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  1. Article ; Online: The effect of environmental changes on locust outbreak dynamics in the downstream area of the Yellow River during the Ming and Qing Dynasties.

    Wang, Xingxing / Li, Gang / Wang, Shuo / Feng, Chenxi / Xu, Wei / Nie, Qifan / Liu, Qian

    The Science of the total environment

    2023  Volume 877, Page(s) 162921

    Abstract: ... data from the Ming and Qing Dynasties, the temporal and spatial relationships between the changes ...

    Abstract Locust outbreaks were one of the primary biological disasters in ancient China. Using historical data from the Ming and Qing Dynasties, the temporal and spatial relationships between the changes in the aquatic environment and the locust dynamics in the downstream areas of the Yellow River were investigated via quantitative statistics, and other factors affecting locust outbreaks were also studied. This study demonstrated that locust, drought and flood outbreaks were spatiotemporally correlated. Locusts and droughts were synchronous for long-term series, but locust outbreaks were weakly correlated with floods. In drought years, the probability of a locust outbreak occurring in the same month as a drought was higher than that in other years and months. The probability of a locust outbreak was higher in the one to two years following a flood than in other years, but locusts were not easily triggered by extreme flooding. In the waterlogged and riverine locust breeding areas, locust outbreaks were more closely related to flooding and drought than in other breeding areas. Affected by the diversion of the Yellow River, the areas of frequent locust outbreaks were around riverine areas. In addition, climate change affects the hydrothermal conditions in which locusts occur, and human activities influence the occurrence of locusts by changing their habitats. Analyzing the relationship between historical locust outbreaks and water system changes provides valuable information for formulating and implementing disaster prevention and mitigation policies in this region.
    MeSH term(s) Animals ; Humans ; Grasshoppers ; Disasters ; Floods ; Disease Outbreaks ; China/epidemiology
    Language English
    Publishing date 2023-03-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: River system changes and locust breeding area evolution in the Qin-Jin region of the Yellow River Basin during the Ming and Qing dynasties and their disaster effects.

    Wang, Shuo / Li, Gang / Feng, Chenxi / Xu, Wei / Wang, Xingxing / Nie, Qifan / Gao, Xing / Liu, Qian

    The Science of the total environment

    2023  Volume 880, Page(s) 163220

    Abstract: ... events in the Qin-Jin region of the Yellow River Basin during the Ming and Qing dynasties (1368-1911 CE ... in the Qin-Jin region of the Yellow River basin during the Ming and Qing dynasties were concentrated ...

    Abstract Based on the locust outbreak records in historical documents, we extracted 654 locust outbreak events in the Qin-Jin region of the Yellow River Basin during the Ming and Qing dynasties (1368-1911 CE), reconstructed the locust disaster index series according to the severity of locust plagues, and compared them with the flood, drought, famine and river disasters in the same period. The objective was to investigate the process of river system changes in the Qin-Jin region of the Yellow River Basin, their relationship with the evolution of the locust breeding area and disaster effects. The results indicate that locust outbreaks in the Qin-Jin region of the Yellow River basin during the Ming and Qing dynasties were concentrated in the summer and autumn, with disaster grades 2 and 3 predominating. The interannual series of locust outbreaks showed "one peak (1644-1650 CE) and four mounds (1527-1537 CE, 1613-1620 CE, 1690-1704 CE, and 1854-1864 CE)". On the 10-year scale, locust outbreaks were positively correlated with famine and moderately associated with drought and river clearing. The spatial distribution of locust-prone areas corresponded well with drought and famine. The locust breeding areas in the Qin-Jin region were dominated by river flooding locust breeding areas, where topographic factors and river changes more influenced locust distribution. The DPSIR model revealed that potential climatic, locust, and demographic "drivers" exerted "pressure" on the Qin-Jin region of the Yellow River Basin, causing changes in the social, economic and environmental "state" of the locust-prone areas, which in turn "impact" people's livelihoods and ultimately led to a series of central-local-populace "responses".
    MeSH term(s) Humans ; Animals ; Rivers ; Grasshoppers ; Disasters ; Floods ; Droughts ; China
    Language English
    Publishing date 2023-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.163220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: River system changes and locust breeding area evolution in the Qin-Jin region of the Yellow River Basin during the Ming and Qing dynasties and their disaster effects

    Wang, Shuo / Li, Gang / Feng, Chenxi / Xu, Wei / Wang, Xingxing / Nie, Qifan / Gao, Xing / Liu, Qian

    Science of the Total Environment. 2023 July, v. 880 p.163220-

    2023  

    Abstract: ... events in the Qin-Jin region of the Yellow River Basin during the Ming and Qing dynasties (1368–1911 CE ... in the Qin-Jin region of the Yellow River basin during the Ming and Qing dynasties were concentrated ...

    Abstract Based on the locust outbreak records in historical documents, we extracted 654 locust outbreak events in the Qin-Jin region of the Yellow River Basin during the Ming and Qing dynasties (1368–1911 CE), reconstructed the locust disaster index series according to the severity of locust plagues, and compared them with the flood, drought, famine and river disasters in the same period. The objective was to investigate the process of river system changes in the Qin-Jin region of the Yellow River Basin, their relationship with the evolution of the locust breeding area and disaster effects. The results indicate that locust outbreaks in the Qin-Jin region of the Yellow River basin during the Ming and Qing dynasties were concentrated in the summer and autumn, with disaster grades 2 and 3 predominating. The interannual series of locust outbreaks showed “one peak (1644–1650 CE) and four mounds (1527–1537 CE, 1613–1620 CE, 1690–1704 CE, and 1854–1864 CE)”. On the 10-year scale, locust outbreaks were positively correlated with famine and moderately associated with drought and river clearing. The spatial distribution of locust-prone areas corresponded well with drought and famine. The locust breeding areas in the Qin-Jin region were dominated by river flooding locust breeding areas, where topographic factors and river changes more influenced locust distribution. The DPSIR model revealed that potential climatic, locust, and demographic “drivers” exerted “pressure” on the Qin-Jin region of the Yellow River Basin, causing changes in the social, economic and environmental “state” of the locust-prone areas, which in turn “impact” people's livelihoods and ultimately led to a series of central-local-populace “responses”.
    Keywords autumn ; drought ; environment ; evolution ; famine ; models ; rivers ; summer ; topography ; watersheds ; Yellow River ; Locust plague ; River system change ; Locust breeding area ; Disaster effects ; Qin-Jin region of the Yellow River Basin ; Environmental significance
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.163220
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Drug-Drug Interactions of Newly Approved Direct-Acting Antiviral Agents in Patients with Hepatitis C.

    Gao, Lu-Hua / Nie, Qing-He / Zhao, Xi-Tai

    International journal of general medicine

    2021  Volume 14, Page(s) 289–301

    Abstract: Hepatitis C is a major health problem worldwide, frequently resulting in cirrhosis and increasing the risk of hepatocellular carcinoma significantly. In recent years, the advent of direct-acting antivirals (DAAs) has dramatically improved the therapeutic ...

    Abstract Hepatitis C is a major health problem worldwide, frequently resulting in cirrhosis and increasing the risk of hepatocellular carcinoma significantly. In recent years, the advent of direct-acting antivirals (DAAs) has dramatically improved the therapeutic outcomes in hepatitis C patients. In the last two years, several new DAA combinations have been approved for the treatment of the hepatitis C virus (HCV) infection, including elbasvir/grazoprevir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, and glecaprevir/pibrentasvir. The newly approved DAA regimens may be prescribed with other drugs simultaneously, increasing the potential of pharmacokinetic interactions. Therefore, the knowledge and management of drug-drug interactions (DDIs) with DAAs should be considered a key issue in HCV therapy. This review summarizes researches of DDIs focusing on newly approved DAAs (elbasvir, grazoprevir, velpatasvir, voxilaprevir, glecaprevir, pibrentasvir) for patients undergoing HCV treatment to provide clinical consideration for comedication. With respect to DDIs, newly approved DAA regimens, including elbasvir/grazoprevir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, and glecaprevir/pibrentasvir, are safely applicable.
    Language English
    Publishing date 2021-01-28
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S283910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Glucocorticoid therapy to improve hepatic failure status].

    Nie, Qing-he

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2012  Volume 20, Issue 6, Page(s) 414–415

    MeSH term(s) Glucocorticoids/therapeutic use ; Humans ; Liver Failure/drug therapy
    Chemical Substances Glucocorticoids
    Language Chinese
    Publishing date 2012-06
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: exFINDER: identify external communication signals using single-cell transcriptomics data.

    He, Changhan / Zhou, Peijie / Nie, Qing

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cells make decisions through their communication with other cells and receiving signals from their environment. Using single-cell transcriptomics, computational tools have been developed to infer cell-cell communication through ligands and receptors. ... ...

    Abstract Cells make decisions through their communication with other cells and receiving signals from their environment. Using single-cell transcriptomics, computational tools have been developed to infer cell-cell communication through ligands and receptors. However, the existing methods only deal with signals sent by the measured cells in the data, the received signals from the external system are missing in the inference. Here, we present exFINDER, a method that identifies such external signals received by the cells in the single-cell transcriptomics datasets by utilizing the prior knowledge of signaling pathways. In particular, exFINDER can uncover external signals that activate the given target genes, infer the external signal-target signaling network (exSigNet), and perform quantitative analysis on exSigNets. The applications of exFINDER to scRNA-seq datasets from different species demonstrate the accuracy and robustness of identifying external signals, revealing critical transition-related signaling activities, inferring critical external signals and targets, clustering signal-target paths, and evaluating relevant biological events. Overall, exFINDER can be applied to scRNA-seq data to reveal the external signal-associated activities and maybe novel cells that send such signals.
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.24.533888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: exFINDER: identify external communication signals using single-cell transcriptomics data.

    He, Changhan / Zhou, Peijie / Nie, Qing

    Nucleic acids research

    2023  Volume 51, Issue 10, Page(s) e58

    Abstract: Cells make decisions through their communication with other cells and receiving signals from their environment. Using single-cell transcriptomics, computational tools have been developed to infer cell-cell communication through ligands and receptors. ... ...

    Abstract Cells make decisions through their communication with other cells and receiving signals from their environment. Using single-cell transcriptomics, computational tools have been developed to infer cell-cell communication through ligands and receptors. However, the existing methods only deal with signals sent by the measured cells in the data, the received signals from the external system are missing in the inference. Here, we present exFINDER, a method that identifies such external signals received by the cells in the single-cell transcriptomics datasets by utilizing the prior knowledge of signaling pathways. In particular, exFINDER can uncover external signals that activate the given target genes, infer the external signal-target signaling network (exSigNet), and perform quantitative analysis on exSigNets. The applications of exFINDER to scRNA-seq datasets from different species demonstrate the accuracy and robustness of identifying external signals, revealing critical transition-related signaling activities, inferring critical external signals and targets, clustering signal-target paths, and evaluating relevant biological events. Overall, exFINDER can be applied to scRNA-seq data to reveal the external signal-associated activities and maybe novel cells that send such signals.
    MeSH term(s) Gene Expression Profiling/methods ; Sequence Analysis, RNA/methods ; Signal Transduction/genetics ; Single-Cell Analysis/methods ; Transcriptome ; Software
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prediction model of no-response before the first transarterial chemoembolization for hepatocellular carcinoma: TACF score.

    Zhong, Jia-Wei / Nie, Dan-Dan / Huang, Ji-Lan / Luo, Rong-Guang / Cheng, Qing-He / Du, Qiao-Ting / Guo, Gui-Hai / Bai, Liang-Liang / Guo, Xue-Yun / Chen, Yan / Chen, Si-Hai

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 184

    Abstract: Previous clinic models for patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) mainly focused on the overall survival, whereas a simple-to-use tool for predicting the response to the first TACE and the management ...

    Abstract Previous clinic models for patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) mainly focused on the overall survival, whereas a simple-to-use tool for predicting the response to the first TACE and the management of risk classification before TACE are lacking. Our aim was to develop a scoring system calculated manually for these patients. A total of 437 patients with hepatocellular carcinoma (HCC) who underwent TACE treatment were carefully selected for analysis. They were then randomly divided into two groups: a training group comprising 350 patients and a validation group comprising 77 patients. Furthermore, 45 HCC patients who had recently undergone TACE treatment been included in the study to validate the model's efficacy and applicability. The factors selected for the predictive model were comprehensively based on the results of the LASSO, univariate and multivariate logistic regression analyses. The discrimination, calibration ability and clinic utility of models were evaluated in both the training and validation groups. A prediction model incorporated 3 objective imaging characteristics and 2 indicators of liver function. The model showed good discrimination, with AUROCs of 0.735, 0.706 and 0.884 and in the training group and validation groups, and good calibration. The model classified the patients into three groups based on the calculated score, including low risk, median risk and high-risk groups, with rates of no response to TACE of 26.3%, 40.2% and 76.8%, respectively. We derived and validated a model for predicting the response of patients with HCC before receiving the first TACE that had adequate performance and utility. This model may be a useful and layered management tool for patients with HCC undergoing TACE.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00803-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Expression Profiles and Functional Analysis of Plasma Exosomal Circular RNAs in Acute Myocardial Infarction.

    He, Guo-Dong / Li, Jie / Nie, Zhi-Qiang / Sun, Shuo / Feng, Ying-Qing / Huang, Yu-Qing

    BioMed research international

    2022  Volume 2022, Page(s) 3458227

    Abstract: Acute myocardial infarction (AMI) is a common cardiovascular disease with high rates of morbidity and mortality globally. The dysregulation of circular RNAs (circRNAs) has been shown to be closely related to various pathological aspects of AMI. However, ... ...

    Abstract Acute myocardial infarction (AMI) is a common cardiovascular disease with high rates of morbidity and mortality globally. The dysregulation of circular RNAs (circRNAs) has been shown to be closely related to various pathological aspects of AMI. However, the function of exosomal circRNAs in AMI has yet to be investigated. The purpose of this study was to investigate the expression profiles of plasma exosomal circRNAs in AMI and explore their potential functionality. The expression profiles of plasma exosomal circRNAs in patients with AMI, stable coronary heart atherosclerotic disease (CAD), and healthy controls were obtained from a GEO expression dataset (GSE159657). We also analyzed bioinformatics functionality, potential pathways, and interaction networks related to the microRNAs associated with the differentially expressed circRNAs. A total of 253 exosomal circRNAs (184 up- and 69 down-regulated) and 182 exosomal circRNAs (94 up- and 88 down-regulated) were identified as being differentially expressed between the control group and the AMI and CAD patients, respectively. Compared with the CAD group, 231 different exosomal circRNAs (177 up- and 54 down-regulated) were identified in the AMI group. Functional analysis suggested that the parental genes of exosomal has_circ_0061776 were significantly enriched in the biological process of lysine degradation. Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway. This study identified the differential expression and functionality of exosomal circRNAs in AMI and provided further understanding of the potential pathogenesis of an exosomal circRNA-related competing endogenous RNA (ceRNA) network in AMI.
    MeSH term(s) Computational Biology ; Gene Regulatory Networks ; Humans ; Lysine/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocardial Infarction/genetics ; RNA, Circular/genetics
    Chemical Substances MIRN214 microRNA, human ; MIRN217 microRNA, human ; MicroRNAs ; RNA, Circular ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/3458227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An Alternative Calibration Method for Measuring N

    Liu, Yuan / Jia, Yongcheng / Chu, Biwu / Li, Shuying / Cao, Qing / Liu, Jun / Ma, Wei / Li, Yuanyuan / Wang, Lei / Nie, Wei / Ma, Qingxin / He, Hong

    Analytical chemistry

    2024  Volume 96, Issue 10, Page(s) 4048–4056

    Abstract: In this work, we developed an alternative calibration method for measuring ... ...

    Abstract In this work, we developed an alternative calibration method for measuring N
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c04089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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