 elevated intracellular MTX, MTX-induced cytotoxicity and apoptosis rate in CEM-C1. However, the inverse results were noticed in cells introduced with miR-411-3p inhibitor or oe-YY1. Meanwhile, it was found that cell relative luciferase activity was reduced after co-transfection of miR-411-3p mimic with YY1-WT, indicating that miR-411-3p targeted YY1. Elevation of YY1 could turn around elevating miR-411-3p's impacts on MTX's cellular uptake and cytotoxicity in CEM-C1 cells. These findings convey that miR-411-3p motivated MTX's cellular uptake and cytotoxic impacts via targeting YY1 in leukemia cells. This study is helpful for learning about the mechanisms underlying MTX responses in ALL patients.
MeSH term(s)	Humans ; Methotrexate/pharmacology ; Yin-Yang ; Biological Transport ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; MicroRNAs/genetics
Chemical Substances	Methotrexate (YL5FZ2Y5U1) ; MicroRNAs ; MIRN411 microRNA, human
Language	English
Publishing date	2023-09-19
Publishing country	Poland
Document type	Journal Article
ZDB-ID	595762-x
ISSN	1734-154X ; 0001-527X
ISSN (online)	1734-154X
ISSN	0001-527X
DOI	10.18388/abp.2020_6242
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Article ; Online: Yin Yang 1 facilitates the activation, inflammation, and extracellular matrix deposition of hepatic stellate cells in hepatic fibrosis.

Fu, Xiao / Luo, Xin / Xiao, Ping / Guo, Ninghong

Pathology international

2024 Volume 74, Issue 4, Page(s) 197–209

Abstract: ... This study investigates the regulatory mechanisms of Yin Yang 1 (YY1) in hepatic fibrosis. Our data reveal ...

Abstract	Chronic hepatic diseases often involve fibrosis as a pivotal factor in their progression. This study investigates the regulatory mechanisms of Yin Yang 1 (YY1) in hepatic fibrosis. Our data reveal that YY1 binds to the prolyl hydroxylase domain 1 (PHD1) promoter. Rats treated with carbon tetrachloride (CCl
MeSH term(s)	Humans ; Rats ; Animals ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/pharmacology ; Transforming Growth Factor beta1/therapeutic use ; Proto-Oncogene Proteins c-akt ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/pharmacology ; Phosphatidylinositol 3-Kinases/therapeutic use ; Yin-Yang ; Liver Cirrhosis/metabolism ; Extracellular Matrix/metabolism ; Inflammation/metabolism ; Carbon Tetrachloride
Chemical Substances	Transforming Growth Factor beta1 ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Carbon Tetrachloride (CL2T97X0V0)
Language	English
Publishing date	2024-02-14
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.13410
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Article: Yin Yang 1 expression predicts a favourable survival in diffuse large B-cell lymphoma.

Xue, Tian / Lin, Jia-Xin / He, Ya-Qi / Li, Ji-Wei / Liu, Ze-Bing / Jia, Yi-Jun / Zhou, Xiao-Yan / Li, Xiao-Qiu / Yu, Bao-Hua

Heliyon

2024 Volume 10, Issue 2, Page(s) e24376

Abstract: Aims: Yin Yang 1 (YY1) is a multifunctional transcription factor that plays an important role ...

Abstract	Aims: Yin Yang 1 (YY1) is a multifunctional transcription factor that plays an important role in tumour development and progression, while its clinical significance in diffuse large B-cell lymphoma (DLBCL) remains largely unexplored. This study aimed to investigate the expression and clinical implications of YY1 in DLBCL. Methods: YY1 expression in 198 cases of DLBCL was determined using immunohistochemistry. The correlation between YY1 expression and clinicopathological parameters as well as the overall survival (OS) and progression-free survival (PFS) of patients was analyzed. Results: YY1 protein expression was observed in 121 out of 198 (61.1 %) DLBCL cases. YY1 expression was significantly more frequent in cases of the GCB subgroup than in the non-GCB subgroup ( Conclusions: YY1 was frequently expressed in DLBCL, especially in those of GCB phenotype and with MYC/BCL2-DE. As an independent prognostic factor, YY1 expression could predict a favourable outcome in DLBCL. In addition, a complex regulatory mechanism might be involved in the interactions between YY1 and MYC, pAKT as well as CXCR4 in DLBCL, which warrants further investigation.
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24376
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Article ; Online: Integrated untargeted and targeted testicular metabolomics to reveal the regulated mechanism of Gushudan on the hypothalamic-pituitary-gonadal axis of kidney-yang-deficiency-syndrome rats.

Lou, Yanwei / Liang, Qinghua / Xin, Ling / Ren, Mengxin / Hang, Qian / Qin, Feng / Xiong, Zhili

Biomedical chromatography : BMC

2024 , Page(s) e5872

Abstract: ... yang-deficiency-syndrome (KYDS). The preventive effect of Gushudan on KYDS has been reported, but its regulatory ...

Abstract	Modern studies have shown that neuroendocrine disorders caused by the dysfunction of the hypothalamic-pituitary-gonadal (HPG) axis are one of the important pathogenetic mechanisms of kidney-yang-deficiency-syndrome (KYDS). The preventive effect of Gushudan on KYDS has been reported, but its regulatory mechanisms on the HPG axis have not been elucidated. In this study, we developed an integrated untargeted and targeted metabolomics analysis strategy to investigate the regulatory mechanism of Gushudan on the HPG axis in rats with KYDS. In untargeted metabolomics, we screened 14 potential biomarkers such as glycine, lysine, and glycerol that were significantly associated with the HPG axis. To explore the effect of changes in the levels of potential biomarkers on KYDS, all of them were quantified in targeted metabolomics. With the quantitative results, correlations between potential biomarkers and testosterone, a functional indicator of the HPG axis, were explored. The results showed that oxidative stress, inflammatory response, and energy depletion, induced by metabolic disorders in rats, were responsible for the decrease in testosterone levels. Gushudan improves metabolic disorders and restores testosterone levels, thus restoring HPG axis dysfunction. This finding elucidates the special metabolic characteristics of KYDS and the therapeutic mechanism of Gushudan from a new perspective.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5872
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Article ; Online: The Yin-Yang roles of protease-activated receptors in inflammatory signalling and diseases.

Zhuo, Xin / Wu, Yue / Fu, Xiujuan / Liang, Xiaoyu / Xiang, Yuxin / Li, Jianbin / Mao, Canquan / Jiang, Yuhong

The FEBS journal

2022 Volume 289, Issue 14, Page(s) 4000–4020

Abstract: ... circulatory, urinary and immune systems. Importantly, there are the Yin-Yang effects, comprising anti- and pro ...

Abstract	Inflammatory diseases have become increasingly prevalent throughout the world. Coronavirus disease 2019 (COVID-19), which has recently become pandemic, also exhibits hyperinflammation and cytokine release syndrome. To address inflammation-related diseases, numerous molecular targets have been explored in preclinical studies and clinical trials. Among them, the protease-activated receptors (PARs) that belong to G protein-coupled receptors are one of the most popular classes of drug targets, participating in inflammatory signalling and diseases. PARs activation can trigger downstream intracellular signalling to modulate a variety of inflammatory responses in multiple systems, including nervous, respiratory, digestive, circulatory, urinary and immune systems. Importantly, there are the Yin-Yang effects, comprising anti- and pro-inflammatory roles, of PARs activation in different types of inflammations, and these are context-dependent. Alternatively, it was recently revealed that PARs not only modulate inflammatory-related tumour progression, but also participate in inflammatory cytokine release related to COVID-19 via direct interaction with severe acute respiratory syndrome coronavirus 2 protein, suggesting that PARs also participate in other diseases via inflammatory responses. In this review, we renew and discuss the findings of PARs as molecular targets for treating inflammatory diseases, highlighting the novel roles of PARs and facilitating a better understanding of their designated values in the specific inflammatory environment.
MeSH term(s)	COVID-19/drug therapy ; Humans ; Inflammation ; Receptors, Proteinase-Activated/metabolism ; Signal Transduction/physiology
Chemical Substances	Receptors, Proteinase-Activated
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16406
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Article: Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study.

Zhang, Ming-Liang / Zhao, Xu / Li, Wei-Xia / Wang, Xiao-Yan / Niu, Ming / Zhang, Hui / Chen, Yu-Long / Kong, De-Xin / Gao, Yuan / Guo, Yu-Ming / Bai, Zhao-Fang / Zhao, Yan-Ling / Tang, Jin-Fa / Xiao, Xiao-He

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 102

Abstract: ... traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang: Aim of the study: Liver ... to investigate the differential responses to BGZ in Yang: Materials and methods: The corresponding ... animal models of Yang: Results: The level changes of liver organ index, alanine aminotransferase (ALT), and ...

Abstract	Ethnopharmacological relevance: Psoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang Aim of the study: Liver injury caused by TCM is a rare but potentially serious adverse drug reaction, and the identification of predisposed individuals for drug-induced liver injury (DILI) remains challenging. The study aimed to investigate the differential responses to BGZ in Yang Materials and methods: The corresponding animal models of Yang Results: The level changes of liver organ index, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), suggested that BGZ has liver-protective and liver-damaging effects on Yang Conclusions: Yin
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00793-x
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Article ; Online: Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats.

Zhan, Xin / Xiao, Yangxin / Jian, Qipan / Dong, Yan / Ke, Chang / Zhou, Zhongshi / Liu, Yanju / Tu, Jiyuan

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 2, Page(s) 117205

Abstract: Ethnopharmacological relevance: Spleen Yang Deficiency Syndrome (SYDS), which is a syndrome ...

Abstract	Ethnopharmacological relevance: Spleen Yang Deficiency Syndrome (SYDS), which is a syndrome commonly treated with Traditional Chinese Medicine (TCM), manifests as overall metabolic dysfunction caused mainly by digestive system disorders. Atractylodes lancea (Thunb.) DC. (AL) is a widely used traditional herb with the efficacy of eliminate dampness and strengthen the spleen, Atractylodes oil (AO) is a medicinal component of AL and can be used to treat various gastrointestinal disorders. However, its effects on SYDS and underlying mechanisms have not been clarified to date. Aim of the study: The present study aimed to investigate the efficacy of AO in the improvement of the symptoms of SYDS in rat and the underlying mechanism by integrating transcriptomics, and metabolomics. Materials and methods: The SYDS rats induced by reserpine were treated with AO. The protective effect of AO on SYDS rats was evaluated by serum biochemical detection, histopathological analyses. Enzyme-linked immunosorbent assay (ELISA), colorimetric assay and immunofluorescence (IF) were performed to determine the levels of relevant indicators of mitochondrial function and energy metabolism in the liver. Liver metabolites and transcript levels were assessed by non-targeted metabolomics and transcriptomics to analyze potential molecular mechanisms and targets. The expression of the corresponding proteins was verified using Western blotting. Results: AO not only regulated the digestion, absorption function and oxidative stress status of SYDS rats, but also improved mitochondrial function and alleviated energy metabolism disorders in SYDS rats. Metabolomic and transcriptomic analyses demonstrated that AO regulation is mainly exerted in amino acid metabolism, unsaturated fatty acid metabolism, TCA cycle as well as PPAR and AMPK signaling pathways. In addition, The AMPK signaling pathway was verified and AO promoted AMPK phosphorylation and the expression of SIRT1, PGC-1α, and PPARα in SYDS rats. Conclusions: The therapeutic effect of AO on SYDS is potentially attributable to activation of the AMPK/SIRT1/PGC-1α signaling pathway, which enhances transport and regulation of energy metabolism.
MeSH term(s)	Rats ; Animals ; Yang Deficiency/drug therapy ; Atractylodes/chemistry ; Sirtuin 1/metabolism ; AMP-Activated Protein Kinases/metabolism ; Transcriptome ; Splenic Diseases/drug therapy
Chemical Substances	Sirtuin 1 (EC 3.5.1.-) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2023-09-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117205
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Article ; Online: Integrated UHPLC-MS untargeted metabolomics and gut microbe metabolism pathway-targeted metabolomics to reveal the prevention mechanism of Gushudan on kidney-yang-deficiency-syndrome rats.

Xin, Ling / Ren, Mengxin / Lou, Yanwei / Yin, Huawen / Qin, Feng / Xiong, Zhili

Journal of pharmaceutical and biomedical analysis

2024 Volume 242, Page(s) 116062

Abstract: ... yang-deficiency-syndrome (KYDS) and its regulation on gut microbe metabolism still need to be further ...

Abstract	Gushudan (GSD) was a traditional Chinese prescription with the remarkable effect of kidney-tonifying and bone-strengthening. However, the potential prevention mechanisms of the GSD on kidney-yang-deficiency-syndrome (KYDS) and its regulation on gut microbe metabolism still need to be further systematically investigated. This study established untargeted urinary metabolomics based on RP/HILIC-UHPLC-Q-Orbitrap HRMS and combined with multivariate statistical analysis to discover differential metabolites and key metabolic pathways. And the gut microbe metabolism pathway-targeted metabolomic based on HILIC-UHPLC-MS/MS was developed and validated to simultaneously determine 15 gut microbe-mediated metabolites in urine samples from the control group (CON), KYDS model group (MOD), GSD-treatment group (GSD) and positive group (POS). The results showed that a total of 36 differential metabolites were discovered in untargeted metabolomics. These differential metabolites included proline, cytosine, butyric acid and nicotinic acid, which were primarily involved in the gut microbe metabolism, amino acid metabolism, energy metabolism and nucleotide metabolism. And GSD played a role in preventing KYDS by regulating these metabolic pathways. The targeted metabolomics found that the levels of 10 gut microbe-mediated metabolites had significant differences in different groups. Among them, compared with the CON group, the levels of lysine, tryptophan, phenylacetylglycine and hippuric acid were increased in the MOD group, while the levels of threonine, leucine, dimethylamine, trimethylamine, succinic acid and butyric acid were decreased, which verified the disorders of gut microbe metabolism in the KYDS rats and GSD had a significant regulatory effect on this disorder. As well as by comparing analysis, it was found that the experimental results were consistent with previous metabolomics and microbiomics of fecal samples. Therefore, this integrated strategy of untargeted and targeted metabolomics not only elucidated the potential prevention mechanism of GSD on KYDS, but also provided a scientific basis for GSD preventing KYDS via the "gut-kidney" axis.
MeSH term(s)	Rats ; Animals ; Tandem Mass Spectrometry ; Chromatography, High Pressure Liquid/methods ; Butyric Acid ; Gastrointestinal Microbiome ; Metabolomics/methods ; Drugs, Chinese Herbal/pharmacology ; Yang Deficiency/metabolism ; Kidney/metabolism ; Biomarkers/metabolism
Chemical Substances	gushudan ; Butyric Acid (107-92-6) ; Drugs, Chinese Herbal ; Biomarkers
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.116062
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