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  1. Article: Bases moléculaires de l'adhérence des globules rouges à l'endothélium.

    Wautier, J-L / Wautier, M-P

    Annales pharmaceutiques francaises

    2011  Volume 69, Issue 1, Page(s) 3–6

    Abstract: The extent of red blood cell adhesion is correlated with the incidence of vascular complications and the severity of the disease. Patients with sickle cell anemia (HbSS) experience vasoocclusive episodes. The adhesion of RBCs from HbSS patients is ... ...

    Title translation Molecular basis of red blood cell adhesion to endothelium.
    Abstract The extent of red blood cell adhesion is correlated with the incidence of vascular complications and the severity of the disease. Patients with sickle cell anemia (HbSS) experience vasoocclusive episodes. The adhesion of RBCs from HbSS patients is increased and related to VLA-4 exposure, which binds to vascular cell adhesion molecule (VCAM-1). Inter Cellular Adhesion Molecule (ICAM-1), CD31, CD36 and glycans are potential receptors for PfEMP1 of RBCs parasited by plasmodium falciparum. The incidence of vascular complications is very high in patients with diabetes mellitus. RBC adhesion is increased and statistically correlated with the severity of the angiopathy. Glycation of RBC membrane proteins is responsible for binding to the receptor for advanced glycation end products (RAGE). Polycythemia Vera (PV) is the most frequent myeloproliferative disorder and characterized by a high occurrence of thrombosis of mesenteric and cerebral vessels. PV is due to a mutation of the Janus kinase 2 (JAK2 V617F). This mutation stimulates erythropoiesis and is the cause of Lu/BCAM (CD239) phosphorylation, which potentiated the interaction with laminin alpha 5. The couple laminin alpha 5 endothelial and phosphorylated Lu/BCAM explained the increased adhesion of RBCs from patients PV to endothelium.
    MeSH term(s) Anemia, Sickle Cell/blood ; Animals ; Cell Adhesion/physiology ; Diabetes Mellitus/blood ; Endothelium, Vascular/physiology ; Erythrocytes/physiology ; Humans ; Malaria, Falciparum/blood ; Polycythemia Vera/blood ; Vascular Diseases/etiology
    Language French
    Publishing date 2011-01
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 307-4
    ISSN 0003-4509
    ISSN 0003-4509
    DOI 10.1016/j.pharma.2010.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Les produits de glycation avancée : un risque pour la santé humaine.

    Wautier, M-P / Tessier, F J / Wautier, J-L

    Annales pharmaceutiques francaises

    2014  Volume 72, Issue 6, Page(s) 400–408

    Abstract: Advanced glycation end products (AGE) result from a chemical reaction between the carbonyl group of reducing sugar and the nucleophilic NH2 of a free amino acid or a protein; lysine and arginine being the main reactive amino acids on proteins. Following ... ...

    Title translation Advanced glycation end products: A risk factor for human health.
    Abstract Advanced glycation end products (AGE) result from a chemical reaction between the carbonyl group of reducing sugar and the nucleophilic NH2 of a free amino acid or a protein; lysine and arginine being the main reactive amino acids on proteins. Following this first step, a molecular rearrangement occurs, rearrangement of Amadori resulting to the formation of Maillard products. Glycation can cause the clouding of the lens by inducing reactions crosslinking proteins. Specialized receptors (RAGE, Galectin 3…) bind AGE. The binding to the receptor causes the formation of free radicals, which have a deleterious effect because they are powerful oxidizing agents, but also play the role of intracellular messenger, altering the cell functions. This is especially true at the level of endothelial cells: the attachment of AGE to RAGE receptor causes an increase in vascular permeability. AGE binding to endothelium RAGE and to monocytes-macrophages, led to the production of cytokines, growth factors, to the expression of adhesion molecules, and the production of procoagulant activity. Diabetic retinopathy is related to excessive secretion of vascular growth factor (vascular endothelial growth factor [VEGF]). AGE-RAGE receptor binding causes the synthesis and secretion of VEGF. Increased permeability, facilitation of leukocyte migration, the production of reactive oxygen species, cytokines and VEGF suggest that the AGE could be an element of a cascade of reactions responsible for the diabetic angiopathy and vascular damages observed during aging and chronic renal failure. Balanced diet or some drugs can limit the deleterious effect of AGE.
    MeSH term(s) Glycation End Products, Advanced/genetics ; Glycation End Products, Advanced/metabolism ; Glycation End Products, Advanced/physiology ; Humans ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/metabolism ; Risk Factors
    Chemical Substances AGER protein, human ; Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products
    Language French
    Publishing date 2014-11
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 307-4
    ISSN 0003-4509
    ISSN 0003-4509
    DOI 10.1016/j.pharma.2014.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Le sens de la médecine, ou, La révolution culturelle dans le système de santé

    Wautier, J.-L

    (Éthique et pratique médicales)

    2013  

    Title variant Révolution culturelle dans le système de santé
    Author's details Jean-Luc Wautier ; avec la collaboration de Marie-Paule Wautier
    Series title Éthique et pratique médicales
    MeSH term(s) Clinical Medicine/trends ; Sociology, Medical
    Language French
    Size 164 p. :, ill., ports. ;, 22 cm.
    Publisher L'Harmattan
    Publishing place Paris
    Document type Book
    ISBN 9782343016122 ; 2343016127
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article: Indications des transfusions de produits sanguins labiles.

    Wautier, J-L

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2005  Volume 12, Issue 1, Page(s) 56–58

    Abstract: ... administered with prophylaxis when the platelet count is lower than 10 g/L. Fresh frozen plasma has now ...

    Title translation Indications for transfusions of labile blood products.
    Abstract Indications for transfusions of red blood cells (RBC) are anemias, which can occur after trauma, in surgery, in obstetrics or oncohematology wards. The main criteria to administer RBC transfusion are hemoglobin level and clinical features. Transfusions are rare when the hemoglobin level is above 10 g/dL and are frequent when it is below 6 g/dL. However clinical setting, patient age, associated diseases, cardiovascular complications are taken into account. Immunocompatibility should always be tested and the transfusion consequences checked immediately and on the long term. Platelet transfusions are performed when the platelet count is low and patients suffered from hemorrhage. In oncohematology patients, platelet transfusion are administered with prophylaxis when the platelet count is lower than 10 g/L. Fresh frozen plasma has now a limited use, only in complex haemostatic disorders and in hemolytic uremic syndrome.
    MeSH term(s) Adolescent ; Adult ; Anemia/blood ; Anemia/therapy ; Blood Loss, Surgical ; Child ; Child, Preschool ; Erythrocyte Transfusion/standards ; Female ; Genetic Diseases, Inborn/blood ; Genetic Diseases, Inborn/therapy ; Hematocrit ; Hemoglobins/analysis ; Hemorrhage/blood ; Hemorrhage/therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Plasma ; Platelet Count ; Platelet Transfusion/standards ; Postoperative Complications/therapy ; Pregnancy ; Pregnancy Complications/therapy ; Thrombocytopenia/blood ; Thrombocytopenia/therapy
    Chemical Substances Hemoglobins
    Language French
    Publishing date 2005-02
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/j.tracli.2004.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 308: Show issues

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  5. Article: Endothelial cells in culture: a model to study in vitro vascular toxicity.

    Chappey, O / Wautier, M P / Wautier, J L

    Toxicology in vitro : an international journal published in association with BIBRA

    2010  Volume 9, Issue 4, Page(s) 411–419

    Abstract: This review discusses the importance of cultured endothelial cells in the evaluation of the potential toxicity of a drug and for understanding the toxic effects of some compounds on the vascular system. Vascular toxicity is observed when subjects are ... ...

    Abstract This review discusses the importance of cultured endothelial cells in the evaluation of the potential toxicity of a drug and for understanding the toxic effects of some compounds on the vascular system. Vascular toxicity is observed when subjects are exposed to chemicals present in the air or after ingestion of xenobiotics or drugs. Furthermore, some drugs can lead to side-effects owing to an alteration of endothelial cell function. Endothelial cells of human and animal origin can be cultured and several of their properties can be studied using different experimental systems. Cyclosporin and penicillamine have been shown to reduce angiogenesis in vitro, as has also been reported for monocrotaline pyrrole. Other components, such as pyrrolizidine alkaloid, were found to be cytotoxic, as demonstrated by chromium-51 or lactate dehydrogenase release. More subtle changes can be detected in peroxidation, phospholipase activity and prostacyclin production. Endothelial cells cultured to confluency can be used to measure in vitro permeability to radiolabelled inulin or albumin. Tunicamycin, an inhibitor of glycosylation, increases permeability. Xenobiotics such as lead inhibit the production of plasminogen activator (t-PA) or by disrupting the thromboxane-A(2)/prostacyclin balance, which promotes a thrombotic process.
    Language English
    Publishing date 2010-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 639064-x
    ISSN 1879-3177 ; 0887-2333
    ISSN (online) 1879-3177
    ISSN 0887-2333
    DOI 10.1016/0887-2333(95)00033-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A new dark side of the Maillard's products.

    Wautier, J L

    Diabetes & metabolism

    2003  Volume 29, Issue 1, Page(s) 86–87

    MeSH term(s) Capillary Permeability ; Diabetic Angiopathies/physiopathology ; Endothelium, Vascular/physiopathology ; Glycation End Products, Advanced/metabolism ; Humans ; Maillard Reaction ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic/metabolism
    Chemical Substances Glycation End Products, Advanced ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic
    Language English
    Publishing date 2003-02-19
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/s1262-3636(07)70013-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1267: Show issues Location:
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  7. Article: Angiopathie diabétique: modifications des fonctions hémostatiques et thrombotiques de l'endothélium.

    Wautier, J L

    Journees annuelles de diabetologie de l'Hotel-Dieu

    2002  , Page(s) 17–21

    Title translation Diabetic angiopathy: changes in hemostatic and thrombotic functions of the endothelium.
    MeSH term(s) Animals ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/physiopathology ; Endothelium, Vascular/physiopathology ; Hemostatics ; Humans ; Thromboplastin/physiology ; Thrombosis
    Chemical Substances Hemostatics ; Thromboplastin (9035-58-9)
    Language French
    Publishing date 2002
    Publishing country France
    Document type Journal Article
    ZDB-ID 603984-4
    ISSN 0075-4439
    ISSN 0075-4439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 322: Show issues Location:
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  8. Article: Evaluation des publications scientifiques et médicales.

    Wautier, J L

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2002  Volume 9, Issue 5-6, Page(s) 359–361

    Abstract: Quality assessment of publications article is now teached during medical studies and will soon be included into the program of the internship examination. The impact factor of medical journals is frequently used to evaluate the scientific quality of an ... ...

    Title translation Evaluation of scientific and medical articles.
    Abstract Quality assessment of publications article is now teached during medical studies and will soon be included into the program of the internship examination. The impact factor of medical journals is frequently used to evaluate the scientific quality of an article and consequently as an index of scientific productivity. Impact factor is an indicator of citation but not of the quality of an article and should not be used as a unique criterion for evaluating the quality of medical or scientific research works.
    MeSH term(s) Curriculum ; Education, Medical ; France ; Humans ; Periodicals as Topic/standards ; Publishing/standards ; Science/standards ; Writing/standards
    Language French
    Publishing date 2002-12-29
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/s1246-7820(02)00264-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Les facteurs de croissance hématopoïétique et les effets secondaires.

    Wautier, J L

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2001  Volume 8, Issue 5, Page(s) 401–402

    Title translation Hematopoietic growth factors and their side effects.
    MeSH term(s) Cardiovascular Diseases/chemically induced ; Hematopoietic Cell Growth Factors/adverse effects ; Hematopoietic Cell Growth Factors/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunologic Deficiency Syndromes/chemically induced ; Recombinant Proteins/adverse effects ; Recombinant Proteins/therapeutic use
    Chemical Substances Hematopoietic Cell Growth Factors ; Recombinant Proteins
    Language French
    Publishing date 2001-11-14
    Publishing country France
    Document type Editorial
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/s1246-7820(01)00195-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Produits de glycation avancée ou glycotoxines: des oubliés de la diététique?

    Wautier, J L

    La Revue du praticien

    2001  Volume 51, Issue 13, Page(s) 1397–1399

    Title translation Advanced glycosylation end products or glycotoxins: under-evaluated components of diet?.
    MeSH term(s) Aged ; Animals ; Diabetes Mellitus/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diet/adverse effects ; Enzyme-Linked Immunosorbent Assay ; Food Analysis ; Glycation End Products, Advanced/analysis ; Glycation End Products, Advanced/metabolism ; Glycation End Products, Advanced/toxicity ; Glycosylation ; Humans ; Kidney Failure, Chronic/metabolism ; Mice ; Rabbits ; Rats ; Research ; Risk Factors ; Time Factors
    Chemical Substances Glycation End Products, Advanced
    Language French
    Publishing date 2001-09-01
    Publishing country France
    Document type Comparative Study ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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