LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 147

Search options

  1. Book ; Thesis: Kandidatengen- und Mutationsanalyse bei diabetischer Nephropathie

    Halama, Niels

    2005  

    Author's details vorgelegt von Niels Halama
    Language German
    Size 79 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2005
    HBZ-ID HT014648104
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 226 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Bowel inflammation in cancer patients: the microbiome, antibiotics and interleukin-9.

    Halama, Niels

    British journal of cancer

    2020  Volume 123, Issue 10, Page(s) 1469–1470

    Abstract: Microbiome composition can impact disease courses and also immunotherapy outcomes in solid tumours. It is still unclear how the microbiome might impact treatments in oncology, but also how modulation via antibiotics might interfere. Elegant work now ... ...

    Abstract Microbiome composition can impact disease courses and also immunotherapy outcomes in solid tumours. It is still unclear how the microbiome might impact treatments in oncology, but also how modulation via antibiotics might interfere. Elegant work now identified interleukin-9 and dysbiosis as relevant factors, providing some answers for these questions.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cell Differentiation ; Dysbiosis/chemically induced ; Dysbiosis/drug therapy ; Gastrointestinal Microbiome ; Humans ; Inflammation/drug therapy ; Interleukin-9 ; Microbiota ; Neoplasms/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Interleukin-9
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-01030-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Machine learning for tissue diagnostics in oncology: brave new world.

    Halama, Niels

    British journal of cancer

    2019  Volume 121, Issue 6, Page(s) 431–433

    Abstract: Machine learning is an exciting technology with broad application in big data analysis, as well as increasingly in specialised healthcare. As a diagnostic tool in tissue workup and pathology, it has the potential for personalised and stratified ... ...

    Abstract Machine learning is an exciting technology with broad application in big data analysis, as well as increasingly in specialised healthcare. As a diagnostic tool in tissue workup and pathology, it has the potential for personalised and stratified approaches, but the limitations and pitfalls need to be better understood and characterised especially in this critical area of medical care.
    MeSH term(s) Algorithms ; Humans ; Image Interpretation, Computer-Assisted/methods ; Machine Learning ; Medical Oncology ; Neoplasms/diagnosis ; Pathology, Clinical ; Prognosis
    Language English
    Publishing date 2019-08-09
    Publishing country England
    Document type Editorial
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-019-0535-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Macrophage repolarisation therapy in colorectal cancer.

    Halama, Niels

    ESMO open

    2018  Volume 3, Issue 5, Page(s) e000426

    Language English
    Publishing date 2018-08-03
    Publishing country England
    Document type Journal Article
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2018-000426
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: The next age of immunotherapy: optimisation, stratification and therapeutic synergies.

    Halama, Niels

    British journal of cancer

    2018  Volume 120, Issue 1, Page(s) 1–2

    Abstract: Cancer immunotherapy has entered a phase of broad application in the treatment of patients with haematologic and solid tumours. From first steps to standard of care, immunotherapy has established its utility and applicability across different cancer ... ...

    Abstract Cancer immunotherapy has entered a phase of broad application in the treatment of patients with haematologic and solid tumours. From first steps to standard of care, immunotherapy has established its utility and applicability across different cancer types. Now it must demonstrate its higher potential in more personalised and stratified approaches.
    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/epidemiology ; Neoplasms/immunology ; Neoplasms/therapy ; Precision Medicine
    Language English
    Publishing date 2018-11-09
    Publishing country England
    Document type Editorial
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-018-0330-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Online ; E-Book: Computational topology for biomedical image and data analysis

    Rojas-Moraleda, Rodrigo / Valous, Nektarios A. / Xiong, Wei / Halama, Niels

    theory and applications

    (Focus series in medical physics and biomedical engineering series)

    2020  

    Abstract: Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Dedication -- Contents -- Series Preface -- Foreword -- Preface -- Contributors -- Authors -- Section I: Theoretical foundations -- Chapter 1: Elements of topology and homology -- 1.1 ... ...

    Author's details Rodrigo Rojas Moraleda, Nektarios A. Valous, Wei Xiong, Niels Halama
    Series title Focus series in medical physics and biomedical engineering series
    Abstract Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Dedication -- Contents -- Series Preface -- Foreword -- Preface -- Contributors -- Authors -- Section I: Theoretical foundations -- Chapter 1: Elements of topology and homology -- 1.1 ELEMENTS OF GROUP THEORY -- 1.1.1 Set -- 1.1.2 Group -- 1.1.3 Ring and field -- 1.1.4 Homomorphism -- 1.1.5 Modular arithmetic -- 1.2 TOPOLOGICAL SPACES -- 1.2.1 Connected topological spaces -- 1.2.2 Continuity and continuous maps -- 1.3 METRIC SPACES -- 1.3.1 Topology in a metric space -- 1.4 ELEMENTS OF AFFINE VECTOR SPACES -- 1.4.1 Affine vector space A -- 1.5 SIMPLICIAL COMPLEXES -- 1.5.1 Geometric simplicial complexes -- 1.5.2 Oriented simplicial complexes -- 1.5.3 Unoriented simplicial complexes -- 1.5.4 Abstract simplicial complexes -- 1.6 HOMOLOGY -- 1.6.1 Homology of oriented simplicial complexes -- 1.6.2 Homology of unoriented simplicial complexes -- 1.6.3 Homology of abstract simplicial complexes -- 1.7 CHAPTER FIGURES -- Chapter 2: Persistent homology of images -- 2.1 INTRODUCTION -- 2.2 DIGITAL IMAGES -- 2.3 A NEIGHBORHOOD SYSTEM FOR IMAGES -- 2.3.1 Spatial-based neighborhood -- 2.3.2 Intensity-based neighborhood -- 2.4 COMPUTING HOMOLOGY FROM IMAGES -- 2.4.1 The digital image function ɸ -- 2.4.2 Projected umbra -- 2.4.3 Inclusion tree of umbra projections -- 2.4.4 Algorithms for computing homology -- 2.4.5 Construction of abstract simplicial complexes -- 2.5 PERSISTENT HOMOLOGY -- 2.5.1 Filtration -- 2.5.2 Persistence -- 2.5.3 Computation of persistent homology -- 2.5.4 Persistence diagram -- 2.6 COMPUTATIONAL COST -- 2.7 CHAPTER FIGURES -- Section II: Case studies -- Chapter 3: Recognizing noise -- 3.1 SYNTHETIC IMAGES -- 3.2 WORKFLOW -- 3.3 RESULTS -- 3.4 CHAPTER FIGURES -- Chapter 4: Image segmentation -- 4.1 INTRODUCTION -- 4.2 MATERIALS AND IMAGE ACQUISITION -- 4.3 FEATURE SPACE.
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (139 Seiten)
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020211114
    ISBN 978-0-429-81099-2 ; 9781138336346 ; 0-429-81099-7 ; 1138336343
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Analysis of an Unselected Patient Cohort With Advanced Colorectal Carcinoma from a Maximum Care Center.

    Zhang, Xin-Wen / Mohr, Jutta / Halama, Niels / Koschny, Ronald

    Anticancer research

    2023  Volume 43, Issue 12, Page(s) 5589–5596

    Abstract: Background/aim: Systemic treatment for metastatic colorectal cancer (CRC) includes chemotherapy in combination with a targeted antibody. Novel targeted therapies and immunotherapies are introduced for specific molecular subgroups. Prognostic relevant ... ...

    Abstract Background/aim: Systemic treatment for metastatic colorectal cancer (CRC) includes chemotherapy in combination with a targeted antibody. Novel targeted therapies and immunotherapies are introduced for specific molecular subgroups. Prognostic relevant determinants are still under investigation.
    Patients and methods: Systemic therapies of an unselected patient cohort with metastatic CRC were retrospectively analyzed. Treatment outcome was evaluated according to time-to-next-treatment (TTNT) and frequency of conversion surgery and compared between subgroups stratified by primary tumor side, molecular profile, sex and age, and metastases sites.
    Results: More than 50% of patients with locally advanced or metastatic CRC underwent secondary resection after first-line systemic therapy. Rectum carcinoma had the best prognosis under anti-EGFR-antibody treatment. Female patients had a worse prognosis than male patients in late disease stage. Young patients demonstrated poor response to systemic therapy, but a high rate of conversion surgeries. Conversely, elderly patients benefited from systemic therapy but underwent surgery less frequently. Liver and lung metastases had a worse prognosis than other metastases sites, whereas lung metastases were more likely to be resected than liver metastases in early disease stage.
    Conclusion: Patient age, sex, primary tumor localization, and metastatic sites are prognostic factors that could guide future treatment decisions for the therapy of metastatic CRC.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Retrospective Studies ; Colorectal Neoplasms/pathology ; Colonic Neoplasms/pathology ; Rectal Neoplasms/therapy ; Rectal Neoplasms/pathology ; Prognosis ; Lung Neoplasms/drug therapy ; Liver Neoplasms/secondary
    Language English
    Publishing date 2023-11-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16761
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: FOLFOX plus cetuximab in first-line therapy of advanced colorectal cancer.

    Ehrenberg, Roland / Halama, Niels

    Annals of translational medicine

    2019  Volume 6, Issue Suppl 2, Page(s) S96

    Language English
    Publishing date 2019-01-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.11.22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Tertiary Lymphoid Structures in Colorectal Cancer Liver Metastases: Association With Immunological and Clinical Parameters and Chemotherapy Response.

    Ahmed, Azaz / Halama, Niels

    Anticancer research

    2020  Volume 40, Issue 11, Page(s) 6367–6373

    Abstract: Background/aim: The presence of TLS (tertiary lymphoid structures) is detectable in the microenvironment of human cancers and linked to better patient outcomes. The role of TLS in colorectal cancer liver metastases (CRCLM) is unclear.: Patients and ... ...

    Abstract Background/aim: The presence of TLS (tertiary lymphoid structures) is detectable in the microenvironment of human cancers and linked to better patient outcomes. The role of TLS in colorectal cancer liver metastases (CRCLM) is unclear.
    Patients and methods: Medical records of patients with CRCLM were reviewed (n=33) and corresponding tissue samples (n=21) were obtained. Whole slide imaging analyses on immunohistochemical staining of immune cell infiltrates and TLS were correlated to clinical outcomes (including chemotherapy response) and other parameters.
    Results: Neither the size (p=0.6) nor the quantity (p=0.47) of TLS was associated with the clinical course. When considering spatial differences, TLS in the invasive margin (IM) were associated with progression-free survival (p=0.03), while TLS in the LM (liver metastasis) were not. Also, TLS in the IM were associated with the presence of CD3
    Conclusion: TLS in the IM are associated with good prognosis in CRCLM, but not chemotherapy response.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; CD3 Complex/immunology ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Female ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/immunology ; Liver Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Progression-Free Survival ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Tertiary Lymphoid Structures/diagnostic imaging ; Tertiary Lymphoid Structures/immunology ; Tertiary Lymphoid Structures/pathology ; Tumor Microenvironment/immunology
    Chemical Substances CD3 Complex
    Language English
    Publishing date 2020-10-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.14657
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Differential Analyses of Peripheral Blood Parameters in CCR5 Inhibition-treated Colorectal Cancer Patients Reveal Dynamic Changes Linked to Clinical Outcomes.

    Ahmed, Azaz / Halama, Niels

    Anticancer research

    2020  Volume 40, Issue 12, Page(s) 6933–6939

    Abstract: Background/aim: Chemokine receptor inhibition is an immunotherapy that modulates the innate arm of the immune system. Previous work in microsatellite-stable metastatic colorectal cancer showed an exploitive loop that could be successfully targeted via C- ...

    Abstract Background/aim: Chemokine receptor inhibition is an immunotherapy that modulates the innate arm of the immune system. Previous work in microsatellite-stable metastatic colorectal cancer showed an exploitive loop that could be successfully targeted via C-C-motive-chemokine-receptor 5 (CCR5) specific blocking, resulting in a selective anti-tumoral activation of macrophages. In the respective trial (MARACON trial, NCT01736813) the peripheral blood laboratory markers and cytokine values were measured over time. Little is known on their role as biomarkers or stratification parameters in immunotherapy trials.
    Patients and methods: Systematic analyses of key laboratory parameters are presented, highlighting specific dynamics of lymphocyte and monocyte percentages, lactate dehydrogenase as well as interleukin-6 and interleukin-8 levels as parameters of a systemic inflammatory readout.
    Results: Specific dynamical changes of lymphocyte and monocyte compositions were noted between different patients, showing a stabilization (or increase) versus decreased numbers over time for monocytes. While lactate dehydrogenase, interleukin-6 and interleukin-8 showed almost uniformly rising levels over time, the systemic monocyte patterns prompted a further evaluation. Stabilized or increasing monocyte percentages were associated with improved overall survival (Kaplan Meier analysis, p=0.025) and with induced overt radiologic necrosis in patients.
    Conclusion: The observed association between monocyte dynamics and imaging findings as well as overall survival suggests that analyses of dynamical parameters in the peripheral blood should be implemented in immunotherapy trials.
    MeSH term(s) Aged ; Biomarkers/blood ; CCR5 Receptor Antagonists/pharmacology ; CCR5 Receptor Antagonists/therapeutic use ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Receptors, CCR5/metabolism
    Chemical Substances Biomarkers ; CCR5 Receptor Antagonists ; CCR5 protein, human ; Receptors, CCR5
    Language English
    Publishing date 2020-12-07
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.14717
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top