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Article ; Online: Uralsaponins M-Y, antiviral triterpenoid saponins from the roots of Glycyrrhiza uralensis.

Song, Wei / Si, Longlong / Ji, Shuai / Wang, Han / Fang, Xiao-mei / Yu, Li-yan / Li, Ren-yong / Liang, Li-na / Zhou, Demin / Ye, Min

Journal of natural products

2014 Volume 77, Issue 7, Page(s) 1632–1643

Abstract: Thirteen new oleanane-type triterpenoid saponins, uralsaponins M-Y (1-13), and 15 known analogues ...

Abstract	Thirteen new oleanane-type triterpenoid saponins, uralsaponins M-Y (1-13), and 15 known analogues (14-28) were isolated from the roots of Glycyrrhiza uralensis Fisch. The structures of 1-13 were identified on the basis of extensive NMR and MS data analyses. The sugar residues were identified by gas chromatography and ion chromatography coupled with pulsed amperometric detection after hydrolysis. Saponins containing a galacturonic acid (1-3) or xylose (5) residue are reported from Glycyrrhiza species for the first time. Compounds 1, 7, 8, and 24 exhibited good inhibitory activities against the influenza virus A/WSN/33 (H1N1) in MDCK cells with IC50 values of 48.0, 42.7, 39.6, and 49.1 μM, respectively, versus 45.6 μM of the positive control oseltamivir phosphate. In addition, compounds 24 and 28 showed anti-HIV activities with IC50 values of 29.5 and 41.7 μM, respectively.
MeSH term(s)	Animals ; Anti-HIV Agents/chemistry ; Anti-HIV Agents/isolation & purification ; Anti-HIV Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Dogs ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Glycyrrhiza uralensis/chemistry ; Humans ; Influenza A Virus, H1N1 Subtype/drug effects ; Madin Darby Canine Kidney Cells ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Oleanolic Acid/analogs & derivatives ; Oleanolic Acid/chemistry ; Oleanolic Acid/isolation & purification ; Oleanolic Acid/pharmacology ; Oseltamivir/pharmacology ; Plant Roots/chemistry ; Saponins/chemistry ; Saponins/isolation & purification ; Saponins/pharmacology
Chemical Substances	Anti-HIV Agents ; Antiviral Agents ; Drugs, Chinese Herbal ; Saponins ; Oseltamivir (20O93L6F9H) ; Oleanolic Acid (6SMK8R7TGJ)
Language	English
Publishing date	2014-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np500253m
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Article: Agostic interaction in the methylidene metal dihydride complexes H2MCH2 (M=Y, Zr, Nb, Mo, Ru, Th, or U).

Roos, Björn O / Lindh, Roland / Cho, Han-Gook / Andrews, Lester

The journal of physical chemistry. A

2007 Volume 111, Issue 28, Page(s) 6420–6424

Abstract: ... onto empty or half empty orbitals of d- or f-type on the metal. No agostic interaction is expected when M=Y ... the metal atom and H(C) in the methylidene metal dihydride complexes H2MCH2, where M is a second row ... due to the formation of a three center bond CH...M, where the electrons in the CH bond are delocalized ...

Abstract	Multiconfigurational quantum chemical methods (complete active space self-consistent field (CASSCF)/second-order perturbation theory (CASPT2)) have been used to study the agostic interaction between the metal atom and H(C) in the methylidene metal dihydride complexes H2MCH2, where M is a second row transition metal or the actinide atoms Th or U. The geometry of some of these complexes is highly irregular due to the formation of a three center bond CH...M, where the electrons in the CH bond are delocalized onto empty or half empty orbitals of d- or f-type on the metal. No agostic interaction is expected when M=Y, where only a single bond with methylene can be formed, or when M=Ru, because of the lack of empty electron accepting metal valence orbitals. The largest agostic interaction is found in the Zr and U complexes.
Language	English
Publishing date	2007-07-19
Publishing country	United States
Document type	Journal Article
ISSN	1089-5639
ISSN	1089-5639
DOI	10.1021/jp071914b
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Article: Luminescence optimization with superior asymmetric ratio (red/orange) and color purity of MBO3:Eu3+@SiO2 (M = Y, Gd and Al) nano down-conversion phosphors

Rambabu, U / Han, Sang-Do

RSC advances. 2013 Jan. 3, v. 3, no. 5

2013

Abstract: ... with an R/O ratio as 6.710 and color coordinates (x = 0.6612, y = 0.3357) is optimized as a remarkable ...

Abstract	Y1−xBO3:Eux3+ (0.07 ≤ x ≤ 0.5 moles) and Y0.7−2x (Gdx, Alx)BO3:Eu3+0.3 (0.05 ≤ x ≤ 0.3 moles) powder phosphors have been synthesized by a novel co-precipitation technique followed by heat treatment. Luminescence optimization was carried out by optimizing the dopant Eu3+ concentration, substitution of Y3+ with Gd3+/Al3+ and finally with SiO2 shell coating. The inversion symmetry of Eu3+ ions were lowered with Eu3+ concentration and substitution of Y3+ with Gd3+/Al3+, respectively. It has been noted that the intensity behavior of PL peaks of Eu3+:5D0 → 7F1, 5D0 → 7F2 are not only sensitive to the inversion symmetry of Eu3+ ions, but also to the monitoring excitation wavelengths. Due to nanosize particle distribution, the optimum activator (Eu3+) concentration (30 mol%) was found to be extremely at higher level, compared to the bulk phosphors. The asymmetric ratio (red/orange) and color purity of the optimized phosphors, Y0.7BO3:Eu0.33+ (with crystallite size, D = 32 nm) and Y0.3Gd0.2Al0.2BO3:Eu3+ (D = 17 nm) were further enhanced with an SiO2 coating. Based on the systematic study, the nanophosphor Y0.7BO3:Eu0.33+@SiO2 with an R/O ratio as 6.710 and color coordinates (x = 0.6612, y = 0.3357) is optimized as a remarkable phosphor having superior features than the commercial, available literature data results.
Keywords	aluminum ; coatings ; color ; coprecipitation ; crystallites ; europium ; gadolinium ; heat treatment ; ions ; luminescence ; monitoring ; silica ; wavelengths ; yttrium
Language	English
Dates of publication	2013-0103
Size	p. 1368-1379.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c2ra21304d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Baseline of visceral fat area and decreased body weight correlate with improved pulmonary function after Roux-en-Y gastric bypass in Chinese obese patients with BMI 28-35 kg/m² and type 2 diabetes: a 6-month follow-up.

Tu, Yinfang / Yu, Haoyong / Bao, Yuqian / Zhang, Pin / Di, Jianzhong / Han, Xiaodong / Jia, Weiping

BMC endocrine disorders

2015 Volume 15, Page(s) 26

Abstract: ... examined in patients that underwent Roux-en-Y Gastric Bypass (RYGB). This study was designed to examine ... with body mass index (BMI) 28-35 kg/m(2) and type 2 diabetes (T2DM) was conducted, focusing on metabolic outcomes and ...

Abstract	Background: Associations between demographic data and pulmonary function have not been adequately examined in patients that underwent Roux-en-Y Gastric Bypass (RYGB). This study was designed to examine changes in body fat distribution and metabolic parameters after RYGB and whether these changes correlated with improved lung function. Methods: A retrospective review of 32 ethnic Chinese with obesity with body mass index (BMI) 28-35 kg/m(2) and type 2 diabetes (T2DM) was conducted, focusing on metabolic outcomes and pulmonary function 6 months after RYGB. Results: Forced expiratory volume during first second (FEV1), percentage of forced expiratory volume during first second (FEV1 [%pred]), forced vital capacity (FVC), and percentage of forced vital capacity (FVC [%pred]) all improved significantly after RYGB. These increases all were negatively correlated with decreases in body weight and visceral fat area (VFA). The improvements of FEV1, FEV1 [%pred] and FVC were also negatively correlated with baseline of body weight and VFA. Furthermore, increases in FEV1 and FVC were independently associated with baseline of VFA (β = -0.003, P = 0.000; β = -0.004, P = 0.002, respectively). Conclusions: The baseline of VFA and weight loss induced by RYGB independently correlated with improved pulmonary function in Chinese patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Body Mass Index ; China/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/surgery ; Female ; Follow-Up Studies ; Gastric Bypass/statistics & numerical data ; Humans ; Intra-Abdominal Fat/pathology ; Lung/physiopathology ; Male ; Middle Aged ; Obesity, Morbid/complications ; Obesity, Morbid/epidemiology ; Obesity, Morbid/physiopathology ; Obesity, Morbid/surgery ; Organ Size ; Respiratory Function Tests ; Retrospective Studies ; Weight Loss/physiology ; Young Adult
Language	English
Publishing date	2015-06-09
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1472-6823
ISSN (online)	1472-6823
DOI	10.1186/s12902-015-0027-0
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Article: Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells.

Lee, Sun-Ryung / Park, Jae-Han / Park, Eui Kyun / Chung, Chin Ha / Kang, Shin-Sung / Bang, Ok-Sun

Journal of cellular physiology

2005 Volume 205, Issue 2, Page(s) 270–277

Abstract: ... M phase in PC12 cells and this Akt activity is correlated with upregulation of NF-Y DNA-binding ... could override cell-growth arrest at G2/M phase and apoptosis that were induced by etoposide treatment ... cell proliferation by arresting the cells at G2/M phase. Expression of myr-Akt also led to an increase in the protein ...

Abstract	Akt is a key downstream effector of the PI3K signaling pathway and plays a role in cell growth and survival. Expression of a myristoylated constitutively active form of Akt (myr-Akt) in PC12 cells could override cell-growth arrest at G2/M phase and apoptosis that were induced by etoposide treatment. On the other hand, inactivation of Akt by expression of its dominant negative mutant form (km-Akt) inhibited cell proliferation by arresting the cells at G2/M phase. Expression of myr-Akt also led to an increase in the protein and mRNA levels of CDK1 and cyclin B1. Furthermore, EMSA data revealed that expression of myr-Akt promoted the binding of NF-Y to the consensus CCAAT promoter sequence, whereas expression of km-Akt almost completely abolished it. Moreover, the Akt activity was minimal in the cells that were arrested at G2/M phase by nocodazole treatment, but reached to a maximal level as the cells progressed to mitosis and G1 phase upon removal of the drug. Treatment with Akt inhibitors, but not with those of MEK or p70S6K, blocked the release of the cells from the nocodazole-induced G2/M arrest, further revealing that the Akt activity is required for G2/M phase transition. These results suggest that Akt facilitate cell-cycle progression at G2/M phase in PC12 cells and this Akt activity is correlated with upregulation of NF-Y DNA-binding activity and cyclin B1/CDK1 gene expression.
MeSH term(s)	Animals ; Blotting, Western ; CCAAT-Binding Factor/metabolism ; Cell Cycle/physiology ; Electrophoretic Mobility Shift Assay ; Enzyme Activation ; G2 Phase ; Mitosis ; PC12 Cells ; Precipitin Tests ; Proto-Oncogene Proteins c-akt/analysis ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Up-Regulation
Chemical Substances	CCAAT-Binding Factor ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2005-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.20395
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Book ; Online: Preliminary studies on suspected chloroquine resistance of Plasmodium falciparum in Sabah, Malaysia / by C. M. Han, Y. S. Huang

Han, C. M / Huang, Y. S / World Health Organization

1974

Abstract: Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/ ... ...

Abstract	Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/74.840, WHO/MAL/75.841-75.846, WHO/MAL/75.847 (WHO/VBC/75.515), WHO/MAL/75.848, WHO/MAL/75.849 (WHO/VBC/75.538), WHO/MAL/75.850, WHO/MAL/75.851 (WHO/VBC/75.541), WHO/MAL/75.852-75.853, WHO/MAL/75.854 (WHO/VBC/75.547), WHO/MAL/75.855 (WHO/VBC/75.569), WHO/MAL/75.856 (WHO/VBC/75.571), WHO/MAL/75.857 (WHO/VBC/75.545), WHO/MAL/75.858-75.863, WHO/MAL/76.864-76.867, WHO/MAL/76.868 (WHO/VBC/76.624), WHO/MAL/76.869-76.873, WHO/MAL/76.874 (WHO/VBC/76.633), WHO/MAL/76.875-76.882, WHO/MAL/76.883 (WHO/VBC/76.634), bound in 1 vol Summary in French p. 6 WHO/MAL/74.831 10 p. (ill., graphs, tables).
Keywords	Malaria ; Plasmodium falciparum ; Chloroquine ; Insecticide resistance ; Malaysia ; Parasitic Diseases and their Control ; prevention and control ; pharmacokinetics
Language	English
Publisher	Geneva : World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Preliminary studies on suspected chloroquine resistance of Plasmodium falciparum in Sabah, Malaysia / by C. M. Han, Y. S. Huang

Han, C. M / Huang, Y. S / World Health Organization

1974

Abstract	Documents : WHO/MAL/74.822-74.824, WHO/MAL/74.825 (WHO/VBC/74.475), WHO/MAL/74.826 (WHO/VBC/74.478), WHO/MAL/74.827 (WHO/VBC/74.486), WHO/MAL/74.828-74.829, WHO/MAL/74.830 (WHO/VBC/74.488), WHO/MAL/74.831-74.838, WHO/MAL/74.839 (WHO/VBC/74.505), WHO/MAL/74.840, WHO/MAL/75.841-75.846, WHO/MAL/75.847 (WHO/VBC/75.515), WHO/MAL/75.848, WHO/MAL/75.849 (WHO/VBC/75.538), WHO/MAL/75.850, WHO/MAL/75.851 (WHO/VBC/75.541), WHO/MAL/75.852-75.853, WHO/MAL/75.854 (WHO/VBC/75.547), WHO/MAL/75.855 (WHO/VBC/75.569), WHO/MAL/75.856 (WHO/VBC/75.571), WHO/MAL/75.857 (WHO/VBC/75.545), WHO/MAL/75.858-75.863, WHO/MAL/76.864-76.867, WHO/MAL/76.868 (WHO/VBC/76.624), WHO/MAL/76.869-76.873, WHO/MAL/76.874 (WHO/VBC/76.633), WHO/MAL/76.875-76.882, WHO/MAL/76.883 (WHO/VBC/76.634), bound in 1 vol Summary in French p. 6 WHO/MAL/74.831 10 p. (ill., graphs, tables).
Keywords	Malaria ; Plasmodium falciparum ; Chloroquine ; Insecticide Resistance ; Malaysia ; Parasitic Diseases and their Control ; prevention and control ; pharmacokinetics
Language	English
Publisher	World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Effect of pelvic peritoneum reconstruction on the prognosis of patients underwent laparoscopic low anterior resection of rectal adenocarcinoma].

Han, Y / Zhi, Q M / Kuang, Y T / Pan, Y

Zhonghua yi xue za zhi

2023 Volume 103, Issue 6, Page(s) 425–430

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Peritoneum/pathology ; Retrospective Studies ; Rectal Neoplasms/surgery ; Prognosis ; Laparoscopy/adverse effects ; Anal Canal/pathology ; Anal Canal/surgery ; Pelvic Floor/pathology ; Adenocarcinoma/surgery ; Adenocarcinoma/pathology ; Treatment Outcome
Language	Chinese
Publishing date	2023-02-09
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20221129-02528
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Article: [Using PGT to give birth to hereditary conductive deafness SYNS1 family a healthy offspring: a case report].

Fu, Y / Huang, S S / Wang, Q Q / Han, M Y / Wang, G J / Kang, D Y / Dai, P / Yuan, Y Y

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2024 Volume 59, Issue 3, Page(s) 243–248

MeSH term(s)	Humans ; Genetic Testing ; Hearing Loss, Conductive ; Deafness/genetics
Language	Chinese
Publishing date	2024-04-01
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.cn115330-20230925-00116
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Article: [Progress on the research of liver diseases in 2023].

Dou, X G / Xu, X Y / Nan, Y M / Wei, L / Han, T / Mao, Y M / Han, Y / Ren, H / Jia, J D / Zhuang, H

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2024 Volume 32, Issue 1, Page(s) 3–15

MeSH term(s)	Humans ; Liver Cirrhosis ; Liver Diseases ; Liver Neoplasms ; Carcinoma, Hepatocellular
Language	Chinese
Publishing date	2024-02-06
Publishing country	China
Document type	Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.cn501113-20240108-00014
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