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Article ; Online: Are We Making Progress in the Hunt for Biomarkers that Could Differentiate Proton Pump Inhibitor-Responsive Eosinophilic Esophagitis?

Sayej, Wael N

Journal of pediatric gastroenterology and nutrition

2021 Volume 74, Issue 2, Page(s) 173–174

MeSH term(s)	Biomarkers ; Diagnosis, Differential ; Eosinophilic Esophagitis/diagnosis ; Eosinophilic Esophagitis/drug therapy ; Humans ; Proton Pump Inhibitors
Chemical Substances	Biomarkers ; Proton Pump Inhibitors
Language	English
Publishing date	2021-10-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003348
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Zs.A 1728: Show issues

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Article ; Online: Severe Necrotizing Pancreatitis in a Pediatric Patient with COVID-19: A Case Report.

Li, Lucinda / Mostafavi, Mojdeh / Miller, John W / Hirsch, Barry / O'Connor, Stephen / Sayej, Wael N

JPGN reports

2023 Volume 4, Issue 2, Page(s) e307

Abstract: We describe a 15-year-old female diagnosed with necrotizing pancreatitis in the setting of coronavirus disease 2019 with severe complications including splenic vein and portal vein thromboses, pleural effusion requiring chest tube, acute hypoxic ... ...

Abstract	We describe a 15-year-old female diagnosed with necrotizing pancreatitis in the setting of coronavirus disease 2019 with severe complications including splenic vein and portal vein thromboses, pleural effusion requiring chest tube, acute hypoxic respiratory failure requiring noninvasive positive-pressure ventilation, and new-onset insulin-dependent diabetes mellitus, requiring over a month-long hospitalization. Following discharge, the patient experienced a prolonged loss of appetite, nausea, and extreme weight loss., During her prolonged hospitalization, she was diagnosed with necrotizing pancreatitis with walled-off collection which was ultimately treated with transgastric endoscopic ultrasound-guided drainage, multiple endoscopic necrosectomies, lumen-apposing metal stents, and double-pigtail plastic stent. Nine months after her initial presentation, patient's clinical symptoms improved, and her weight stabilized. This case highlights the importance of recognizing acute and necrotizing pancreatitis and its morbidities as complications associated with coronavirus disease 2019.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Case Reports
ISSN	2691-171X
ISSN (online)	2691-171X
DOI	10.1097/PG9.0000000000000307
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Article ; Online: Oral immunotherapy for peanut allergy induces eosinophilic esophagitis: three pediatric case reports.

Semancik, Eileen / Sayej, Wael N

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2016 Volume 27, Issue 5, Page(s) 539–541

MeSH term(s)	Administration, Oral ; Arachis/immunology ; Child ; Desensitization, Immunologic/methods ; Diet Therapy ; Endoscopy ; Eosinophilic Esophagitis/diagnosis ; Eosinophilic Esophagitis/etiology ; Esophagus/diagnostic imaging ; Esophagus/pathology ; Humans ; Male ; Peanut Hypersensitivity/complications ; Peanut Hypersensitivity/diagnosis ; Vomiting/diagnosis
Language	English
Publishing date	2016
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.12554
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Zs.A 3096: Show issues

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Article ; Online: Primary Cutaneous Follicle Center Lymphoma in a 16-Year-old boy With Crohn Disease Exposed to Infliximab and Methotrexate.

Sayej, Wael N / Isakoff, Michael S / DiGiuseppe, Joseph A / Moote, Douglas / Balarezo, Fabiola / Finck, Christine / Hyams, Jeffrey S

Journal of pediatric gastroenterology and nutrition

2020 Volume 70, Issue 2, Page(s) e49–e50

MeSH term(s)	Adolescent ; Crohn Disease/drug therapy ; Humans ; Infliximab/adverse effects ; Lymphoma, Follicular/drug therapy ; Male ; Methotrexate/adverse effects ; Skin Neoplasms
Chemical Substances	Infliximab (B72HH48FLU) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000002578
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Zs.A 1728: Show issues

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Article: Efficacy of Dairy Free Diet and 6-Food Elimination Diet as Initial Therapy for Pediatric Eosinophilic Esophagitis: A Retrospective Single-Center Study.

Wong, Jonathan / Goodine, Sue / Samela, Kate / Vance, Katherine S / Chatfield, Beth / Wang, Zhu / Sayej, Wael N

Pediatric gastroenterology, hepatology & nutrition

2020 Volume 23, Issue 1, Page(s) 79–88

Abstract: ... the inclusion criteria for initial treatment with DFD (n=102) or SFED (n=50). Response for DFD was 56.9% and ...

Abstract	Purpose: Management of eosinophilic esophagitis (EoE) varies from center to center. In this study, we evaluated the effectiveness of a dairy-free diet (DFD) and the 6-Food Elimination Diet (SFED) as initial therapies for the treatment of EoE in our practice. Methods: This was a retrospective study of children who had been treated for EoE at Connecticut Children's Medical Center, Hartford, CT, USA. Pre- and post-treatment endoscopy findings and histology results of patients treated with DFD or SFED were examined. Results: One hundred fifty-two patients (age 9.2±5.2 years, 76.3% male, 69.7% caucasian) met the inclusion criteria for initial treatment with DFD (n=102) or SFED (n=50). Response for DFD was 56.9% and for SFED was 52.0%. Response based on treatment duration (<10, 10-12, and >12 weeks) were 81.8%, 50.0%, and 55.1% for DFD, and 68.8%, 50.0%, and 40.0% for SFED. Response based on age (<6, 6-12, and >12 years) were 59.3%, 42.9%, and 67.5% for DFD, and 36.4%, 58.8%, and 72.7% for SFED. In patients treated with DFD, concomitant proton pump inhibitor (PPI) administration resulted in improved outcomes ( Conclusion: DFD and SFED are effective first line therapies for EoE. DFD should be tried first before extensive elimination diets. Concomitant therapy with PPI's may be helpful.
Language	English
Publishing date	2020-01-09
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3032413-0
ISSN	2234-8840 ; 2234-8646
ISSN (online)	2234-8840
ISSN	2234-8646
DOI	10.5223/pghn.2020.23.1.79
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Article ; Online: Expanding and characterizing esophageal epithelial cells obtained from children with eosinophilic esophagitis.

Sayej, Wael N / Foster, Christopher / Jensen, Todd / Chatfield, Sydney / Finck, Christine

Pediatric research

2018 Volume 84, Issue 2, Page(s) 306–313

Abstract: Background: The role of epithelial cells in eosinophilic esophagitis (EoE) is not well understood. In this study, our aim was to isolate, culture, and expand esophageal epithelial cells obtained from patients with or without EoE and characterize ... ...

Abstract	Background: The role of epithelial cells in eosinophilic esophagitis (EoE) is not well understood. In this study, our aim was to isolate, culture, and expand esophageal epithelial cells obtained from patients with or without EoE and characterize differences observed over time in culture. Methods: Biopsies were obtained at the time of endoscopy from children with EoE or suspected to have EoE. We established patient-derived esophageal epithelial cell (PDEEC) lines utilizing conditional reprogramming methods. We determined integrin profiles, gene expression, MHC class II expression, and reactivity to antigen stimulation. Results: The PDEECs were found to maintain their phenotype over several passages. There were differences in integrin profiles and gene expression levels in EoE-Active compared to normal controls and EoE-Remission patients. Once stimulated with antigens, PDEECs express MHC class II molecules on their surface, and when co-cultured with autologous T-cells, there is increased IL-6 and TNF-α secretion in EoE-Active patients vs. controls. Conclusion: We are able to isolate, culture, and expand esophageal epithelial cells from pediatric patients with and without EoE. Once stimulated with antigens, these cells express MHC class II molecules and behave as non-professional antigen-presenting cells. This method will help us in developing an ex vivo, individualized, patient-specific model for diagnostic testing for causative antigens.
MeSH term(s)	3T3 Cells ; Adolescent ; Animals ; Biopsy ; Child ; Child, Preschool ; Endoscopy ; Eosinophilic Esophagitis/diagnosis ; Eosinophilic Esophagitis/metabolism ; Epithelial Cells/metabolism ; Esophagus/cytology ; Gene Expression Profiling ; Histocompatibility Antigens Class II/metabolism ; Humans ; Inflammation ; Integrins/metabolism ; Mice ; T-Lymphocytes/metabolism
Chemical Substances	Histocompatibility Antigens Class II ; Integrins
Language	English
Publishing date	2018-06-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-018-0033-9
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Polyurethane scaffolds seeded with autologous cells can regenerate long esophageal gaps: An esophageal atresia treatment model.

Jensen, Todd / Wanczyk, Heather / Sharma, Ishna / Mitchell, Adam / Sayej, Wael N / Finck, Christine

Journal of pediatric surgery

2018 Volume 54, Issue 9, Page(s) 1744–1754

Abstract: Background: Pediatric patients suffering from long gap esophageal defects or injuries are in desperate need of innovative treatment options. Our study demonstrates that two different cell sources can adhere to and proliferate on a retrievable synthetic ... ...

Abstract	Background: Pediatric patients suffering from long gap esophageal defects or injuries are in desperate need of innovative treatment options. Our study demonstrates that two different cell sources can adhere to and proliferate on a retrievable synthetic scaffold. In feasibility testing of translational applicability, these cell seeded scaffolds were implanted into piglets and demonstrated esophageal regeneration. Methods: Either porcine esophageal epithelial cells or porcine amniotic fluid was obtained and cultured in 3 dimensions on a polyurethane scaffold (Biostage). The amniotic fluid was obtained prior to birth of the piglet and was a source of mesenchymal stem cells (AF-MSC). Scaffolds that had been seeded were implanted into their respective Yucatan mini-swine. The cell seeded scaffolds in the bioreactor were evaluated for cell viability, proliferation, genotypic expression, and metabolism. Feasibility studies with implantation evaluated tissue regeneration and functional recovery of the esophagus. Results: Both cell types seeded onto scaffolds in the bioreactor demonstrated viability, adherence and metabolism over time. The seeded scaffolds demonstrated increased expression of VEGF after 6 days in culture. Once implanted, endoscopy 3 weeks after surgery revealed an extruded scaffold with newly regenerated tissue. Both cell seeded scaffolds demonstrated epithelial and muscle regeneration and the piglets were able to eat and grow over time. Conclusions: Autologous esophageal epithelial cells or maternal AF-MSC can be cultured on a 3D scaffold in a bioreactor. These cells maintain viability, proliferation, and adherence over time. Implantation into piglets demonstrated esophageal regeneration with extrusion of the scaffold. This sets the stage for translational application in a neonatal model of esophageal atresia.
MeSH term(s)	Animals ; Disease Models, Animal ; Epithelial Cells/cytology ; Esophageal Atresia/surgery ; Esophagus/cytology ; Polyurethanes/therapeutic use ; Swine ; Tissue Engineering/methods ; Tissue Scaffolds ; Transplantation, Autologous/methods
Chemical Substances	Polyurethanes
Language	English
Publishing date	2018-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2018.09.024
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Zs.A 607: Show issues

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Article ; Online: Retrospective Comparison of Fluticasone Propionate and Oral Viscous Budesonide in Children With Eosinophilic Esophagitis.

Fable, Jacqueline M / Fernandez, Marina / Goodine, Susan / Lerer, Trudy / Sayej, Wael N

Journal of pediatric gastroenterology and nutrition

2017 Volume 66, Issue 1, Page(s) 26–32

Abstract: Background: Eosinophilic esophagitis (EoE) is treated with dietary modification and/or pharmacologic management with swallowed topical steroids. Swallowed fluticasone propionate (FP) and oral viscous budesonide (OVB) have proven to be effective in ... ...

Abstract	Background: Eosinophilic esophagitis (EoE) is treated with dietary modification and/or pharmacologic management with swallowed topical steroids. Swallowed fluticasone propionate (FP) and oral viscous budesonide (OVB) have proven to be effective in resolving symptoms and reversing histologic changes in children and adults with EoE. There are minimal comparative studies between the 2 agents. Objective: The aim of the study was to retrospectively compare endoscopic and histologic outcomes after FP versus OVB therapy in children with EoE in our center. Methods: We performed a retrospective chart review of subjects diagnosed with EoE at a tertiary care center between 2010 and 2015. Inclusion criteria were FP or OVB therapy for ≥8 weeks along with pre- and post-treatment endoscopic evaluation. Demographic and clinical features and endoscopic and histologic assessment were recorded for comparative analysis. Histologic response was defined as <15 eos/hpf and remission as <5 eos/hpf. Results: The study included 68 EoE patients (20 FP and 48 OVB) with a mean age of 10.6 ± 5.2 years (range 1-20 years); 81% were boys and 68% were Caucasian. No significant demographic or clinical differences were noted between the 2 study groups. Overall histologic response to topical steroids was seen in 44 of 68 (65%) patients. A significantly greater number of patients achieved histologic response with OVB (36/48, 75%) than with FP (8/20, 40%) (P = 0.0059). Mean pretreatment peak eos/hpf was 46 ± 19 in the FP group versus 45 ± 23 in the OVB group. Mean post-treatment peak eos/hpf was 20 ± 29 in the FP group versus 12 ± 16 in the OVB group (P = 0.002). There was also a significantly greater difference in the change of absolute eos/hpf from pre- to post-treatment in the OVB group (-33) versus FP (18) (P = 0.047). A greater number of OVB-treated patients without asthma had a histologic response compared to those with asthma (P = 0.031). The response to OVB was not affected by the delivery vehicle, namely sucralose (Splenda) versus Neocate Duocal. Conclusions: Our data suggest that treatment with OVB leads to better endoscopic and histologic outcomes than FP. Adherence to treatment and history of asthma are major determining factors in the response to treatments. Using Neocate Duocal as the OVB delivery vehicle is just as effective as sucralose.
MeSH term(s)	Administration, Inhalation ; Administration, Oral ; Adolescent ; Anti-Inflammatory Agents/therapeutic use ; Budesonide/therapeutic use ; Child ; Child, Preschool ; Drug Administration Schedule ; Eosinophilic Esophagitis/diagnostic imaging ; Eosinophilic Esophagitis/drug therapy ; Eosinophilic Esophagitis/pathology ; Esophagoscopy ; Female ; Fluticasone/therapeutic use ; Humans ; Infant ; Male ; Retrospective Studies ; Treatment Outcome ; Young Adult
Chemical Substances	Anti-Inflammatory Agents ; Budesonide (51333-22-3) ; Fluticasone (CUT2W21N7U)
Language	English
Publishing date	2017-03-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000001626
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Zs.A 1728: Show issues

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Article ; Online: Ulcer of the Duodenum Caused by a Pancreatic Neuroendocrine Tumor in an Adolescent.

Grossi, Victoria / Bezler, Natalie / Sayej, Wael

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2016 Volume 15, Issue 1, Page(s) A45–A46

MeSH term(s)	Adolescent ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Diagnostic Errors ; Duodenal Ulcer/etiology ; Endoscopy, Digestive System ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/secondary ; Male ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/secondary ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Tomography, X-Ray Computed ; Weight Loss
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2016-09-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2016.08.042
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Zs.A 5836: Show issues

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Article ; Online: Two Cases of Helicobacter pylori-Negative Gastric Outlet Obstruction in Children.

Patel, Raza A / Baker, Susan S / Sayej, Wael N / Baker, Robert D

Case reports in gastrointestinal medicine

2011 Volume 2011, Page(s) 749850

Abstract: Gastric outlet obstruction (GOO) in children is most commonly caused by idiopathic hypertrophic pyloric stenosis. Prior to proton pump inhibitors and H2 blockers, peptic ulcer disease (PUD) secondary to H. pylori was a cause of GOO. Both patients ... ...

Abstract	Gastric outlet obstruction (GOO) in children is most commonly caused by idiopathic hypertrophic pyloric stenosis. Prior to proton pump inhibitors and H2 blockers, peptic ulcer disease (PUD) secondary to H. pylori was a cause of GOO. Both patients presented with a history of weight loss, vomiting, and abdominal pain. Their diagnosis of PUD and GOO was made by EGD and UGI. H. pylori testing was negative for both on multiple occasions but still received H. pylori eradication therapy. Patient 1 after failing pharmaceutical management underwent surgery for definitive treatment. Patient 2 underwent six therapeutic pyloric dilations before undergoing surgery as definitive treatment. These cases suggest that GOO secondary to PUD occurs in the absence of H. pylori infection and surgical management can provide definitive therapy.
Language	English
Publishing date	2011-08-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627636-7
ISSN	2090-6536 ; 2090-6528
ISSN (online)	2090-6536
ISSN	2090-6528
DOI	10.1155/2011/749850
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