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  1. Article ; Online: Time to Transfer as a Quality Improvement Imperative: Implications of a Hub-and-Spoke Health System Model on the Timing of Emergency Procedures.

    Ginzberg, Sara P / Roberson, Jeffrey L / Nehemiah, Ariel / Ballester, Jacqueline M Soegaard / Warshauer, Alexander K / Wachtel, Heather / Erdman, Margaret S / Dlugosz, Katlin L / George, Lisa J / Lynn, Jenny C / Martin, Niels D / Myers, Jennifer S

    Joint Commission journal on quality and patient safety

    2023  Volume 49, Issue 10, Page(s) 539–546

    Abstract: Background: In the increasingly prevalent hub-and-spoke health system model, specialized services are centralized at a hub hospital, while spoke hospitals offer more limited services and transfer patients to the hub as needed. In one urban, academic ... ...

    Abstract Background: In the increasingly prevalent hub-and-spoke health system model, specialized services are centralized at a hub hospital, while spoke hospitals offer more limited services and transfer patients to the hub as needed. In one urban, academic health system, a community hospital without procedural capabilities was recently incorporated as a spoke. The goal of this study was to assess the timeliness of emergent procedures for patients presenting to the spoke hospital under this model.
    Methods: The authors performed a retrospective cohort study of patients transferred from the spoke hospital to the hub hospital for emergency procedures after the health system restructuring (April 2021-October 2022). The primary outcome was the proportion of patients who arrived within their goal transfer time. Secondary outcomes were time from transfer request to procedure start and whether procedure start occurred within guideline-recommended treatment time frames for ST-elevation myocardial infarction (STEMI), necrotizing soft tissue infection (NSTI), and acute limb ischemia (ALI).
    Results: A total of 335 patients were transferred for emergency procedural intervention during the study period, most commonly for interventional cardiology (23.9%), endoscopy or colonoscopy (11.0%), or bone or soft tissue debridement (10.7%). Overall, 65.7% of patients were transferred within the goal time. 23.5% of patients with STEMI met goal door-to-balloon time, and more patients with NSTI (55.6%) and ALI (100%) underwent intervention within the guideline-recommended time frame.
    Conclusion: A hub-and-spoke health system model can provide access to specialized procedures in a high-volume, resource-rich setting. However, ongoing performance improvement is required to ensure that patients with emergency conditions receive timely intervention.
    MeSH term(s) Humans ; ST Elevation Myocardial Infarction ; Retrospective Studies ; Quality Improvement ; Hospitals ; Time Factors ; Patient Transfer
    Language English
    Publishing date 2023-06-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1553-7250 ; 1070-3241 ; 1549-3741
    DOI 10.1016/j.jcjq.2023.06.008
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  2. Article ; Online: Symptomatic mucosal involvement in pachyonychia congenita: challenges in infants and young children.

    Goldberg, I / Mashiah, J / Kutz, A / Derowe, A / Warshauer, E / Schwartz, M E / Smith, F / Sprecher, E / Hansen, C D

    The British journal of dermatology

    2019  Volume 182, Issue 3, Page(s) 708–713

    Abstract: Background: Pachyonychia congenita (PC) is a rare autosomal dominant genodermatosis caused by a mutation in any one of five keratin genes (KRT6A, KRT6B, KRT6C, KRT16 or KRT17). Characteristic features of PC are painful palmoplantar keratoderma, variable ...

    Abstract Background: Pachyonychia congenita (PC) is a rare autosomal dominant genodermatosis caused by a mutation in any one of five keratin genes (KRT6A, KRT6B, KRT6C, KRT16 or KRT17). Characteristic features of PC are painful palmoplantar keratoderma, variable nail dystrophy, cysts, follicular hyperkeratosis and often oral leukokeratosis. Although oral leukokeratosis can go unnoticed, mucosal involvement of the oral cavity and upper airways can manifest with pain during feeding, hoarseness, stridor and, occasionally, life-threatening obstruction.
    Objectives: To characterize patients with PC with symptomatic mucosal involvement.
    Methods: We present a case series of nine children with PC with symptomatic mucosal involvement, all with heterozygous mutations in KRT6A. Seven patients complained of painful feeding problems. Four patients were diagnosed with failure to thrive, three of whom required a feeding tube. Simple feeding solutions were beneficial in most cases. Seven patients had laryngeal involvement and one patient died at 4 years of age from acute laryngeal obstruction.
    Conclusions: It is important for dermatologists and otolaryngologists to be aware that symptomatic mucosal involvement, and very rarely laryngeal obstruction, can occur in patients with PC. Usually simple feeding solutions may prevent complications and failure to thrive. What's already known about this topic? Pachyonychia congenita (PC) is a rare autosomal dominant genodermatosis due to a mutation in any one of five keratin genes. Symptomatic mucosal involvement is an important clinical feature of PC and appears to be more pronounced in KRT6A mutation carriers. Only leukokeratosis is frequently seen in PC and can be one of the earliest signs of disease. Laryngeal involvement is a less common feature. It might be symptomatic but usually presents as hoarseness, stridor and, occasionally, as a life-threatening respiratory distress. What does this study add? In most cases of laryngeal involvement, there is no need for any intervention. Although pain and feeding difficulties are usually attributed to the oral leukokeratosis, they can be related to a phenomenon called 'first bite syndrome' (FBS). Symptomatic mucosal involvement with feeding difficulty is important but can be managed in most cases with simple feeding solutions (e.g. softer nipple with a larger hole, thicker formula and feeding with a syringe). Linked Comment: Youssefian and Vahidnezhad. Br J Dermatol 2020; 182:536-537.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Infant ; Keratin-6/genetics ; Keratins ; Keratoderma, Palmoplantar ; Mutation ; Pachyonychia Congenita/diagnosis ; Pachyonychia Congenita/genetics
    Chemical Substances Keratin-6 ; Keratins (68238-35-7)
    Language English
    Publishing date 2019-12-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.18742
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  3. Article ; Online: Increasing the discrimination power of ancestry- and identity-informative SNP loci within the ForenSeq™ DNA Signature Prep Kit.

    King, Jonathan L / Churchill, Jennifer D / Novroski, Nicole M M / Zeng, Xiangpei / Warshauer, David H / Seah, Lay-Hong / Budowle, Bruce

    Forensic science international. Genetics

    2018  Volume 36, Page(s) 60–76

    Abstract: The use of single nucleotide polymorphisms (SNPs) in forensic genetics has been limited to challenged samples with low template and/or degraded DNA. The recent introduction of massively parallel sequencing (MPS) technologies has expanded the potential ... ...

    Abstract The use of single nucleotide polymorphisms (SNPs) in forensic genetics has been limited to challenged samples with low template and/or degraded DNA. The recent introduction of massively parallel sequencing (MPS) technologies has expanded the potential applications of these markers and increased the discrimination power of well-established loci by considering variation in the flanking regions of target loci. The ForenSeq Signature Preparation Kit contains 165 SNP amplicons for ancestry- (aiSNPs), identity- (iiSNPs), and phenotype-inference (piSNPs). In this study, 714 individuals from four major populations (African American, AFA; East Asian, ASN; US Caucasian, CAU; and Southwest US Hispanic, HIS) previously reported by Churchill et al. [Forensic Sci Int Genet. 30 (2017) 81-92; DOI: https://doi.org/10.1016/j.fsigen.2017.06.004] were assessed using STRait Razor v2s to determine the level of diversity in the flanking regions of these amplicons. The results show that nearly 70% of loci showed some level of flanking region variation with 22 iiSNPs and 8 aiSNPs categorized as microhaplotypes in this study. The heterozygosities of these microhaplotypes approached, and in one instance surpassed, those of some core STR loci. Also, the impact of the flanking region on other forensic parameters (e.g., power of exclusion and power of discrimination) was examined. Sixteen of the 94 iiSNPs had an effective allele number greater than 2.00 across the four populations. To assess what effect the flanking region information had on the ancestry inference, genotype probabilities and likelihood ratios were determined. Additionally, concordance with the ForenSeq UAS and Nextera Rapid Capture was evaluated, and patterns of heterozygote imbalance were identified. Pairwise comparison of the iiSNP diplotypes determined the probability of detecting a mixture (i.e., observing ≥ 3 haplotypes) using these loci alone was 0.9952. The improvement in random match probabilities for the full regions over the target iiSNPs was found to be significant. When combining the iiSNPs with the autosomal STRs, the combined match probabilities ranged from 6.40 × 10
    MeSH term(s) Continental Population Groups/genetics ; DNA Fingerprinting ; Forensic Genetics/instrumentation ; Forensic Genetics/methods ; Gene Frequency ; Haplotypes ; High-Throughput Nucleotide Sequencing ; Humans ; Likelihood Functions ; Microsatellite Repeats ; Polymorphism, Single Nucleotide ; Principal Component Analysis ; Sequence Analysis, DNA
    Language English
    Publishing date 2018-06-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2018.06.005
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  4. Article ; Online: A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.

    Warshauer, Jeremy T / Belk, Julia A / Chan, Alice Y / Wang, Jiaxi / Gupta, Alexander R / Shi, Quanming / Skartsis, Nikolaos / Peng, Yani / Phipps, Jonah D / Acenas, Dante / Smith, Jennifer A / Tamaki, Stanley J / Tang, Qizhi / Gardner, James M / Satpathy, Ansuman T / Anderson, Mark S

    The Journal of experimental medicine

    2021  Volume 218, Issue 8

    Abstract: Naturally occurring cases of monogenic type 1 diabetes (T1D) help establish direct mechanisms driving this complex autoimmune disease. A recently identified de novo germline gain-of-function (GOF) mutation in the transcriptional regulator STAT3 was found ...

    Abstract Naturally occurring cases of monogenic type 1 diabetes (T1D) help establish direct mechanisms driving this complex autoimmune disease. A recently identified de novo germline gain-of-function (GOF) mutation in the transcriptional regulator STAT3 was found to cause neonatal T1D. We engineered a novel knock-in mouse incorporating this highly diabetogenic human STAT3 mutation (K392R) and found that these mice recapitulated the human autoimmune diabetes phenotype. Paired single-cell TCR and RNA sequencing revealed that STAT3-GOF drives proliferation and clonal expansion of effector CD8+ cells that resist terminal exhaustion. Single-cell ATAC-seq showed that these effector T cells are epigenetically distinct and have differential chromatin architecture induced by STAT3-GOF. Analysis of islet TCR clonotypes revealed a CD8+ cell reacting against known antigen IGRP, and STAT3-GOF in an IGRP-reactive TCR transgenic model demonstrated that STAT3-GOF intrinsic to CD8+ cells is sufficient to accelerate diabetes onset. Altogether, these findings reveal a diabetogenic CD8+ T cell response that is restrained in the presence of normal STAT3 activity and drives diabetes pathogenesis.
    MeSH term(s) Animals ; Autoimmunity ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Chemotaxis/genetics ; Cross-Priming/immunology ; Cytotoxicity, Immunologic/genetics ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Disease Models, Animal ; Epigenesis, Genetic ; Gain of Function Mutation ; Heterozygote ; Humans ; Immune Tolerance/genetics ; Mice ; Mutation/genetics ; Phenotype ; STAT3 Transcription Factor/genetics ; Up-Regulation
    Chemical Substances STAT3 Transcription Factor ; STAT3 protein, human
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20210759
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  5. Article ; Online: Strengthening Public Health in Wisconsin Through the Wisconsin Clinical Laboratory Network.

    Bateman, Allen C / Bowles, Erin J / Munson, Erik / Podzorski, Raymond P / Beck, Eric T / Dern, Richard / Sterkel, Alana K / Warshauer, David M / Shult, Peter A

    Public health reports (Washington, D.C. : 1974)

    2019  Volume 134, Issue 2_suppl, Page(s) 6S–10S

    Abstract: The Wisconsin Clinical Laboratory Network (WCLN) at the University of Wisconsin-Madison is a partnership of 138 clinical and public health laboratories (as of February 2019) coordinated by the Wisconsin State Laboratory of Hygiene. This article describes ...

    Abstract The Wisconsin Clinical Laboratory Network (WCLN) at the University of Wisconsin-Madison is a partnership of 138 clinical and public health laboratories (as of February 2019) coordinated by the Wisconsin State Laboratory of Hygiene. This article describes the WCLN, its current activities, and lessons learned through this partnership. A laboratory technical advisory group, which consists of representatives from clinical laboratories, provides clinical laboratory perspective to the WCLN and fosters communication among laboratories. Activities and resources available through the WCLN include annual regional meetings, annual technical workshops, webinars, an email listserv, laboratory informational messages, in-person visits by a WCLN coordinator to clinical laboratories, and laboratory-based surveillance data and summaries distributed by the Wisconsin State Laboratory of Hygiene. One challenge to maintaining the WCLN is securing continual funding for network activities. Key lessons learned from this partnership of more than 20 years include the importance of in-person meetings, the clinical perspective of the laboratory technical advisory group, and providing activities and resources to clinical laboratories to foster sharing of data and clinical specimens for public health surveillance and outbreak response.
    MeSH term(s) Cooperative Behavior ; Humans ; Laboratories/economics ; Laboratories/organization & administration ; Organizational Case Studies ; Public Health/economics ; Public Health/standards ; Public Health Surveillance ; Public-Private Sector Partnerships ; Wisconsin
    Language English
    Publishing date 2019-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120953-x
    ISSN 1468-2877 ; 0033-3549
    ISSN (online) 1468-2877
    ISSN 0033-3549
    DOI 10.1177/0033354919837196
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  6. Article ; Online: Harmonization of Bordetella pertussis real-time PCR diagnostics in the United States in 2012.

    Williams, Margaret M / Taylor, Thomas H / Warshauer, David M / Martin, Monte D / Valley, Ann M / Tondella, M Lucia

    Journal of clinical microbiology

    2014  Volume 53, Issue 1, Page(s) 118–123

    Abstract: Real-time PCR (rt-PCR) is an important diagnostic tool for the identification of Bordetella pertussis, Bordetella holmesii, and Bordetella parapertussis. Most U.S. public health laboratories (USPHLs) target IS481, present in 218 to 238 copies in the B. ... ...

    Abstract Real-time PCR (rt-PCR) is an important diagnostic tool for the identification of Bordetella pertussis, Bordetella holmesii, and Bordetella parapertussis. Most U.S. public health laboratories (USPHLs) target IS481, present in 218 to 238 copies in the B. pertussis genome and 32 to 65 copies in B. holmesii. The CDC developed a multitarget PCR assay to differentiate B. pertussis, B. holmesii, and B. parapertussis and provided protocols and training to 19 USPHLs. The 2012 performance exercise (PE) assessed the capability of USPHLs to detect these three Bordetella species in clinical samples. Laboratories were recruited by the Wisconsin State Proficiency Testing program through the Association of Public Health Laboratories, in partnership with the CDC. Spring and fall PE panels contained 12 samples each of viable Bordetella and non-Bordetella species in saline. Fifty and 53 USPHLs participated in the spring and fall PEs, respectively, using a variety of nucleic acid extraction methods, PCR platforms, and assays. Ninety-six percent and 94% of laboratories targeted IS481 in spring and fall, respectively, in either singleplex or multiplex assays. In spring and fall, respectively, 72% and 79% of USPHLs differentiated B. pertussis and B. holmesii and 68% and 72% identified B. parapertussis. IS481 cycle threshold (CT) values for B. pertussis samples had coefficients of variation (CV) ranging from 10% to 28%. Of the USPHLs that differentiated B. pertussis and B. holmesii, sensitivity was 96% and specificity was 95% for the combined panels. The 2012 PE demonstrated increased harmonization of rt-PCR Bordetella diagnostic protocols in USPHLs compared to that of the previous survey.
    MeSH term(s) Bordetella pertussis/classification ; Bordetella pertussis/genetics ; History, 21st Century ; Humans ; Laboratory Proficiency Testing ; Real-Time Polymerase Chain Reaction/methods ; Real-Time Polymerase Chain Reaction/standards ; Reproducibility of Results ; Sensitivity and Specificity ; United States/epidemiology ; Whooping Cough/diagnosis ; Whooping Cough/epidemiology ; Whooping Cough/history ; Whooping Cough/microbiology
    Language English
    Publishing date 2014-10-29
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.02368-14
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  7. Article: Leiomyoma of the extraperitoneal round ligament: CT demonstration.

    Warshauer, D M / Mandel, S R

    Clinical imaging

    1999  Volume 23, Issue 6, Page(s) 375–376

    Abstract: We report the computed tomography (CT) description of a leiomyoma involving the extraperitional portion of the round ligament. Although unusual, such a lesion may mimic other mass lesions in this vicinity including adenopathy, endometriomas, and inguinal ...

    Abstract We report the computed tomography (CT) description of a leiomyoma involving the extraperitional portion of the round ligament. Although unusual, such a lesion may mimic other mass lesions in this vicinity including adenopathy, endometriomas, and inguinal hernias.
    MeSH term(s) Contrast Media ; Female ; Follow-Up Studies ; Humans ; Leiomyoma/diagnostic imaging ; Leiomyoma/surgery ; Middle Aged ; Peritoneal Neoplasms/diagnostic imaging ; Peritoneal Neoplasms/surgery ; Radiographic Image Enhancement/methods ; Round Ligament of Uterus/diagnostic imaging ; Round Ligament of Uterus/surgery ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Contrast Media
    Language English
    Publishing date 1999-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1028123-x
    ISSN 0899-7071
    ISSN 0899-7071
    DOI 10.1016/s0899-7071(98)00021-7
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  8. Article: Adult intussusception detected at CT or MR imaging: clinical-imaging correlation.

    Warshauer, D M / Lee, J K

    Radiology

    1999  Volume 212, Issue 3, Page(s) 853–860

    Abstract: Purpose: To determine the clinical presentation in cases of adult intussusception demonstrated at computed tomography (CT) or magnetic resonance (MR) imaging and to correlate the imaging appearance with clinical diagnosis.: Materials and methods: ... ...

    Abstract Purpose: To determine the clinical presentation in cases of adult intussusception demonstrated at computed tomography (CT) or magnetic resonance (MR) imaging and to correlate the imaging appearance with clinical diagnosis.
    Materials and methods: Retrospective review of CT and MR images and clinical records of all patients with an intussusception demonstrated on CT or MR images from January 1, 1991, through April 30, 1998.
    Results: Thirty-three patients had one or more intussusceptions demonstrated on CT (n = 30) or MR (n = 3) images. Twenty-nine patients had enteroenteric intussusceptions, and four had intussusceptions involving the colon. Ten patients (30%) had a neoplastic lead point, including all four of the intussusceptions involving the colon (benign mass, n = 3; malignant mass, n = 7). In 23 cases (70%), no neoplastic lead point was identified. A variety of causes were implicated in these cases, with 16 cases (48%) classified as idiopathic. Enteric intussusceptions in the nonneoplastic group were shorter in length (median, 4 vs 10.8 cm; P = .002), smaller in diameter (median, 3 vs 4 cm; P = .002), and less likely to be associated with obstruction (4.3% vs 50%; P = .02).
    Conclusion: Less than one-third of adult intussusceptions demonstrated at CT or MR imaging were caused by a neoplastic lead point. Almost half of adult cases in this series were idiopathic.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colonic Diseases/diagnosis ; Colonic Diseases/etiology ; Colonic Neoplasms/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Intestinal Neoplasms/diagnosis ; Intussusception/diagnosis ; Intussusception/etiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 1999-09
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiology.212.3.r99au43853
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  9. Article: Primacy among the primates: killing chimpanzees to help humans.

    Warshauer, D M

    JAMA

    1985  Volume 254, Issue 3, Page(s) 356

    MeSH term(s) Animal Experimentation ; Animals ; Ecology ; Ethics, Medical ; Humans ; Pan troglodytes ; Transplantation, Heterologous
    Language English
    Publishing date 1985-07-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
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    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
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  10. Article ; Online: Massively parallel sequencing of 68 insertion/deletion markers identifies novel microhaplotypes for utility in human identity testing.

    Wendt, Frank R / Warshauer, David H / Zeng, Xiangpei / Churchill, Jennifer D / Novroski, Nicole M M / Song, Bing / King, Jonathan L / LaRue, Bobby L / Budowle, Bruce

    Forensic science international. Genetics

    2016  Volume 25, Page(s) 198–209

    Abstract: Short tandem repeat (STR) loci are the traditional markers used for kinship, missing persons, and direct comparison human identity testing. These markers hold considerable value due to their highly polymorphic nature, amplicon size, and ability to be ... ...

    Abstract Short tandem repeat (STR) loci are the traditional markers used for kinship, missing persons, and direct comparison human identity testing. These markers hold considerable value due to their highly polymorphic nature, amplicon size, and ability to be multiplexed. However, many STRs are still too large for use in analysis of highly degraded DNA. Small bi-allelic polymorphisms, such as insertions/deletions (INDELs), may be better suited for analyzing compromised samples, and their allele size differences are amenable to analysis by capillary electrophoresis. The INDEL marker allelic states range in size from 2 to 6 base pairs, enabling small amplicon size. In addition, heterozygote balance may be increased by minimizing preferential amplification of the smaller allele, as is more common with STR markers. Multiplexing a large number of INDELs allows for generating panels with high discrimination power. The Nextera™ Rapid Capture Custom Enrichment Kit (Illumina, Inc., San Diego, CA) and massively parallel sequencing (MPS) on the Illumina MiSeq were used to sequence 68 well-characterized INDELs in four major US population groups. In addition, the STR Allele Identification Tool: Razor (STRait Razor) was used in a novel way to analyze INDEL sequences and detect adjacent single nucleotide polymorphisms (SNPs) and other polymorphisms. This application enabled the discovery of unique allelic variants, which increased the discrimination power and decreased the single-locus random match probabilities (RMPs) of 22 of these well-characterized INDELs which can be considered as microhaplotypes. These findings suggest that additional microhaplotypes containing human identification (HID) INDELs may exist elsewhere in the genome.
    MeSH term(s) Continental Population Groups/genetics ; DNA Fingerprinting/methods ; Genetic Markers ; Genetics, Population ; Haplotypes ; Heterozygote ; High-Throughput Nucleotide Sequencing ; Humans ; INDEL Mutation ; Polymorphism, Single Nucleotide
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2016-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2016.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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