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  1. Article ; Online: Genetic disorders and genetic manipulation at the blood-brain barriers.

    Keep, Richard F / Jones, Hazel C / Drewes, Lester R

    Fluids and barriers of the CNS

    2023  Volume 20, Issue 1, Page(s) 29

    MeSH term(s) Blood-Brain Barrier ; Brain
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-023-00428-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A year in review: brain barriers and brain fluids research in 2022.

    Keep, Richard F / Jones, Hazel C / Hamilton, Mark G / Drewes, Lester R

    Fluids and barriers of the CNS

    2023  Volume 20, Issue 1, Page(s) 30

    Abstract: This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit ... ...

    Abstract This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers (choroid plexus and meninges), signaling within the neurovascular unit and elements of the brain fluid systems. It further discusses how brain barriers and brain fluid systems are impacted in CNS diseases, their role in disease progression and progress being made in treating such diseases.
    MeSH term(s) Blood-Brain Barrier ; Brain ; Choroid Plexus ; Cerebrospinal Fluid
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Editorial
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-023-00429-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity.

    Keep, Richard F / Jones, Hazel C / Drewes, Lester R

    Fluids and barriers of the CNS

    2022  Volume 19, Issue 1, Page(s) 48

    Abstract: This editorial highlights advances in brain barrier and brain fluid research in 2021. It covers research on components of the blood-brain barrier, neurovascular unit and brain fluid systems; how brain barriers and brain fluid systems are impacted by ... ...

    Abstract This editorial highlights advances in brain barrier and brain fluid research in 2021. It covers research on components of the blood-brain barrier, neurovascular unit and brain fluid systems; how brain barriers and brain fluid systems are impacted by neurological disorders and their role in disease progression; and advances in strategies for treating such disorders.
    MeSH term(s) Biological Transport ; Blood-Brain Barrier ; Brain ; Humans ; Nervous System Diseases
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-022-00343-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Frontiers in cerebral vascular biology

    Drewes, Lester R.

    transport and its regulation ; [proceedings of CVB '92, a Conference on Frontiers in Cerebral Vascular Biology: Transport and Its Regulation ; held July 11 - 13, 1992, in Duluth, Minnesota]

    (Advances in experimental medicine and biology ; 331)

    1993  

    Event/congress CVB (1992, DuluthMinn.)
    Author's details ed. by Lester R. Drewes
    Series title Advances in experimental medicine and biology ; 331
    Collection
    Keywords Blood-Brain Barrier / physiology / congresses ; Brain / blood supply / congresses ; Biological Transport / physiology / congresses ; Cell Communication / physiology / congresses ; Blut-Hirn-Schranke ; Gehirn ; Durchblutung
    Subject Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse
    Language English
    Size X, 295 S. : Ill., graph. Darst.
    Publisher Plenum Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT004540523
    ISBN 0-306-44416-X ; 978-0-306-44416-6
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -331- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood-brain barrier and neurovascular unit.

    Keep, Richard F / Jones, Hazel C / Drewes, Lester R

    Fluids and barriers of the CNS

    2021  Volume 18, Issue 1, Page(s) 24

    Abstract: This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid and the glymphatic system; disease states ... ...

    Abstract This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid and the glymphatic system; disease states impacting the brain barriers and brain fluids; drug delivery to the brain. This editorial also highlights the recently completed Fluids Barriers CNS thematic series entitled, 'Advances in in vitro modeling of the blood-brain barrier and neurovascular unit'. Such in vitro modeling is progressing rapidly.
    MeSH term(s) Animals ; Biomedical Research/trends ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain/metabolism ; Brain/pathology ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Choroid Plexus/metabolism ; Choroid Plexus/pathology ; Glymphatic System/metabolism ; Glymphatic System/pathology ; Humans ; Hydrocephalus/metabolism ; Hydrocephalus/pathology ; Hydrocephalus/psychology ; Mental Disorders/metabolism ; Mental Disorders/pathology ; Mental Disorders/psychology ; Neurovascular Coupling/physiology
    Language English
    Publishing date 2021-05-21
    Publishing country England
    Document type Editorial
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-021-00258-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CNS fluid and solute movement: physiology, modelling and imaging.

    Jones, Hazel C / Keep, Richard F / Drewes, Lester R

    Fluids and barriers of the CNS

    2020  Volume 17, Issue 1, Page(s) 12

    MeSH term(s) Animals ; Central Nervous System ; Cerebrospinal Fluid ; Humans ; Models, Neurological
    Language English
    Publishing date 2020-02-04
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-020-0174-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: This was the year that was: brain barriers and brain fluid research in 2019.

    Keep, Richard F / Jones, Hazel C / Drewes, Lester R

    Fluids and barriers of the CNS

    2020  Volume 17, Issue 1, Page(s) 20

    Abstract: This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and pressing needs. Topics include recent advances related to: the cerebral endothelium and the neurovascular unit; ...

    Abstract This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and pressing needs. Topics include recent advances related to: the cerebral endothelium and the neurovascular unit; the choroid plexus, arachnoid membrane; cerebrospinal fluid and the glymphatic hypothesis; the impact of disease states on brain barriers and brain fluids; drug delivery to the brain; and translation of preclinical data to the clinic. This editorial also mourns the loss of two important figures in the field, Malcolm B. Segal and Edward G. Stopa.
    MeSH term(s) Animals ; Blood-Brain Barrier/physiology ; Brain/metabolism ; Brain/physiology ; Brain Diseases/metabolism ; Brain Diseases/physiopathology ; Cerebrospinal Fluid ; Glymphatic System/physiology ; Humans
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Editorial
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-020-00181-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Frizzled fissure to improve central nervous system drug delivery?

    Drewes, Lester R

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2014  Volume 34, Issue 8, Page(s) 1257

    Abstract: Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a ... ...

    Abstract Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a major efflux transporter, is controlled by non-canonical Wnt signaling. Inhibition of this pathway leads to downregulation of P-glycoprotein and increased transcellular drug transport and reveals a potential strategy for improving drug delivery for treatment of neurologic diseases.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; Blood-Brain Barrier/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Humans ; Wnt Signaling Pathway ; beta Catenin/metabolism ; rho-Associated Kinases/metabolism ; rhoA GTP-Binding Protein/metabolism
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; beta Catenin ; RHOA protein, human (124671-05-2) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; rhoA GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2014-06-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1038/jcbfm.2014.98
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Brain Endothelial Cells: Metabolic Flux and Energy Metabolism.

    McDonald, Cade J / Blankenheim, Zachery J / Drewes, Lester R

    Handbook of experimental pharmacology

    2021  Volume 273, Page(s) 59–79

    Abstract: The neurovascular unit (NVU) consists of multiple cell types including brain endothelial cells, pericytes, astrocytes, and neurons that function collectively to maintain homeostasis within the CNS microenvironment. As the principal barrier-forming ... ...

    Abstract The neurovascular unit (NVU) consists of multiple cell types including brain endothelial cells, pericytes, astrocytes, and neurons that function collectively to maintain homeostasis within the CNS microenvironment. As the principal barrier-forming component of the NVU, the endothelial cells perform an array of complex functions that require substantial energy resources. The principal metabolic pathways for producing ATP are glycolysis and mitochondrial oxidative phosphorylation. While previous studies have demonstrated that glycolysis is a primary pathway for most endothelial cells, details about the energy producing pathways of brain endothelial cells are not fully characterized. The contributions of glycolysis and mitochondrial respiration to energy metabolism are quantifiable using metabolic flux analysis that measures cellular oxygen consumption and acidification (proton production) in a closed microtiter plate format. ATP production rates are then calculated. The bioenergetics of the human brain microvascular endothelial cell line, hCMEC/D3, indicate that these cells exhibit relatively elevated rates of glycolytic flux and glycolytic ATP production, thus confirming their glycolytic nature even in the presence of abundant oxygen. Furthermore, energy producing pathways involving mitochondrial respiration are relatively low, although contributing significantly to total ATP production. Interestingly, the bioenergetics of the hCMEC/D3 cells are relatively similar to those of human primary brain microvascular endothelial cells (hBVECs). These findings allow a quantitative understanding of the bioenergetics of brain endothelial cells in a cultured and proliferative state and also provide a platform for comparative studies of disease states and conditions involving exposures to drugs or metabolic disruptors.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Brain/metabolism ; Endothelial Cells/metabolism ; Energy Metabolism ; Glycolysis ; Humans
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2021-07-06
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  10. Article ; Online: The year in review: progress in brain barriers and brain fluid research in 2018.

    Keep, Richard F / Jones, Hazel C / Drewes, Lester R

    Fluids and barriers of the CNS

    2019  Volume 16, Issue 1, Page(s) 4

    Abstract: This editorial focuses on the progress made in brain barrier and brain fluid research in 2018. It highlights some recent advances in knowledge and techniques, as well as prevalent themes and controversies. Areas covered include: modeling, the brain ... ...

    Abstract This editorial focuses on the progress made in brain barrier and brain fluid research in 2018. It highlights some recent advances in knowledge and techniques, as well as prevalent themes and controversies. Areas covered include: modeling, the brain endothelium, the neurovascular unit, the blood-CSF barrier and CSF, drug delivery, fluid movement within the brain, the impact of disease states, and heterogeneity.
    MeSH term(s) Animals ; Blood-Brain Barrier ; Drug Delivery Systems ; Humans ; Hydrodynamics ; Models, Neurological ; Neurovascular Coupling
    Language English
    Publishing date 2019-02-05
    Publishing country England
    Document type Editorial
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-019-0124-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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