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  1. Book ; Online: Metabolic Health in Normal and Abnormal Sleep

    Jun, Jonathan C. / Pamidi, Sushmita / Mokhlesi, Babak / Miranda Hoyos, Camilla

    2020  

    Keywords Medicine ; Endocrinology ; metabolism ; sleep ; sleep apnea ; obesity ; circadian
    Size 1 electronic resource (141 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230014
    ISBN 9782889637027 ; 2889637026
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Conference proceedings: Adult and pediatric sleep disordered breathing

    Mokhlesi, Babak

    virtual symposium

    (Proceedings of the American Thoracic Society ; 5,2)

    2008  

    Title variant Adult and pediatric sleep-disordered breathing
    Author's details guest ed.: Babak Mokhlesi
    Series title Proceedings of the American Thoracic Society ; 5,2
    Collection
    Language English
    Size S. 135 - 284 : Ill., graph. Darst.
    Publisher American Thoracic Society
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015442704
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Obstructive sleep apnea during REM sleep and hypertension: new findings from a clinical cohort.

    McCullough, Lindsay M / Mokhlesi, Babak

    Sleep

    2023  Volume 46, Issue 3

    MeSH term(s) Humans ; Sleep, REM ; Sleep Apnea, Obstructive/complications ; Sleep Apnea Syndromes ; Hypertension/complications
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Short sleep, sleep apnoea-associated hypoxaemic burden and kidney function: more questions than answers.

    Neborak, Julie M / Mokhlesi, Babak

    Thorax

    2021  Volume 76, Issue 7, Page(s) 638–639

    MeSH term(s) Humans ; Hypoxia ; Kidney ; Sleep ; Sleep Apnea Syndromes/complications
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2020-216618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Obstructive sleep apnea and pulmonary hypertension: the pendulum swings again.

    Yang, Jenny Z / Mokhlesi, Babak / Mesarwi, Omar A

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2022  Volume 19, Issue 2, Page(s) 209–211

    MeSH term(s) Humans ; Hypertension, Pulmonary/complications ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy ; Hypertension
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Can Long-term Treatment of Obstructive Sleep Apnea With CPAP Improve Glycemia and Prevent Type 2 Diabetes?

    Reutrakul, Sirimon / Mokhlesi, Babak

    Diabetes care

    2020  Volume 43, Issue 8, Page(s) 1681–1683

    MeSH term(s) Blood Glucose ; Cardiovascular Diseases ; Continuous Positive Airway Pressure ; Diabetes Mellitus, Type 2/complications ; Humans ; Sleep Apnea, Obstructive/therapy
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dci20-0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sleep Hypoventilation: A State-of-the-Art Overview.

    Mokhlesi, Babak

    Sleep medicine clinics

    2014  Volume 9, Issue 3, Page(s) xv–xvi

    Language English
    Publishing date 2014-10-08
    Publishing country United States
    Document type Journal Article
    ISSN 1556-4088
    ISSN (online) 1556-4088
    DOI 10.1016/j.jsmc.2014.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Impact of Sex Chromosomes in the Sexual Dimorphism of Pulmonary Arterial Hypertension.

    Predescu, Dan N / Mokhlesi, Babak / Predescu, Sanda A

    The American journal of pathology

    2022  Volume 192, Issue 4, Page(s) 582–594

    Abstract: Pulmonary arterial hypertension (PAH) is a sex-biased disease with a poorly understood female prevalence. Emerging research suggests that nonhormonal factors, such as the XX or XY sex chromosome complement and sex bias in gene expression, may also lead ... ...

    Abstract Pulmonary arterial hypertension (PAH) is a sex-biased disease with a poorly understood female prevalence. Emerging research suggests that nonhormonal factors, such as the XX or XY sex chromosome complement and sex bias in gene expression, may also lead to sex-based differences in PAH incidence, penetrance, and progression. Typically, one of females' two X chromosomes is epigenetically silenced to offer a gender-balanced gene expression. Recent data demonstrate that the long noncoding RNA X-inactive specific transcript, essential for X chromosome inactivation and dosage compensation of X-linked gene expression, shows elevated levels in female PAH lung specimens compared with controls. This molecular event leads to incomplete inactivation of the females' second X chromosome, abnormal expression of X-linked gene(s) involved in PAH pathophysiology, and a pulmonary artery endothelial cell (PAEC) proliferative phenotype. Moreover, the pathogenic proliferative p38 mitogen-activated protein kinase/ETS transcription factor ELK1 (Elk1)/cFos signaling is mechanistically linked to the sexually dimorphic proliferative response of PAECs in PAH. Apprehending the complicated relationship between long noncoding RNA X-inactive specific transcript and X-linked genes and how this relationship integrates into a sexually dimorphic proliferation of PAECs and PAH sex paradox remain challenging. We highlight herein new findings related to how the sex chromosome complement and sex-differentiated epigenetic mechanisms to control gene expression are decisive players in the sexual dimorphism of PAH. Pharmacologic interventions in the light of the newly elucidated mechanisms are discussed.
    MeSH term(s) Female ; Humans ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Artery ; RNA, Long Noncoding ; Sex Characteristics ; Sex Chromosomes/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2022.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Taking to "heart" the proposed legislation for permanent daylight saving time.

    Carter, Jason R / Knutson, Kristen L / Mokhlesi, Babak

    American journal of physiology. Heart and circulatory physiology

    2022  Volume 323, Issue 1, Page(s) H100–H102

    Abstract: In March 2022, the US Senate passed the Sunshine Protection Act that would abolish the biannual change in clocks each fall and spring and permanently adopt daylight saving time that aligns with the "spring forward" time change each March. A number of ... ...

    Abstract In March 2022, the US Senate passed the Sunshine Protection Act that would abolish the biannual change in clocks each fall and spring and permanently adopt daylight saving time that aligns with the "spring forward" time change each March. A number of scientific and medical societies have endorsed the abolishment of the biannual clock change, but oppose the permanent adoption of daylight saving time. Instead, leading organizations such as the American Academy of Sleep Medicine (AASM) and the Society for Research on Biological Rhythms (SRBR) position statements highlight peer-reviewed evidence in favor of a permanent shift to standard time. The present perspectives will summarize some of the key AASM and SRBR recommendations, with a particular focus on the potential cardiovascular implications of a legislative change that would result in a permanent switch to either standard time or daylight saving time. Collectively, although there is building scientific consensus that abolishing the biannual time change has several sleep and circadian health benefits, the preponderance of evidence is opposite to the current legislation and instead suggests a permanent switch to standard time may offer the maximum health and safety benefits. This scientific evidence should be considered as the United States House of Representatives considers the Sunshine Protection Act.
    MeSH term(s) Cardiovascular System ; Circadian Rhythm ; Heart ; Seasons ; Sleep ; Time Factors ; United States
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00218.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Adenotonsillectomy Significantly Reduces Central Apneas in Patients with a Predominantly Obstructive Sleep Apnea component.

    Judd, Ryan T / Mokhlesi, Babak / Shogan, Andrea / Baroody, Fuad M

    The Laryngoscope

    2022  Volume 133, Issue 3, Page(s) E7

    MeSH term(s) Humans ; Sleep Apnea, Central ; Sleep Apnea, Obstructive/surgery ; Sleep Apnea Syndromes ; Adenoidectomy ; Tonsillectomy
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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