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Article ; Online: Effects of P

Mauro, Annunziata / Berardinelli, Paolo / Russo, Valentina / Bernabò, Nicola / Martelli, Alessandra / Nardinocchi, Delia / Di Giacinto, Oriana / Turriani, Maura / Barboni, Barbara

International journal of molecular sciences

2021 Volume 22, Issue 24

Abstract: ... angiogenesis, the role exerted by the switch on of Progesterone (P ...

Abstract	The development of an adequate blood vessel network is crucial for the accomplishment of ovarian follicle growth and ovulation, which is necessary to support the proliferative and endocrine functions of the follicular cells. Although the Vascular Endothelial Growth Factor (VEGF) through gonadotropins guides ovarian angiogenesis, the role exerted by the switch on of Progesterone (P
MeSH term(s)	Animals ; Female ; Gonadotropins/metabolism ; Granulosa Cells/drug effects ; Granulosa Cells/metabolism ; Humans ; Mifepristone/pharmacology ; Ovarian Follicle/drug effects ; Ovarian Follicle/metabolism ; Ovary/drug effects ; Ovary/metabolism ; Progesterone/metabolism ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Signal Transduction/drug effects ; Swine ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Gonadotropins ; Vascular Endothelial Growth Factor A ; Mifepristone (320T6RNW1F) ; Progesterone (4G7DS2Q64Y) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2021-12-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222413520
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spunti di riflessione sul webinar COVID-19 di E&P.

Faustini, Annunziata

Epidemiologia e prevenzione

2021 Volume 45, Issue 1-2, Page(s) 3–4

Title translation	Food for thoughts on E&P webinar about COVID-19.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Education, Distance ; Humans ; Italy/epidemiology
Language	Italian
Publishing date	2021-04-21
Publishing country	Italy
Document type	Letter
ZDB-ID	1038112-0
ISSN	1120-9763
ISSN	1120-9763
DOI	10.19191/EP21.1-2.P003.025
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Zs.A 2748: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 265: Show issues

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Article ; Online: Negative Solvatochromism in a N-Linked p-Pyridiniumcalix[4]arene Derivative.

Iuliano, Veronica / Talotta, Carmen / Gaeta, Carmine / Soriente, Annunziata / De Rosa, Margherita / Geremia, Silvano / Hickey, Neal / Mennucci, Benedetta / Neri, Placido

Organic letters

2019 Volume 21, Issue 8, Page(s) 2704–2707

Abstract: ... of a N-linked p-pyridiniumcalix[4]arenediol derivative 1. In the solid state, 1 forms a dimeric assembly ...

Abstract	In this paper, we report the synthesis, structural characterization, and solvatochromic properties of a N-linked p-pyridiniumcalix[4]arenediol derivative 1. In the solid state, 1 forms a dimeric assembly stabilized by a network of weak H-bonding interactions involving acetonitrile solvent molecules. In solution, 1 shows a peculiar negative solvatochromism which was rationalized with the aid of TD-DFT calculations. The species responsible for this phenomenon is the monodeprotonated betainic form of 1 which is easily formed at pH close to neutrality.
Language	English
Publishing date	2019-04-02
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.9b00683
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Article ; Online: Exploiting the p-Bromodienone Route for the Formation and Trapping of Calixarene Oxenium Cations with Enamine Nucleophiles.

Soriente, Annunziata / De Rosa, Margherita / La Manna, Pellegrino / Talotta, Carmen / Gaeta, Carmine / Spinella, Aldo / Neri, Placido

The Journal of organic chemistry

2018 Volume 83, Issue 11, Page(s) 5947–5953

Abstract: This study shows that calixarene p-bromodienone derivatives can act as precursors for the formation ... of oxenium cations, which can be trapped with enamine C-nucleophiles. When calixarene p-bromodienones were ...

Abstract	This study shows that calixarene p-bromodienone derivatives can act as precursors for the formation of oxenium cations, which can be trapped with enamine C-nucleophiles. When calixarene p-bromodienones were treated with enamines, in the presence of AgClO
Language	English
Publishing date	2018-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.8b00431
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Article: Negative Solvatochromism in a N-Linked p-Pyridiniumcalix[4]arene Derivative

Iuliano, Veronica / Carmen Talotta / Carmine Gaeta / Annunziata Soriente / Margherita De Rosa / Silvano Geremia / Neal Hickey / Benedetta Mennucci / Placido Neri

Organic letters. 2019 Apr. 02, v. 21, no. 8

2019

Abstract: ... of a N-linked p-pyridiniumcalix[4]arenediol derivative 1. In the solid state, 1 forms a dimeric assembly ...

Abstract	In this paper, we report the synthesis, structural characterization, and solvatochromic properties of a N-linked p-pyridiniumcalix[4]arenediol derivative 1. In the solid state, 1 forms a dimeric assembly stabilized by a network of weak H-bonding interactions involving acetonitrile solvent molecules. In solution, 1 shows a peculiar negative solvatochromism which was rationalized with the aid of TD-DFT calculations. The species responsible for this phenomenon is the monodeprotonated betainic form of 1 which is easily formed at pH close to neutrality.
Keywords	acetonitrile ; aromatic hydrocarbons ; chemical reactions ; chemical structure ; hydrogen bonding ; pH ; solvents
Language	English
Dates of publication	2019-0402
Size	p. 2704-2707.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.9b00683
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nucleophilic Functionalization of the Calix[6]arene Para- and Meta-Position via p-Bromodienone Route.

De Rosa, Margherita / Soriente, Annunziata / Concilio, Gerardo / Talotta, Carmen / Gaeta, Carmine / Neri, Placido

The Journal of organic chemistry

2015 Volume 80, Issue 14, Page(s) 7295–7300

Abstract: It is here demonstrated that the p-bromodienone route, previously reported for calix[4]arenes, is ... nucleophiles can be introduced at the calix[6]arene exo rim. In addition, the reaction of a calix[6]arene p ...

Abstract	It is here demonstrated that the p-bromodienone route, previously reported for calix[4]arenes, is also effective for the functionalization of the calix[6]arene macrocycle. Thus, alcoholic O-nucleophiles can be introduced at the calix[6]arene exo rim. In addition, the reaction of a calix[6]arene p-bromodienone derivative with an actived aromatic substrate, such as resorcinol, led to the first example of a meta-functionalized, inherently chiral calix[6]arene derivative.
Language	English
Publishing date	2015-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.5b00978
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Article ; Online: Effects of P 4 Antagonist RU486 on VEGF and Its Receptors’ Signaling during the In Vivo Transition from the Preovulatory to Periovulatory Phase of Ovarian Follicles

Annunziata Mauro / Paolo Berardinelli / Valentina Russo / Nicola Bernabò / Alessandra Martelli / Delia Nardinocchi / Oriana Di Giacinto / Maura Turriani / Barbara Barboni

International Journal of Molecular Sciences, Vol 22, Iss 13520, p

2021 Volume 13520

Abstract: ... angiogenesis, the role exerted by the switch on of Progesterone (P 4 ) during the periovulatory phase remains ... out in presence or absence of P 4 receptor antagonist RU486. Spatio-temporal expression profiles ... administration of P 4 antagonist RU486 inhibits follicular VEGF receptors’ signaling mainly acting on the theca ...

Abstract	The development of an adequate blood vessel network is crucial for the accomplishment of ovarian follicle growth and ovulation, which is necessary to support the proliferative and endocrine functions of the follicular cells. Although the Vascular Endothelial Growth Factor (VEGF) through gonadotropins guides ovarian angiogenesis, the role exerted by the switch on of Progesterone (P 4 ) during the periovulatory phase remains to be clarified. The present research aimed to investigate in vivo VEGF-mediated mechanisms by inducing the development of periovulatory follicles using a pharmacologically validated synchronization treatment carried out in presence or absence of P 4 receptor antagonist RU486. Spatio-temporal expression profiles of VEGF, FLT1, and FLK1 receptors and the two major MAPK/ERKs and PI3K/AKT downstream pathways were analyzed on granulosa and on theca compartment. For the first time, the results demonstrated that in vivo administration of P 4 antagonist RU486 inhibits follicular VEGF receptors’ signaling mainly acting on the theca layer by downregulating the activation of ERKs and AKTs. Under the effect of RU486, periovulatory follicles’ microarchitecture did not move towards the periovulatory stage. The present evidence provides new insights on P 4 in vivo biological effects in driving vascular and tissue remodeling during the periovulatory phase.
Keywords	gonadotropins ; progesterone ; signal transduction ; ERKs ; AKT ; ovary ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 18F-fluorodeoxyglucose positron emission tomographic scan in solid-type p-stage-I pulmonary adenocarcinomas: what can produce false-negative results?

Lococo, Filippo / Galeone, Carla / Formisano, Debora / Bellafiore, Salvatore / Filice, Angelina / Annunziata, Tartaglione / Cesario, Alfredo / Rapicetta, Cristian / Fioroni, Federica / Ricchetti, Tommaso / Paci, Massimiliano

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2016 Volume 51, Issue 4, Page(s) 667–673

Abstract: ... of the 255 patients with p-stage-1 non-small-cell lung cancer observed and treated (surgically ... criteria] of 94 consecutive solid-type p-stage-1 PAs. Univariable and multivariable logistic analyses were ... interquartile range (IQR) 2.8-10.3]. Higher SUVmax values ( P < 0.001) were observed in those PAs larger than 2 ...

Abstract	Objective: False-negative (FN) uptake of 18F-fluorodeoxyglucose (FDG) can be divided into those cases related to technological limitations of positron emission tomography (PET) and those related to inherent properties of neoplasms. Our goal was to clarify possible factors causing FN PET results in patients with solid-type pulmonary adenocarcinomas (PAs). Methods: From January 2007 to December 2014, of the 255 patients with p-stage-1 non-small-cell lung cancer observed and treated (surgically) in our institution, we retrospectively reviewed the PET/computed tomography (CT) records, the clinical information, the preoperative thin-section CT images, and the pathological features [classified by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) subtyping criteria] of 94 consecutive solid-type p-stage-1 PAs. Univariable and multivariable logistic analyses were used to identify and weigh the independent predictors of the PET findings using the following variables: body weight, blood glucose level, tumour size, tumour location, and histological classification. Results: There were 58 men and 36 women (mean age = 68.7 ± 8.9 years, range 42-85). Considering the maximum standardized uptake value (SUVmax) ≥ 2.5 as a 'PET-positive' result, 77 lesions (81.9%) proved PET positive and 17 lesions (18.1%), PET negative (with SUVmax < 2.5). Overall, the median SUVmax value was 5.7 [interquartile range (IQR) 2.8-10.3]. Higher SUVmax values ( P < 0.001) were observed in those PAs larger than 2 cm in their major axis (median SUVmax = 9.0; IQR 4.6-14.6); in PAs < 2 cm, the median SUVmax was 4.1; IQR 2.2-5.9. When clustering the cohort in two histological classes (class A, colloid/mucinous/lepidic versus class B, micropapillary/solid/acinar/papillary), the radiometabolic patterns were significantly different (median SUVmax = 2.8; IQR 1.7-4.9 in class A vs median = 7.4 IQR 4.5-13.9 in class B, P < 0.001). Significant PET FN rates were reported in (i) PAs measuring < 2 cm in their major axis (27.9%), (ii) lesions located in the lower zones of the lung (31.0%), and (iii) class A tumours (37.5%). In the multivariable logistic analysis, histological type (IASLC/ATS/ERS aggregated clusters) proved to be the only independent relevant factor for determining whether PET results were negative or positive (OR:7.23, 95% CI: 2.05-25.43, P = 0.002). Conclusions: The IASLC/ATS/ERS pattern significantly influences FDG uptake in solid-type p-stage-1 PAs. The fact that colloid/mucinous/lepidic adenocarcinomas have a notable tendency to produce negative findings on PET scans warrants particular attention.
MeSH term(s)	Adenocarcinoma/blood ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adenocarcinoma of Lung ; Adult ; Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Body Weight ; False Negative Reactions ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms/blood ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals ; Retrospective Studies
Chemical Substances	Blood Glucose ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2016-11-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezw394
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Zs.A 2303: Show issues

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Article: Florilegio del XIIo Convegno Nazionale S.I.P.O. Società Italiana di Psiconcologia "La riabilitazione in oncologia: integrazione di saperi e tecniche".

Annunziata, Maria Antonietta

Giornale italiano di medicina del lavoro ed ergonomia

2012 Volume 34, Issue 2 Suppl B, Page(s) B5–6

Title translation	Anthology of the XIIth National Conference S.I.P.O. Italian Society of Psycho-Oncology "Rehabilitation in oncology: integration of knowledge and techniques.".
MeSH term(s)	Affective Symptoms/etiology ; Affective Symptoms/rehabilitation ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Caregivers/psychology ; Congresses as Topic ; Evidence-Based Medicine ; Humans ; Italy ; Medical Oncology ; Meditation ; Nausea/chemically induced ; Nausea/prevention & control ; Neoplasms/drug therapy ; Neoplasms/psychology ; Neoplasms/rehabilitation ; Patient Care Team ; Sexuality ; Societies, Medical ; Stress, Psychological/etiology ; Stress, Psychological/rehabilitation ; Vomiting/chemically induced ; Vomiting/prevention & control ; Yoga
Language	Italian
Publishing date	2012-04
Publishing country	Italy
Document type	Editorial ; Introductory Journal Article
ZDB-ID	603103-1
ISSN	1592-7830 ; 0391-9889
ISSN	1592-7830 ; 0391-9889
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Article: Exploiting the p-Bromodienone Route for the Formation and Trapping of Calixarene Oxenium Cations with Enamine Nucleophiles

Soriente, Annunziata / Aldo Spinella / Carmen Talotta / Carmine Gaeta / Margherita De Rosa / Pellegrino La Manna / Placido Neri

Journal of organic chemistry. 2018 May 09, v. 83, no. 11

2018

Abstract	This study shows that calixarene p-bromodienone derivatives can act as precursors for the formation of oxenium cations, which can be trapped with enamine C-nucleophiles. When calixarene p-bromodienones were treated with enamines, in the presence of AgClO4, the lower rim-substituted C–O–C products were obtained by an electrophilic attack of the intermediate calixarene-oxenium cation with a contemporary cone-to-partial-cone inversion of the involved aromatic ring.
Keywords	aromatic compounds ; cations ; chemical reactions ; chemical structure ; enamines ; Lewis acids ; Lewis bases ; organic chemistry
Language	English
Dates of publication	2018-0509
Size	p. 5947-5953.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.8b00431
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