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  1. Book ; Online ; E-Book: Diabetes and aging-related complications

    Yamagishi, Sho-ichi

    2018  

    Author's details Sho-ichi Yamagishi editor
    Keywords Medicine ; Diabetes ; Metabolic diseases ; Geriatrics
    Subject code 616.462 ; 616.46
    Language English
    Size 1 Online-Ressource (viii, 212 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019619011
    ISBN 978-981-10-4376-5 ; 9789811043758 ; 981-10-4376-0 ; 9811043752
    DOI 10.1007/978-981-10-4376-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A Clinical Case of Probable Sitosterolemia.

    Terasaki, Michishige / Izumi, Mikiko / Yamagishi, Sho-Ichi

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Sitosterolemia is a rare genetic lipid disorder characterized by elevated plant sterols in the serum. A 24-year-old Japanese woman was referred to our hospital due to a high serum low-density lipoprotein cholesterol (LDL-C) level of 332 mg/dL. At first, ... ...

    Abstract Sitosterolemia is a rare genetic lipid disorder characterized by elevated plant sterols in the serum. A 24-year-old Japanese woman was referred to our hospital due to a high serum low-density lipoprotein cholesterol (LDL-C) level of 332 mg/dL. At first, she was suspected to suffer from familial hypercholesterolemia, and thus received lipid-lowering agents. Although her LDL-C level remained high (220 mg/dL) with diet therapy plus 10 mg/day rosuvastatin, it was drastically decreased to 46 mg/dL with the addition of 10 mg/day ezetimibe. Finally, her LDL-C level was well-controlled at about 70 mg/dL with 10 mg/day ezetimibe alone. Furthermore, while her serum sitosterol level was elevated at 10.5 μg/mL during the first visit to our hospital, it decreased to 3.6 μg/mL with the 10 mg/day ezetimibe treatment alone. These observations suggest that she might probably suffer from sitosterolemia. Therefore, targeted gene sequencing analysis was performed using custom panels focusing on the exome regions of 21 lipid-associated genes, including
    MeSH term(s) Humans ; Female ; Young Adult ; Adult ; Proprotein Convertase 9 ; Cholesterol, LDL ; ATP Binding Cassette Transporter, Subfamily G, Member 5/genetics ; Lipid Metabolism, Inborn Errors/diagnosis ; Lipid Metabolism, Inborn Errors/drug therapy ; Lipid Metabolism, Inborn Errors/genetics ; Phytosterols/adverse effects ; Phytosterols/genetics ; Ezetimibe/therapeutic use ; Hyperlipoproteinemia Type II/genetics ; Hypercholesterolemia ; Intestinal Diseases
    Chemical Substances PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Cholesterol, LDL ; ATP Binding Cassette Transporter, Subfamily G, Member 5 ; Phytosterols ; Ezetimibe (EOR26LQQ24)
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031535
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  3. Article ; Online: Concerns about clinical efficacy and safety of warfarin in diabetic patients with atrial fibrillation.

    Yamagishi, Sho-Ichi

    Cardiovascular diabetology

    2019  Volume 18, Issue 1, Page(s) 12

    Abstract: Atrial fibrillation (AF) is one of the most common arrhythmias in elderly people. The risk of thromboembolic stroke is increased in AF patients, especially those with diabetes. Anticoagulant therapy, such as warfarin and non-vitamin K oral anticoagulants ...

    Abstract Atrial fibrillation (AF) is one of the most common arrhythmias in elderly people. The risk of thromboembolic stroke is increased in AF patients, especially those with diabetes. Anticoagulant therapy, such as warfarin and non-vitamin K oral anticoagulants (NOACs), is recommended for diabetic patients with AF. However, recent guidelines do not preferentially recommend NOACs over warfarin for diabetic patients. Variability of glycemic control in diabetic patients could affect the pharmacokinetics and anticoagulant activity of warfarin, therefore, the risk-benefit balance of warfarin is prone to be compromised in diabetic patients with AF. Furthermore, since warfarin inhibits the vitamin K-dependent gamma-glutamyl carboxylation of proteins, including osteocalcin and matrix Gla protein, use of warfarin may increase the risk of osteoporotic bone fracture and vascular calcification, both of which are the leading causes of morbidity that diminish the quality of life in diabetic patients. Even though the cost of NOACs is high, NOACs may be preferable to warfarin for the treatment of diabetic patients with AF.
    MeSH term(s) Administration, Oral ; Age Factors ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/pharmacokinetics ; Atrial Fibrillation/blood ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Blood Coagulation/drug effects ; Clinical Decision-Making ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Male ; Osteoporotic Fractures/chemically induced ; Osteoporotic Fractures/epidemiology ; Risk Assessment ; Risk Factors ; Stroke/blood ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/prevention & control ; Thromboembolism/blood ; Thromboembolism/diagnosis ; Thromboembolism/epidemiology ; Thromboembolism/prevention & control ; Treatment Outcome ; Vascular Calcification/chemically induced ; Vascular Calcification/epidemiology ; Warfarin/administration & dosage ; Warfarin/adverse effects ; Warfarin/pharmacokinetics
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2019-01-28
    Publishing country England
    Document type Journal Article
    ISSN 1475-2840
    ISSN (online) 1475-2840
    DOI 10.1186/s12933-019-0818-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of Advanced Glycation Endproduct (AGE)-Receptor for Advanced Glycation Endproduct (RAGE) Axis in Cardiovascular Disease and Its Therapeutic Intervention.

    Yamagishi, Sho-Ichi

    Circulation journal : official journal of the Japanese Circulation Society

    2019  Volume 83, Issue 9, Page(s) 1822–1828

    Abstract: Despite the early loss of glycemic differences between the original intensive therapy group and conventional treatment in the DCCT/EDIC and UKPDS 80 trials, a continued reduction in microvascular risk and risk reductions for emergency myocardial ... ...

    Abstract Despite the early loss of glycemic differences between the original intensive therapy group and conventional treatment in the DCCT/EDIC and UKPDS 80 trials, a continued reduction in microvascular risk and risk reductions for emergency myocardial infarction and all-cause death were observed 10-30 years after the end of these trials. These observations demonstrated that so-called "metabolic memory" could cause chronic abnormalities in diabetic vessels that are not easily reversed, even by subsequent improvement in blood glucose levels, thus suggesting a long-term beneficial influence of early metabolic control; that is, legacy effects on the risk of vascular complications and death in patients with both type 1 and type 2 diabetes. Formation and accumulation of advanced glycation endproducts (AGEs) are known to progress at an accelerated rate under diabetes. Furthermore, AGEs are hardly degraded and remain for a long time in diabetic vessels even after glycemic control is improved. Therefore, AGEs could explain why former cumulative diabetic exposure could contribute to current progression of vascular complications in diabetes. Here, the clinical utility of measurement of serum and tissue accumulation levels of AGEs for evaluating the prevalence and severity of numerous types of cardiovascular disease is reviewed and novel therapeutic strategies that could target the AGE-RAGE axis in CVD are discussed.
    MeSH term(s) Animals ; Aptamers, Nucleotide/therapeutic use ; Blood Glucose/metabolism ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cardiovascular System/drug effects ; Cardiovascular System/metabolism ; Cardiovascular System/physiopathology ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/metabolism ; Diet, Healthy ; Glycation End Products, Advanced/antagonists & inhibitors ; Glycation End Products, Advanced/metabolism ; Humans ; Receptor for Advanced Glycation End Products/antagonists & inhibitors ; Receptor for Advanced Glycation End Products/metabolism ; Risk Factors ; Risk Reduction Behavior ; Signal Transduction
    Chemical Substances AGER protein, human ; Aptamers, Nucleotide ; Blood Glucose ; Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products
    Language English
    Publishing date 2019-07-30
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-19-0618
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  5. Article ; Online: Endothelial dysfunction as a common soil of lower urinary tract symptoms and cardiovascular disease.

    Yamagishi, Sho-Ichi

    International journal of cardiology

    2018  Volume 261, Page(s) 209–210

    MeSH term(s) Cardiovascular Diseases ; Humans ; Lower Urinary Tract Symptoms ; Soil ; Vascular Diseases
    Chemical Substances Soil
    Language English
    Publishing date 2018--15
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2018.03.033
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  6. Article ; Online: Are Finger Skin Fluorophores Other Than Advanced Glycation End Products (AGEs) Associated With Impaired Musculoskeletal Properties?

    Yamagishi, Sho-Ichi

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2018  Volume 75, Issue 2, Page(s) 401–402

    MeSH term(s) Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products ; Skin
    Chemical Substances Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products
    Language English
    Publishing date 2018-12-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/gly280
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  7. Article ; Online: Sex disparity in cardiovascular mortality rates associated with diabetes.

    Yamagishi, Sho-Ichi

    Diabetes/metabolism research and reviews

    2018  Volume 34, Issue 8, Page(s) e3059

    MeSH term(s) Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/mortality ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/mortality ; Diabetic Angiopathies/metabolism ; Diabetic Angiopathies/mortality ; Estradiol/blood ; Estradiol/physiology ; Glycation End Products, Advanced/metabolism ; Health Status Disparities ; Humans ; Mortality ; Nitric Oxide/metabolism ; Receptor for Advanced Glycation End Products/metabolism ; Sex Factors ; Sex Ratio
    Chemical Substances Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products ; Nitric Oxide (31C4KY9ESH) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2018-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3059
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  8. Article ; Online: Clinical markers associated with glycaemic response to dipeptidyl peptidase-4 inhibitor therapy.

    Yamagishi, Sho-Ichi

    Diabetes/metabolism research and reviews

    2018  Volume 34, Issue 7, Page(s) e3024

    MeSH term(s) Animals ; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl Peptidase 4/blood ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Glycated Hemoglobin A/drug effects ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Treatment Outcome ; Vildagliptin/pharmacology ; Vildagliptin/therapeutic use
    Chemical Substances Biomarkers ; Blood Glucose ; Dipeptidyl-Peptidase IV Inhibitors ; Glycated Hemoglobin A ; Hypoglycemic Agents ; hemoglobin A1c protein, human ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Vildagliptin (I6B4B2U96P)
    Language English
    Publishing date 2018-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3024
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  9. Article ; Online: Structural Abnormality or Vascular Dysfunction? A Road to Ruin.

    Yamagishi, Sho-Ichi

    Journal of atherosclerosis and thrombosis

    2016  Volume 23, Issue 11, Page(s) 1255–1256

    MeSH term(s) Endothelium, Vascular/chemistry ; Endothelium, Vascular/pathology ; Humans ; Vascular Diseases/physiopathology
    Language English
    Publishing date 2016-11-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED047
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  10. Article: [Diabetic macrovascular complications].

    Yamagishi, Sho-ichi

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73, Issue 3, Page(s) 479–483

    Abstract: Reactive derivatives from non-enzymatic glucose-protein condensation reactions, as well as lipids and nucleic acids exposed to reducing sugars, form a heterogeneous group of irreversible adducts called "advanced glycation end products(AGEs)". The ... ...

    Abstract Reactive derivatives from non-enzymatic glucose-protein condensation reactions, as well as lipids and nucleic acids exposed to reducing sugars, form a heterogeneous group of irreversible adducts called "advanced glycation end products(AGEs)". The formation and accumulation of AGEs have been known to progress at an accelerated rate under diabetes. There is accumulating evidence that AGEs and their receptor (RAGE) interaction elicits oxidative stress generation and subsequently evokes inflammatory and thrombogenic reactions, thereby being involved in vascular complications in diabetes. We, along with others, have recently found that pigment epithelium-derived factor(PEDF), a glycoprotein that belongs to the superfamily of serine protease inhibitors, has neuroprotective, anti-angiogenic, anti-oxidative, and anti-inflammatory properties both in cell culture and animal models. In this review, we discuss the role of AGE-RAGE axis in diabetic macroangiopathy and its therapeutic intervention by PEDF.
    MeSH term(s) Diabetic Angiopathies/drug therapy ; Diabetic Angiopathies/etiology ; Glycation End Products, Advanced/metabolism ; Humans
    Chemical Substances Glycation End Products, Advanced
    Language Japanese
    Publishing date 2015-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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