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Article ; Online: Cadmium and zinc accumulation and tolerance in two Egyptian cultivars (S53 and V120) of

Sorour, Ahmed A / Badr, Reem / Mahmoud, Nermen / Abdel-Latif, Amani

International journal of phytoremediation

2024 , Page(s) 1–12

Abstract: One of the most important oil crops in the world, sunflower ( ...

Abstract	One of the most important oil crops in the world, sunflower (
Language	English
Publishing date	2024-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2055357-2
ISSN	1549-7879 ; 1522-6514
ISSN (online)	1549-7879
ISSN	1522-6514
DOI	10.1080/15226514.2024.2343842
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Article ; Online: Lysophosphatidic Acid-Mediated Inflammation at the Heart of Heart Failure.

Chaudhary, Rajesh / Suhan, Tahra / Tarhuni, Mahmud W / Abdel-Latif, Ahmed

Current cardiology reports

2024 Volume 26, Issue 3, Page(s) 113–120

Abstract: Purpose of review: The primary aim of this review is to provide an in-depth examination of the role bioactive lipids-namely lysophosphatidic acid (LPA) and ceramides-play in inflammation-mediated cardiac remodeling during heart failure. With the global ... ...

Abstract	Purpose of review: The primary aim of this review is to provide an in-depth examination of the role bioactive lipids-namely lysophosphatidic acid (LPA) and ceramides-play in inflammation-mediated cardiac remodeling during heart failure. With the global prevalence of heart failure on the rise, it is critical to understand the underlying molecular mechanisms contributing to its pathogenesis. Traditional studies have emphasized factors such as oxidative stress and neurohormonal activation, but emerging research has shed light on bioactive lipids as central mediators in heart failure pathology. By elucidating these intricacies, this review aims to: Bridge the gap between basic research and clinical practice by highlighting clinically relevant pathways contributing to the pathogenesis and prognosis of heart failure. Provide a foundation for the development of targeted therapies that could mitigate the effects of LPA and ceramides on heart failure. Serve as a comprehensive resource for clinicians and researchers interested in the molecular biology of heart failure, aiding in better diagnostic and therapeutic decisions. Recent findings: Recent findings have shed light on the central role of bioactive lipids, specifically lysophosphatidic acid (LPA) and ceramides, in heart failure pathology. Traditional studies have emphasized factors such as hypoxia-mediated cardiomyocyte loss and neurohormonal activation in the development of heart failure. Emerging research has elucidated the intricacies of bioactive lipid-mediated inflammation in cardiac remodeling and the development of heart failure. Studies have shown that LPA and ceramides contribute to the pathogenesis of heart failure by promoting inflammation, fibrosis, and apoptosis in cardiac cells. Additionally, recent studies have identified potential targeted therapies that could mitigate the effects of bioactive lipids on heart failure, including LPA receptor antagonists and ceramide synthase inhibitors. These recent findings provide a promising avenue for the development of targeted therapies that could improve the diagnosis and treatment of heart failure. In this review, we highlight the pivotal role of inflammation induced by bioactive lipid signaling and its influence on the pathogenesis of heart failure. By critically assessing the existing literature, we provide a comprehensive resource for clinicians and researchers interested in the molecular mechanisms of heart failure. Our review aims to bridge the gap between basic research and clinical practice by providing actionable insights and a foundation for the development of targeted therapies that could mitigate the effects of bioactive lipids on heart failure. We hope that this review will aid in better diagnostic and therapeutic decisions, further advancing our collective understanding and management of heart failure.
MeSH term(s)	Humans ; Ventricular Remodeling ; Lysophospholipids/metabolism ; Heart Failure/drug therapy ; Heart Failure/etiology ; Inflammation ; Ceramides
Chemical Substances	lysophosphatidic acid (PG6M3969SG) ; Lysophospholipids ; Ceramides
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-024-02023-8
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Article ; Online: Immune mechanisms of cardiac aging.

Goldstein, Daniel R / Abdel-Latif, Ahmed

The journal of cardiovascular aging

2023 Volume 3, Issue 2

Abstract: Advances in healthcare and improvements in living conditions have led to rising life expectancy worldwide. Aging is associated with excessive oxidative stress, a chronic inflammatory state, and limited tissue healing, all of which result in an increased ... ...

Abstract	Advances in healthcare and improvements in living conditions have led to rising life expectancy worldwide. Aging is associated with excessive oxidative stress, a chronic inflammatory state, and limited tissue healing, all of which result in an increased risk of heart failure. In fact, the prevalence of heart failure approaches 40% in the ninth decade of life, with the majority of these cases suffering from heart failure with preserved ejection fraction (HFpEF). In cardiomyocytes (CMs), age-related mitochondrial dysfunction results in disrupted calcium signaling and covalent protein-linked aggregates, which cause cardiomyocyte functional disturbances, resulting in increased stiffness and diastolic dysfunction. Importantly, aging is also associated with chronic low-grade, sterile inflammation, which alters the function of interstitial cardiac cells and leads to cardiac fibrosis. Taken together, cardiac aging is associated with cellular, structural, and functional changes in the heart that contribute to the rising prevalence of heart failure in older people.
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article
ISSN	2768-5993
ISSN (online)	2768-5993
DOI	10.20517/jca.2023.02
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Article ; Online: C-Reactive Protein Levels and Risk of Cardiovascular Diseases: A Two-Sample Bidirectional Mendelian Randomization Study.

Kuppa, Annapurna / Tripathi, Himi / Al-Darraji, Ahmed / Tarhuni, Wadea M / Abdel-Latif, Ahmed

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Elevated C-reactive protein (CRP) levels are an indicator of inflammation, a major risk factor for cardiovascular disease (CVD). However, this potential association in observational studies remains inconclusive. We performed a two-sample bidirectional ... ...

Abstract	Elevated C-reactive protein (CRP) levels are an indicator of inflammation, a major risk factor for cardiovascular disease (CVD). However, this potential association in observational studies remains inconclusive. We performed a two-sample bidirectional Mendelian randomization (MR) study using publicly available GWAS summary statistics to evaluate the relationship between CRP and CVD. Instrumental variables (IVs) were carefully selected, and multiple approaches were used to make robust conclusions. Horizontal pleiotropy and heterogeneity were evaluated using the MR-Egger intercept and Cochran's Q-test. The strength of the IVs was determined using F-statistics. The causal effect of CRP on the risk of hypertensive heart disease (HHD) was statistically significant, but we did not observe a significant causal relationship between CRP and the risk of myocardial infarction, coronary artery disease, heart failure, or atherosclerosis. Our primary analyses, after performing outlier correction using MR-PRESSO and the Multivariable MR method, revealed that IVs that increased CRP levels also increased the HHD risk. However, after excluding outlier IVs identified using PhenoScanner, the initial MR results were altered, but the sensitivity analyses remained congruent with the results from the primary analyses. We found no evidence of reverse causation between CVD and CRP. Our findings warrant updated MR studies to confirm the role of CRP as a clinical biomarker for HHD.
MeSH term(s)	Humans ; Cardiovascular Diseases/genetics ; C-Reactive Protein/genetics ; Mendelian Randomization Analysis ; Heart Diseases ; Hypertension/genetics ; Genome-Wide Association Study
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119129
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Article ; Online: Designing Efficient Metal-Free Dye-Sensitized Solar Cells: A Detailed Computational Study.

Mustafa, Fatma M / Abdel Khalek, Ahmed A / Mahboob, Abdulla Azzam / Abdel-Latif, Mahmoud K

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 17

Abstract: The modulation of molecular characteristics in metal-free organic dyes holds significant importance in dye-sensitized solar cells (DSSCs). The D-π-A molecular design, based on the furan moiety (π) in the conjugated spacer between the arylamine (D) and ... ...

Abstract	The modulation of molecular characteristics in metal-free organic dyes holds significant importance in dye-sensitized solar cells (DSSCs). The D-π-A molecular design, based on the furan moiety (π) in the conjugated spacer between the arylamine (D) and the 2-cyanoacrylic acid (A), was developed and theoretically evaluated for its potential application in DSSCs. Utilizing linear response time-dependent density functional theory (TDDFT) with the CAM-B3LYP functional, different donor and acceptor groups were characterized in terms of the electronic absorption properties of these dyes. All the studied dye sensitizers demonstrate the ability to inject electrons into the semiconductor's conduction band (TiO
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28176177
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Article: Cellular Therapy for Ischemic Heart Disease: An Update.

Peng, Hsuan / Abdel-Latif, Ahmed

Advances in experimental medicine and biology

2020 Volume 1201, Page(s) 195–213

Abstract: Ischemic heart disease (IHD), which includes heart failure (HF) induced by heart attack (myocardial infarction, MI), is a significant cause of morbidity and mortality worldwide (Benjamin, et al. Circulation 139:e56-e66, 2019). MI occurs at an alarmingly ... ...

Abstract	Ischemic heart disease (IHD), which includes heart failure (HF) induced by heart attack (myocardial infarction, MI), is a significant cause of morbidity and mortality worldwide (Benjamin, et al. Circulation 139:e56-e66, 2019). MI occurs at an alarmingly high rate in the United States (approx. One case every 40 seconds), and the failure to repair damaged myocardium is the leading cause of recurrent heart attacks, heart failure (HF), and death within 5 years of MI (Benjamin, et al. Circulation 139:e56-e66, 2019). At present, HF represents an unmet need with no approved clinical therapies to replace the damaged myocardium. As the population ages, the number of heart failure patients is projected to increase, doubling the annual cost by 2030 (Benjamin, et al. Circulation 139:e56-e66, 2019). In the past decades, stem cell therapy has become a promising strategy for cardiac regeneration. However, stem cell-based therapy yielded modest success in human clinical trials. This chapter examines the types of cells examined in cardiac therapy in the setting of IHD, with a brief introduction to ongoing research aiming at enhancing the therapeutic potential of transplanted cells.
MeSH term(s)	Cell- and Tissue-Based Therapy ; Heart ; Heart Failure/pathology ; Heart Failure/therapy ; Humans ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy ; Myocardial Ischemia/pathology ; Myocardial Ischemia/therapy ; Myocardium/pathology ; Regeneration ; Stem Cell Transplantation
Language	English
Publishing date	2020-01-03
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-31206-0_10
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Article ; Online: Efficient D-π-π-A-Type Dye Sensitizer Based on a Benzothiadiazole Moiety: A Computational Study.

Mustafa, Fatma M / Abdel-Latif, Mahmoud K / Abdel-Khalek, Ahmed A / Kühn, Oliver

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 13

Abstract: The design of highly efficient sensitizers is one of the most significant areas in dye-sensitized solar cell (DSSC) research. We studied a series of benzothiadiazole-based D-π-π-A organic dyes, putting emphasis on the influence of the donor moiety on the ...

Abstract	The design of highly efficient sensitizers is one of the most significant areas in dye-sensitized solar cell (DSSC) research. We studied a series of benzothiadiazole-based D-π-π-A organic dyes, putting emphasis on the influence of the donor moiety on the DSSC's efficiency. Using (linear-response time-dependent) density functional theory ((TD)DFT)) with the CAM-B3LYP functional, different donor groups were characterized in terms of electronic absorption spectra and key photovoltaic parameters. As a reference, a dye was considered that had a benzothiadiazole fragment linked via thiophene rings to a diphenylamine donor and a cyanoacrylic-acid acceptor. The different systems were first studied in terms of individual performance parameters, which eventually aggregated into power conversion efficiency. Only the amino-substituted species showed a modest increase, whereas the dimethylamino case showed a decrease.
MeSH term(s)	Models, Molecular ; Solar Energy ; Thiadiazoles ; Coloring Agents
Chemical Substances	benzo-1,2,3-thiadiazole (273-77-8) ; Thiadiazoles ; Coloring Agents
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28135185
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Article ; Online: Tissue distribution, placental transfer and excretion of silver nanoparticles in pregnant rats after a single oral dose.

Abdel-Halim, Khaled Y / Salim, Elsayed I / Abdel-Latif, Ahmed S / Abu-Risha, Sally E

Environmental analysis, health and toxicology

2023 Volume 38, Issue 4, Page(s) e2023023–0

Abstract: A quantitative assessment of silver nanoparticles (AgNPs) in fluids and some organs of pregnant rats as well as their fetal blood were carried out in this study. A single oral dose (1mg/kg) of AgNPs with a size range of 4-20 nm was administered to ... ...

Abstract	A quantitative assessment of silver nanoparticles (AgNPs) in fluids and some organs of pregnant rats as well as their fetal blood were carried out in this study. A single oral dose (1mg/kg) of AgNPs with a size range of 4-20 nm was administered to pregnant rats on the 19th of gestation. Five groups were euthanized after 10 min, 1, 6, 12, and 24 hr as well as the control group. Total Silver (Ag) contents were measured in bloods (maternal and fetal) and several organs using Inductive Coupled Plasma Optical Emission Spectroscopy (ICP-OES) followed by acid digestion. In maternal blood, AgNPs were found to increase time-dependently after 12 and 24 hr into 0.135 and 0.224 μg/ml, but it was slightly higher in fetal blood (0.32 and 0.31 μg/ml) after 10 min and 1 hr. In other samples: kidneys, liver, spleen, placenta, and uterus the data indicated that NPs were rapidly absorbed from the dosing site (gastrointestinal tract) as evidenced by the detection of Ag in the analyzed samples (fluids and tissues). On the other hand, the cumulative percentages of excretion level in urine was 8.25% which was higher than in feces (4.77%) after 24 hr. These findings indicate the ability of AgNPs to accumulate in pregnant rats and transfer to their fetus imposing adverse outcomes and male formation. Thus, further investigations must be followed for direct and/or indirect exposure to such NPs before decision for their practices.
Language	English
Publishing date	2023-11-14
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2671-9525
ISSN (online)	2671-9525
DOI	10.5620/eaht.2023023
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Article ; Online: Evaluation of different probiotics on growth, body composition, antioxidant capacity, and histoarchitecture of Mugil capito.

Shehata, Akram Ismael / Soliman, Ali A / Ahmed, Hamada A / Gewaily, Mahmoud S / Amer, Asem A / Shukry, Mustafa / Abdel-Latif, Hany M R

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7379

Abstract: We investigated the dietary effects of the single application of Saccharomyces cerevisiae, Lactobacillus bulgaricus, and their combination on growth, proximate composition of whole fish body, antioxidant defense, and histoarchitecture of hapa-reared ... ...

Abstract	We investigated the dietary effects of the single application of Saccharomyces cerevisiae, Lactobacillus bulgaricus, and their combination on growth, proximate composition of whole fish body, antioxidant defense, and histoarchitecture of hapa-reared Mugil capito. Healthy fish (Fish weighed = 10.30 ± 0.10 g at first) were randomly allocated into 4 equal groups, each with three replicates. These groups were designed as follows: (1) a group fed a basal diet without probiotics (control), (2) a group fed a diet containing S. cerevisiae (4 g/kg diet), (3) a group fed a diet containing L. bulgaricus (2 g/kg diet), and (4) the last group fed a diet containing a combination of both, all for a duration of 60 days. Probiotic-treated groups showed significantly better growth and nutrition utilization than the control group. Significant differences were observed in the crude fat and crude protein contents among the groups, with the combination group exhibiting the highest levels. However, there were no significant variations in ash content across all groups. The highest hepatic antioxidant capacity (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) enzyme activities) was observed in the combination group. Thiobarbituric acid reactive substance (TBARS) concentrations were decreased significantly in all probiotic groups, suggesting improved oxidative stress resilience in these groups. The histomorphological analysis of the hepatopancreatic tissues revealed well-arranged parenchyma, increased glycogen storage, and melanomacrophage centers in probiotic-treated groups, particularly the combined probiotics group. Furthermore, the probiotic supplementation improved the histoarchitecture of the intestinal villi compared to the control group. To put it briefly, combined dietary administration of these probiotics improved growth, body composition, antioxidant defenses, and hepatic and intestinal health in hapa-reared M. capito, highlighting their promising role in promoting welfare and productivity.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Saccharomyces cerevisiae/metabolism ; Probiotics/pharmacology ; Diet ; Fishes/metabolism ; Body Composition ; Animal Feed/analysis ; Dietary Supplements/analysis
Chemical Substances	Antioxidants
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57489-x
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Article ; Online: Potential impacts of climate change on renewable energy in Egypt.

Hassaan, Mahmoud Adel / Abdrabo, Mohamed Abdel Karim Aly / Hussein, Hadeer Ahmed / Ghanem, Azza Abdallah Abdelhamid / Abdel-Latif, Hany

Environmental monitoring and assessment

2024 Volume 196, Issue 3, Page(s) 268

Abstract: The need for renewable energy sources is recently necessitated by attaining sustainability and climate change mitigation. Accordingly, the use of renewable energy sources has been growing rapidly during the last two decades. Yet, the potentials of ... ...

Abstract	The need for renewable energy sources is recently necessitated by attaining sustainability and climate change mitigation. Accordingly, the use of renewable energy sources has been growing rapidly during the last two decades. Yet, the potentials of renewable energy sources are generally influenced by several climatic factors that either determine the source of energy such as wind speed in the case of wind power or affect the performance of system such as the reduction in solar PV power production due to temperature increase. This highlights the need for assessing climate change impacts on renewable energy sources in the future to ensure their reliability and sustainability.This paper is intended to assess impacts of climate change on wind and solar potential energy in Egypt by the year 2065 under RCP 8.5 scenario. For this purpose, a GIS-based methodology of three main steps was applied. The results revealed that solar energy potential in Egypt is expected to be relatively less vulnerable to climate change compared to wind energy. In this respect, it was found that while wind energy potential was estimated to range ± 12%. By the year 2065 under RCP 8.5 scenario, PV module power is expected to decrease by about 1.3% on average. Such assessment can assist in developing more sustainable and flexible renewable energy policy in Egypt.
MeSH term(s)	Climate Change ; Egypt ; Reproducibility of Results ; Environmental Monitoring ; Renewable Energy ; Wind
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-024-12428-1
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